Incidental Mutation 'R6489:Or4f7'
ID 522608
Institutional Source Beutler Lab
Gene Symbol Or4f7
Ensembl Gene ENSMUSG00000093804
Gene Name olfactory receptor family 4 subfamily F member 7
Synonyms Olfr276, GA_x6K02T2Q125-72882187-72881249, MOR245-7, MOR245-7, MOR245-28_p, GA_x6K02T2N82Q-3465-3764, Olfr1303
MMRRC Submission 044621-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # R6489 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 111644131-111645069 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 111644405 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Tryptophan at position 222 (L222W)
Ref Sequence ENSEMBL: ENSMUSP00000149015 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099609] [ENSMUST00000216114]
AlphaFold A2AVW1
Predicted Effect probably damaging
Transcript: ENSMUST00000099609
AA Change: L222W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000097204
Gene: ENSMUSG00000093804
AA Change: L222W

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 2.3e-43 PFAM
Pfam:7TM_GPCR_Srsx 35 302 2.5e-6 PFAM
Pfam:7tm_1 41 287 2.4e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216114
AA Change: L222W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6329 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.3%
  • 20x: 90.6%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadvl T C 11: 69,901,145 (GRCm39) T650A probably benign Het
Alkbh7 T A 17: 57,305,979 (GRCm39) S127T probably damaging Het
Ank3 G A 10: 69,827,459 (GRCm39) A565T probably benign Het
App G T 16: 84,853,408 (GRCm39) D223E unknown Het
Arhgef2 C A 3: 88,550,321 (GRCm39) S675R probably damaging Het
Atg14 T C 14: 47,786,480 (GRCm39) D258G probably damaging Het
Calhm5 A T 10: 33,968,502 (GRCm39) W184R probably damaging Het
Cbr1b A T 16: 93,427,286 (GRCm39) probably null Het
Ckap2l T C 2: 129,111,034 (GRCm39) D721G possibly damaging Het
Cog8 T C 8: 107,776,933 (GRCm39) T481A probably benign Het
Colec10 C A 15: 54,325,609 (GRCm39) probably null Het
Cplx3 A T 9: 57,521,009 (GRCm39) probably null Het
Dhx9 T C 1: 153,332,389 (GRCm39) probably benign Het
Dock1 T C 7: 134,592,270 (GRCm39) M935T probably damaging Het
Dsg4 T A 18: 20,604,420 (GRCm39) N962K possibly damaging Het
Dym T C 18: 75,213,297 (GRCm39) V173A probably benign Het
Exoc3l4 A G 12: 111,395,131 (GRCm39) Y583C probably damaging Het
Flnb G A 14: 7,867,551 (GRCm38) V103M probably damaging Het
Fzd1 T A 5: 4,807,336 (GRCm39) Q82L probably benign Het
Gabrr1 A G 4: 33,162,855 (GRCm39) I474V probably benign Het
Galnt11 G T 5: 25,469,964 (GRCm39) W521L probably damaging Het
Glb1l3 A G 9: 26,738,127 (GRCm39) V420A probably benign Het
H1f7 A T 15: 98,154,888 (GRCm39) L87* probably null Het
Homer2 T C 7: 81,274,026 (GRCm39) T57A probably benign Het
Ihh T A 1: 74,985,670 (GRCm39) T272S probably damaging Het
Il27ra T C 8: 84,758,179 (GRCm39) M524V probably benign Het
Mdp1 C A 14: 55,897,848 (GRCm39) probably benign Het
Med12l A G 3: 59,164,828 (GRCm39) K1436R probably damaging Het
Megf10 C T 18: 57,424,879 (GRCm39) S1006F probably benign Het
Miga1 A T 3: 151,984,645 (GRCm39) I426N probably damaging Het
Mtmr6 C T 14: 60,537,963 (GRCm39) T654I possibly damaging Het
Nbeal1 A G 1: 60,370,101 (GRCm39) S2673G possibly damaging Het
Nup93 T A 8: 95,028,716 (GRCm39) H193Q probably benign Het
Or1e25 T A 11: 73,494,265 (GRCm39) N286K probably damaging Het
Or52ae9 T C 7: 103,389,875 (GRCm39) N191D probably benign Het
