Incidental Mutation 'PIT4131001:Ttc28'
| ID |
523198 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc28
|
| Ensembl Gene |
ENSMUSG00000033209 |
| Gene Name |
tetratricopeptide repeat domain 28 |
| Synonyms |
TPRBK, 2310015L07Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
PIT4131001 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
111027669-111437646 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 111040719 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 36
(T36S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000136116
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040111]
[ENSMUST00000156290]
|
| AlphaFold |
Q80XJ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000040111
AA Change: T36S
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000136116
Gene: ENSMUSG00000033209
AA Change: T36S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
339 |
372 |
1.78e-1 |
SMART |
|
TPR
|
379 |
412 |
2.82e-4 |
SMART |
|
TPR
|
419 |
452 |
9.98e-5 |
SMART |
|
TPR
|
459 |
492 |
1.88e0 |
SMART |
|
TPR
|
499 |
532 |
1.11e1 |
SMART |
|
TPR
|
539 |
572 |
2.93e-2 |
SMART |
|
TPR
|
579 |
612 |
1.21e-3 |
SMART |
|
TPR
|
619 |
652 |
4.91e-4 |
SMART |
|
TPR
|
659 |
692 |
7.56e-5 |
SMART |
|
TPR
|
699 |
732 |
8.29e0 |
SMART |
|
TPR
|
739 |
772 |
1.63e0 |
SMART |
|
TPR
|
779 |
812 |
1.24e0 |
SMART |
|
TPR
|
819 |
852 |
7.98e-4 |
SMART |
|
TPR
|
859 |
892 |
8.74e0 |
SMART |
|
TPR
|
902 |
935 |
5.43e-6 |
SMART |
|
TPR
|
942 |
975 |
4.09e-1 |
SMART |
|
TPR
|
982 |
1015 |
9.98e-5 |
SMART |
|
TPR
|
1022 |
1055 |
7.12e-1 |
SMART |
|
TPR
|
1062 |
1095 |
5.69e0 |
SMART |
|
TPR
|
1102 |
1135 |
3.14e-2 |
SMART |
|
TPR
|
1142 |
1175 |
2.84e1 |
SMART |
|
low complexity region
|
1259 |
1277 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1415 |
1738 |
7.3e-77 |
PFAM |
|
low complexity region
|
1972 |
1990 |
N/A |
INTRINSIC |
|
low complexity region
|
2014 |
2031 |
N/A |
INTRINSIC |
|
low complexity region
|
2033 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2155 |
2171 |
N/A |
INTRINSIC |
|
low complexity region
|
2283 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2327 |
2352 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143505
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156290
AA Change: T36S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000137609
Gene: ENSMUSG00000033209
AA Change: T36S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
308 |
341 |
1.78e-1 |
SMART |
|
TPR
|
348 |
381 |
2.82e-4 |
SMART |
|
TPR
|
388 |
421 |
9.98e-5 |
SMART |
|
TPR
|
428 |
461 |
1.88e0 |
SMART |
|
TPR
|
468 |
501 |
1.11e1 |
SMART |
|
TPR
|
508 |
541 |
2.93e-2 |
SMART |
|
TPR
|
548 |
581 |
1.21e-3 |
SMART |
|
TPR
|
588 |
621 |
4.91e-4 |
SMART |
|
TPR
|
628 |
661 |
7.56e-5 |
SMART |
|
TPR
|
668 |
701 |
8.29e0 |
SMART |
|
TPR
|
708 |
741 |
1.63e0 |
SMART |
|
TPR
|
748 |
781 |
1.24e0 |
SMART |
|
TPR
|
788 |
821 |
7.98e-4 |
SMART |
|
TPR
|
828 |
861 |
8.74e0 |
SMART |
|
TPR
|
871 |
904 |
5.43e-6 |
SMART |
|
TPR
|
911 |
944 |
4.09e-1 |
SMART |
|
TPR
|
951 |
984 |
9.98e-5 |
SMART |
|
TPR
|
991 |
1024 |
7.12e-1 |
SMART |
|
TPR
|
1031 |
1064 |
5.69e0 |
SMART |
|
TPR
|
1071 |
1104 |
3.14e-2 |
SMART |
|
TPR
|
1111 |
1144 |
2.84e1 |
SMART |
|
low complexity region
|
1228 |
1246 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1384 |
1707 |
1.1e-76 |
PFAM |
|
low complexity region
