Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01123:Scpep1'

52342

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scpep1

Ensembl Gene

ENSMUSG00000000278

Gene Name

serine carboxypeptidase 1

Synonyms

4833411K15Rik, 2410018F01Rik, Risc

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01123

Quality Score

Status

Chromosome

Chromosomal Location

88924020-88955465 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 88941328 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 192 (N192S)

Ref Sequence

ENSEMBL: ENSMUSP00000000287 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000287]

AlphaFold

Q920A5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000000287
AA Change: N192S

PolyPhen 2 Score 0.790 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000000287
Gene: ENSMUSG00000000278
AA Change: N192S

Domain	Start	End	E-Value	Type
signal peptide	1	28	N/A	INTRINSIC
Pfam:Peptidase_S10	29	451	2e-99	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a gene trapped allele exhibit no abnormal phenotype. Mice homozygous for a knock-out allele exhibit abnormal blood vessel healing. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310057J18Rik	G	T	10: 28,973,938 (GRCm38)	D167E	probably damaging	Het
Aadat	A	T	8: 60,526,614 (GRCm38)	E170V	probably benign	Het
Acsf2	T	C	11: 94,570,450 (GRCm38)	E300G	probably benign	Het
Agbl3	C	T	6: 34,846,976 (GRCm38)	Q859*	probably null	Het
Arhgap11a	T	C	2: 113,834,773 (GRCm38)		probably benign	Het
Arhgef40	C	A	14: 51,994,346 (GRCm38)	Q730K	probably damaging	Het
Armc3	C	T	2: 19,201,805 (GRCm38)	P13L	possibly damaging	Het
B3gnt2	T	A	11: 22,836,490 (GRCm38)	T233S	probably benign	Het
Bnc1	G	A	7: 81,973,707 (GRCm38)	Q591*	probably null	Het
Bsn	A	T	9: 108,115,986 (GRCm38)	F856I	probably damaging	Het
CK137956	T	A	4: 127,935,850 (GRCm38)	T558S	probably benign	Het
Coq8b	G	A	7: 27,240,084 (GRCm38)	V180I	probably damaging	Het
Csmd1	A	T	8: 17,534,928 (GRCm38)	L16Q	possibly damaging	Het
Dhx37	A	G	5: 125,419,088 (GRCm38)	S769P	possibly damaging	Het
Diras1	T	A	10: 81,022,415 (GRCm38)	M1L	probably damaging	Het
Fam161b	A	G	12: 84,357,664 (GRCm38)	W81R	probably benign	Het
Fat4	A	T	3: 38,957,269 (GRCm38)	I2173L	probably benign	Het
Fbn2	T	C	18: 58,104,081 (GRCm38)	T617A	possibly damaging	Het
Gabrq	G	A	X: 72,836,833 (GRCm38)	D311N	probably benign	Het
Isl2	G	T	9: 55,545,462 (GRCm38)	G335C	probably damaging	Het
Kbtbd7	T	C	14: 79,428,612 (GRCm38)	V628A	probably damaging	Het
Kmt2d	T	C	15: 98,837,148 (GRCm38)	M5378V	unknown	Het
Lrrc23	G	T	6: 124,778,819 (GRCm38)	D75E	probably benign	Het
Mab21l3	G	A	3: 101,835,130 (GRCm38)	T38M	probably benign	Het
Matn1	T	C	4: 130,950,011 (GRCm38)	I177T	possibly damaging	Het
Mtor	T	C	4: 148,453,037 (GRCm38)	S60P	probably benign	Het
Naip6	T	C	13: 100,304,438 (GRCm38)	E278G	probably benign	Het
Nsun6	T	C	2: 15,048,978 (GRCm38)	I7V	possibly damaging	Het
Pabpc6	A	T	17: 9,668,147 (GRCm38)	S492T	probably benign	Het
Pakap	C	T	4: 57,757,627 (GRCm38)	Q188*	probably null	Het
Pom121	A	T	5: 135,391,706 (GRCm38)	V287D	unknown	Het
Ptprq	A	T	10: 107,686,218 (GRCm38)	F624Y	probably damaging	Het
Ptprr	A	G	10: 116,188,317 (GRCm38)	T178A	probably benign	Het
Pygm	A	G	19: 6,391,394 (GRCm38)	N473S	probably benign	Het
Ros1	A	T	10: 52,120,809 (GRCm38)	Y1256N	probably damaging	Het
Serpina1f	A	G	12: 103,694,006 (GRCm38)	S6P	possibly damaging	Het
Sgca	T	A	11: 94,972,287 (GRCm38)	Q80L	probably damaging	Het
Skint6	A	G	4: 112,804,682 (GRCm38)	L1235P	possibly damaging	Het
Slc23a2	A	C	2: 132,056,816 (GRCm38)	N600K	probably benign	Het
Spata20	T	C	11: 94,483,395 (GRCm38)	T350A	probably benign	Het
Syne1	G	T	10: 5,344,921 (GRCm38)	Y1227*	probably null	Het
Unc13c	T	C	9: 73,933,197 (GRCm38)	Y124C	probably benign	Het
Usp40	G	A	1: 87,986,123 (GRCm38)	T416I	probably benign	Het
Vmn1r200	T	C	13: 22,395,401 (GRCm38)	W116R	probably benign	Het
Vps4a	T	C	8: 107,039,219 (GRCm38)		probably benign	Het
Zfyve16	A	G	13: 92,492,522 (GRCm38)	V1469A	probably damaging	Het

