Incidental Mutation 'R6531:Zfp367'
ID 522376
Institutional Source Beutler Lab
Gene Symbol Zfp367
Ensembl Gene ENSMUSG00000044934
Gene Name zinc finger protein 367
Synonyms 8030486J21Rik, ZFF29a, ZFF29b
MMRRC Submission 044657-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6531 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 64280836-64301013 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 64292064 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 189 (Y189C)
Ref Sequence ENSEMBL: ENSMUSP00000113331 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059817] [ENSMUST00000117241]
AlphaFold Q0VDT2
Predicted Effect probably damaging
Transcript: ENSMUST00000059817
AA Change: Y189C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000050854
Gene: ENSMUSG00000044934
AA Change: Y189C

DomainStartEndE-ValueType
low complexity region 5 14 N/A INTRINSIC
low complexity region 37 59 N/A INTRINSIC
low complexity region 77 94 N/A INTRINSIC
low complexity region 105 113 N/A INTRINSIC
ZnF_C2H2 157 179 3.44e-4 SMART
ZnF_C2H2 185 209 2.4e-3 SMART
coiled coil region 299 332 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000117241
AA Change: Y189C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113331
Gene: ENSMUSG00000044934
AA Change: Y189C

DomainStartEndE-ValueType
low complexity region 5 14 N/A INTRINSIC
low complexity region 37 59 N/A INTRINSIC
low complexity region 77 94 N/A INTRINSIC
low complexity region 105 113 N/A INTRINSIC
ZnF_C2H2 157 179 3.44e-4 SMART
ZnF_C2H2 185 209 2.4e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134136
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152644
Meta Mutation Damage Score 0.8626 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.2%
  • 20x: 90.6%
Validation Efficiency 100% (46/46)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A G 6: 91,926,980 (GRCm39) E880G possibly damaging Het
Acsbg2 T A 17: 57,153,617 (GRCm39) I529F probably damaging Het
Ahcyl2 T G 6: 29,886,161 (GRCm39) M359R probably benign Het
Aldh5a1 G T 13: 25,102,547 (GRCm39) D305E probably benign Het
Catsper2 C G 2: 121,230,261 (GRCm39) V358L possibly damaging Het
Cd200r4 C T 16: 44,653,868 (GRCm39) Q222* probably null Het
Col4a2 T A 8: 11,458,135 (GRCm39) D270E probably benign Het
Cux1 T C 5: 136,303,973 (GRCm39) D1401G probably benign Het
Cyp3a59 T A 5: 146,035,027 (GRCm39) M235K probably benign Het
Dock3 T C 9: 106,844,415 (GRCm39) D895G probably benign Het
Dync1h1 T C 12: 110,584,354 (GRCm39) F586L probably damaging Het
Elmo1 G T 13: 20,756,616 (GRCm39) R568L possibly damaging Het
Epb41 T C 4: 131,684,947 (GRCm39) T711A probably benign Het
Grm7 T A 6: 111,335,386 (GRCm39) M599K probably benign Het
Hivep3 A T 4: 119,980,073 (GRCm39) K1704* probably null Het
Ighv1-62-3 C A 12: 115,424,626 (GRCm39) C115F probably damaging Het
Krt78 A G 15: 101,860,708 (GRCm39) Y200H probably benign Het
Lamb2 A T 9: 108,360,925 (GRCm39) H549L possibly damaging Het
Mroh3 A G 1: 136,112,091 (GRCm39) I759T probably benign Het
Ncbp2 CGTCTGGATG CG 16: 31,775,161 (GRCm39) probably null Het
Nol6 G T 4: 41,118,154 (GRCm39) P828T probably benign Het
Or1j15 G A 2: 36,459,353 (GRCm39) V248I probably damaging Het
Or4c3 A G 2: 89,851,801 (GRCm39) V203A probably benign Het
Or5m5 A G 2: 85,814,651 (GRCm39) I156V probably benign Het
Or8w1 A G 2: 87,465,873 (GRCm39) Y73H probably damaging Het
Ovgp1 A C 3: 105,894,387 (GRCm39) probably benign Het
Pitpnm3 T A 11: 71,962,313 (GRCm39) Q230L possibly damaging Het
Pkn1 C T 8: 84,396,922 (GRCm39) V910I probably benign Het
Plcb1 T A 2: 135,167,722 (GRCm39) probably null Het
Ppp1r12c A G 7: 4,485,788 (GRCm39) probably null Het
Rassf5 T A 1: 131,172,551 (GRCm39) Q106L possibly damaging Het
Rfc1 T C 5: 65,470,322 (GRCm39) K62E possibly damaging Het
Sf3b1 C T 1: 55,058,554 (GRCm39) E12K probably damaging Het
Slc4a1ap A T 5: 31,705,982 (GRCm39) D691V probably benign Het
Speg T A 1: 75,399,401 (GRCm39) F2283I probably benign Het
Styxl2 A T 1: 165,937,615 (GRCm39) probably null Het
Synj2 A G 17: 6,084,114 (GRCm39) K267E probably damaging Het
Tg A T 15: 66,711,211 (GRCm39) Y991F probably damaging Het
Tlk1 A T 2: 70,572,427 (GRCm39) D380E probably benign Het
Trim43b A T 9: 88,967,418 (GRCm39) L405H probably damaging Het
Ttf2 A G 3: 100,863,576 (GRCm39) I586T probably damaging Het
Ugt2b36 T A 5: 87,229,445 (GRCm39) R213S probably damaging Het
Vmn1r198 T A 13: 22,538,577 (GRCm39) M21K probably benign Het
Wdr35 A T 12: 9,028,685 (GRCm39) Y101F probably benign Het
Other mutations in Zfp367
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01147:Zfp367 APN 13 64,283,253 (GRCm39) missense probably damaging 1.00
IGL03151:Zfp367 APN 13 64,293,445 (GRCm39) missense probably damaging 1.00
IGL03267:Zfp367 APN 13 64,292,097 (GRCm39) splice site probably benign
fisher UTSW 13 64,293,457 (GRCm39) missense probably damaging 1.00
Otter UTSW 13 64,292,069 (GRCm39) nonsense probably null
R4608:Zfp367 UTSW 13 64,283,238 (GRCm39) missense probably damaging 1.00
R6180:Zfp367 UTSW 13 64,283,204 (GRCm39) missense probably damaging 1.00
R7727:Zfp367 UTSW 13 64,293,457 (GRCm39) missense probably damaging 1.00
R8247:Zfp367 UTSW 13 64,300,482 (GRCm39) missense probably benign
R8754:Zfp367 UTSW 13 64,292,069 (GRCm39) nonsense probably null
R9557:Zfp367 UTSW 13 64,300,586 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATAGCTTGGGGATGGGAGTTTA -3'
(R):5'- TTTATGGAGGAGAGGCGCTC -3'

Sequencing Primer
(F):5'- AGCTTGGGGATGGGAGTTTATGATG -3'
(R):5'- GCTCCAGTGCCACCCTTTG -3'
Posted On 2018-06-06