|
1941 |
1959 |
N/A |
INTRINSIC |
|
low complexity region
|
1983 |
2000 |
N/A |
INTRINSIC |
|
low complexity region
|
2002 |
2014 |
N/A |
INTRINSIC |
|
low complexity region
|
2124 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2252 |
2262 |
N/A |
INTRINSIC |
|
low complexity region
|
2296 |
2321 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 0.0%
- 3x: 0.0%
- 10x: 0.0%
- 20x: 0.0%
|
| Validation Efficiency |
92% (126/137) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 129 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010B08Rik |
C |
T |
2: 173,561,599 (GRCm39) |
|
probably benign |
Het |
| Alpk2 |
G |
A |
18: 65,439,450 (GRCm39) |
H648Y |
possibly damaging |
Het |
| Ambp |
A |
G |
4: 63,062,502 (GRCm39) |
Y246H |
probably damaging |
Het |
| Amz1 |
T |
C |
5: 140,735,088 (GRCm39) |
|
probably null |
Het |
| Anks6 |
G |
A |
4: 47,027,109 (GRCm39) |
T703I |
probably damaging |
Het |
| Armc2 |
A |
G |
10: 41,823,883 (GRCm39) |
|
probably benign |
Het |
| Atp7b |
T |
A |
8: 22,484,672 (GRCm39) |
I1347F |
probably damaging |
Het |
| Atp8a1 |
C |
T |
5: 67,779,945 (GRCm39) |
W1149* |
probably null |
Het |
| Auh |
A |
G |
13: 52,995,046 (GRCm39) |
I173T |
probably damaging |
Het |
| Axin2 |
T |
C |
11: 108,814,829 (GRCm39) |
L239P |
possibly damaging |
Het |
| Bbs1 |
A |
T |
19: 4,949,287 (GRCm39) |
F257L |
possibly damaging |
Het |
| Cacna2d2 |
C |
T |
9: 107,401,867 (GRCm39) |
P774L |
probably damaging |
Het |
| Card6 |
A |
G |
15: 5,137,788 (GRCm39) |
L22P |
probably damaging |
Het |
| Ccdc171 |
C |
T |
4: 83,579,946 (GRCm39) |
|
|
Het |
| Ccn2 |
T |
C |
10: 24,471,988 (GRCm39) |
V70A |
probably damaging |
Het |
| Cdc14a |
T |
A |
3: 116,122,310 (GRCm39) |
N219I |
possibly damaging |
Het |
| Cfap65 |
G |
T |
1: 74,967,501 (GRCm39) |
N192K |
probably benign |
Het |
| Col14a1 |
T |
C |
15: 55,312,272 (GRCm39) |
|
probably benign |
Het |
| Col5a1 |
A |
G |
2: 27,914,665 (GRCm39) |
T94A |
probably benign |
Het |
| Col6a5 |
T |
C |
9: 105,759,113 (GRCm39) |
N2031S |
probably damaging |
Het |
| Col7a1 |
T |
C |
9: 108,794,989 (GRCm39) |
|
probably benign |
Het |
| Cyld |
T |
C |
8: 89,473,543 (GRCm39) |
S739P |
probably damaging |
Het |
| Dbr1 |
A |
G |
9: 99,466,072 (GRCm39) |
|
probably null |
Het |
| Dip2b |
T |
C |
15: 100,100,233 (GRCm39) |
L1267P |
probably damaging |
Het |
| Dolk |
A |
G |
2: 30,175,586 (GRCm39) |
M153T |
probably benign |
Het |
| Duxf1 |
C |
T |
10: 58,060,704 (GRCm39) |
E17K |
possibly damaging |
Het |
| Duxf1 |
G |
A |
10: 58,060,136 (GRCm39) |
|
probably benign |
Het |
| Duxf1 |
A |
G |
10: 58,059,276 (GRCm39) |
C493R |
probably benign |
Het |
| Duxf3 |
A |
C |
10: 58,067,498 (GRCm39) |
S27A |
probably benign |
Het |
| Eef1d |
C |
T |
15: 75,775,581 (GRCm39) |
R26H |
probably benign |
Homo |
| Efcab5 |
C |
T |
11: 77,028,517 (GRCm39) |
|
|
Het |
| Epc1 |
T |
C |
18: 6,449,246 (GRCm39) |
D467G |
probably damaging |
Het |
| Fancm |
T |
G |
12: 65,152,196 (GRCm39) |
M884R |
probably benign |
Het |
| Fbxo24 |
G |
T |
5: 137,620,164 (GRCm39) |
H15N |
probably damaging |
Het |
| Frem1 |
A |
G |
4: 82,924,045 (GRCm39) |
F305L |
probably damaging |
Het |
| Fstl5 |
A |
G |
3: 76,567,006 (GRCm39) |
D550G |
probably damaging |
Het |
| Gcnt3 |
T |
G |
9: 69,941,326 (GRCm39) |
K414T |
possibly damaging |
Het |
| Gm10718 |
A |
T |
9: 3,024,417 (GRCm39) |
T134S |
