Incidental Mutation 'IGL00470:Tars3'
ID 5231
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tars3
Ensembl Gene ENSMUSG00000030515
Gene Name threonyl-tRNA synthetase 3
Synonyms A530046H20Rik, Tarsl2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.178) question?
Stock # IGL00470
Quality Score
Status
Chromosome 7
Chromosomal Location 65294646-65341839 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 65338656 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 689 (M689T)
Ref Sequence ENSEMBL: ENSMUSP00000032728 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032726] [ENSMUST00000032728] [ENSMUST00000065574] [ENSMUST00000107495] [ENSMUST00000129166] [ENSMUST00000206517] [ENSMUST00000206934] [ENSMUST00000206628] [ENSMUST00000143508]
AlphaFold Q8BLY2
Predicted Effect probably benign
Transcript: ENSMUST00000032726
SMART Domains Protein: ENSMUSP00000032726
Gene: ENSMUSG00000078681

DomainStartEndE-ValueType
low complexity region 8 22 N/A INTRINSIC
Pfam:TM2 165 214 5.1e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000032728
AA Change: M689T

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000032728
Gene: ENSMUSG00000030515
AA Change: M689T

DomainStartEndE-ValueType
low complexity region 2 18 N/A INTRINSIC
coiled coil region 44 68 N/A INTRINSIC
Pfam:TGS 151 210 8.8e-14 PFAM
tRNA_SAD 316 365 1.26e-16 SMART
Pfam:tRNA-synt_2b 464 675 2.2e-35 PFAM
Pfam:HGTP_anticodon 687 778 1.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000065574
SMART Domains Protein: ENSMUSP00000064967
Gene: ENSMUSG00000078681

DomainStartEndE-ValueType
low complexity region 8 22 N/A INTRINSIC
Pfam:TM2 196 245 6.3e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000107495
SMART Domains Protein: ENSMUSP00000103119
Gene: ENSMUSG00000078681

DomainStartEndE-ValueType
low complexity region 8 22 N/A INTRINSIC
Pfam:TM2 196 245 5e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127354
Predicted Effect probably benign
Transcript: ENSMUST00000129166
Predicted Effect probably benign
Transcript: ENSMUST00000206361
Predicted Effect probably benign
Transcript: ENSMUST00000206517
Predicted Effect probably benign
Transcript: ENSMUST00000206934
Predicted Effect probably benign
Transcript: ENSMUST00000206837
Predicted Effect probably benign
Transcript: ENSMUST00000206628
Predicted Effect probably benign
Transcript: ENSMUST00000143508
SMART Domains Protein: ENSMUSP00000116848
Gene: ENSMUSG00000078681

