Incidental Mutation 'IGL01073:Slfn1'
ID52231
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Slfn1
Ensembl Gene ENSMUSG00000078763
Gene Nameschlafen 1
Synonyms
Accession Numbers

MGI: 1313259

Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01073
Quality Score
Status
Chromosome11
Chromosomal Location83116849-83122670 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 83121337 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 93 (Y93F)
Ref Sequence ENSEMBL: ENSMUSP00000047782 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037994]
Predicted Effect probably benign
Transcript: ENSMUST00000037994
AA Change: Y93F

PolyPhen 2 Score 0.089 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000047782
Gene: ENSMUSG00000078763
AA Change: Y93F

DomainStartEndE-ValueType
Pfam:AlbA_2 193 325 1.1e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214874
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null mutation were normal life span. No change in thymus cellularity or alteration in the expression of a variety of cell surface markers were found. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted(3)

Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd24 A G 10: 81,639,322 D110G possibly damaging Het
Ccnd3 A G 17: 47,594,845 T104A probably benign Het
Cntnap5b A T 1: 100,076,030 D245V probably benign Het
Cryab A G 9: 50,754,555 K82R probably damaging Het
Dnmt3b G A 2: 153,670,842 probably benign Het
Eif2b5 A T 16: 20,500,296 K99* probably null Het
Fam222b A G 11: 78,154,488 I292V probably damaging Het
Itpr1 A C 6: 108,413,820 N1560T probably benign Het
Lca5 T A 9: 83,395,475 K605N probably damaging Het
Letm1 T C 5: 33,748,800 D424G possibly damaging Het
Mtif3 C A 5: 146,958,980 R99L probably damaging Het
Nrxn3 A G 12: 89,254,740 M430V probably benign Het
Olfr1226 A T 2: 89,193,137 L299Q possibly damaging Het
Pgap2 T A 7: 102,226,454 probably benign Het
Phf11c A T 14: 59,389,348 S129T probably benign Het
Ptpro A G 6: 137,377,088 N154S probably damaging Het
Rfng C T 11: 120,783,921 R81H probably benign Het
Rnf38 A G 4: 44,137,645 M280T probably benign Het
Rrp7a G A 15: 83,118,081 A185V probably benign Het
Slc22a2 C A 17: 12,584,349 F23L probably benign Het
Slc35f1 A G 10: 53,021,960 T156A probably benign Het
Snrnp200 A T 2: 127,214,912 probably benign Het
Sos1 A G 17: 80,422,747 F701S probably damaging Het
Tmem203 A C 2: 25,255,724 I19L probably benign Het
Usp8 A T 2: 126,718,114 K18N probably damaging Het
Vmn2r115 G A 17: 23,345,997 R286K probably benign Het
Vmn2r23 A C 6: 123,712,800 T212P possibly damaging Het
Other mutations in Slfn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0193:Slfn1 UTSW 11 83121843 missense probably damaging 0.99
R0414:Slfn1 UTSW 11 83121270 missense probably benign
R0736:Slfn1 UTSW 11 83121081 missense probably benign 0.07
R1398:Slfn1 UTSW 11 83121142 missense probably damaging 0.98
R1508:Slfn1 UTSW 11 83121355 missense probably damaging 1.00
R1960:Slfn1 UTSW 11 83121753 missense possibly damaging 0.89
R2207:Slfn1 UTSW 11 83121166 missense possibly damaging 0.95
R3079:Slfn1 UTSW 11 83121160 missense probably benign 0.05
R4572:Slfn1 UTSW 11 83121463 missense probably benign 0.04
R4700:Slfn1 UTSW 11 83121649 missense probably benign 0.05
R4731:Slfn1 UTSW 11 83121835 missense probably damaging 1.00
R5907:Slfn1 UTSW 11 83121176 missense possibly damaging 0.85
R5934:Slfn1 UTSW 11 83121944 nonsense probably null
R7206:Slfn1 UTSW 11 83122011 missense probably benign 0.00
R7421:Slfn1 UTSW 11 83121141 missense possibly damaging 0.94
R7711:Slfn1 UTSW 11 83121263 missense possibly damaging 0.92
R8223:Slfn1 UTSW 11 83121419 missense probably damaging 1.00
Posted On2013-06-21