Incidental Mutation 'IGL01062:Tex21'
ID52418
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tex21
Ensembl Gene ENSMUSG00000021056
Gene Nametestis expressed gene 21
Synonyms4931412D23Rik, tsec-2, 4931406F04Rik, 4931421K24Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.097) question?
Stock #IGL01062
Quality Score
Status
Chromosome12
Chromosomal Location76198686-76246746 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 76198944 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 526 (D526G)
Ref Sequence ENSEMBL: ENSMUSP00000021453 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021453]
Predicted Effect probably benign
Transcript: ENSMUST00000021453
AA Change: D526G

PolyPhen 2 Score 0.031 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000021453
Gene: ENSMUSG00000021056
AA Change: D526G

DomainStartEndE-ValueType
coiled coil region 83 190 N/A INTRINSIC
coiled coil region 308 356 N/A INTRINSIC
coiled coil region 409 447 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110017D15Rik T A 4: 41,511,433 E93D probably damaging Het
Aen G A 7: 78,907,302 M299I probably damaging Het
Amer3 A G 1: 34,586,739 K20E probably damaging Het
Arhgap31 A G 16: 38,601,456 L1416P probably damaging Het
Avpr1a G A 10: 122,449,529 C242Y probably damaging Het
Bclaf3 T C X: 159,553,419 Y281H probably benign Het
Cdc14a T A 3: 116,274,712 probably benign Het
Cfap206 C T 4: 34,721,562 S162N probably damaging Het
Cntn4 T C 6: 106,618,278 probably benign Het
Cyp3a44 T A 5: 145,794,339 D217V possibly damaging Het
Eprs A G 1: 185,379,615 E274G probably benign Het
Ercc6l2 G T 13: 63,847,454 Q354H probably null Het
Glb1l A T 1: 75,201,238 I392N probably damaging Het
Gm3173 T C 14: 4,514,887 probably null Het
Grasp A G 15: 101,228,896 probably benign Het
Hadh C T 3: 131,240,991 V219M probably damaging Het
Hspb9 A G 11: 100,713,935 H29R possibly damaging Het
Iqgap3 G T 3: 88,110,122 V240L probably benign Het
Jmjd1c T C 10: 67,226,715 S1616P probably damaging Het
Knl1 A G 2: 119,076,980 I1662V probably benign Het
Mapre3 A G 5: 30,864,896 I236V probably benign Het
Med17 T C 9: 15,279,621 E58G probably benign Het
Myh6 T C 14: 54,952,292 E1099G probably damaging Het
Myt1 T A 2: 181,797,729 V348D probably damaging Het
Nat10 A T 2: 103,743,048 I368N probably damaging Het
Nol6 T C 4: 41,118,205 I811V probably benign Het
Oas1d C A 5: 120,919,064 Y244* probably null Het
Olfr49 A T 14: 54,282,724 M57K probably damaging Het
Osbpl1a A G 18: 12,905,075 V273A probably benign Het
Pigw T C 11: 84,877,943 R187G probably benign Het
Plekhg5 G A 4: 152,108,496 D603N probably damaging Het
Ptprk T C 10: 28,580,418 V1058A probably damaging Het
Robo4 G A 9: 37,406,000 S537N probably benign Het
Rptn T A 3: 93,397,182 F607L probably benign Het
Sall1 A G 8: 89,033,344 V44A probably damaging Het
Sh3bp4 C A 1: 89,143,960 Q177K probably benign Het
Srrt C A 5: 137,296,307 G779V probably damaging Het
Tmem57 A T 4: 134,833,297 V125E probably damaging Het
Ttc37 T A 13: 76,155,462 L1225* probably null Het
Vmn1r10 A G 6: 57,113,836 S138G possibly damaging Het
Yars2 C T 16: 16,306,542 R338* probably null Het
Zfp454 T C 11: 50,874,206 E22G probably benign Het
Zzef1 T A 11: 72,874,969 C1441S probably benign Het
Other mutations in Tex21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00472:Tex21 APN 12 76206797 missense probably damaging 1.00
IGL00923:Tex21 APN 12 76245111 missense probably damaging 1.00
IGL01063:Tex21 APN 12 76198818 missense probably benign 0.34
IGL02624:Tex21 APN 12 76214624 missense probably damaging 1.00
IGL03349:Tex21 APN 12 76221591 missense probably benign 0.14
IGL03387:Tex21 APN 12 76198920 missense probably damaging 1.00
IGL03412:Tex21 APN 12 76245006 critical splice donor site probably null
R0189:Tex21 UTSW 12 76239533 missense probably benign 0.13
R0730:Tex21 UTSW 12 76204166 missense probably benign 0.25
R1521:Tex21 UTSW 12 76204270 missense probably benign 0.38
R1572:Tex21 UTSW 12 76206891 missense probably benign 0.03
R1700:Tex21 UTSW 12 76221672 missense probably damaging 0.99
R1941:Tex21 UTSW 12 76221684 missense possibly damaging 0.68
R4654:Tex21 UTSW 12 76217086 missense probably benign 0.32
R4943:Tex21 UTSW 12 76221700 missense probably damaging 1.00
R6175:Tex21 UTSW 12 76198933 missense probably benign 0.00
R6262:Tex21 UTSW 12 76212532 missense probably damaging 0.99
R6738:Tex21 UTSW 12 76239509 missense probably benign 0.12
R6759:Tex21 UTSW 12 76204312 critical splice acceptor site probably null
R6890:Tex21 UTSW 12 76239455 critical splice donor site probably null
Z1176:Tex21 UTSW 12 76204120 missense probably damaging 1.00
Posted On2013-06-21