Incidental Mutation 'IGL01086:Coro6'
ID 52256
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Coro6
Ensembl Gene ENSMUSG00000020836
Gene Name coronin 6
Synonyms clipin E
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01086
Quality Score
Status
Chromosome 11
Chromosomal Location 77353237-77361310 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 77357374 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 194 (C194*)
Ref Sequence ENSEMBL: ENSMUSP00000104028 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021190] [ENSMUST00000037593] [ENSMUST00000052515] [ENSMUST00000079770] [ENSMUST00000092892] [ENSMUST00000102493] [ENSMUST00000108391] [ENSMUST00000145934] [ENSMUST00000130255]
AlphaFold Q920M5
Predicted Effect probably null
Transcript: ENSMUST00000021190
AA Change: C194*
SMART Domains Protein: ENSMUSP00000021190
Gene: ENSMUSG00000020836
AA Change: C194*

DomainStartEndE-ValueType
DUF1899 4 68 7.45e-34 SMART
WD40 67 110 2.1e-7 SMART
WD40 120 160 2.07e-6 SMART
WD40 163 203 2.73e-6 SMART
DUF1900 257 391 1.19e-91 SMART
low complexity region 414 429 N/A INTRINSIC
coiled coil region 430 463 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000037593
SMART Domains Protein: ENSMUSP00000073584
Gene: ENSMUSG00000037907

DomainStartEndE-ValueType
ANK 13 43 3.16e2 SMART
ANK 47 76 2.85e-5 SMART
ANK 80 109 1.17e2 SMART
Pfam:GPCR_chapero_1 163 491 5.5e-111 PFAM
UIM 503 522 1.81e-1 SMART
low complexity region 552 580 N/A INTRINSIC
UIM 585 604 3.15e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000052515
AA Change: C194*
SMART Domains Protein: ENSMUSP00000056862
Gene: ENSMUSG00000020836
AA Change: C194*

DomainStartEndE-ValueType
DUF1899 4 68 7.45e-34 SMART
WD40 67 110 2.1e-7 SMART
WD40 120 160 2.07e-6 SMART
WD40 163 203 2.73e-6 SMART
DUF1900 217 351 1.19e-91 SMART
low complexity region 374 389 N/A INTRINSIC
coiled coil region 390 424 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000079770
AA Change: C194*
SMART Domains Protein: ENSMUSP00000078703
Gene: ENSMUSG00000020836
AA Change: C194*

DomainStartEndE-ValueType
DUF1899 4 68 7.45e-34 SMART
WD40 67 110 2.1e-7 SMART
WD40 120 160 2.07e-6 SMART
WD40 163 203 2.73e-6 SMART
DUF1900 217 351 1.19e-91 SMART
low complexity region 374 389 N/A INTRINSIC
coiled coil region 390 423 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000092892
SMART Domains Protein: ENSMUSP00000090568
Gene: ENSMUSG00000037907

DomainStartEndE-ValueType
ANK 13 43 3.16e2 SMART
ANK 47 76 2.85e-5 SMART
ANK 80 109 1.17e2 SMART
Pfam:GPCR_chapero_1 163 490 3.2e-110 PFAM
UIM 503 522 1.81e-1 SMART
low complexity region 673 686 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000102493
AA Change: C194*
SMART Domains Protein: ENSMUSP00000099551
Gene: ENSMUSG00000020836
AA Change: C194*

DomainStartEndE-ValueType
DUF1899 4 68 7.45e-34 SMART
WD40 67 110 2.1e-7 SMART
WD40 120 160 2.07e-6 SMART
WD40 163 203 2.73e-6 SMART
DUF1900 257 391 1.19e-91 SMART
low complexity region 414 429 N/A INTRINSIC
coiled coil region 430 463 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000108391
AA Change: C194*
SMART Domains Protein: ENSMUSP00000104028
Gene: ENSMUSG00000020836
AA Change: C194*

DomainStartEndE-ValueType
DUF1899 4 68 7.45e-34 SMART
WD40 67 110 2.1e-7 SMART
WD40 120 160 2.07e-6 SMART
WD40 163 203 2.73e-6 SMART
DUF1900 257 391 1.19e-91 SMART
low complexity region 414 429 N/A INTRINSIC
coiled coil region 430 463 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143872
Predicted Effect probably benign
Transcript: ENSMUST00000145934
SMART Domains Protein: ENSMUSP00000119633
Gene: ENSMUSG00000037907

