Incidental Mutation 'R6562:Fcrls'
ID522416
Institutional Source Beutler Lab
Gene Symbol Fcrls
Ensembl Gene ENSMUSG00000015852
Gene NameFc receptor-like S, scavenger receptor
SynonymsIFGP2, Msr2, Fcrh2, moFcRH2sc, 2810439C17Rik
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #R6562 (G1)
Quality Score225.009
Status Validated
Chromosome3
Chromosomal Location87250758-87263738 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 87257328 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Serine at position 297 (I297S)
Ref Sequence ENSEMBL: ENSMUSP00000088508 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090986] [ENSMUST00000146512]
Predicted Effect probably benign
Transcript: ENSMUST00000090986
AA Change: I297S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000088508
Gene: ENSMUSG00000015852
AA Change: I297S

DomainStartEndE-ValueType
IG 23 106 1.32e-3 SMART
IGc2 122 186 2.77e-6 SMART
IGc2 226 291 1.09e-4 SMART
IG 315 396 1e-3 SMART
SR 402 503 7.29e-36 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000146512
SMART Domains Protein: ENSMUSP00000115780
Gene: ENSMUSG00000015852

DomainStartEndE-ValueType
IG 23 106 1.32e-3 SMART
Pfam:Ig_2 111 176 6.1e-6 PFAM
Pfam:Ig_3 111 176 1.4e-4 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.9%
Validation Efficiency 100% (60/60)
MGI Phenotype PHENOTYPE: Female homozygous mutant mice are larger than controls and show increased mean body weight, total tissue mass, lean body mass and total body fat. Homozygous mutant mice eshow a decreased mean percentage of CD8 cells in the peripheral blood. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931408C20Rik T A 1: 26,682,362 T1246S possibly damaging Het
4933434E20Rik A G 3: 90,063,236 K26E probably benign Het
Abt1 T G 13: 23,423,588 E82A probably damaging Het
Actr8 A G 14: 29,986,454 probably null Het
Akap12 G T 10: 4,356,141 E984* probably null Het
Ankrd13a C A 5: 114,804,392 probably benign Het
Ankrd13c T A 3: 157,999,672 S411T probably damaging Het
Arhgef28 A G 13: 97,988,139 probably null Het
Arhgef3 A T 14: 27,152,996 probably benign Het
Atad5 T C 11: 80,133,206 S1712P probably benign Het
Bbs12 A G 3: 37,320,240 E394G probably damaging Het
Ccdc158 T G 5: 92,662,722 K102N probably damaging Het
Ccdc169 A G 3: 55,150,814 N89S probably damaging Het
Cenpu T C 8: 46,572,823 I132T possibly damaging Het
Cnrip1 G A 11: 17,078,539 W157* probably null Het
Ctnnd1 A G 2: 84,624,308 S53P probably benign Het
Dcpp3 AGGCCATGCTGGCC AGGCC 17: 23,917,598 probably benign Het
Dock7 A T 4: 98,991,410 V969D probably damaging Het
Ehd2 C A 7: 15,957,567 R280L probably benign Het
Entpd5 T C 12: 84,386,200 T218A probably damaging Het
Frmpd2 T A 14: 33,571,915 L1346Q probably benign Het
Fry T C 5: 150,326,149 S142P probably damaging Het
Gbgt1 A T 2: 28,504,886 I179F probably damaging Het
Gm17067 A T 7: 42,708,729 S116R probably damaging Het
Gm5565 G T 5: 146,158,154 P261T probably damaging Het
Gm609 C T 16: 45,444,079 E39K probably benign Het
Kat6a T C 8: 22,911,787 F391L probably benign Het
Kcnmb4 A T 10: 116,473,184 probably null Het
Krt6a T A 15: 101,691,659 H386L probably benign Het
L3mbtl1 C T 2: 162,970,204 T723I probably benign Het
Lamb2 A T 9: 108,487,008 R1049W possibly damaging Het
Lrmda T C 14: 22,598,186 probably benign Het
Lysmd2 C T 9: 75,635,409 T95I unknown Het
Ndst3 A G 3: 123,552,532 S698P probably damaging Het
Nin T C 12: 70,055,954 D300G probably damaging Het
Nutf2 G T 8: 105,875,626 D23Y probably benign Het
