Incidental Mutation 'R6566:Rgs16'
ID 522655
Institutional Source Beutler Lab
Gene Symbol Rgs16
Ensembl Gene ENSMUSG00000026475
Gene Name regulator of G-protein signaling 16
Synonyms Rgsr
MMRRC Submission 044690-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R6566 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 153616099-153621212 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 153619546 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 184 (S184L)
Ref Sequence ENSEMBL: ENSMUSP00000027748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027748]
AlphaFold P97428
PDB Structure Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation [X-RAY DIFFRACTION]
Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation [X-RAY DIFFRACTION]
Predicted Effect unknown
Transcript: ENSMUST00000027748
AA Change: S184L
SMART Domains Protein: ENSMUSP00000027748
Gene: ENSMUSG00000026475
AA Change: S184L

DomainStartEndE-ValueType
RGS 64 180 3.69e-49 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191474
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.6%
Validation Efficiency 100% (36/36)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased fatty acid oxidation and circulating ketone levels when fed a high-fat diet. Mice homozygous for a different knock-out allele exhibit impaired Th1 and Th2 chemotaxis and increased susceptibility toparasitic infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 A G 15: 91,075,321 (GRCm39) I164T probably damaging Het
Adad2 C T 8: 120,340,971 (GRCm39) P164S probably benign Het
Adcy3 T A 12: 4,244,324 (GRCm39) L278H probably damaging Het
Aldh16a1 A C 7: 44,792,651 (GRCm39) D670E probably benign Het
Bcat1 A G 6: 144,961,210 (GRCm39) M131T probably damaging Het
Dcstamp T C 15: 39,617,732 (GRCm39) F47S possibly damaging Het
Dsg1b T C 18: 20,530,499 (GRCm39) F385L probably damaging Het
Exoc8 A C 8: 125,622,783 (GRCm39) L528R probably damaging Het
Fat4 T C 3: 39,011,275 (GRCm39) V2125A possibly damaging Het
Gm57859 C T 11: 113,578,824 (GRCm39) P73L probably damaging Het
Hecw1 T C 13: 14,471,868 (GRCm39) D600G probably damaging Het
Ice2 G A 9: 69,323,511 (GRCm39) V669I probably benign Het
Khdc4 C T 3: 88,618,961 (GRCm39) T555M probably damaging Het
Lsr T A 7: 30,671,508 (GRCm39) Y75F possibly damaging Het
Mrps30 C A 13: 118,523,662 (GRCm39) V37L probably benign Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Or6c217 T A 10: 129,737,947 (GRCm39) I211L probably benign Het
Pign A G 1: 105,565,906 (GRCm39) probably null Het
Plcd3 A G 11: 102,964,626 (GRCm39) Y582H probably damaging Het
Rad9b A G 5: 122,490,630 (GRCm39) W29R probably damaging Het
Rb1cc1 T A 1: 6,319,316 (GRCm39) F912I probably benign Het
Runx2 A G 17: 45,125,375 (GRCm39) probably null Het
Serpina1f T A 12: 103,659,794 (GRCm39) I163F probably damaging Het
Serpina9 T C 12: 103,963,296 (GRCm39) E404G possibly damaging Het
Slc4a4 T C 5: 89,297,192 (GRCm39) S511P possibly damaging Het
Speg A T 1: 75,365,107 (GRCm39) E390V probably damaging Het
Syne3 A G 12: 104,912,966 (GRCm39) V614A probably benign Het
Tmc5 T C 7: 118,247,067 (GRCm39) S524P probably damaging Het
Tuba4a G A 1: 75,193,930 (GRCm39) T51I probably damaging Het
Tymp T A 15: 89,257,803 (GRCm39) T421S probably benign Het
Uvssa A G 5: 33,549,520 (GRCm39) R394G possibly damaging Het
Wdr7 T G 18: 63,888,126 (GRCm39) I533S possibly damaging Het
Zbtb5 G A 4: 44,994,508 (GRCm39) T292M probably damaging Het
Zfp944 T G 17: 22,558,726 (GRCm39) K174Q possibly damaging Het
Other mutations in Rgs16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01919:Rgs16 APN 1 153,617,804 (GRCm39) missense probably damaging 0.99
IGL02319:Rgs16 APN 1 153,617,852 (GRCm39) missense probably damaging 1.00
LCD18:Rgs16 UTSW 1 153,619,976 (GRCm39) utr 3 prime probably benign
R0295:Rgs16 UTSW 1 153,619,483 (GRCm39) missense probably damaging 1.00
R1355:Rgs16 UTSW 1 153,619,414 (GRCm39) missense probably damaging 0.99
R4639:Rgs16 UTSW 1 153,617,781 (GRCm39) missense probably damaging 1.00
R5398:Rgs16 UTSW 1 153,616,246 (GRCm39) missense probably benign 0.01
R6629:Rgs16 UTSW 1 153,619,420 (GRCm39) missense probably damaging 0.98
R7208:Rgs16 UTSW 1 153,617,416 (GRCm39) missense probably damaging 1.00
R8195:Rgs16 UTSW 1 153,616,689 (GRCm39) missense probably benign 0.00
R9125:Rgs16 UTSW 1 153,617,874 (GRCm39) missense probably null 1.00
R9140:Rgs16 UTSW 1 153,619,381 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCACAGGTGAACATAGATCACG -3'
(R):5'- GGTCCTGGAAATGAGGAGTCTC -3'

Sequencing Primer
(F):5'- GGTGAACATAGATCACGAGACCC -3'
(R):5'- CCACCACAGTATCTGGAGGAG -3'
Posted On 2018-06-06