Mutagenetix > Incidental Mutation

Incidental Mutation 'PIT4131001:Vmn2r98'

523269

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

PIT4131001 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19053460-19082411 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 19080961 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 742 (V742F)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: V742F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: V742F

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

1x: 0.0%
3x: 0.0%
10x: 0.0%
20x: 0.0%

Validation Efficiency

92% (126/137)

Allele List at MGI

Other mutations in this stock

Total: 129 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010B08Rik	C	T	2: 173,719,806 (GRCm38)		probably benign	Het
A530032D15Rik	G	A	1: 85,099,620 (GRCm38)	A75V	probably benign	Het
Alpk2	G	A	18: 65,306,379 (GRCm38)	H648Y	possibly damaging	Het
Ambp	A	G	4: 63,144,265 (GRCm38)	Y246H	probably damaging	Het
Amz1	T	C	5: 140,749,333 (GRCm38)		probably null	Het
Anks6	G	A	4: 47,027,109 (GRCm38)	T703I	probably damaging	Het
Armc2	A	G	10: 41,947,887 (GRCm38)		probably benign	Het
Atp7b	T	A	8: 21,994,656 (GRCm38)	I1347F	probably damaging	Het
Atp8a1	C	T	5: 67,622,602 (GRCm38)	W1149*	probably null	Het
Auh	A	G	13: 52,841,010 (GRCm38)	I173T	probably damaging	Het
AW822073	C	T	10: 58,224,882 (GRCm38)	E17K	possibly damaging	Het
AW822073	G	A	10: 58,224,314 (GRCm38)		probably benign	Het
AW822073	A	G	10: 58,223,454 (GRCm38)	C493R	probably benign	Het
Axin2	T	C	11: 108,924,003 (GRCm38)	L239P	possibly damaging	Het
Bbs1	A	T	19: 4,899,259 (GRCm38)	F257L	possibly damaging	Het
C130026I21Rik	A	C	1: 85,245,674 (GRCm38)		probably benign	Het
Cacna2d2	C	T	9: 107,524,668 (GRCm38)	P774L	probably damaging	Het
Card6	A	G	15: 5,108,306 (GRCm38)	L22P	probably damaging	Het
Ccdc171	C	T	4: 83,661,709 (GRCm38)			Het
Cdc14a	T	A	3: 116,328,661 (GRCm38)	N219I	possibly damaging	Het
Cfap65	G	T	1: 74,928,342 (GRCm38)	N192K	probably benign	Het
Col14a1	T	C	15: 55,448,876 (GRCm38)		probably benign	Het
Col5a1	A	G	2: 28,024,653 (GRCm38)	T94A	probably benign	Het
Col6a5	T	C	9: 105,881,914 (GRCm38)	N2031S	probably damaging	Het
Col7a1	T	C	9: 108,965,921 (GRCm38)		probably benign	Het
Ctgf	T	C	10: 24,596,090 (GRCm38)	V70A	probably damaging	Het
Cyld	T	C	8: 88,746,915 (GRCm38)	S739P	probably damaging	Het
Dbr1	A	G	9: 99,584,019 (GRCm38)		probably null	Het
Dip2b	T	C	15: 100,202,352 (GRCm38)	L1267P	probably damaging	Het
Dolk	A	G	2: 30,285,574 (GRCm38)	M153T	probably benign	Het
Duxf3	A	C	10: 58,231,676 (GRCm38)	S27A	probably benign	Het
Eef1d	C	T	15: 75,903,732 (GRCm38)	R26H	probably benign	Homo
Efcab5	C	T	11: 77,137,691 (GRCm38)			Het
Epc1	T	C	18: 6,449,246 (GRCm38)	D467G	probably damaging	Het
Fancm	T	G	12: 65,105,422 (GRCm38)	M884R	probably benign	Het
Fbxo24	G	T	5: 137,621,902 (GRCm38)	H15N	probably damaging	Het
Frem1	A	G	4: 83,005,808 (GRCm38)	F305L	probably damaging	Het
Fstl5	A	G	3: 76,659,699 (GRCm38)	D550G	probably damaging	Het
Gcnt3	T	G	9: 70,034,044 (GRCm38)	K414T	possibly damaging	Het
Gm10471	A	T	5: 26,086,487 (GRCm38)	F107Y	probably benign	Het
Gm10471	C	G	5: 26,089,095 (GRCm38)	W28C	probably damaging	Het
Gm10718	A	T	9: 3,024,417 (GRCm38)	T134S	probably benign	Het
Gm10722	A	G,C	9: 3,001,414 (GRCm38)		probably benign	Het
Gm10800	A	C	2: 98,666,548 (GRCm38)	F220C	probably benign	Het
Gm10800	T	C	2: 98,666,818 (GRCm38)	R152G	probably benign	Homo
Gm10800	C	A	2: 98,666,905 (GRCm38)	V123F	probably benign	Homo
Gm10801	A	G	2: 98,662,303 (GRCm38)	R23G	probably benign	Homo
Gm11168	C	T	9: 3,004,605 (GRCm38)	P49S	probably benign	Het
