Incidental Mutation 'R6621:Zfp174'
ID 524466
Institutional Source Beutler Lab
Gene Symbol Zfp174
Ensembl Gene ENSMUSG00000054939
Gene Name zinc finger protein 174
Synonyms LOC385674
MMRRC Submission 044744-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6621 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 3665132-3676744 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 3665819 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 28 (E28G)
Ref Sequence ENSEMBL: ENSMUSP00000045805 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041778] [ENSMUST00000214238] [ENSMUST00000214590]
AlphaFold B9EJW5
Predicted Effect probably damaging
Transcript: ENSMUST00000041778
AA Change: E28G

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000045805
Gene: ENSMUSG00000054939
AA Change: E28G

DomainStartEndE-ValueType
SCAN 42 154 6.21e-65 SMART
low complexity region 298 311 N/A INTRINSIC
ZnF_C2H2 326 348 5.99e-4 SMART
ZnF_C2H2 354 376 1.36e-2 SMART
ZnF_C2H2 382 404 1.43e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000214238
Predicted Effect probably benign
Transcript: ENSMUST00000214590
Meta Mutation Damage Score 0.3629 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.6%
Validation Efficiency 100% (36/36)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with three Cys2-His2-type zinc fingers in the carboxy-terminus, a putative nuclear localization signal, and an amino-terminus SCAN box which forms homodimers. This protein is believed to function as a transcriptional repressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2016]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430548M08Rik C T 8: 120,872,162 (GRCm39) T30M possibly damaging Het
Abcb8 T C 5: 24,599,508 (GRCm39) F8L probably benign Het
Akap13 G T 7: 75,219,729 (GRCm39) C44F probably damaging Het
Ankrd34a A G 3: 96,505,531 (GRCm39) N245S possibly damaging Het
Ccdc186 T C 19: 56,801,919 (GRCm39) D66G probably benign Het
Chat C T 14: 32,140,970 (GRCm39) A476T probably damaging Het
Cpsf1 T C 15: 76,487,719 (GRCm39) D100G probably damaging Het
Cpt1a T A 19: 3,428,472 (GRCm39) F615L probably damaging Het
Dpp4 T A 2: 62,182,484 (GRCm39) D599V probably damaging Het
Dpysl5 T C 5: 30,941,813 (GRCm39) probably null Het
Fam234a A G 17: 26,432,855 (GRCm39) L460P probably damaging Het
Fsip2 T G 2: 82,820,158 (GRCm39) V5297G possibly damaging Het
Gm28363 A G 1: 117,655,087 (GRCm39) D102G probably benign Het
Greb1 A G 12: 16,742,718 (GRCm39) V1377A probably damaging Het
Hat1 T A 2: 71,252,059 (GRCm39) F264I probably benign Het
Kif3a A G 11: 53,469,957 (GRCm39) I152M probably damaging Het
Lemd2 T C 17: 27,414,366 (GRCm39) S323G probably benign Het
Manea T C 4: 26,340,363 (GRCm39) probably null Het
Mcm9 T C 10: 53,439,409 (GRCm39) E588G probably damaging Het
Mllt3 T G 4: 87,759,034 (GRCm39) K338T possibly damaging Het
Nrxn1 T C 17: 90,469,610 (GRCm39) T1324A probably damaging Het
Nudt8 T A 19: 4,051,320 (GRCm39) Y64N probably benign Het
Or13a27 A G 7: 139,925,368 (GRCm39) F178S probably damaging Het
Or2y15 A G 11: 49,350,598 (GRCm39) I31V probably benign Het
Or51ah3 A G 7: 103,210,085 (GRCm39) T134A possibly damaging Het
Or5ac15 A T 16: 58,940,287 (GRCm39) W49R probably benign Het
Or5w14 A G 2: 87,541,899 (GRCm39) V117A probably benign Het
Or8c9 A T 9: 38,241,758 (GRCm39) I289F probably damaging Het
Osm T A 11: 4,189,541 (GRCm39) D108E probably benign Het
Pde8a A G 7: 80,942,878 (GRCm39) probably null Het
Phtf2 T C 5: 21,017,954 (GRCm39) probably benign Het
Rnf214 T C 9: 45,807,468 (GRCm39) D245G probably damaging Het
Slc10a7 T C 8: 79,242,263 (GRCm39) I50T probably damaging Het
Slc5a6 A G 5: 31,198,122 (GRCm39) V251A probably damaging Het
Sun3 T A 11: 8,966,242 (GRCm39) T320S probably damaging Het
Other mutations in Zfp174
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01603:Zfp174 APN 16 3,672,153 (GRCm39) missense probably benign
R0558:Zfp174 UTSW 16 3,666,118 (GRCm39) missense possibly damaging 0.56
R1141:Zfp174 UTSW 16 3,667,321 (GRCm39) missense probably benign 0.07
R1378:Zfp174 UTSW 16 3,667,353 (GRCm39) missense probably benign 0.15
R1846:Zfp174 UTSW 16 3,672,599 (GRCm39) missense probably benign 0.14
R2089:Zfp174 UTSW 16 3,672,506 (GRCm39) missense possibly damaging 0.93
R2091:Zfp174 UTSW 16 3,672,506 (GRCm39) missense possibly damaging 0.93
R2091:Zfp174 UTSW 16 3,672,506 (GRCm39) missense possibly damaging 0.93
R5784:Zfp174 UTSW 16 3,672,438 (GRCm39) missense probably benign 0.01
R6710:Zfp174 UTSW 16 3,665,921 (GRCm39) missense probably damaging 1.00
R6976:Zfp174 UTSW 16 3,665,804 (GRCm39) missense possibly damaging 0.92
R7104:Zfp174 UTSW 16 3,672,269 (GRCm39) missense probably benign
R7241:Zfp174 UTSW 16 3,666,111 (GRCm39) missense probably benign 0.29
R7774:Zfp174 UTSW 16 3,667,215 (GRCm39) missense probably damaging 1.00
R7821:Zfp174 UTSW 16 3,666,041 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCTTTGCAGTCCTTCCAGG -3'
(R):5'- TCACCAGGAGCTCCAAAATCTG -3'

Sequencing Primer
(F):5'- AGGGAGGCTTCGTTCCTAAC -3'
(R):5'- GAGCTCCAAAATCTGCTCTTTAGTG -3'
Posted On 2018-06-22