Other mutations in Scpep1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00909:Scpep1	APN	11	88,952,477 (GRCm38)	missense	probably damaging	1.00
IGL02341:Scpep1	APN	11	88,944,488 (GRCm38)	missense	probably benign	0.30
IGL03078:Scpep1	APN	11	88,935,831 (GRCm38)	missense	possibly damaging	0.67
IGL03014:Scpep1	UTSW	11	88,933,445 (GRCm38)	splice site	probably null
R1652:Scpep1	UTSW	11	88,952,434 (GRCm38)	nonsense	probably null
R1966:Scpep1	UTSW	11	88,952,414 (GRCm38)	missense	probably damaging	1.00
R4275:Scpep1	UTSW	11	88,947,142 (GRCm38)	splice site	probably null
R4330:Scpep1	UTSW	11	88,935,903 (GRCm38)	nonsense	probably null
R4331:Scpep1	UTSW	11	88,935,903 (GRCm38)	nonsense	probably null
R4360:Scpep1	UTSW	11	88,930,244 (GRCm38)	missense	possibly damaging	0.78
R4502:Scpep1	UTSW	11	88,944,385 (GRCm38)	missense	probably benign	0.00
R4885:Scpep1	UTSW	11	88,935,911 (GRCm38)	missense	probably benign	0.20
R4896:Scpep1	UTSW	11	88,941,296 (GRCm38)	missense	probably damaging	1.00
R5010:Scpep1	UTSW	11	88,941,349 (GRCm38)	missense	probably benign	0.30
R5229:Scpep1	UTSW	11	88,937,045 (GRCm38)	missense	probably damaging	1.00
R5899:Scpep1	UTSW	11	88,934,576 (GRCm38)	critical splice donor site	probably null
R5999:Scpep1	UTSW	11	88,929,313 (GRCm38)	missense	possibly damaging	0.85
R6975:Scpep1	UTSW	11	88,947,205 (GRCm38)	missense	probably damaging	0.98
R7098:Scpep1	UTSW	11	88,929,185 (GRCm38)	missense	possibly damaging	0.59
R7637:Scpep1	UTSW	11	88,929,220 (GRCm38)	missense	probably damaging	1.00
R7790:Scpep1	UTSW	11	88,933,521 (GRCm38)	missense	possibly damaging	0.70
R8285:Scpep1	UTSW	11	88,952,467 (GRCm38)	missense	probably damaging	1.00
R8750:Scpep1	UTSW	11	88,944,472 (GRCm38)	missense	probably damaging	1.00

Posted On

2013-06-21