probably benign |
Het |
| Gm10722 |
A |
G,C |
9: 3,001,414 (GRCm39) |
|
probably benign |
Het |
| Gm10800 |
T |
C |
2: 98,497,163 (GRCm39) |
R152G |
probably benign |
Homo |
| Gm10800 |
C |
A |
2: 98,497,250 (GRCm39) |
V123F |
probably benign |
Homo |
| Gm10800 |
A |
C |
2: 98,496,893 (GRCm39) |
F220C |
probably benign |
Het |
| Gm10801 |
A |
G |
2: 98,492,648 (GRCm39) |
R23G |
probably benign |
Homo |
| Gm11168 |
C |
T |
9: 3,004,605 (GRCm39) |
P49S |
probably benign |
Het |
| Gm21738 |
G |
A |
14: 19,417,330 (GRCm38) |
S66L |
probably benign |
Het |
| Hjurp |
TCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCTG |
T |
1: 88,194,000 (GRCm39) |
|
probably benign |
Het |
| Hmgcr |
A |
G |
13: 96,795,562 (GRCm39) |
Y336H |
probably damaging |
Het |
| Hoxa13 |
G |
C |
6: 52,260,648 (GRCm38) |
|
probably benign |
Homo |
| Hoxa13 |
C |
G |
6: 52,260,647 (GRCm38) |
|
probably benign |
Homo |
| Igf2bp3 |
A |
C |
6: 49,094,084 (GRCm39) |
|
probably null |
Het |
| Kcnb2 |
A |
T |
1: 15,383,200 (GRCm39) |
K175N |
possibly damaging |
Het |
| Kdr |
T |
C |
5: 76,102,631 (GRCm39) |
|
probably benign |
Het |
| Kif5c |
A |
G |
2: 49,584,044 (GRCm39) |
K160E |
probably damaging |
Het |
| Kif7 |
A |
T |
7: 79,360,817 (GRCm39) |
V186E |
probably damaging |
Het |
| Krt16 |
T |
A |
11: 100,139,575 (GRCm39) |
T48S |
unknown |
Het |
| Liph |
T |
C |
16: 21,814,119 (GRCm39) |
M1V |
probably null |
Het |
| Mctp2 |
A |
G |
7: 71,740,005 (GRCm39) |
F795S |
probably damaging |
Het |
| Muc4 |
T |
A |
16: 32,755,699 (GRCm38) |
|
probably benign |
Homo |
| Muc4 |
C |
G |
16: 32,755,676 (GRCm38) |
|
probably benign |
Homo |
| Muc4 |
T |
A |
16: 32,755,684 (GRCm38) |
|
probably benign |
Homo |
| Myo15a |
G |
T |
11: 60,373,953 (GRCm39) |
A1267S |
probably damaging |
Het |
| Myo15a |
T |
C |
11: 60,386,280 (GRCm39) |
Y1802H |
probably damaging |
Het |
| Myo7b |
G |
A |
18: 32,094,259 (GRCm39) |
T1963I |
probably benign |
Het |
| Nadk2 |
TG |
T |
15: 9,100,232 (GRCm39) |
|
probably null |
Homo |
| Naip5 |
T |
C |
13: 100,356,268 (GRCm39) |
N1116D |
probably benign |
Het |
| Naip5 |
T |
C |
13: 100,356,247 (GRCm39) |
R1123G |
probably benign |
Het |
| Nap1l1 |
A |
G |
10: 111,322,583 (GRCm39) |
D61G |
probably null |
Het |
| Napsa |
A |
T |
7: 44,230,875 (GRCm39) |
T81S |
probably damaging |
Het |
| Ngp |
T |
C |
9: 110,251,337 (GRCm39) |
|
probably benign |
Het |
| Nktr |
T |
A |
9: 121,570,687 (GRCm39) |
V143E |
probably damaging |
Het |
| Obscn |
A |
G |
11: 58,957,890 (GRCm39) |
|
probably null |
Het |
| Or10ag53 |
G |
A |
2: 87,082,973 (GRCm39) |
A231T |
probably benign |
Het |
| Or11i1 |
T |
C |
3: 106,729,282 (GRCm39) |
I198V |
probably benign |
Het |
| Or4f56 |
G |
A |
2: 111,703,649 (GRCm39) |
L184F |
probably benign |
Het |
| Or52ab2 |
C |
T |
7: 102,970,076 (GRCm39) |
R153* |
probably null |
Het |
| Or52d3 |
G |
A |
7: 104,229,237 (GRCm39) |
R128Q |
probably damaging |
Het |
| Or6p1 |
A |
G |
1: 174,258,390 (GRCm39) |
Y132C |
probably damaging |
Het |
| Paip2b |
A |
G |
6: 83,785,823 (GRCm39) |
Y136H |
probably damaging |
Het |
| Pde2a |
G |
T |
7: 101,160,361 (GRCm39) |
R845L |
probably damaging |
Het |
| Pgap2 |
A |
G |
7: 101,886,405 (GRCm39) |
Y197C |
possibly damaging |
Het |
| Phf11b |
A |
G |
14: 59,560,611 (GRCm39) |
|
probably benign |
Het |
| Pitpnm2 |
A |
T |
5: 124,269,178 (GRCm39) |
D481E |
probably benign |
