Incidental Mutation 'R6584:Ifna9'
ID 524269
Institutional Source Beutler Lab
Gene Symbol Ifna9
Ensembl Gene ENSMUSG00000095270
Gene Name interferon alpha 9
Synonyms Ifa9
MMRRC Submission 044708-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R6584 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 88510050-88510622 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 88510375 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 83 (L83P)
Ref Sequence ENSEMBL: ENSMUSP00000099871 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102807]
AlphaFold P09235
Predicted Effect probably damaging
Transcript: ENSMUST00000102807
AA Change: L83P

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000099871
Gene: ENSMUSG00000095270
AA Change: L83P

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 1.68e-67 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agr2 G A 12: 36,045,625 (GRCm39) R37Q probably benign Het
Amfr T C 8: 94,700,783 (GRCm39) D559G probably benign Het
Atg2b T C 12: 105,624,254 (GRCm39) Y711C probably damaging Het
Brd10 T C 19: 29,696,128 (GRCm39) N1122D possibly damaging Het
Clgn T C 8: 84,126,665 (GRCm39) I122T probably benign Het
Ets1 T A 9: 32,645,293 (GRCm39) F180Y probably damaging Het
Fbxw14 C G 9: 109,115,611 (GRCm39) C53S possibly damaging Het
Igf2r A G 17: 12,920,137 (GRCm39) C1401R probably damaging Het
Il22 A T 10: 118,040,932 (GRCm39) M13L probably benign Het
Il9r A G 11: 32,141,782 (GRCm39) Y319H probably benign Het
Itgb5 T C 16: 33,705,400 (GRCm39) F230S probably damaging Het
Klk1b27 T A 7: 43,703,935 (GRCm39) I26N possibly damaging Het
Lrba C T 3: 86,571,883 (GRCm39) R300C probably damaging Het
Map3k4 A C 17: 12,479,378 (GRCm39) Y730D probably damaging Het
Ogfrl1 T G 1: 23,408,944 (GRCm39) K427N probably benign Het
Or1o1 G A 17: 37,716,796 (GRCm39) R119H probably benign Het
Paxip1 G A 5: 27,963,450 (GRCm39) H792Y probably damaging Het
Phf20 T C 2: 156,136,043 (GRCm39) S621P probably damaging Het
Pramel22 T A 4: 143,382,040 (GRCm39) T219S possibly damaging Het
Slitrk3 C A 3: 72,956,558 (GRCm39) G738V probably damaging Het
Smurf1 T C 5: 144,819,333 (GRCm39) D598G probably damaging Het
St6galnac2 A G 11: 116,585,330 (GRCm39) S19P probably benign Het
Stra6l G A 4: 45,869,635 (GRCm39) probably null Het
Tbc1d9 C A 8: 83,987,629 (GRCm39) Q863K probably damaging Het
Traf1 T A 2: 34,848,070 (GRCm39) D8V probably damaging Het
Vmn2r24 T G 6: 123,792,764 (GRCm39) M697R possibly damaging Het
Wdr27 T A 17: 15,122,031 (GRCm39) Y625F probably damaging Het
Wdr49 T C 3: 75,245,065 (GRCm39) M339V probably benign Het
Other mutations in Ifna9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01788:Ifna9 APN 4 88,510,097 (GRCm39) missense probably damaging 1.00
IGL02268:Ifna9 APN 4 88,510,591 (GRCm39) nonsense probably null
R0579:Ifna9 UTSW 4 88,510,508 (GRCm39) missense possibly damaging 0.84
R1530:Ifna9 UTSW 4 88,510,409 (GRCm39) missense possibly damaging 0.83
R1663:Ifna9 UTSW 4 88,510,220 (GRCm39) missense probably benign 0.00
R1872:Ifna9 UTSW 4 88,510,492 (GRCm39) missense probably damaging 0.97
R3923:Ifna9 UTSW 4 88,510,508 (GRCm39) missense possibly damaging 0.84
R4534:Ifna9 UTSW 4 88,510,285 (GRCm39) missense possibly damaging 0.76
R4882:Ifna9 UTSW 4 88,510,540 (GRCm39) missense probably benign 0.01
R5440:Ifna9 UTSW 4 88,510,048 (GRCm39) splice site probably null
R6008:Ifna9 UTSW 4 88,510,600 (GRCm39) missense probably null 1.00
R6464:Ifna9 UTSW 4 88,510,487 (GRCm39) missense possibly damaging 0.93
R6899:Ifna9 UTSW 4 88,510,300 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTTCATAGCCAGCTGGGAG -3'
(R):5'- GTGGTGATAAGCTACTGGTCAAC -3'

Sequencing Primer
(F):5'- TCATAGCCAGCTGGGAGTCTTC -3'
(R):5'- GATAAGCTACTGGTCAACCTGCTC -3'
Posted On 2018-06-22