Incidental Mutation 'R6582:Fyb2'
ID 524140
Institutional Source Beutler Lab
Gene Symbol Fyb2
Ensembl Gene ENSMUSG00000078612
Gene Name FYN binding protein 2
Synonyms 1700024P16Rik
MMRRC Submission 044706-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R6582 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 104770653-104874060 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 104802739 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Aspartic acid at position 214 (N214D)
Ref Sequence ENSEMBL: ENSMUSP00000102415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106803] [ENSMUST00000106804]
AlphaFold A2A995
Predicted Effect probably benign
Transcript: ENSMUST00000106803
AA Change: N214D

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000102415
Gene: ENSMUSG00000078612
AA Change: N214D

DomainStartEndE-ValueType
low complexity region 120 132 N/A INTRINSIC
low complexity region 340 349 N/A INTRINSIC
low complexity region 442 459 N/A INTRINSIC
low complexity region 537 549 N/A INTRINSIC
low complexity region 567 578 N/A INTRINSIC
low complexity region 682 697 N/A INTRINSIC
SH3 735 791 3.82e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106804
AA Change: N150D

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000102416
Gene: ENSMUSG00000078612
AA Change: N150D

DomainStartEndE-ValueType
low complexity region 56 68 N/A INTRINSIC
low complexity region 276 285 N/A INTRINSIC
low complexity region 378 395 N/A INTRINSIC
low complexity region 473 485 N/A INTRINSIC
low complexity region 503 514 N/A INTRINSIC
low complexity region 618 633 N/A INTRINSIC
SH3 671 727 3.82e0 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,297,384 (GRCm39) T2369A probably benign Het
Abhd6 T G 14: 8,042,828 (GRCm38) probably null Het
Abhd6 G T 14: 8,042,826 (GRCm38) G128C probably damaging Het
Acsm3 A G 7: 119,378,896 (GRCm39) E426G probably benign Het
Ankrd11 T C 8: 123,618,368 (GRCm39) D1828G probably benign Het
Asmt T A X: 169,108,766 (GRCm39) probably null Het
Casp4 A G 9: 5,324,884 (GRCm39) Q232R probably benign Het
Cenpt A T 8: 106,575,833 (GRCm39) L171* probably null Het
Chd3 AGCGGCGGCGGCGGCGGCGG AGCGGCGGCGGCGGCGG 11: 69,259,982 (GRCm39) probably benign Het
Col5a2 G T 1: 45,429,275 (GRCm39) H948N possibly damaging Het
Dnah9 G T 11: 65,951,923 (GRCm39) H1859N probably damaging Het
Dscaml1 G A 9: 45,664,104 (GRCm39) R1993Q probably benign Het
Fbxw8 C A 5: 118,263,028 (GRCm39) R217L probably benign Het
Flnb T G 14: 7,892,275 (GRCm38) probably null Het
Gbp2b A G 3: 142,316,801 (GRCm39) E484G possibly damaging Het
Gzmk A G 13: 113,317,045 (GRCm39) Y45H probably damaging Het
Ivl CCTGCTGCTGCTGCT CCTGCTGCTGCT 3: 92,479,217 (GRCm39) probably benign Het
Kcnj6 A G 16: 94,633,685 (GRCm39) V142A possibly damaging Het
Klri2 A T 6: 129,716,096 (GRCm39) I81K possibly damaging Het
Lama3 T A 18: 12,710,897 (GRCm39) V3144E probably damaging Het
Mark1 G A 1: 184,644,786 (GRCm39) S390L possibly damaging Het
Mbd3l1 T C 9: 18,396,024 (GRCm39) Y50H probably benign Het
Mcat T C 15: 83,433,383 (GRCm39) N220S probably benign Het
Muc2 A G 7: 141,282,941 (GRCm39) E81G probably benign Het
Neto1 A T 18: 86,512,985 (GRCm39) K327* probably null Het
Or10j3 G T 1: 173,031,847 (GRCm39) R308L probably benign Het
Or4a67 A T 2: 88,598,587 (GRCm39) L24Q probably damaging Het
Or52p1 A T 7: 104,267,648 (GRCm39) Y254F probably damaging Het
Or52u1 T C 7: 104,237,218 (GRCm39) L69P probably damaging Het
Pidd1 A T 7: 141,019,494 (GRCm39) V722D probably damaging Het
Ppp2r2a G T 14: 67,257,253 (GRCm39) H326N probably damaging Het
Smarca5 G A 8: 81,446,281 (GRCm39) T473I probably damaging Het
Spg11 C A 2: 121,922,773 (GRCm39) W892L probably damaging Het
Tas2r110 T A 6: 132,845,248 (GRCm39) I93N possibly damaging Het
Tiam2 CGGG CGGGG 17: 3,464,897 (GRCm39) probably null Het
Vmn1r71 T A 7: 10,482,608 (GRCm39) I27F probably benign Het
