Incidental Mutation 'R6508:Mgat3'
ID 524033
Institutional Source Beutler Lab
Gene Symbol Mgat3
Ensembl Gene ENSMUSG00000042428
Gene Name mannoside acetylglucosaminyltransferase 3
Synonyms GnT-III, 1110038J12Rik
MMRRC Submission 044638-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.220) question?
Stock # R6508 (G1)
Quality Score 204.009
Status Not validated
Chromosome 15
Chromosomal Location 80057922-80099720 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 80096225 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 351 (S351P)
Ref Sequence ENSEMBL: ENSMUSP00000043077 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044970]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000044970
AA Change: S351P

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000043077
Gene: ENSMUSG00000042428
AA Change: S351P

DomainStartEndE-ValueType
transmembrane domain 7 26 N/A INTRINSIC
low complexity region 73 87 N/A INTRINSIC
Pfam:Glyco_transf_17 191 362 3.2e-28 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit reduced DEN and PB-induced hepatic tumors and reduced hepatocyte proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm2 G A 4: 144,291,590 (GRCm39) R39* probably null Het
Brca2 A T 5: 150,460,058 (GRCm39) E444D possibly damaging Het
Camkk2 G T 5: 122,884,382 (GRCm39) N346K probably damaging Het
Car4 C A 11: 84,856,469 (GRCm39) D252E possibly damaging Het
Chd1 A G 17: 15,958,895 (GRCm39) K649R probably benign Het
Col12a1 A G 9: 79,557,231 (GRCm39) Y1966H probably damaging Het
Crppa C T 12: 36,476,298 (GRCm39) A180V possibly damaging Het
Cts6 T A 13: 61,344,221 (GRCm39) H277L probably damaging Het
Dcc G T 18: 71,439,144 (GRCm39) P1246Q probably damaging Het
Dlg5 G A 14: 24,188,774 (GRCm39) T1739I probably benign Het
Eci1 T A 17: 24,656,283 (GRCm39) N164K probably damaging Het
Entpd7 G A 19: 43,679,525 (GRCm39) R26H probably damaging Het
Fanci A G 7: 79,093,516 (GRCm39) K1008E probably damaging Het
Htr2b T C 1: 86,030,186 (GRCm39) T170A possibly damaging Het
Irgm2 A G 11: 58,110,327 (GRCm39) E18G probably benign Het
Kdm1a A T 4: 136,281,621 (GRCm39) V630E probably damaging Het
Keap1 G A 9: 21,143,010 (GRCm39) T501I possibly damaging Het
L3mbtl3 T A 10: 26,194,325 (GRCm39) H424L unknown Het
Lrrc14b C T 13: 74,511,337 (GRCm39) D248N possibly damaging Het
Macf1 T A 4: 123,363,535 (GRCm39) D3364V probably damaging Het
Map3k20 G A 2: 72,272,253 (GRCm39) G794S probably benign Het
Mcat T C 15: 83,433,452 (GRCm39) Q34R probably benign Het
Mettl4 T C 17: 95,051,373 (GRCm39) E148G probably damaging Het
Mllt1 A T 17: 57,234,054 (GRCm39) I44N probably damaging Het
Mlxipl G T 5: 135,157,474 (GRCm39) A337S probably benign Het
Naip1 A G 13: 100,572,973 (GRCm39) F254L probably damaging Het
Obscn A T 11: 58,944,973 (GRCm39) probably null Het
Or10q1 C T 19: 13,726,718 (GRCm39) P83S probably damaging Het
Pcdh12 G A 18: 38,414,390 (GRCm39) R912* probably null Het
Pcdh17 A G 14: 84,685,419 (GRCm39) N629D probably damaging Het
Pcnx1 T C 12: 81,959,479 (GRCm39) I170T probably damaging Het
Pgr A G 9: 8,956,290 (GRCm39) Y746C probably damaging Het
Pramel29 A T 4: 143,934,171 (GRCm39) L312* probably null Het
Pum2 T C 12: 8,798,861 (GRCm39) Y991H probably benign Het
Rcc1l A T 5: 134,198,077 (GRCm39) V185D probably damaging Het
Scarb1 A T 5: 125,381,389 (GRCm39) S52T possibly damaging Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Spata4 T C 8: 55,053,887 (GRCm39) S18P probably benign Het
Stard13 G A 5: 150,986,754 (GRCm39) T134I probably benign Het
Tbc1d32 C T 10: 56,100,786 (GRCm39) C64Y probably damaging Het
Tll1 T G 8: 64,551,494 (GRCm39) I296L probably damaging Het
Tmem229b T G 12: 79,011,680 (GRCm39) T84P probably damaging Het
Ttn T C 2: 76,544,757 (GRCm39) T32782A possibly damaging Het
Vmn1r73 G A 7: 11,490,631 (GRCm39) V150I possibly damaging Het
Vmn2r80 T A 10: 79,030,290 (GRCm39) F705L probably benign Het
Other mutations in Mgat3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Mgat3 APN 15 80,096,634 (GRCm39) missense probably damaging 1.00
IGL01134:Mgat3 APN 15 80,096,377 (GRCm39) missense probably benign 0.17
R0077:Mgat3 UTSW 15 80,096,778 (GRCm39) missense probably benign 0.00
R1171:Mgat3 UTSW 15 80,095,838 (GRCm39) missense probably benign 0.26
R1885:Mgat3 UTSW 15 80,095,820 (GRCm39) missense probably benign 0.25
R1886:Mgat3 UTSW 15 80,095,820 (GRCm39) missense probably benign 0.25
R1986:Mgat3 UTSW 15 80,096,390 (GRCm39) missense probably benign 0.04
R2125:Mgat3 UTSW 15 80,096,087 (GRCm39) missense probably benign 0.00
R3081:Mgat3 UTSW 15 80,096,055 (GRCm39) missense probably benign 0.33
R4819:Mgat3 UTSW 15 80,096,550 (GRCm39) missense probably damaging 1.00
R4992:Mgat3 UTSW 15 80,096,743 (GRCm39) missense probably benign
R5083:Mgat3 UTSW 15 80,095,499 (GRCm39) missense possibly damaging 0.92
R5356:Mgat3 UTSW 15 80,096,655 (GRCm39) missense probably damaging 1.00
R5356:Mgat3 UTSW 15 80,095,811 (GRCm39) missense possibly damaging 0.88
R6784:Mgat3 UTSW 15 80,096,401 (GRCm39) missense probably damaging 0.98
R7021:Mgat3 UTSW 15 80,096,655 (GRCm39) missense probably damaging 1.00
R7056:Mgat3 UTSW 15 80,096,097 (GRCm39) missense probably damaging 0.99
R7592:Mgat3 UTSW 15 80,095,193 (GRCm39) missense probably damaging 0.96
R7774:Mgat3 UTSW 15 80,095,743 (GRCm39) missense probably damaging 0.96
R7819:Mgat3 UTSW 15 80,095,973 (GRCm39) nonsense probably null
R8559:Mgat3 UTSW 15 80,096,370 (GRCm39) missense probably damaging 1.00
R8678:Mgat3 UTSW 15 80,096,472 (GRCm39) missense possibly damaging 0.74
R9285:Mgat3 UTSW 15 80,096,538 (GRCm39) missense probably damaging 1.00
R9483:Mgat3 UTSW 15 80,095,641 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ATTGCGGATGACTACCTGCG -3'
(R):5'- TGAAGCACCAGGAGCAATGC -3'

Sequencing Primer
(F):5'- GATGACTACCTGCGCACCTTC -3'
(R):5'- GACCACTGCACTAGGATGTG -3'
Posted On 2018-06-22