Het |
| Pxk |
A |
T |
14: 8,152,130 (GRCm38) |
H482L |
probably benign |
Het |
| Rad50 |
A |
G |
11: 53,585,726 (GRCm39) |
|
probably null |
Het |
| Rbmyf1 |
T |
A |
Y: 2,787,132 (GRCm39) |
N228Y |
probably benign |
Het |
| Rbmyf5 |
T |
C |
Y: 3,297,411 (GRCm39) |
H235R |
probably benign |
Het |
| Rbmyf6 |
C |
T |
Y: 3,328,944 (GRCm39) |
A241T |
possibly damaging |
Het |
| Rnf220 |
A |
G |
4: 117,134,566 (GRCm39) |
|
probably null |
Het |
| Saxo5 |
T |
A |
8: 3,526,062 (GRCm39) |
S72T |
possibly damaging |
Het |
| Selenbp1 |
C |
T |
3: 94,844,607 (GRCm39) |
T88M |
probably damaging |
Het |
| Sft2d1 |
T |
C |
17: 8,609,863 (GRCm39) |
I104T |
possibly damaging |
Het |
| Sik1 |
A |
G |
17: 32,070,305 (GRCm39) |
S135P |
probably damaging |
Het |
| Slc16a3 |
T |
C |
11: 120,846,172 (GRCm39) |
F34L |
probably damaging |
Het |
| Slc6a20b |
T |
C |
9: 123,612,126 (GRCm38) |
N85S |
probably benign |
Homo |
| Snrnp27 |
T |
C |
6: 86,659,893 (GRCm39) |
R34G |
unknown |
Het |
| Sos2 |
T |
C |
12: 69,664,851 (GRCm39) |
H393R |
probably benign |
Het |
| Sp110 |
C |
T |
1: 85,513,971 (GRCm39) |
R262Q |
probably benign |
Het |
| Sp110 |
T |
C |
1: 85,513,975 (GRCm39) |
R261G |
probably benign |
Het |
| Sp140 |
T |
A |
1: 85,528,893 (GRCm39) |
Y5N |
probably benign |
Het |
| Sp140 |
A |
G |
1: 85,570,942 (GRCm39) |
S461G |
probably benign |
Het |
| Sp140 |
G |
C |
1: 85,538,603 (GRCm39) |
K113N |
probably benign |
Het |
| Sp140l1 |
G |
A |
1: 85,077,341 (GRCm39) |
A75V |
probably benign |
Het |
| Sp140l2 |
A |
C |
1: 85,223,395 (GRCm39) |
|
probably benign |
Het |
| Speer4a2 |
C |
G |
5: 26,294,093 (GRCm39) |
W28C |
probably damaging |
Het |
| Speer4a2 |
A |
T |
5: 26,291,485 (GRCm39) |
F107Y |
probably benign |
Het |
| Ssrp1 |
G |
A |
2: 84,868,760 (GRCm39) |
V40M |
probably damaging |
Het |
| Tada2a |
T |
C |
11: 83,970,563 (GRCm39) |
E202G |
probably damaging |
Het |
| Tcf20 |
C |
A |
15: 82,735,785 (GRCm39) |
A1889S |
probably damaging |
Het |
| Tdrd12 |
A |
T |
7: 35,180,528 (GRCm39) |
Y828* |
probably null |
Het |
| Tlr2 |
T |
A |
3: 83,745,756 (GRCm39) |
D109V |
probably benign |
Het |
| Tomm40 |
G |
A |
7: 19,437,016 (GRCm39) |
T17M |
probably damaging |
Het |
| Tsga10ip |
T |
C |
19: 5,440,161 (GRCm39) |
T135A |
possibly damaging |
Het |
| Tspan8 |
G |
A |
10: 115,653,515 (GRCm39) |
V4M |
probably damaging |
Het |
| Ugt1a6b |
G |
A |
1: 88,146,112 (GRCm39) |
R519Q |
probably damaging |
Het |
| Ugt1a6b |
TTCA |
T |
1: 88,143,880 (GRCm39) |
|
probably benign |
Het |
| Ugt1a6b |
G |
A |
1: 88,143,976 (GRCm39) |
A199T |
probably damaging |
Het |
| Unc45a |
A |
G |
7: 79,976,109 (GRCm39) |
M790T |
possibly damaging |
Het |
| Vav3 |
T |
C |
3: 109,571,751 (GRCm39) |
|
probably null |
Het |
| Vcpkmt |
G |
A |
12: 69,629,552 (GRCm39) |
S70L |
probably benign |
Het |
| Vmn1r3 |
C |
T |
4: 3,184,691 (GRCm39) |
M205I |
probably damaging |
Het |
| Vmn1r3 |
C |
T |
4: 3,184,774 (GRCm39) |
V178I |
probably benign |
Het |
| Vmn2r66 |
T |
C |
7: 84,644,301 (GRCm39) |
Q703R |
probably damaging |
Het |
| Vmn2r98 |
G |
T |
17: 19,301,223 (GRCm39) |
V742F |
probably benign |
Het |
| Wfdc8 |
A |
G |
2: 164,439,696 (GRCm39) |
S229P |
possibly damaging |
Het |
| Xpo4 |
A |
T |
14: 57,822,068 (GRCm39) |
C1083S |
probably null |
Het |
| Zbtb38 |
T |
C |
9: 96,568,369 (GRCm39) |
D905G |
probably damaging |
Het |
| Zbtb8b |
A |
