Incidental Mutation 'R6565:Lilra6'
ID 522619
Institutional Source Beutler Lab
Gene Symbol Lilra6
Ensembl Gene ENSMUSG00000030427
Gene Name leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
Synonyms 7M1, Pira3
MMRRC Submission 044689-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R6565 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 3911279-3918502 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3918019 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 42 (W42R)
Ref Sequence ENSEMBL: ENSMUSP00000088188 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]
AlphaFold A0A0B4J1F3
Predicted Effect probably benign
Transcript: ENSMUST00000038176
AA Change: W42R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: W42R

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 40 105 3.11e0 SMART
IG 129 315 4.53e-2 SMART
IG_like 237 302 1.54e-1 SMART
IG_like 328 415 1.79e1 SMART
IG_like 429 517 2.66e1 SMART
IG 529 618 8.59e-3 SMART
low complexity region 637 646 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000090689
AA Change: W42R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: W42R

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
IG_like 34 118 7.25e0 SMART
IG_like 129 220 1.62e2 SMART
IG_like 290 377 1.79e1 SMART
IG_like 391 479 2.66e1 SMART
IG 491 580 8.59e-3 SMART
low complexity region 599 608 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131255
Predicted Effect probably benign
Transcript: ENSMUST00000206077
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206851
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A1bg C A 15: 60,792,659 (GRCm39) C96F probably damaging Het
Abca7 C T 10: 79,847,622 (GRCm39) P1764L probably damaging Het
Acvr1 G A 2: 58,369,769 (GRCm39) T80M probably damaging Het
Adgrb2 T C 4: 129,913,069 (GRCm39) L1398P probably damaging Het
B4galnt3 G A 6: 120,194,440 (GRCm39) Q362* probably null Het
Cadm3 G T 1: 173,169,276 (GRCm39) Q246K possibly damaging Het
Cdc14b T C 13: 64,373,444 (GRCm39) T110A probably benign Het
Cyp2c55 A C 19: 39,030,566 (GRCm39) D466A probably benign Het
Dmrtb1 T C 4: 107,536,542 (GRCm39) Y308C probably damaging Het
Fat3 T C 9: 15,826,623 (GRCm39) D4443G probably benign Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Grin2d A G 7: 45,484,179 (GRCm39) L772P probably damaging Het
Gsdme T C 6: 50,206,429 (GRCm39) N138S probably damaging Het
Hmgb4 T A 4: 128,154,388 (GRCm39) Y60F probably benign Het
Ift172 G A 5: 31,433,227 (GRCm39) A554V possibly damaging Het
Iigp1 T A 18: 60,523,839 (GRCm39) V319E probably damaging Het
Kit A G 5: 75,806,513 (GRCm39) T673A probably damaging Het
Mia3 A T 1: 183,112,340 (GRCm39) H477Q probably damaging Het
Oas1b C A 5: 120,952,611 (GRCm39) Q101K possibly damaging Het
Or2v1 A G 11: 49,025,639 (GRCm39) M207V probably damaging Het
Or51a5 T C 7: 102,771,445 (GRCm39) H178R probably damaging Het
Plcl1 T A 1: 55,737,117 (GRCm39) C819* probably null Het
Pmfbp1 C T 8: 110,252,060 (GRCm39) Q402* probably null Het
Rps19bp1 CCTTCTTCTTCTTCTTCTTCTT CCTTCTTCTTCTTCTTCTT 15: 80,145,250 (GRCm39) probably benign Het
Skor2 C G 18: 76,947,607 (GRCm39) A443G possibly damaging Het
Tapbpl A G 6: 125,205,307 (GRCm39) V213A probably benign Het
Trim52 G A 14: 106,344,653 (GRCm39) D104N probably damaging Het
Other mutations in Lilra6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Lilra6 APN 7 3,914,553 (GRCm39) missense probably benign 0.04