Olfr801 G A 10: 129,670,139 P127S probably damaging Het
Ovgp1 A G 3: 105,980,273 Y300C probably damaging Het
Pgghg A G 7: 140,946,593 I633V probably benign Het
Pik3r3 C T 4: 116,299,809 Q496* probably null Het
Pkn3 G T 2: 30,080,687 probably null Het
Plin2 A T 4: 86,658,595 S298T probably benign Het
Prdm8 T C 5: 98,183,343 V18A possibly damaging Het
Rel C A 11: 23,757,026 G59* probably null Het
Siglecg A G 7: 43,409,057 R123G possibly damaging Het
Slc13a1 T A 6: 24,150,793 I49F probably benign Het
Slc39a10 T A 1: 46,835,564 T193S probably benign Het
Slc9a3 T A 13: 74,155,161 V191E probably damaging Het
Sult2b1 A C 7: 45,742,246 S39A probably benign Het
Tead1 A G 7: 112,861,443 T185A probably benign Het
Tmem67 A G 4: 12,053,445 probably null Het
Trim12c A T 7: 104,345,134 probably null Het
Trpm6 T A 19: 18,838,042 F1164Y probably damaging Het
Ube2d1 C T 10: 71,262,241 D16N probably benign Het
Vmn2r24 A T 6: 123,780,427 I85F probably benign Het
Vwde T A 6: 13,193,123 N406Y possibly damaging Het
Wdr54 A T 6: 83,155,068 probably null Het
Zcchc14 A T 8: 121,604,103 N840K probably damaging Het
Zfp451 C A 1: 33,762,179 S1052I possibly damaging Het
Other mutations in Fcrls
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01568:Fcrls APN 3 87256679 missense probably damaging 0.99
IGL01959:Fcrls APN 3 87259632 missense probably damaging 0.97
IGL02409:Fcrls APN 3 87252723 missense probably benign 0.00
IGL02677:Fcrls APN 3 87259387 missense probably benign 0.01
IGL02957:Fcrls APN 3 87262194 missense possibly damaging 0.59
IGL02974:Fcrls APN 3 87257397 missense possibly damaging 0.89
IGL02992:Fcrls APN 3 87259466 missense probably damaging 0.99
R0052:Fcrls UTSW 3 87256778 missense possibly damaging 0.94
R0052:Fcrls UTSW 3 87256778 missense possibly damaging 0.94
R0131:Fcrls UTSW 3 87258959 missense possibly damaging 0.90
R1171:Fcrls UTSW 3 87256860 missense probably benign 0.24
R1319:Fcrls UTSW 3 87262177 critical splice donor site probably null
R1522:Fcrls UTSW 3 87256707 missense possibly damaging 0.64
R1696:Fcrls UTSW 3 87259518 missense possibly damaging 0.95
R1742:Fcrls UTSW 3 87259043 missense possibly damaging 0.76
R2156:Fcrls UTSW 3 87257341 missense probably benign 0.43
R2255:Fcrls UTSW 3 87257348 nonsense probably null
R2257:Fcrls UTSW 3 87259621 missense probably damaging 0.99
R2434:Fcrls UTSW 3 87256698 missense probably damaging 1.00
R2680:Fcrls UTSW 3 87257349 missense probably damaging 0.99
R3552:Fcrls UTSW 3 87259410 missense possibly damaging 0.73
R4866:Fcrls UTSW 3 87263466 missense possibly damaging 0.65
R4883:Fcrls UTSW 3 87259615 missense possibly damaging 0.48
R5654:Fcrls UTSW 3 87257544 missense probably benign
R5771:Fcrls UTSW 3 87263468 missense probably damaging 0.98
R5917:Fcrls UTSW 3 87256787 missense probably damaging 0.99
R6349:Fcrls UTSW 3 87252496 missense probably damaging 0.99
R6954:Fcrls UTSW 3 87263676 critical splice donor site probably benign
R7059:Fcrls UTSW 3 87257340 missense possibly damaging 0.82
R7188:Fcrls UTSW 3 87259523 missense probably benign 0.13
R7201:Fcrls UTSW 3 87252627 missense probably damaging 0.99
R7369:Fcrls UTSW 3 87256701 missense possibly damaging 0.59
R7431:Fcrls UTSW 3 87258926 missense probably damaging 0.99
R7610:Fcrls UTSW 3 87252697 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGTTGCCCCACACTATCTG -3'
(R):5'- CTGGGCTAATCACATTCTCCTG -3'

Sequencing Primer
(F):5'- GCCCTCTTTCAGTTCTGATGTGG -3'
(R):5'- GGCTAATCACATTCTCCTGGCATAG -3'
Posted On2018-06-06