Incidental Mutation 'R6582:Vmn1r71'
ID 524148
Institutional Source Beutler Lab
Gene Symbol Vmn1r71
Ensembl Gene ENSMUSG00000059206
Gene Name vomeronasal 1 receptor 71
Synonyms V1re13
MMRRC Submission 044706-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R6582 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 10481429-10483465 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 10482608 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 27 (I27F)
Ref Sequence ENSEMBL: ENSMUSP00000154779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079113] [ENSMUST00000226874] [ENSMUST00000227003] [ENSMUST00000227702] [ENSMUST00000227940] [ENSMUST00000228248] [ENSMUST00000228374] [ENSMUST00000228098] [ENSMUST00000228526] [ENSMUST00000228561]
AlphaFold Q8VIC0
Predicted Effect probably benign
Transcript: ENSMUST00000079113
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000078116
Gene: ENSMUSG00000059206
AA Change: I27F

DomainStartEndE-ValueType
Pfam:TAS2R 3 304 2e-8 PFAM
Pfam:7tm_1 22 289 3.1e-6 PFAM
Pfam:V1R 34 297 4.8e-28 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210233
Predicted Effect probably benign
Transcript: ENSMUST00000226874
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000227003
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000227702
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000227940
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000228248
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000228374
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000228098
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000228526
AA Change: I27F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect probably benign
Transcript: ENSMUST00000228561
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 100% (40/40)
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,297,384 (GRCm39) T2369A probably benign Het
Abhd6 T G 14: 8,042,828 (GRCm38) probably null Het
Abhd6 G T 14: 8,042,826 (GRCm38) G128C probably damaging Het
Acsm3 A G 7: 119,378,896 (GRCm39) E426G probably benign Het
Ankrd11 T C 8: 123,618,368 (GRCm39) D1828G probably benign Het
Asmt T A X: 169,108,766 (GRCm39) probably null Het
Casp4 A G 9: 5,324,884 (GRCm39) Q232R probably benign Het
Cenpt A T 8: 106,575,833 (GRCm39) L171* probably null Het
Chd3 AGCGGCGGCGGCGGCGGCGG AGCGGCGGCGGCGGCGG 11: 69,259,982 (GRCm39) probably benign Het
Col5a2 G T 1: 45,429,275 (GRCm39) H948N possibly damaging Het
Dnah9 G T 11: 65,951,923 (GRCm39) H1859N probably damaging Het
Dscaml1 G A 9: 45,664,104 (GRCm39) R1993Q probably benign Het
Fbxw8 C A 5: 118,263,028 (GRCm39) R217L probably benign Het
Flnb T G 14: 7,892,275 (GRCm38) probably null Het
Fyb2 A G 4: 104,802,739 (GRCm39) N214D probably benign Het
Gbp2b A G 3: 142,316,801 (GRCm39) E484G possibly damaging Het
Gzmk A G 13: 113,317,045 (GRCm39) Y45H probably damaging Het
Ivl CCTGCTGCTGCTGCT CCTGCTGCTGCT 3: 92,479,217 (GRCm39) probably benign Het
Kcnj6 A G 16: 94,633,685 (GRCm39) V142A possibly damaging Het
Klri2 A T 6: 129,716,096 (GRCm39) I81K possibly damaging Het
Lama3 T A 18: 12,710,897 (GRCm39) V3144E probably damaging Het
Mark1 G A 1: 184,644,786 (GRCm39) S390L possibly damaging Het
Mbd3l1 T C 9: 18,396,024 (GRCm39) Y50H probably benign Het
Mcat T C 15: 83,433,383 (GRCm39) N220S probably benign Het
Muc2 A G 7: 141,282,941 (GRCm39) E81G probably benign Het
