Incidental Mutation 'R6648:Socs4'
ID 524384
Institutional Source Beutler Lab
Gene Symbol Socs4
Ensembl Gene ENSMUSG00000048379
Gene Name suppressor of cytokine signaling 4
Synonyms Socs7, 3110032M18Rik, A730004F22Rik
MMRRC Submission 044769-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.368) question?
Stock # R6648 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 47514388-47533559 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 47527633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 189 (N189K)
Ref Sequence ENSEMBL: ENSMUSP00000066031 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065562] [ENSMUST00000227413]
AlphaFold Q91ZA6
Predicted Effect probably benign
Transcript: ENSMUST00000065562
AA Change: N189K

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000066031
Gene: ENSMUSG00000048379
AA Change: N189K

DomainStartEndE-ValueType
low complexity region 30 47 N/A INTRINSIC
Pfam:SOCS 55 108 6.8e-23 PFAM
low complexity region 219 232 N/A INTRINSIC
SH2 281 367 1.11e-16 SMART
SOCS 377 420 1.69e-16 SMART
SOCS_box 383 419 1.13e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000227413
Meta Mutation Damage Score 0.0752 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.4%
Validation Efficiency 98% (42/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 T C 17: 45,827,490 (GRCm39) Y511H probably damaging Het
Arhgef38 A T 3: 132,838,236 (GRCm39) I600N probably damaging Het
Cacna1g A T 11: 94,323,395 (GRCm39) C1270S probably damaging Het
Ccar2 T G 14: 70,376,674 (GRCm39) D890A probably benign Het
Cep76 A T 18: 67,752,804 (GRCm39) V548D probably benign Het
Chat T G 14: 32,176,651 (GRCm39) Q41P probably benign Het
Ddx24 T A 12: 103,374,634 (GRCm39) N850I probably benign Het
Dst A G 1: 34,301,122 (GRCm39) I5879V possibly damaging Het
Ece1 A G 4: 137,648,470 (GRCm39) T92A probably benign Het
Ecrg4 T A 1: 43,777,851 (GRCm39) F87I probably damaging Het
Fpgs G T 2: 32,574,799 (GRCm39) C439* probably null Het
H2-Q4 A T 17: 35,601,981 (GRCm39) E281V probably damaging Het
Hydin A G 8: 111,252,299 (GRCm39) probably null Het
Iqgap2 T C 13: 95,818,719 (GRCm39) E679G probably benign Het
Kif12 A T 4: 63,089,554 (GRCm39) probably null Het
Kif21b T C 1: 136,080,135 (GRCm39) V557A probably benign Het
Mki67 C G 7: 135,299,169 (GRCm39) S1955T probably damaging Het
Mybpc1 G A 10: 88,358,861 (GRCm39) T1110M probably damaging Het
Myh9 T C 15: 77,650,972 (GRCm39) H1625R probably benign Het
Nbeal2 G A 9: 110,466,710 (GRCm39) T704M probably damaging Het
Or1ad6 G A 11: 50,860,000 (GRCm39) D52N probably damaging Het
Or5a21 A T 19: 12,311,130 (GRCm39) M30K probably benign Het
Osbpl9 C A 4: 108,948,876 (GRCm39) Q91H possibly damaging Het
Pcsk5 A T 19: 17,553,185 (GRCm39) L665Q probably damaging Het
Pgm5 T C 19: 24,838,996 (GRCm39) D53G probably benign Het
Plcd4 A G 1: 74,591,172 (GRCm39) D189G probably benign Het
Plxnb1 A T 9: 108,933,398 (GRCm39) Q676L probably benign Het
Prss33 A G 17: 24,053,676 (GRCm39) S134P probably benign Het
Rln1 G T 19: 29,309,521 (GRCm39) T86K probably benign Het
Rnf213 G A 11: 119,370,746 (GRCm39) A4785T possibly damaging Het
Rsf1 GGCG GGCGACGGCCGCG 7: 97,229,113 (GRCm39) probably benign Het
Sh3tc2 T C 18: 62,148,111 (GRCm39) C1274R probably benign Het
Slc35a5 A T 16: 44,964,280 (GRCm39) F318I probably damaging Het
Slc41a3 T C 6: 90,596,490 (GRCm39) F20L probably damaging Het
Tiam2 A T 17: 3,557,148 (GRCm39) E1196V probably damaging Het
Tmc3 T A 7: 83,246,751 (GRCm39) V164D probably damaging Het
Trim46 T C 3: 89,142,549 (GRCm39) E623G possibly damaging Het
Ubr4 C A 4: 139,180,030 (GRCm39) C3403* probably null Het
Vmn1r194 A T 13: 22,428,694 (GRCm39) T104S probably benign Het
Vmn2r112 A T 17: 22,837,467 (GRCm39) I643F probably damaging Het
Zfp1002 T C 2: 150,097,097 (GRCm39) I111V probably benign Het
Zmynd11 T G 13: 9,763,057 (GRCm39) S95R probably benign Het
Zswim4 C A 8: 84,957,543 (GRCm39) R175L probably benign Het
Other mutations in Socs4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00495:Socs4 APN 14 47,527,709 (GRCm39) missense probably benign
IGL01942:Socs4 APN 14 47,528,107 (GRCm39) nonsense probably null
IGL02039:Socs4 APN 14 47,527,650 (GRCm39) missense probably benign
IGL02117:Socs4 APN 14 47,528,264 (GRCm39) missense probably damaging 1.00
R0281:Socs4 UTSW 14 47,527,325 (GRCm39) missense probably benign 0.25
R0703:Socs4 UTSW 14 47,527,505 (GRCm39) missense probably damaging 1.00
R0763:Socs4 UTSW 14 47,528,112 (GRCm39) missense probably damaging 1.00
R0842:Socs4 UTSW 14 47,527,426 (GRCm39) missense probably damaging 0.98
R1133:Socs4 UTSW 14 47,527,651 (GRCm39) missense probably benign 0.01
R1280:Socs4 UTSW 14 47,528,370 (GRCm39) missense probably benign 0.23
R1619:Socs4 UTSW 14 47,527,740 (GRCm39) missense possibly damaging 0.87
R1632:Socs4 UTSW 14 47,527,034 (GRCm39) start gained probably benign
R5058:Socs4 UTSW 14 47,527,589 (GRCm39) nonsense probably null
R6008:Socs4 UTSW 14 47,527,618 (GRCm39) missense probably damaging 0.98
R6925:Socs4 UTSW 14 47,527,195 (GRCm39) nonsense probably null
R7408:Socs4 UTSW 14 47,527,296 (GRCm39) missense probably benign 0.00
R9162:Socs4 UTSW 14 47,528,301 (GRCm39) missense probably damaging 0.99
R9234:Socs4 UTSW 14 47,527,716 (GRCm39) missense probably benign 0.00
R9428:Socs4 UTSW 14 47,528,034 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGCTCAGATTTAGCCTTTAGG -3'
(R):5'- AGTCGATCTGGGTGTGGAAC -3'

Sequencing Primer
(F):5'- GGTGGCATTTTATTAAACGACACAC -3'
(R):5'- TGCCTCCAACTGCAGGATC -3'
Posted On 2018-06-22