Mutagenetix > Incidental Mutations

Incidental Mutation 'R6531:Ovgp1'

522330

Institutional Source

Beutler Lab

Gene Symbol

Ovgp1

Ensembl Gene

ENSMUSG00000074340

Gene Name

oviductal glycoprotein 1

Synonyms

Chit5, MOGP, muc9, mucin 9, OGP, oviductin

MMRRC Submission

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6531 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

105973711-105987423 bp(+) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to C at 105987071 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000132424 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000573] [ENSMUST00000163626]

Predicted Effect

unknown
Transcript: ENSMUST00000000573
AA Change: D720A

SMART Domains

Protein: ENSMUSP00000000573
Gene: ENSMUSG00000074340
AA Change: D720A

Domain	Start	End	E-Value	Type
low complexity region	4	13	N/A	INTRINSIC
Glyco_18	22	360	1.38e-134	SMART
low complexity region	486	515	N/A	INTRINSIC
low complexity region	533	626	N/A	INTRINSIC
low complexity region	637	648	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000092878

Predicted Effect

probably benign
Transcript: ENSMUST00000163626

SMART Domains

Protein: ENSMUSP00000132424
Gene: ENSMUSG00000074340

Domain	Start	End	E-Value	Type
Glyco_18	9	226	8.52e-21	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000167642

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.2%
20x: 90.6%

Validation Efficiency

100% (46/46)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for disruptions in this gene show no phenotypic abnormalities. Female reproduction is essentially normal. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	A	G	6: 91,949,999	E880G	possibly damaging	Het
Acsbg2	T	A	17: 56,846,617	I529F	probably damaging	Het
Ahcyl2	T	G	6: 29,886,162	M359R	probably benign	Het
Aldh5a1	G	T	13: 24,918,564	D305E	probably benign	Het
Catsper2	C	G	2: 121,399,780	V358L	possibly damaging	Het
Cd200r4	C	T	16: 44,833,505	Q222*	probably null	Het
Col4a2	T	A	8: 11,408,135	D270E	probably benign	Het
Cux1	T	C	5: 136,275,119	D1401G	probably benign	Het
Cyp3a59	T	A	5: 146,098,217	M235K	probably benign	Het
Dock3	T	C	9: 106,967,216	D895G	probably benign	Het
Dusp27	A	T	1: 166,110,046		probably null	Het
Dync1h1	T	C	12: 110,617,920	F586L	probably damaging	Het
Elmo1	G	T	13: 20,572,446	R568L	possibly damaging	Het
Epb41	T	C	4: 131,957,636	T711A	probably benign	Het
Grm7	T	A	6: 111,358,425	M599K	probably benign	Het
Hivep3	A	T	4: 120,122,876	K1704*	probably null	Het
Ighv1-62-3	C	A	12: 115,461,006	C115F	probably damaging	Het
Krt78	A	G	15: 101,952,273	Y200H	probably benign	Het
Lamb2	A	T	9: 108,483,726	H549L	possibly damaging	Het
Mroh3	A	G	1: 136,184,353	I759T	probably benign	Het
Ncbp2	CGTCTGGATG	CG	16: 31,956,343		probably null	Het
Nol6	G	T	4: 41,118,154	P828T	probably benign	Het
Olfr1030	A	G	2: 85,984,307	I156V	probably benign	Het
Olfr1132	A	G	2: 87,635,529	Y73H	probably damaging	Het
Olfr1264	A	G	2: 90,021,457	V203A	probably benign	Het
Olfr344	G	A	2: 36,569,341	V248I	probably damaging	Het
Pitpnm3	T	A	11: 72,071,487	Q230L	possibly damaging	Het
Pkn1	C	T	8: 83,670,293	V910I	probably benign	Het
Plcb1	T	A	2: 135,325,802		probably null	Het
Ppp1r12c	A	G	7: 4,482,789		probably null	Het
Rassf5	T	A	1: 131,244,814	Q106L	possibly damaging	Het
Rfc1	T	C	5: 65,312,979	K62E	possibly damaging	Het
Sf3b1	C	T	1: 55,019,395	E12K	probably damaging	Het
Slc4a1ap	A	T	5: 31,548,638	D691V	probably benign	Het
Speg	T	A	1: 75,422,757	F2283I	probably benign	Het
Synj2	A	G	17: 6,033,839	K267E	probably damaging	Het
Tg	A	T	15: 66,839,362	Y991F	probably damaging	Het
Tlk1	A	T	2: 70,742,083	D380E	probably benign	Het
Trim43b	A	T	9: 89,085,365	L405H	probably damaging	Het
Ttf2	A	G	3: 100,956,260	I586T	probably damaging	Het
Ugt2b36	T	A	5: 87,081,586	R213S	probably damaging	Het
Vmn1r198	T	A	13: 22,354,407	M21K	probably benign	Het
Wdr35	A	T	12: 8,978,685	Y101F	probably benign	Het
Zfp367	T	C	13: 64,144,250	Y189C	probably damaging	Het

