Incidental Mutation 'R6575:Fcrla'
ID 523376
Institutional Source Beutler Lab
Gene Symbol Fcrla
Ensembl Gene ENSMUSG00000038421
Gene Name Fc receptor-like A
Synonyms mFREB, Freb1, Fcrx, mFcrX, FREB, FCRL1
MMRRC Submission 044699-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6575 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 170745163-170755169 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 170749797 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 87 (S87P)
Ref Sequence ENSEMBL: ENSMUSP00000124859 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046322] [ENSMUST00000159149] [ENSMUST00000159171] [ENSMUST00000162136] [ENSMUST00000162887]
AlphaFold Q920A9
Predicted Effect probably damaging
Transcript: ENSMUST00000046322
AA Change: S87P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000036380
Gene: ENSMUSG00000038421
AA Change: S87P

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 49 62 N/A INTRINSIC
IG 95 177 5.75e-4 SMART
IG 188 272 1.4e-7 SMART
low complexity region 281 296 N/A INTRINSIC
low complexity region 310 323 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000159149
AA Change: S58P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125074
Gene: ENSMUSG00000038421
AA Change: S58P

DomainStartEndE-ValueType
low complexity region 20 33 N/A INTRINSIC
IG 66 148 5.75e-4 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000159171
AA Change: S86P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124853
Gene: ENSMUSG00000038421
AA Change: S86P

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
low complexity region 48 61 N/A INTRINSIC
IG 94 176 5.75e-4 SMART
IG 187 271 1.4e-7 SMART
low complexity region 280 295 N/A INTRINSIC
low complexity region 309 322 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159266
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161050
Predicted Effect probably damaging
Transcript: ENSMUST00000162136
AA Change: S87P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124859
Gene: ENSMUSG00000038421
AA Change: S87P

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
low complexity region 49 62 N/A INTRINSIC
Pfam:Ig_2 83 150 2.2e-6 PFAM
Pfam:Ig_2 156 215 1e-3 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000162887
AA Change: S25P

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000124469
Gene: ENSMUSG00000038421
AA Change: S25P