DomainStartEndE-ValueType
Pfam:GPCR_chapero_1 2 276 9.7e-90 PFAM
UIM 288 307 1.81e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000130255
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016H13Rik T A 5: 103,796,729 (GRCm39) R104S probably damaging Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Aim2 A G 1: 173,282,999 (GRCm39) Y27C probably damaging Het
Apol7b T C 15: 77,308,114 (GRCm39) E127G probably damaging Het
Atp10a T C 7: 58,474,066 (GRCm39) F1118L probably damaging Het
Cacna1e T C 1: 154,347,347 (GRCm39) D940G probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Clip4 G A 17: 72,131,789 (GRCm39) V376I probably benign Het
Cmklr2 T C 1: 63,222,650 (GRCm39) E195G probably benign Het
Crebbp T C 16: 3,997,416 (GRCm39) M223V probably benign Het
Dkk4 T A 8: 23,116,857 (GRCm39) C157S probably damaging Het
Dnah14 T C 1: 181,579,611 (GRCm39) L3048S probably benign Het
Dscaml1 T C 9: 45,613,960 (GRCm39) probably benign Het
Gria2 T C 3: 80,599,688 (GRCm39) Y732C probably damaging Het
Igkv4-59 T C 6: 69,415,707 (GRCm39) I7V probably benign Het
Lamc3 T C 2: 31,788,488 (GRCm39) F216S probably damaging Het
Lcn6 T C 2: 25,570,792 (GRCm39) F61L probably benign Het
Nup205 T A 6: 35,185,871 (GRCm39) probably benign Het
Or5w18 T A 2: 87,633,544 (GRCm39) Y266* probably null Het
Otof C T 5: 30,533,617 (GRCm39) probably null Het
Pik3c2b T C 1: 133,019,356 (GRCm39) C1035R probably damaging Het
Pla1a T C 16: 38,227,984 (GRCm39) N298D probably benign Het
Poteg T A 8: 27,963,648 (GRCm39) probably benign Het
Pwp1 T C 10: 85,715,757 (GRCm39) probably null Het
Scel A G 14: 103,849,827 (GRCm39) I631V probably benign Het
Scn3a T A 2: 65,300,503 (GRCm39) M1288L probably benign Het
Serpina11 T A 12: 103,952,329 (GRCm39) D147V probably damaging Het
Shroom3 T A 5: 93,096,311 (GRCm39) C1266S probably benign Het
Slc12a7 A G 13: 73,962,962 (GRCm39) Y1054C probably damaging Het
Srms A G 2: 180,854,216 (GRCm39) V117A probably damaging Het
Tmem161b T C 13: 84,370,541 (GRCm39) probably benign Het
Tmem94 A T 11: 115,681,110 (GRCm39) T158S probably benign Het
Tomm40l T C 1: 171,047,878 (GRCm39) probably null Het
Traf6 A G 2: 101,515,128 (GRCm39) I95V probably benign Het
Ttc13 A G 8: 125,402,085 (GRCm39) I686T probably damaging Het
Zmat2 C T 18: 36,929,163 (GRCm39) H104Y probably damaging Het
Other mutations in Coro6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00952:Coro6 APN 11 77,359,291 (GRCm39) missense probably damaging 1.00
IGL03184:Coro6 APN 11 77,354,779 (GRCm39) missense probably damaging 1.00
R0365:Coro6 UTSW 11 77,354,916 (GRCm39) missense probably benign 0.28
R1712:Coro6 UTSW 11 77,360,293 (GRCm39) missense probably benign 0.19
R1738:Coro6 UTSW 11 77,360,251 (GRCm39) missense probably benign 0.02
R2900:Coro6 UTSW 11 77,358,639 (GRCm39) missense probably benign
R3081:Coro6 UTSW 11 77,359,738 (GRCm39) missense probably damaging 1.00
R3700:Coro6 UTSW 11 77,358,129 (GRCm39) missense probably damaging 1.00
R4503:Coro6 UTSW 11 77,360,272 (GRCm39) missense probably benign 0.31
R4740:Coro6 UTSW 11 77,360,025 (GRCm39) missense possibly damaging 0.59
R4749:Coro6 UTSW 11 77,359,974 (GRCm39) missense probably damaging 1.00
R5501:Coro6 UTSW 11 77,358,622 (GRCm39) missense probably damaging 1.00
R5996:Coro6 UTSW 11 77,357,322 (GRCm39) missense probably benign 0.02
R6590:Coro6 UTSW 11 77,356,606 (GRCm39) missense probably benign 0.31
R6619:Coro6 UTSW 11 77,357,030 (GRCm39) missense possibly damaging 0.85
R6690:Coro6 UTSW 11 77,356,606 (GRCm39) missense probably benign 0.31
R7052:Coro6 UTSW 11 77,357,056 (GRCm39) missense probably benign 0.16
R7207:Coro6 UTSW 11 77,358,089 (GRCm39) missense possibly damaging 0.46
R7775:Coro6 UTSW 11 77,356,599 (GRCm39) missense probably benign 0.00
R8743:Coro6 UTSW 11 77,357,265 (GRCm39) missense probably damaging 0.98
R8865:Coro6 UTSW 11 77,359,917 (GRCm39) missense probably damaging 1.00
R9169:Coro6 UTSW 11 77,359,329 (GRCm39) missense probably damaging 1.00
R9384:Coro6 UTSW 11 77,360,218 (GRCm39) missense probably benign 0.32
X0064:Coro6 UTSW 11 77,359,434 (GRCm39) critical splice donor site probably null
Z1176:Coro6 UTSW 11 77,358,691 (GRCm39) frame shift probably null
Z1177:Coro6 UTSW 11 77,359,935 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21