G |
4: 129,321,308 (GRCm39) |
*518Q |
probably null |
Het |
| Zfp600 |
TC |
T |
4: 146,131,802 (GRCm39) |
|
probably null |
Het |
| Zfp992 |
C |
T |
4: 146,550,569 (GRCm39) |
P97S |
probably benign |
Het |
|
| Other mutations in Ttc28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Ttc28
|
APN |
5 |
111,373,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Ttc28
|
APN |
5 |
111,434,255 (GRCm39) |
nonsense |
probably null |
|
|
IGL00969:Ttc28
|
APN |
5 |
111,373,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01366:Ttc28
|
APN |
5 |
111,233,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01528:Ttc28
|
APN |
5 |
111,249,826 (GRCm39) |
splice site |
probably benign |
|
|
IGL01558:Ttc28
|
APN |
5 |
111,431,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01973:Ttc28
|
APN |
5 |
111,372,101 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02040:Ttc28
|
APN |
5 |
111,040,802 (GRCm39) |
nonsense |
probably null |
|
|
IGL02432:Ttc28
|
APN |
5 |
111,371,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Ttc28
|
APN |
5 |
111,373,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02819:Ttc28
|
APN |
5 |
111,414,449 (GRCm39) |
missense |
probably benign |
|
|
IGL02830:Ttc28
|
APN |
5 |
111,434,105 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02893:Ttc28
|
APN |
5 |
111,433,251 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03387:Ttc28
|
APN |
5 |
111,381,208 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0142:Ttc28
|
UTSW |
5 |
111,425,323 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0166:Ttc28
|
UTSW |
5 |
111,373,500 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0328:Ttc28
|
UTSW |
5 |
111,431,933 (GRCm39) |
splice site |
probably benign |
|
|
R0582:Ttc28
|
UTSW |
5 |
111,331,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0812:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0828:Ttc28
|
UTSW |
5 |
111,371,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0833:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1013:Ttc28
|
UTSW |
5 |
111,424,831 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1168:Ttc28
|
UTSW |
5 |
111,378,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1194:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Ttc28
|
UTSW |
5 |
111,433,635 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1386:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1537:Ttc28
|
UTSW |
5 |
111,433,184 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1539:Ttc28
|
UTSW |
5 |
111,248,677 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1558:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1560:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1561:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1566:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Ttc28
|
UTSW |
5 |
111,425,034 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1775:Ttc28
|
UTSW |
5 |
111,424,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1909:Ttc28
|
UTSW |
5 |
111,431,920 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1911:Ttc28
|
UTSW |
5 |
111,428,616 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1970:Ttc28
|
UTSW |
5 |
111,383,501 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1990:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1992:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2066:Ttc28