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4732463B04Rik G T 12: 84,090,578 (GRCm39) probably benign Het
Abcd1 T C X: 72,761,154 (GRCm39) L173P probably damaging Het
Adam18 T A 8: 25,118,149 (GRCm39) D41V probably damaging Het
Armh4 A T 14: 50,010,460 (GRCm39) S416T probably damaging Het
Aspa T G 11: 73,204,447 (GRCm39) probably benign Het
Cacna2d1 T A 5: 16,451,654 (GRCm39) probably benign Het
Cracd G A 5: 77,013,903 (GRCm39) probably benign Het
Cubn T A 2: 13,283,229 (GRCm39) I3570L probably benign Het
Cyp2j13 G A 4: 95,950,275 (GRCm39) P242L probably damaging Het
Cysrt1 T C 2: 25,129,513 (GRCm39) probably benign Het
Dchs1 A T 7: 105,407,414 (GRCm39) L2100H probably damaging Het
Ddb1 G A 19: 10,589,028 (GRCm39) A229T possibly damaging Het
Dst A T 1: 34,228,043 (GRCm39) I1554F probably damaging Het
Dvl3 C T 16: 20,349,689 (GRCm39) P554L probably damaging Het
Fcgbp C A 7: 27,774,511 (GRCm39) C28* probably null Het
Gm773 T C X: 55,247,373 (GRCm39) D53G probably benign Het
Hhat A G 1: 192,399,325 (GRCm39) Y272H probably damaging Het
Inpp5k T C 11: 75,536,351 (GRCm39) S310P probably benign Het
Kat2a G A 11: 100,596,210 (GRCm39) R782W probably damaging Het
Kcnh5 T C 12: 74,944,570 (GRCm39) D893G probably benign Het
Lama2 T C 10: 27,119,738 (GRCm39) T709A probably benign Het
Mcm8 G A 2: 132,669,457 (GRCm39) V281I probably benign Het
Men1 G A 19: 6,387,237 (GRCm39) probably null Het
Nup133 T G 8: 124,665,822 (GRCm39) D201A probably damaging Het
Oxct2a A G 4: 123,217,183 (GRCm39) L66P possibly damaging Het
Pcbp2 C T 15: 102,399,148 (GRCm39) A224V probably damaging Het
Phf8-ps T A 17: 33,284,837 (GRCm39) H655L probably benign Het
Pla2g4e G A 2: 120,015,719 (GRCm39) S275F probably benign Het
Pxk T C 14: 8,130,754 (GRCm38) F118L probably damaging Het
Sp2 C T 11: 96,845,387 (GRCm39) R578H probably damaging Het
Sphkap A G 1: 83,255,631 (GRCm39) M706T possibly damaging Het
Trrap T C 5: 144,754,848 (GRCm39) V2008A probably damaging Het
Txndc2 A T 17: 65,945,569 (GRCm39) S203T probably benign Het
Txnrd1 T G 10: 82,711,496 (GRCm39) D42E probably damaging Het
Zswim8 G A 14: 20,773,249 (GRCm39) D1746N probably damaging Het
Other mutations in Tars3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Tars3 APN 7 65,302,007 (GRCm39) critical splice acceptor site probably null
IGL00594:Tars3 APN 7 65,325,880 (GRCm39) critical splice donor site probably null
IGL01352:Tars3 APN 7 65,308,658 (GRCm39) missense possibly damaging 0.80
IGL01519:Tars3 APN 7 65,313,634 (GRCm39) missense probably damaging 1.00
IGL01726:Tars3 APN 7 65,332,566 (GRCm39) missense possibly damaging 0.46
IGL02370:Tars3 APN 7 65,310,913 (GRCm39) missense probably benign 0.17
IGL02729:Tars3 APN 7 65,332,567 (GRCm39) missense probably damaging 0.97
IGL03234:Tars3 APN 7 65,302,026 (GRCm39) missense probably benign 0.06
gary UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R8254_tarsl2_650 UTSW 7 65,325,809 (GRCm39) missense probably benign
smart_money UTSW 7 65,327,890 (GRCm39) missense probably damaging 1.00
R0127:Tars3 UTSW 7 65,314,717 (GRCm39) missense probably benign 0.19
R0153:Tars3 UTSW 7 65,333,829 (GRCm39) missense probably damaging 1.00
R0605:Tars3 UTSW 7 65,327,819 (GRCm39) missense probably damaging 1.00
R1070:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R1450:Tars3 UTSW 7 65,297,244 (GRCm39) missense probably benign 0.01
R1467:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R1467:Tars3 UTSW 7 65,305,444 (GRCm39) missense probably damaging 1.00
R2142:Tars3 UTSW 7 65,308,645 (GRCm39) missense probably benign
R2143:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2144:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2145:Tars3 UTSW 7 65,305,539 (GRCm39) missense possibly damaging 0.57
R2208:Tars3 UTSW 7 65,332,596 (GRCm39) missense probably damaging 1.00
R3713:Tars3 UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R3715:Tars3 UTSW 7 65,338,700 (GRCm39) critical splice donor site probably null
R3914:Tars3 UTSW 7 65,333,556 (GRCm39) missense probably benign 0.05
R3929:Tars3 UTSW 7 65,333,791 (GRCm39) splice site probably null
R4008:Tars3 UTSW 7 65,327,876 (GRCm39) missense probably damaging 1.00
R4064:Tars3 UTSW 7 65,302,018 (GRCm39) missense possibly damaging 0.90
R4367:Tars3 UTSW 7 65,332,567 (GRCm39) missense probably damaging 0.97
R4652:Tars3 UTSW 7 65,339,717 (GRCm39) missense probably damaging 1.00
R4825:Tars3 UTSW 7 65,297,302 (GRCm39) missense probably benign 0.38
R4901:Tars3 UTSW 7 65,341,042 (GRCm39) missense probably benign 0.05
R4999:Tars3 UTSW 7 65,308,683 (GRCm39) missense probably damaging 0.99
R5423:Tars3 UTSW 7 65,333,567 (GRCm39) missense probably benign 0.00
R5756:Tars3 UTSW 7 65,325,724 (GRCm39) missense probably benign 0.22
R5772:Tars3 UTSW 7 65,333,873 (GRCm39) missense probably damaging 1.00
R6160:Tars3 UTSW 7 65,332,527 (GRCm39) missense probably benign 0.32
R6230:Tars3 UTSW 7 65,336,184 (GRCm39) splice site probably null
R6424:Tars3 UTSW 7 65,305,487 (GRCm39) missense probably damaging 1.00
R6615:Tars3 UTSW 7 65,327,890 (GRCm39) missense probably damaging 1.00
R6792:Tars3 UTSW 7 65,312,051 (GRCm39) missense probably damaging 1.00
R7350:Tars3 UTSW 7 65,308,672 (GRCm39) missense probably damaging 1.00
R7549:Tars3 UTSW 7 65,297,341 (GRCm39) missense probably damaging 0.96
R7592:Tars3 UTSW 7 65,308,619 (GRCm39) missense probably benign 0.01
R7634:Tars3 UTSW 7 65,325,760 (GRCm39) missense probably damaging 0.99
R7710:Tars3 UTSW 7 65,314,717 (GRCm39) missense probably benign 0.19
R7808:Tars3 UTSW 7 65,302,009 (GRCm39) missense probably benign 0.01
R7875:Tars3 UTSW 7 65,327,899 (GRCm39) missense probably benign 0.05
R8254:Tars3 UTSW 7 65,325,809 (GRCm39) missense probably benign
R8793:Tars3 UTSW 7 65,294,673 (GRCm39) start gained probably benign
R9162:Tars3 UTSW 7 65,332,518 (GRCm39) missense probably benign 0.01
R9200:Tars3 UTSW 7 65,302,013 (GRCm39) missense probably benign
R9461:Tars3 UTSW 7 65,339,719 (GRCm39) missense possibly damaging 0.68
R9533:Tars3 UTSW 7 65,333,808 (GRCm39) critical splice acceptor site probably null
Z1177:Tars3 UTSW 7 65,302,012 (GRCm39) nonsense probably null
Posted On 2012-04-20