Vsnl1 A G 12: 11,376,489 (GRCm39) V132A probably benign Het
Wdsub1 T C 2: 59,708,652 (GRCm39) T74A probably damaging Het
Ywhaz T C 15: 36,791,166 (GRCm39) Y19C probably damaging Het
Other mutations in Fyb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00664:Fyb2 APN 4 104,872,913 (GRCm39) missense probably damaging 1.00
IGL01155:Fyb2 APN 4 104,856,583 (GRCm39) missense probably benign 0.00
IGL01632:Fyb2 APN 4 104,853,008 (GRCm39) missense probably benign
IGL01746:Fyb2 APN 4 104,802,404 (GRCm39) missense probably benign 0.01
IGL02381:Fyb2 APN 4 104,805,863 (GRCm39) splice site probably benign
IGL02590:Fyb2 APN 4 104,836,250 (GRCm39) missense probably damaging 1.00
IGL02885:Fyb2 APN 4 104,861,118 (GRCm39) missense probably damaging 0.99
IGL03114:Fyb2 APN 4 104,852,975 (GRCm39) missense probably damaging 0.97
IGL03189:Fyb2 APN 4 104,872,939 (GRCm39) missense probably damaging 1.00
IGL03231:Fyb2 APN 4 104,843,460 (GRCm39) nonsense probably null
R0076:Fyb2 UTSW 4 104,802,661 (GRCm39) missense possibly damaging 0.46
R0662:Fyb2 UTSW 4 104,852,895 (GRCm39) missense possibly damaging 0.46
R0723:Fyb2 UTSW 4 104,873,063 (GRCm39) missense probably benign 0.00
R1216:Fyb2 UTSW 4 104,852,903 (GRCm39) missense possibly damaging 0.86
R1672:Fyb2 UTSW 4 104,808,059 (GRCm39) missense probably benign 0.10
R1710:Fyb2 UTSW 4 104,861,113 (GRCm39) missense probably damaging 1.00
R1900:Fyb2 UTSW 4 104,802,652 (GRCm39) missense probably benign 0.06
R1965:Fyb2 UTSW 4 104,770,846 (GRCm39) missense probably benign 0.00
R2106:Fyb2 UTSW 4 104,802,769 (GRCm39) missense probably benign 0.01
R5191:Fyb2 UTSW 4 104,852,994 (GRCm39) missense possibly damaging 0.88
R5236:Fyb2 UTSW 4 104,805,957 (GRCm39) missense probably benign 0.00
R5277:Fyb2 UTSW 4 104,872,876 (GRCm39) missense probably damaging 1.00
R5502:Fyb2 UTSW 4 104,802,521 (GRCm39) missense probably damaging 1.00
R5769:Fyb2 UTSW 4 104,872,841 (GRCm39) missense probably damaging 1.00
R5769:Fyb2 UTSW 4 104,870,518 (GRCm39) missense probably damaging 1.00
R6167:Fyb2 UTSW 4 104,802,661 (GRCm39) missense possibly damaging 0.46
R6169:Fyb2 UTSW 4 104,857,713 (GRCm39) missense probably benign 0.16
R6371:Fyb2 UTSW 4 104,852,975 (GRCm39) missense probably damaging 0.97
R6713:Fyb2 UTSW 4 104,847,432 (GRCm39) missense probably benign 0.16
R6719:Fyb2 UTSW 4 104,867,656 (GRCm39) missense probably benign 0.07
R7484:Fyb2 UTSW 4 104,870,499 (GRCm39) missense probably benign 0.01
R7534:Fyb2 UTSW 4 104,856,545 (GRCm39) nonsense probably null
R7590:Fyb2 UTSW 4 104,802,443 (GRCm39) missense probably benign 0.01
R7699:Fyb2 UTSW 4 104,867,651 (GRCm39) missense probably benign 0.07
R7700:Fyb2 UTSW 4 104,867,651 (GRCm39) missense probably benign 0.07
R8041:Fyb2 UTSW 4 104,857,681 (GRCm39) missense possibly damaging 0.82
R8298:Fyb2 UTSW 4 104,806,028 (GRCm39) missense probably damaging 0.99
R8300:Fyb2 UTSW 4 104,857,689 (GRCm39) missense probably damaging 1.00
R8755:Fyb2 UTSW 4 104,861,086 (GRCm39) missense unknown
R8817:Fyb2 UTSW 4 104,802,652 (GRCm39) missense probably benign 0.06
R8873:Fyb2 UTSW 4 104,856,538 (GRCm39) missense probably damaging 1.00
R8914:Fyb2 UTSW 4 104,857,700 (GRCm39) missense probably benign 0.09
R9224:Fyb2 UTSW 4 104,853,105 (GRCm39) missense probably benign 0.44
R9434:Fyb2 UTSW 4 104,847,534 (GRCm39) missense probably damaging 0.99
R9512:Fyb2 UTSW 4 104,853,100 (GRCm39) missense probably benign 0.00
R9589:Fyb2 UTSW 4 104,872,833 (GRCm39) missense probably damaging 1.00
R9634:Fyb2 UTSW 4 104,856,579 (GRCm39) nonsense probably null
R9758:Fyb2 UTSW 4 104,802,961 (GRCm39) missense probably benign 0.01
X0018:Fyb2 UTSW 4 104,802,407 (GRCm39) missense probably benign 0.04
Z1176:Fyb2 UTSW 4 104,770,857 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GGCTCAGGGAGATGAACTTCAG -3'
(R):5'- ATACACTGGAGGCTTTGGAGG -3'

Sequencing Primer
(F):5'- AAGACTTCAAGTTCCTCGGG -3'
(R):5'- AGGTCACGGGTGATTTTCTC -3'
Posted On 2018-06-22