DomainStartEndE-ValueType
Pfam:Ig_2 28 78 1.4e-7 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a targeted allele exhibit largely normal T-dependent and T-independent antibody responses with an increase in IgG1 after secondary challenge with sheep red blood cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900026A02Rik T C 5: 113,330,683 (GRCm39) Y1177C probably damaging Het
Acnat1 A G 4: 49,450,785 (GRCm39) Y109H possibly damaging Het
Adgrf3 T A 5: 30,401,522 (GRCm39) K835N possibly damaging Het
Afg1l T C 10: 42,194,712 (GRCm39) D360G probably damaging Het
Ap3s1 C T 18: 46,887,448 (GRCm39) T27M probably benign Het
Atp8b4 A G 2: 126,256,284 (GRCm39) L225P probably damaging Het
Bicra G A 7: 15,713,056 (GRCm39) T997I probably benign Het
Bod1l T C 5: 41,995,411 (GRCm39) R112G probably damaging Het
Cabin1 T C 10: 75,561,535 (GRCm39) T989A possibly damaging Het
Cog1 C A 11: 113,546,887 (GRCm39) Q494K probably benign Het
Cyb5rl T C 4: 106,942,550 (GRCm39) Y160H probably benign Het
Dnajb8 A G 6: 88,200,057 (GRCm39) N198D probably damaging Het
Eif1ad11 T C 12: 87,994,117 (GRCm39) I115T probably damaging Het
Eif3l C A 15: 78,970,778 (GRCm39) Q351K possibly damaging Het
Esr1 T C 10: 4,916,301 (GRCm39) probably benign Het
Fam3c G T 6: 22,329,607 (GRCm39) A40D probably damaging Het
Glra1 A G 11: 55,411,822 (GRCm39) Y246H probably damaging Het
Gm45871 T A 18: 90,609,844 (GRCm39) C361S probably damaging Het
Greb1l A G 18: 10,547,347 (GRCm39) N1522D possibly damaging Het
Hcn4 T C 9: 58,731,435 (GRCm39) M214T unknown Het
Heatr5b A T 17: 79,070,418 (GRCm39) V1665E probably damaging Het
Hemgn C A 4: 46,395,990 (GRCm39) M415I possibly damaging Het
Hibadh G A 6: 52,524,013 (GRCm39) T295I probably damaging Het
Iars1 T C 13: 49,878,745 (GRCm39) L947P probably damaging Het
Icam2 G A 11: 106,269,585 (GRCm39) T178I probably damaging Het
Lbr A G 1: 181,663,763 (GRCm39) S86P probably damaging Het
Lipe G A 7: 25,082,749 (GRCm39) T801I probably benign Het
Lrp6 T C 6: 134,518,934 (GRCm39) T44A possibly damaging Het
Malrd1 A G 2: 15,847,439 (GRCm39) H1193R probably benign Het
Mroh2a GCCC GC 1: 88,159,979 (GRCm39) probably null Het
Myh10 A G 11: 68,699,676 (GRCm39) I1671V probably benign Het
Or2c1 A G 16: 3,656,894 (GRCm39) D19G probably benign Het
Osbpl9 T C 4: 108,930,129 (GRCm39) D334G possibly damaging Het
Pdcd11 A G 19: 47,098,117 (GRCm39) D801G probably damaging Het
Pfdn4 C A 2: 170,358,556 (GRCm39) D16E probably benign Het
Pmp22 C T 11: 63,049,099 (GRCm39) A114V probably damaging Het
Rrp9 C T 9: 106,360,778 (GRCm39) T253I probably damaging Het
Speer1m A T 5: 11,970,612 (GRCm39) K62* probably null Het
Tnrc6a A G 7: 122,769,133 (GRCm39) T308A probably damaging Het
Trgv4 T A 13: 19,369,250 (GRCm39) C34S probably benign Het
Trhr A G 15: 44,092,602 (GRCm39) M280V possibly damaging Het
Trp53bp1 G A 2: 121,059,084 (GRCm39) H926Y probably damaging Het
Trpv5 A T 6: 41,652,903 (GRCm39) I90K probably benign Het
Ttn T C 2: 76,719,259 (GRCm39) probably benign Het
Vav1 A C 17: 57,612,280 (GRCm39) R513S probably damaging Het
Vmn2r100 A T 17: 19,741,671 (GRCm39) T128S probably benign Het
Zfp687 T C 3: 94,915,700 (GRCm39) Y1024C probably damaging Het
Zfp938 C A 10: 82,061,160 (GRCm39) G487* probably null Het
Znrf2 A G 6: 54,855,430 (GRCm39) Y73C probably damaging Het
Other mutations in Fcrla
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00089:Fcrla APN 1 170,755,067 (GRCm39) missense probably benign 0.00
IGL01712:Fcrla APN 1 170,749,192 (GRCm39) splice site probably null
IGL03323:Fcrla APN 1 170,755,114 (GRCm39) utr 5 prime probably benign
R0113:Fcrla UTSW 1 170,749,868 (GRCm39) start codon destroyed probably null 0.04
R1457:Fcrla UTSW 1 170,748,573 (GRCm39) missense probably damaging 1.00
R1917:Fcrla UTSW 1 170,755,095 (GRCm39) nonsense probably null
R4331:Fcrla UTSW 1 170,749,245 (GRCm39) missense possibly damaging 0.74
R4819:Fcrla UTSW 1 170,748,508 (GRCm39) missense probably damaging 0.99
R4923:Fcrla UTSW 1 170,748,682 (GRCm39) missense probably damaging 1.00
R5000:Fcrla UTSW 1 170,749,959 (GRCm39) missense probably benign 0.03
R5441:Fcrla UTSW 1 170,752,991 (GRCm39) intron probably benign
R5459:Fcrla UTSW 1 170,745,738 (GRCm39) missense possibly damaging 0.68
R7369:Fcrla UTSW 1 170,749,886 (GRCm39) missense probably benign 0.23
R7786:Fcrla UTSW 1 170,748,426 (GRCm39) missense possibly damaging 0.93
R9276:Fcrla UTSW 1 170,755,135 (GRCm39) unclassified probably benign
R9482:Fcrla UTSW 1 170,745,949 (GRCm39) missense probably benign 0.00
R9585:Fcrla UTSW 1 170,749,868 (GRCm39) start codon destroyed probably null 0.04
R9622:Fcrla UTSW 1 170,749,808 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGACTGCTCACGGTATTTCCTC -3'
(R):5'- TCCCCAAGTTGCAGTATCATTC -3'

Sequencing Primer
(F):5'- CACGGTATTTCCTCACCCTG -3'
(R):5'- AGCAGCTGCCAGTTCAGAGAC -3'
Posted On 2018-06-22