Neto1 A T 18: 86,512,985 (GRCm39) K327* probably null Het
Or10j3 G T 1: 173,031,847 (GRCm39) R308L probably benign Het
Or4a67 A T 2: 88,598,587 (GRCm39) L24Q probably damaging Het
Or52p1 A T 7: 104,267,648 (GRCm39) Y254F probably damaging Het
Or52u1 T C 7: 104,237,218 (GRCm39) L69P probably damaging Het
Pidd1 A T 7: 141,019,494 (GRCm39) V722D probably damaging Het
Ppp2r2a G T 14: 67,257,253 (GRCm39) H326N probably damaging Het
Smarca5 G A 8: 81,446,281 (GRCm39) T473I probably damaging Het
Spg11 C A 2: 121,922,773 (GRCm39) W892L probably damaging Het
Tas2r110 T A 6: 132,845,248 (GRCm39) I93N possibly damaging Het
Tiam2 CGGG CGGGG 17: 3,464,897 (GRCm39) probably null Het
Vsnl1 A G 12: 11,376,489 (GRCm39) V132A probably benign Het
Wdsub1 T C 2: 59,708,652 (GRCm39) T74A probably damaging Het
Ywhaz T C 15: 36,791,166 (GRCm39) Y19C probably damaging Het
Other mutations in Vmn1r71
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00984:Vmn1r71 APN 7 10,482,046 (GRCm39) missense probably damaging 0.99
IGL01921:Vmn1r71 APN 7 10,482,199 (GRCm39) missense probably benign 0.16
IGL02397:Vmn1r71 APN 7 10,482,199 (GRCm39) missense probably benign 0.27
IGL02654:Vmn1r71 APN 7 10,482,242 (GRCm39) missense probably benign 0.42
IGL02900:Vmn1r71 APN 7 10,482,601 (GRCm39) missense probably benign 0.28
IGL03236:Vmn1r71 APN 7 10,482,211 (GRCm39) missense probably benign 0.11
IGL03269:Vmn1r71 APN 7 10,482,571 (GRCm39) missense possibly damaging 0.88
FR4976:Vmn1r71 UTSW 7 10,482,048 (GRCm39) missense probably benign
R0389:Vmn1r71 UTSW 7 10,482,238 (GRCm39) missense probably benign 0.05
R0443:Vmn1r71 UTSW 7 10,482,238 (GRCm39) missense probably benign 0.05
R0470:Vmn1r71 UTSW 7 10,482,019 (GRCm39) missense possibly damaging 0.64
R0471:Vmn1r71 UTSW 7 10,482,019 (GRCm39) missense possibly damaging 0.64
R0472:Vmn1r71 UTSW 7 10,482,019 (GRCm39) missense possibly damaging 0.64
R0567:Vmn1r71 UTSW 7 10,482,556 (GRCm39) missense probably damaging 1.00
R1498:Vmn1r71 UTSW 7 10,482,575 (GRCm39) missense probably benign 0.01
R1745:Vmn1r71 UTSW 7 10,482,196 (GRCm39) missense probably benign 0.05
R2350:Vmn1r71 UTSW 7 10,481,846 (GRCm39) missense probably benign 0.00
R2970:Vmn1r71 UTSW 7 10,482,641 (GRCm39) missense possibly damaging 0.67
R3522:Vmn1r71 UTSW 7 10,481,792 (GRCm39) missense probably benign 0.03
R4193:Vmn1r71 UTSW 7 10,482,175 (GRCm39) missense possibly damaging 0.55
R4736:Vmn1r71 UTSW 7 10,481,791 (GRCm39) missense possibly damaging 0.94
R5115:Vmn1r71 UTSW 7 10,481,885 (GRCm39) missense probably benign 0.00
R6108:Vmn1r71 UTSW 7 10,482,545 (GRCm39) missense probably benign 0.01
R6455:Vmn1r71 UTSW 7 10,482,331 (GRCm39) missense probably benign 0.01
R6696:Vmn1r71 UTSW 7 10,482,401 (GRCm39) missense probably damaging 0.96
R6778:Vmn1r71 UTSW 7 10,482,143 (GRCm39) missense probably benign 0.02
R7347:Vmn1r71 UTSW 7 10,482,428 (GRCm39) missense not run
R7631:Vmn1r71 UTSW 7 10,482,378 (GRCm39) missense probably damaging 1.00
R7795:Vmn1r71 UTSW 7 10,482,136 (GRCm39) missense probably damaging 0.98
R7820:Vmn1r71 UTSW 7 10,482,652 (GRCm39) missense possibly damaging 0.85
R7836:Vmn1r71 UTSW 7 10,482,277 (GRCm39) missense possibly damaging 0.51
Predicted Primers PCR Primer
(F):5'- GTGCAAATGGACATACTTCGAC -3'
(R):5'- TGGATTAAAGGTGTCCTCTTTCAC -3'

Sequencing Primer
(F):5'- GGACATACTTCGACTAAATCCTTG -3'
(R):5'- TCTTTCACCATAGTCTAGAACCAG -3'
Posted On 2018-06-22