Incidental Mutation 'R6582:Or10j3'
ID 524127
Institutional Source Beutler Lab
Gene Symbol Or10j3
Ensembl Gene ENSMUSG00000046643
Gene Name olfactory receptor family 10 subfamily J member 3B
Synonyms Olfr1405-ps1, GA_x6K02T2R7CC-643715-642847, Olfr218, GA_x6K02SYWG4P-534-1100, MOR267-3, MOR267-3
MMRRC Submission 044706-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.136) question?
Stock # R6582 (G1)
Quality Score 213.009
Status Validated
Chromosome 1
Chromosomal Location 173030925-173031866 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 173031847 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 308 (R308L)
Ref Sequence ENSEMBL: ENSMUSP00000150815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057548] [ENSMUST00000215844] [ENSMUST00000216603]
AlphaFold E9PWV2
Predicted Effect probably benign
Transcript: ENSMUST00000057548
AA Change: R308L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000053317
Gene: ENSMUSG00000046643
AA Change: R308L

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 3.4e-58 PFAM
Pfam:7tm_1 42 291 2.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215844
AA Change: R308L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000216603
AA Change: R308L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,297,384 (GRCm39) T2369A probably benign Het
Abhd6 G T 14: 8,042,826 (GRCm38) G128C probably damaging Het
Abhd6 T G 14: 8,042,828 (GRCm38) probably null Het
Acsm3 A G 7: 119,378,896 (GRCm39) E426G probably benign Het
Ankrd11 T C 8: 123,618,368 (GRCm39) D1828G probably benign Het
Asmt T A X: 169,108,766 (GRCm39) probably null Het
Casp4 A G 9: 5,324,884 (GRCm39) Q232R probably benign Het
Cenpt A T 8: 106,575,833 (GRCm39) L171* probably null Het
Chd3 AGCGGCGGCGGCGGCGGCGG AGCGGCGGCGGCGGCGG 11: 69,259,982 (GRCm39) probably benign Het
Col5a2 G T 1: 45,429,275 (GRCm39) H948N possibly damaging Het
Dnah9 G T 11: 65,951,923 (GRCm39) H1859N probably damaging Het
Dscaml1 G A 9: 45,664,104 (GRCm39) R1993Q probably benign Het
Fbxw8 C A 5: 118,263,028 (GRCm39) R217L probably benign Het
Flnb T G 14: 7,892,275 (GRCm38) probably null Het
Fyb2 A G 4: 104,802,739 (GRCm39) N214D probably benign Het
Gbp2b A G 3: 142,316,801 (GRCm39) E484G possibly damaging Het
Gzmk A G 13: 113,317,045 (GRCm39) Y45H probably damaging Het
Ivl CCTGCTGCTGCTGCT CCTGCTGCTGCT 3: 92,479,217 (GRCm39) probably benign Het
Kcnj6 A G 16: 94,633,685 (GRCm39) V142A possibly damaging Het
Klri2 A T 6: 129,716,096 (GRCm39) I81K possibly damaging Het
Lama3 T A 18: 12,710,897 (GRCm39) V3144E probably damaging Het
Mark1 G A 1: 184,644,786 (GRCm39) S390L possibly damaging Het
Mbd3l1 T C 9: 18,396,024 (GRCm39) Y50H probably benign Het
Mcat T C 15: 83,433,383 (GRCm39) N220S probably benign Het
Muc2 A G 7: 141,282,941 (GRCm39) E81G probably benign Het
Neto1 A T 18: 86,512,985 (GRCm39) K327* probably null Het
Or4a67 A T 2: 88,598,587 (GRCm39) L24Q probably damaging Het
Or52p1 A T 7: 104,267,648 (GRCm39) Y254F probably damaging Het
Or52u1 T C 7: 104,237,218 (GRCm39) L69P probably damaging Het
Pidd1 A T 7: 141,019,494 (GRCm39) V722D probably damaging Het
Ppp2r2a G T 14: 67,257,253 (GRCm39) H326N probably damaging Het
Smarca5 G A 8: 81,446,281 (GRCm39) T473I probably damaging Het
Spg11 C A 2: 121,922,773 (GRCm39) W892L probably damaging Het
Tas2r110 T A 6: 132,845,248 (GRCm39) I93N possibly damaging Het
Tiam2 CGGG CGGGG 17: 3,464,897 (GRCm39) probably null Het
Vmn1r71 T A 7: 10,482,608 (GRCm39) I27F probably benign Het
Vsnl1 A G 12: 11,376,489 (GRCm39) V132A probably benign Het
Wdsub1 T C 2: 59,708,652 (GRCm39) T74A probably damaging Het
Ywhaz T C 15: 36,791,166 (GRCm39) Y19C probably damaging Het
Other mutations in Or10j3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03404:Or10j3 APN 1 173,031,766 (GRCm39) missense probably benign 0.08
R0265:Or10j3 UTSW 1 173,031,484 (GRCm39) missense probably benign 0.10
R1388:Or10j3 UTSW 1 173,031,445 (GRCm39) missense probably benign 0.01
R1463:Or10j3 UTSW 1 173,030,934 (GRCm39) missense probably benign
R1547:Or10j3 UTSW 1 173,031,239 (GRCm39) nonsense probably null
R1698:Or10j3 UTSW 1 173,030,938 (GRCm39) missense probably damaging 1.00
R1892:Or10j3 UTSW 1 173,031,795 (GRCm39) missense probably damaging 1.00
R4773:Or10j3 UTSW 1 173,031,796 (GRCm39) missense probably damaging 1.00
R4939:Or10j3 UTSW 1 173,031,030 (GRCm39) missense possibly damaging 0.95
R5473:Or10j3 UTSW 1 173,031,732 (GRCm39) missense probably benign 0.02
R6149:Or10j3 UTSW 1 173,031,582 (GRCm39) missense probably benign 0.15
R7151:Or10j3 UTSW 1 173,031,633 (GRCm39) missense probably damaging 1.00
R8120:Or10j3 UTSW 1 173,031,502 (GRCm39) missense probably benign 0.31
R8510:Or10j3 UTSW 1 173,031,411 (GRCm39) missense probably damaging 0.96
R8967:Or10j3 UTSW 1 173,031,039 (GRCm39) missense probably benign 0.14
R9238:Or10j3 UTSW 1 173,031,352 (GRCm39) missense probably benign 0.01
R9292:Or10j3 UTSW 1 173,031,099 (GRCm39) missense probably damaging 1.00
R9358:Or10j3 UTSW 1 173,031,741 (GRCm39) missense probably damaging 1.00
R9517:Or10j3 UTSW 1 173,031,346 (GRCm39) missense possibly damaging 0.80
R9624:Or10j3 UTSW 1 173,031,672 (GRCm39) missense probably benign 0.30
Z1176:Or10j3 UTSW 1 173,031,364 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGATTGCCTCAGCTGAAGG -3'
(R):5'- TCACTTGCATGCATATAAAGGCAC -3'

Sequencing Primer
(F):5'- CCGGAAGAAGGCCTTTGC -3'
(R):5'- GCATGCATATAAAGGCACTAAAATG -3'
Posted On 2018-06-22