Pdcd11 C T 19: 47,098,191 (GRCm39) R826C probably damaging Het
Pde4dip G A 3: 97,662,907 (GRCm39) R521* probably null Het
Phf2 T C 13: 48,979,658 (GRCm39) S158G unknown Het
Pla2g15 A G 8: 106,889,826 (GRCm39) E366G probably benign Het
Plekhm2 A T 4: 141,359,344 (GRCm39) H494Q probably damaging Het
Prpsap2 A T 11: 61,639,890 (GRCm39) M87K probably damaging Het
Rbm19 T G 5: 120,258,195 (GRCm39) S137A probably benign Het
Ryr2 T A 13: 11,848,893 (GRCm39) I363L probably benign Het
Samd9l T C 6: 3,376,896 (GRCm39) T122A probably benign Het
Scn4a G C 11: 106,240,006 (GRCm39) D70E probably benign Het
Slc12a3 T A 8: 95,061,632 (GRCm39) V293D possibly damaging Het
Slc6a7 T C 18: 61,140,615 (GRCm39) Y139C probably damaging Het
Slco2b1 A T 7: 99,339,762 (GRCm39) C9* probably null Het
Slitrk1 A T 14: 109,148,735 (GRCm39) S659T possibly damaging Het
Son T G 16: 91,452,044 (GRCm39) S264A possibly damaging Het
Svep1 C A 4: 58,100,066 (GRCm39) G1326V probably damaging Het
Tcf12 A G 9: 71,922,918 (GRCm39) probably null Het
Ttn A G 2: 76,645,062 (GRCm39) V11185A probably damaging Het
Ubap2 T C 4: 41,203,574 (GRCm39) probably null Het
Utp15 G T 13: 98,387,117 (GRCm39) F434L probably damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Vsnl1 T G 12: 11,382,219 (GRCm39) probably benign Het
Yod1 G A 1: 130,645,275 (GRCm39) G19S probably damaging Het
Zbtb34 A C 2: 33,301,558 (GRCm39) S328A probably damaging Het
Zdbf2 T C 1: 63,346,637 (GRCm39) I1672T possibly damaging Het
Other mutations in Or4f7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Or4f7 APN 2 111,644,126 (GRCm39) utr 3 prime probably benign
IGL02442:Or4f7 APN 2 111,644,336 (GRCm39) missense probably benign 0.26
IGL02563:Or4f7 APN 2 111,644,162 (GRCm39) missense probably benign
IGL03064:Or4f7 APN 2 111,644,768 (GRCm39) missense possibly damaging 0.86
R0081:Or4f7 UTSW 2 111,644,213 (GRCm39) missense probably damaging 1.00
R0139:Or4f7 UTSW 2 111,644,699 (GRCm39) missense possibly damaging 0.54
R0624:Or4f7 UTSW 2 111,645,056 (GRCm39) missense probably damaging 1.00
R0926:Or4f7 UTSW 2 111,644,892 (GRCm39) missense probably damaging 1.00
R1436:Or4f7 UTSW 2 111,644,906 (GRCm39) missense probably damaging 1.00
R2099:Or4f7 UTSW 2 111,644,177 (GRCm39) missense probably benign 0.18
R5255:Or4f7 UTSW 2 111,644,523 (GRCm39) missense probably benign 0.02
R6034:Or4f7 UTSW 2 111,644,702 (GRCm39) missense probably damaging 1.00
R6034:Or4f7 UTSW 2 111,644,702 (GRCm39) missense probably damaging 1.00
R6101:Or4f7 UTSW 2 111,644,598 (GRCm39) missense probably benign 0.00
R6385:Or4f7 UTSW 2 111,644,964 (GRCm39) missense probably benign
R6978:Or4f7 UTSW 2 111,644,155 (GRCm39) missense probably benign 0.03
R7410:Or4f7 UTSW 2 111,644,271 (GRCm39) missense probably benign 0.00
R8507:Or4f7 UTSW 2 111,645,051 (GRCm39) missense probably benign 0.23
R8897:Or4f7 UTSW 2 111,644,576 (GRCm39) missense probably benign 0.01
R9084:Or4f7 UTSW 2 111,644,996 (GRCm39) missense probably damaging 1.00
R9096:Or4f7 UTSW 2 111,644,196 (GRCm39) nonsense probably null
R9097:Or4f7 UTSW 2 111,644,196 (GRCm39) nonsense probably null
R9784:Or4f7 UTSW 2 111,644,604 (GRCm39) missense probably damaging 1.00
Z1176:Or4f7 UTSW 2 111,644,379 (GRCm39) missense probably benign 0.22
Predicted Primers PCR Primer
(F):5'- TGAATGTGTAGATAACTGGGTTCAG -3'
(R):5'- CACTCATTGTTCCAGCTGGC -3'

Sequencing Primer
(F):5'- TGTGTAGATAACTGGGTTCAGAAAAG -3'
(R):5'- AGCTGGCTTTTCTTATTGACTTAC -3'
Posted On 2018-06-06