|
UTSW |
5 |
111,373,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2112:Ttc28
|
UTSW |
5 |
111,424,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2158:Ttc28
|
UTSW |
5 |
111,325,483 (GRCm39) |
intron |
probably benign |
|
|
R2192:Ttc28
|
UTSW |
5 |
111,371,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2267:Ttc28
|
UTSW |
5 |
111,373,869 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2384:Ttc28
|
UTSW |
5 |
111,424,074 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2989:Ttc28
|
UTSW |
5 |
111,371,881 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3881:Ttc28
|
UTSW |
5 |
111,331,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3919:Ttc28
|
UTSW |
5 |
111,433,245 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4455:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4456:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4522:Ttc28
|
UTSW |
5 |
111,428,038 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4548:Ttc28
|
UTSW |
5 |
111,419,090 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4591:Ttc28
|
UTSW |
5 |
111,371,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4633:Ttc28
|
UTSW |
5 |
111,371,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc28
|
UTSW |
5 |
111,424,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Ttc28
|
UTSW |
5 |
111,433,095 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4790:Ttc28
|
UTSW |
5 |
111,372,083 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4803:Ttc28
|
UTSW |
5 |
111,425,329 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4840:Ttc28
|
UTSW |
5 |
111,433,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4969:Ttc28
|
UTSW |
5 |
111,424,121 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5019:Ttc28
|
UTSW |
5 |
111,249,930 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5130:Ttc28
|
UTSW |
5 |
111,040,722 (GRCm39) |
missense |
probably benign |
|
|
R5150:Ttc28
|
UTSW |
5 |
111,373,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Ttc28
|
UTSW |
5 |
111,325,489 (GRCm39) |
intron |
probably benign |
|
|
R5254:Ttc28
|
UTSW |
5 |
111,419,104 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5518:Ttc28
|
UTSW |
5 |
111,373,794 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5851:Ttc28
|
UTSW |
5 |
111,383,335 (GRCm39) |
splice site |
probably benign |
|
|
R5931:Ttc28
|
UTSW |
5 |
111,232,975 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6011:Ttc28
|
UTSW |
5 |
111,434,309 (GRCm39) |
missense |
probably benign |
|
|
R6176:Ttc28
|
UTSW |
5 |
111,371,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6221:Ttc28
|
UTSW |
5 |
111,419,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6398:Ttc28
|
UTSW |
5 |
111,424,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6717:Ttc28
|
UTSW |
5 |
111,433,302 (GRCm39) |
missense |
probably benign |
|
|
R6770:Ttc28
|
UTSW |
5 |
111,434,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6901:Ttc28
|
UTSW |
5 |
111,424,891 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7038:Ttc28
|
UTSW |
5 |
111,414,445 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7073:Ttc28
|
UTSW |
5 |
111,371,282 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7101:Ttc28
|
UTSW |
5 |
111,232,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7135:Ttc28
|
UTSW |
5 |
111,427,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Ttc28