Gm21677	T	C	Y: 3,297,411 (GRCm38)	H235R	probably benign	Het
Gm21693	C	T	Y: 3,328,944 (GRCm38)	A241T	possibly damaging	Het
Gm21738	G	A	14: 19,417,330 (GRCm38)	S66L	probably benign	Het
Gm4064	T	A	Y: 2,787,132 (GRCm38)	N228Y	probably benign	Het
Hjurp	TCTGGGAGGGCTTGCTCCGGGGGCAGTGTGTCCTGTTCTTGTGCAGCCCCTG	T	1: 88,266,278 (GRCm38)		probably benign	Het
Hmgcr	A	G	13: 96,659,054 (GRCm38)	Y336H	probably damaging	Het
Hoxa13	C	G	6: 52,260,647 (GRCm38)		probably benign	Homo
Hoxa13	G	C	6: 52,260,648 (GRCm38)		probably benign	Homo
Igf2bp3	A	C	6: 49,117,150 (GRCm38)		probably null	Het
Kcnb2	A	T	1: 15,312,976 (GRCm38)	K175N	possibly damaging	Het
Kdr	T	C	5: 75,941,971 (GRCm38)		probably benign	Het
Kif5c	A	G	2: 49,694,032 (GRCm38)	K160E	probably damaging	Het
Kif7	A	T	7: 79,711,069 (GRCm38)	V186E	probably damaging	Het
Krt16	T	A	11: 100,248,749 (GRCm38)	T48S	unknown	Het
Liph	T	C	16: 21,995,369 (GRCm38)	M1V	probably null	Het
Mctp2	A	G	7: 72,090,257 (GRCm38)	F795S	probably damaging	Het
Muc4	C	G	16: 32,755,676 (GRCm38)		probably benign	Homo
Muc4	T	A	16: 32,755,684 (GRCm38)		probably benign	Homo
Muc4	T	A	16: 32,755,699 (GRCm38)		probably benign	Homo
Myo15	T	C	11: 60,495,454 (GRCm38)	Y1802H	probably damaging	Het
Myo15	G	T	11: 60,483,127 (GRCm38)	A1267S	probably damaging	Het
Myo7b	G	A	18: 31,961,206 (GRCm38)	T1963I	probably benign	Het
Nadk2	TG	T	15: 9,100,143 (GRCm38)		probably null	Homo
Naip5	T	C	13: 100,219,760 (GRCm38)	N1116D	probably benign	Het
Naip5	T	C	13: 100,219,739 (GRCm38)	R1123G	probably benign	Het
Nap1l1	A	G	10: 111,486,722 (GRCm38)	D61G	probably null	Het
Napsa	A	T	7: 44,581,451 (GRCm38)	T81S	probably damaging	Het
Ngp	T	C	9: 110,422,269 (GRCm38)		probably benign	Het
Nktr	T	A	9: 121,741,621 (GRCm38)	V143E	probably damaging	Het
Obscn	A	G	11: 59,067,064 (GRCm38)		probably null	Het
Olfr1115	G	A	2: 87,252,629 (GRCm38)	A231T	probably benign	Het
Olfr1305	G	A	2: 111,873,304 (GRCm38)	L184F	probably benign	Het
Olfr266	T	C	3: 106,821,966 (GRCm38)	I198V	probably benign	Het
Olfr414	A	G	1: 174,430,824 (GRCm38)	Y132C	probably damaging	Het
Olfr597	C	T	7: 103,320,869 (GRCm38)	R153*	probably null	Het
Olfr653	G	A	7: 104,580,030 (GRCm38)	R128Q	probably damaging	Het
Paip2b	A	G	6: 83,808,841 (GRCm38)	Y136H	probably damaging	Het
Pde2a	G	T	7: 101,511,154 (GRCm38)	R845L	probably damaging	Het
Pgap2	A	G	7: 102,237,198 (GRCm38)	Y197C	possibly damaging	Het
Phf11b	A	G	14: 59,323,162 (GRCm38)		probably benign	Het
Pitpnm2	A	T	5: 124,131,115 (GRCm38)	D481E	probably benign	Het
Pxk	A	T	14: 8,152,130 (GRCm38)	H482L	probably benign	Het
Rad50	A	G	11: 53,694,899 (GRCm38)		probably null	Het
Rnf220	A	G	4: 117,277,369 (GRCm38)		probably null	Het
Selenbp1	C	T	3: 94,937,296 (GRCm38)	T88M	probably damaging	Het
Sft2d1	T	C	17: 8,391,031 (GRCm38)	I104T	possibly damaging	Het
Sik1	A	G	17: 31,851,331 (GRCm38)	S135P	probably damaging	Het
Slc16a3	T	C	11: 120,955,346 (GRCm38)	F34L	probably damaging	Het
Slc6a20b	T	C	9: 123,612,126 (GRCm38)	N85S	probably benign	Homo
Snrnp27	T	C	6: 86,682,911 (GRCm38)	R34G	unknown	Het
Sos2	T	C	12: 69,618,077 (GRCm38)	H393R	probably benign	Het
Sp110	T	C	1: 85,586,254 (GRCm38)	R261G	probably benign	Het
Sp110	C	T	1: 85,586,250 (GRCm38)	R262Q	probably benign	Het
Sp140	T	A	1: 85,601,172 (GRCm38)	Y5N	probably benign	Het
Sp140	A	G	1: 85,643,221 (GRCm38)	S461G	probably benign	Het
Sp140	G	C	1: 85,610,882 (GRCm38)	K113N	probably benign	Het
Ssrp1	G	A	2: 85,038,416 (GRCm38)	V40M	probably damaging	Het
Tada2a	T	C	11: 84,079,737 (GRCm38)	E202G	probably damaging	Het
Tcf20	C	A	15: 82,851,584 (GRCm38)	A1889S	probably damaging	Het
Tdrd12	A	T	7: 35,481,103 (GRCm38)	Y828*	probably null	Het
