Incidental Mutation 'R6616:Or2y11'
ID 524073
Institutional Source Beutler Lab
Gene Symbol Or2y11
Ensembl Gene ENSMUSG00000095187
Gene Name olfactory receptor family 2 subfamily Y member 11
Synonyms MOR256-26, Olfr1381, GA_x6K02T2QP88-5884501-5883566
MMRRC Submission 044739-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R6616 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 49442576-49443511 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 49442868 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 98 (V98E)
Ref Sequence ENSEMBL: ENSMUSP00000149881 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167248] [ENSMUST00000213256] [ENSMUST00000215360]
AlphaFold Q7TQT4
Predicted Effect probably damaging
Transcript: ENSMUST00000167248
AA Change: V98E

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000126003
Gene: ENSMUSG00000095187
AA Change: V98E

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 5.9e-48 PFAM
Pfam:7TM_GPCR_Srsx 35 219 2.4e-5 PFAM
Pfam:7tm_1 41 289 1.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213256
AA Change: V98E

PolyPhen 2 Score 0.970 (Sensitivity: 0.77; Specificity: 0.96)
Predicted Effect probably benign
Transcript: ENSMUST00000215360
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.8%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 A T 17: 24,603,509 (GRCm39) H567L probably damaging Het
Adck1 T A 12: 88,427,958 (GRCm39) M525K unknown Het
Alpi T C 1: 87,028,836 (GRCm39) I74V possibly damaging Het
Ccdc168 C A 1: 44,100,634 (GRCm39) V155L possibly damaging Het
Creb5 A C 6: 53,662,295 (GRCm39) Q197H possibly damaging Het
Cyp2b13 A G 7: 25,785,306 (GRCm39) K225R probably benign Het
Dock1 G A 7: 134,710,221 (GRCm39) E1143K possibly damaging Het
Eef2kmt T A 16: 5,065,346 (GRCm39) D287V probably damaging Het
Eif2ak4 T A 2: 118,285,326 (GRCm39) Y1046* probably null Het
Fbxw10 T A 11: 62,743,850 (GRCm39) M252K probably benign Het
Fnip2 A C 3: 79,388,189 (GRCm39) H847Q probably benign Het
Frmd3 A T 4: 74,105,725 (GRCm39) D457V probably damaging Het
Gm13941 T G 2: 110,931,520 (GRCm39) E37D unknown Het
Grin1 T A 2: 25,182,122 (GRCm39) I870F possibly damaging Het
Grin2b A C 6: 135,709,549 (GRCm39) D1332E probably benign Het
Gtpbp4 G A 13: 9,039,141 (GRCm39) T201I possibly damaging Het
Heatr4 A G 12: 84,026,904 (GRCm39) C118R probably benign Het
Hltf T A 3: 20,163,651 (GRCm39) probably null Het
Hmcn1 C T 1: 150,599,008 (GRCm39) probably null Het
Hpd A T 5: 123,310,123 (GRCm39) L367Q probably damaging Het
Htr1b A G 9: 81,514,487 (GRCm39) I40T probably benign Het
Il16 A G 7: 83,295,684 (GRCm39) S464P probably benign Het
Lrp1b T A 2: 40,589,643 (GRCm39) D75V unknown Het
Map3k4 A T 17: 12,490,231 (GRCm39) L400Q probably damaging Het
Mcts2 T A 2: 152,529,582 (GRCm39) I131N possibly damaging Het
Mroh2b A C 15: 4,982,764 (GRCm39) I1528L probably benign Het
Muc4 A C 16: 32,602,378 (GRCm39) D3467A possibly damaging Het
Mypn A T 10: 63,005,091 (GRCm39) C339S probably damaging Het
Ncoa5 A T 2: 164,852,483 (GRCm39) Y130* probably null Het
Or11g27 T A 14: 50,771,364 (GRCm39) I165N probably benign Het
Pcdha4 A G 18: 37,086,953 (GRCm39) T379A probably benign Het
Pkp4 C G 2: 59,180,896 (GRCm39) Y720* probably null Het
Prl5a1 C T 13: 28,333,839 (GRCm39) T114I probably benign Het
Rnd3 A G 2: 51,024,169 (GRCm39) S137P probably damaging Het
Rtel1 G A 2: 180,994,579 (GRCm39) E680K possibly damaging Het
Sbsn T A 7: 30,452,704 (GRCm39) V573D possibly damaging Het
Scaf8 A T 17: 3,218,330 (GRCm39) L233F unknown Het
Sec23a A T 12: 59,043,941 (GRCm39) I241K possibly damaging Het
Secisbp2l A T 2: 125,610,146 (GRCm39) S258T probably damaging Het
Skint4 A G 4: 111,975,427 (GRCm39) H121R possibly damaging Het
Sptbn1 T A 11: 30,074,030 (GRCm39) E1346D probably benign Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Het
Stpg4 A G 17: 87,730,124 (GRCm39) Y74H probably damaging Het
Tenm4 G A 7: 96,202,703 (GRCm39) R106H probably benign Het
Tmc4 A G 7: 3,674,057 (GRCm39) V374A possibly damaging Het
Unc45b G A 11: 82,802,645 (GRCm39) R47Q probably damaging Het
Xirp1 A G 9: 119,848,080 (GRCm39) S268P probably damaging Het
Zfp990 A T 4: 145,263,715 (GRCm39) I238L probably benign Het
Zswim5 A G 4: 116,843,938 (GRCm39) D992G possibly damaging Het
Other mutations in Or2y11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Or2y11 APN 11 49,442,964 (GRCm39) missense probably damaging 1.00
IGL02166:Or2y11 APN 11 49,442,757 (GRCm39) missense probably damaging 1.00
IGL02723:Or2y11 APN 11 49,443,506 (GRCm39) missense probably benign 0.28
R0518:Or2y11 UTSW 11 49,443,291 (GRCm39) missense probably damaging 1.00
R0521:Or2y11 UTSW 11 49,443,291 (GRCm39) missense probably damaging 1.00
R2109:Or2y11 UTSW 11 49,443,260 (GRCm39) missense probably damaging 1.00
R4198:Or2y11 UTSW 11 49,443,461 (GRCm39) missense possibly damaging 0.61
R6155:Or2y11 UTSW 11 49,443,411 (GRCm39) missense possibly damaging 0.93
R6181:Or2y11 UTSW 11 49,443,120 (GRCm39) missense probably damaging 0.97
R6250:Or2y11 UTSW 11 49,442,711 (GRCm39) missense probably damaging 1.00
R6372:Or2y11 UTSW 11 49,442,757 (GRCm39) missense probably damaging 1.00
R7391:Or2y11 UTSW 11 49,443,371 (GRCm39) missense probably damaging 1.00
R9030:Or2y11 UTSW 11 49,442,808 (GRCm39) missense probably damaging 1.00
R9566:Or2y11 UTSW 11 49,443,162 (GRCm39) missense probably benign
Z1177:Or2y11 UTSW 11 49,443,111 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCAACACCGTGATCATCATTC -3'
(R):5'- TGATTCAGTTGGTGTCCACAC -3'

Sequencing Primer
(F):5'- GTGATCATCATTCTGTCTCGACTGG -3'
(R):5'- CATCACAAGGCTTGTCTGGATCAG -3'
Posted On 2018-06-22