|
UTSW |
5 |
111,373,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7454:Ttc28
|
UTSW |
5 |
111,433,350 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7461:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7596:Ttc28
|
UTSW |
5 |
111,427,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7613:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7625:Ttc28
|
UTSW |
5 |
111,433,085 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7648:Ttc28
|
UTSW |
5 |
111,331,258 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7735:Ttc28
|
UTSW |
5 |
111,414,544 (GRCm39) |
splice site |
probably null |
|
|
R8030:Ttc28
|
UTSW |
5 |
111,433,922 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8205:Ttc28
|
UTSW |
5 |
111,373,596 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8246:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8247:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8269:Ttc28
|
UTSW |
5 |
111,425,325 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8292:Ttc28
|
UTSW |
5 |
111,371,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8346:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8356:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8423:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8424:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8426:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8441:Ttc28
|
UTSW |
5 |
111,325,507 (GRCm39) |
nonsense |
probably null |
|
|
R8494:Ttc28
|
UTSW |
5 |
111,383,506 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8508:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8510:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8729:Ttc28
|
UTSW |
5 |
111,383,509 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8845:Ttc28
|
UTSW |
5 |
111,372,041 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9003:Ttc28
|
UTSW |
5 |
111,424,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9185:Ttc28
|
UTSW |
5 |
111,371,342 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9187:Ttc28
|
UTSW |
5 |
111,249,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Ttc28
|
UTSW |
5 |
111,325,525 (GRCm39) |
missense |
unknown |
|
|
R9251:Ttc28
|
UTSW |
5 |
111,040,698 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9372:Ttc28
|
UTSW |
5 |
111,331,073 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9466:Ttc28
|
UTSW |
5 |
111,330,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9563:Ttc28
|
UTSW |
5 |
111,371,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9606:Ttc28
|
UTSW |
5 |
111,433,140 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9691:Ttc28
|
UTSW |
5 |
111,431,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9709:Ttc28
|
UTSW |
5 |
111,433,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
V8831:Ttc28
|
UTSW |
5 |
111,248,578 (GRCm39) |
missense |
probably benign |
0.11 |
|
Z1088:Ttc28
|
UTSW |
5 |
111,434,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Ttc28
|
UTSW |
5 |
111,414,432 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,433,605 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,426,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTTGGCTGTTTCAAGGAAAGC -3'
(R):5'- CATGTAGGCTGCAGATCTGTTG -3'
Sequencing Primer
(F):5'- TGGCTGTTTCAAGGAAAGCATATG -3'
(R):5'- AGGCTGCAGATCTGTTGCTATAC -3'
|
| Posted On |
2018-06-12 |
Incidental Mutation