Tex45	T	A	8: 3,476,062 (GRCm38)	S72T	possibly damaging	Het
Tlr2	T	A	3: 83,838,449 (GRCm38)	D109V	probably benign	Het
Tomm40	G	A	7: 19,703,091 (GRCm38)	T17M	probably damaging	Het
Tsga10ip	T	C	19: 5,390,133 (GRCm38)	T135A	possibly damaging	Het
Tspan8	G	A	10: 115,817,610 (GRCm38)	V4M	probably damaging	Het
Ttc28	A	T	5: 110,892,853 (GRCm38)	T36S	probably benign	Het
Ugt1a6b	TTCA	T	1: 88,216,158 (GRCm38)		probably benign	Het
Ugt1a6b	G	A	1: 88,216,254 (GRCm38)	A199T	probably damaging	Het
Ugt1a6b	G	A	1: 88,218,390 (GRCm38)	R519Q	probably damaging	Het
Unc45a	A	G	7: 80,326,361 (GRCm38)	M790T	possibly damaging	Het
Vav3	T	C	3: 109,664,435 (GRCm38)		probably null	Het
Vcpkmt	G	A	12: 69,582,778 (GRCm38)	S70L	probably benign	Het
Vmn1r3	C	T	4: 3,184,691 (GRCm38)	M205I	probably damaging	Het
Vmn1r3	C	T	4: 3,184,774 (GRCm38)	V178I	probably benign	Het
Vmn2r66	T	C	7: 84,995,093 (GRCm38)	Q703R	probably damaging	Het
Wfdc8	A	G	2: 164,597,776 (GRCm38)	S229P	possibly damaging	Het
Xpo4	A	T	14: 57,584,611 (GRCm38)	C1083S	probably null	Het
Zbtb38	T	C	9: 96,686,316 (GRCm38)	D905G	probably damaging	Het
Zbtb8b	A	G	4: 129,427,515 (GRCm38)	*518Q	probably null	Het
Zfp600	TC	T	4: 146,195,232 (GRCm38)		probably null	Het
Zfp992	C	T	4: 146,466,112 (GRCm38)	P97S	probably benign	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19,065,745 (GRCm38)	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19,065,185 (GRCm38)	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19,065,758 (GRCm38)	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19,065,259 (GRCm38)	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19,066,451 (GRCm38)	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19,066,440 (GRCm38)	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19,066,440 (GRCm38)	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19,066,286 (GRCm38)	missense	probably benign
IGL02123:Vmn2r98	APN	17	19,080,679 (GRCm38)	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19,065,851 (GRCm38)	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19,065,821 (GRCm38)	missense	probably benign
IGL02650:Vmn2r98	APN	17	19,080,961 (GRCm38)	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19,065,259 (GRCm38)	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19,066,013 (GRCm38)	missense	probably benign
IGL02807:Vmn2r98	APN	17	19,081,021 (GRCm38)	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19,065,980 (GRCm38)	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19,069,845 (GRCm38)	missense	possibly damaging	0.92
R0122:Vmn2r98	UTSW	17	19,066,400 (GRCm38)	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19,066,347 (GRCm38)	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19,066,347 (GRCm38)	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19,065,827 (GRCm38)	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19,053,613 (GRCm38)	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19,080,497 (GRCm38)	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19,080,520 (GRCm38)	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19,080,749 (GRCm38)	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19,065,948 (GRCm38)	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19,065,178 (GRCm38)	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19,067,383 (GRCm38)	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19,080,908 (GRCm38)	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19,066,440 (GRCm38)	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19,066,418 (GRCm38)	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19,065,333 (GRCm38)	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19,081,291 (GRCm38)	missense	unknown