Other mutations in Ovgp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00973:Ovgp1	APN	3	105981277	nonsense	probably null
IGL01152:Ovgp1	APN	3	105986172	missense	possibly damaging	0.94
IGL01458:Ovgp1	APN	3	105974991	missense	probably benign	0.01
IGL01646:Ovgp1	APN	3	105978349	missense	probably damaging	1.00
IGL01768:Ovgp1	APN	3	105981351	critical splice donor site	probably null
IGL02712:Ovgp1	APN	3	105986513	unclassified	probably benign
IGL03065:Ovgp1	APN	3	105986366	missense	probably benign	0.01
IGL03140:Ovgp1	APN	3	105979906	missense	probably damaging	1.00
IGL03272:Ovgp1	APN	3	105981325	missense	probably damaging	0.99
PIT4472001:Ovgp1	UTSW	3	105986990	missense	unknown
R0277:Ovgp1	UTSW	3	105979892	intron	probably benign
R0560:Ovgp1	UTSW	3	105986410	unclassified	probably benign
R0718:Ovgp1	UTSW	3	105974830	splice site	probably benign
R0743:Ovgp1	UTSW	3	105974932	missense	probably damaging	1.00
R1362:Ovgp1	UTSW	3	105986575	unclassified	probably benign
R1556:Ovgp1	UTSW	3	105986752	unclassified	probably benign
R1776:Ovgp1	UTSW	3	105977798	missense	possibly damaging	0.52
R1831:Ovgp1	UTSW	3	105985068	missense	probably benign	0.04
R1986:Ovgp1	UTSW	3	105974935	missense	probably damaging	1.00
R2004:Ovgp1	UTSW	3	105986993	unclassified	probably benign
R2156:Ovgp1	UTSW	3	105977717	missense	possibly damaging	0.49
R2254:Ovgp1	UTSW	3	105986912	unclassified	probably benign
R2860:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R2861:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3117:Ovgp1	UTSW	3	105986452	unclassified	probably benign
R3793:Ovgp1	UTSW	3	105980171	missense	probably benign	0.03
R3835:Ovgp1	UTSW	3	105986315	missense	probably benign	0.00
R3894:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R3894:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R3895:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986596	unclassified	probably benign
R4050:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4467:Ovgp1	UTSW	3	105977711	missense	probably benign	0.04
R4611:Ovgp1	UTSW	3	105986567	unclassified	probably benign
R4628:Ovgp1	UTSW	3	105980323	intron	probably null
R4738:Ovgp1	UTSW	3	105979918	missense	probably damaging	1.00
R4944:Ovgp1	UTSW	3	105979953	missense	possibly damaging	0.66
R5110:Ovgp1	UTSW	3	105977783	missense	probably damaging	1.00
R6540:Ovgp1	UTSW	3	105986581	nonsense	probably null
R6562:Ovgp1	UTSW	3	105980273	missense	probably damaging	1.00
R6601:Ovgp1	UTSW	3	105986431	unclassified	probably benign
R6906:Ovgp1	UTSW	3	105986873	unclassified	probably benign
R7313:Ovgp1	UTSW	3	105987071	missense	unknown
R7430:Ovgp1	UTSW	3	105986302	missense	probably damaging	0.99
R7430:Ovgp1	UTSW	3	105986303	missense	possibly damaging	0.62
R7566:Ovgp1	UTSW	3	105974310	start gained	probably benign
R7684:Ovgp1	UTSW	3	105979956	missense	probably damaging	0.99
R7805:Ovgp1	UTSW	3	105986794	missense	unknown
R7820:Ovgp1	UTSW	3	105986521	unclassified	probably benign
R8039:Ovgp1	UTSW	3	105976023	missense	probably benign	0.26
Z1177:Ovgp1	UTSW	3	105986840	missense	unknown

Predicted Primers

PCR Primer
(F):5'- GTCTGTAACCCCTACGGAGATG -3'
(R):5'- CCTCGGATTTGCCACCAATG -3'

Sequencing Primer
(F):5'- CTACGGAGATGGATACGACTCTTTTC -3'
(R):5'- CACCAATGGAGCTCATGATCTTTG -3'

Posted On

2018-06-06