IGL00569:Lilra6 APN 7 3,917,588 (GRCm39) missense probably damaging 0.99
IGL00899:Lilra6 APN 7 3,916,056 (GRCm39) missense probably damaging 1.00
IGL00955:Lilra6 APN 7 3,914,403 (GRCm39) splice site probably benign
IGL01585:Lilra6 APN 7 3,917,498 (GRCm39) missense probably benign 0.01
IGL02195:Lilra6 APN 7 3,917,549 (GRCm39) missense probably benign 0.00
IGL02586:Lilra6 APN 7 3,911,819 (GRCm39) missense probably benign 0.36
IGL02719:Lilra6 APN 7 3,915,991 (GRCm39) missense possibly damaging 0.96
IGL03166:Lilra6 APN 7 3,915,626 (GRCm39) missense possibly damaging 0.69
IGL03329:Lilra6 APN 7 3,917,647 (GRCm39) splice site probably benign
R0233:Lilra6 UTSW 7 3,917,935 (GRCm39) missense possibly damaging 0.69
R0233:Lilra6 UTSW 7 3,917,935 (GRCm39) missense possibly damaging 0.69
R0423:Lilra6 UTSW 7 3,917,774 (GRCm39) splice site probably benign
R0483:Lilra6 UTSW 7 3,916,138 (GRCm39) missense probably benign 0.02
R0511:Lilra6 UTSW 7 3,915,784 (GRCm39) missense possibly damaging 0.77
R1472:Lilra6 UTSW 7 3,915,718 (GRCm39) missense probably damaging 1.00
R1560:Lilra6 UTSW 7 3,914,407 (GRCm39) critical splice donor site probably null
R1584:Lilra6 UTSW 7 3,915,661 (GRCm39) missense probably damaging 1.00
R1781:Lilra6 UTSW 7 3,918,066 (GRCm39) missense probably benign 0.28
R2411:Lilra6 UTSW 7 3,914,453 (GRCm39) missense probably damaging 1.00
R2420:Lilra6 UTSW 7 3,917,857 (GRCm39) missense probably damaging 1.00
R4021:Lilra6 UTSW 7 3,914,417 (GRCm39) missense probably benign 0.20
R4074:Lilra6 UTSW 7 3,917,889 (GRCm39) missense probably benign 0.23
R4284:Lilra6 UTSW 7 3,911,803 (GRCm39) missense possibly damaging 0.76
R4508:Lilra6 UTSW 7 3,915,028 (GRCm39) nonsense probably null
R4894:Lilra6 UTSW 7 3,915,530 (GRCm39) missense probably benign 0.01
R4977:Lilra6 UTSW 7 3,917,382 (GRCm39) missense probably benign 0.01
R5048:Lilra6 UTSW 7 3,918,440 (GRCm39) critical splice donor site probably null
R5164:Lilra6 UTSW 7 3,917,880 (GRCm39) missense probably damaging 1.00
R5185:Lilra6 UTSW 7 3,917,635 (GRCm39) missense probably benign 0.00
R5527:Lilra6 UTSW 7 3,917,586 (GRCm39) start gained probably benign
R6281:Lilra6 UTSW 7 3,914,972 (GRCm39) missense probably damaging 1.00
R6480:Lilra6 UTSW 7 3,915,932 (GRCm39) missense probably damaging 1.00
R6512:Lilra6 UTSW 7 3,917,387 (GRCm39) missense probably benign 0.06
R7017:Lilra6 UTSW 7 3,911,707 (GRCm39) missense possibly damaging 0.93
R7095:Lilra6 UTSW 7 3,916,196 (GRCm39) missense probably damaging 1.00
R7747:Lilra6 UTSW 7 3,915,995 (GRCm39) missense probably benign 0.16
R8056:Lilra6 UTSW 7 3,915,551 (GRCm39) missense probably damaging 1.00
R8280:Lilra6 UTSW 7 3,916,046 (GRCm39) missense probably benign 0.01
R9197:Lilra6 UTSW 7 3,915,716 (GRCm39) missense possibly damaging 0.94
R9354:Lilra6 UTSW 7 3,914,628 (GRCm39) missense probably damaging 1.00
R9379:Lilra6 UTSW 7 3,916,166 (GRCm39) missense probably damaging 1.00
R9406:Lilra6 UTSW 7 3,917,853 (GRCm39) missense probably benign
R9462:Lilra6 UTSW 7 3,914,994 (GRCm39) missense probably damaging 0.97
R9649:Lilra6 UTSW 7 3,917,521 (GRCm39) missense possibly damaging 0.47
Z1176:Lilra6 UTSW 7 3,918,073 (GRCm39) critical splice acceptor site probably null
Z1177:Lilra6 UTSW 7 3,915,580 (GRCm39) missense possibly damaging 0.48
Predicted Primers PCR Primer
(F):5'- AGCCTGATGATTCATCCTGGG -3'
(R):5'- TCTCTTCAGATCCAGGAGCC -3'

Sequencing Primer
(F):5'- GTGTTGTAGGAACATCGATATTGACC -3'
(R):5'- TTCAGATCCAGGAGCCATGCC -3'
Posted On 2018-06-06