R2238:Vmn2r98	UTSW	17	19,065,951 (GRCm38)	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19,080,436 (GRCm38)	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19,065,819 (GRCm38)	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19,081,177 (GRCm38)	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19,067,402 (GRCm38)	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19,065,863 (GRCm38)	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19,065,863 (GRCm38)	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19,065,863 (GRCm38)	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19,080,625 (GRCm38)	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19,066,092 (GRCm38)	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19,069,745 (GRCm38)	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19,066,340 (GRCm38)	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19,066,157 (GRCm38)	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19,066,044 (GRCm38)	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19,053,553 (GRCm38)	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19,080,719 (GRCm38)	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19,069,754 (GRCm38)	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19,069,753 (GRCm38)	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19,067,383 (GRCm38)	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19,080,899 (GRCm38)	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19,065,998 (GRCm38)	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19,066,074 (GRCm38)	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19,065,881 (GRCm38)	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19,065,801 (GRCm38)	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19,065,248 (GRCm38)	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19,066,268 (GRCm38)	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19,080,922 (GRCm38)	missense	probably benign
R7068:Vmn2r98	UTSW	17	19,065,313 (GRCm38)	missense	probably benign
R7607:Vmn2r98	UTSW	17	19,067,308 (GRCm38)	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19,080,535 (GRCm38)	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19,067,198 (GRCm38)	splice site	probably null
R7915:Vmn2r98	UTSW	17	19,067,231 (GRCm38)	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19,053,650 (GRCm38)	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19,081,163 (GRCm38)	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19,080,769 (GRCm38)	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19,066,270 (GRCm38)	missense	probably benign
R8952:Vmn2r98	UTSW	17	19,065,269 (GRCm38)	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19,066,121 (GRCm38)	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19,066,121 (GRCm38)	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19,081,219 (GRCm38)	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19,066,515 (GRCm38)	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19,067,255 (GRCm38)	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19,081,234 (GRCm38)	missense	possibly damaging	0.78
R9753:Vmn2r98	UTSW	17	19,065,403 (GRCm38)	missense	probably benign	0.27
Z1177:Vmn2r98	UTSW	17	19,067,423 (GRCm38)	nonsense	probably null
Z1177:Vmn2r98	UTSW	17	19,065,136 (GRCm38)	critical splice acceptor site	probably null

Predicted Primers

PCR Primer
(F):5'- TGGTCCTTGCCTTTAAGATCAG -3'
(R):5'- ATGGCCACCATGACCTTTCC -3'

Sequencing Primer
(F):5'- CCTTTAAGATCAGTTTTCCAGGGAG -3'
(R):5'- ACCTTTCCTTTAGTGCTGTGGTAGAC -3'

Posted On

2018-06-12