Incidental Mutation 'R6623:Lnx2'
ID 524597
Institutional Source Beutler Lab
Gene Symbol Lnx2
Ensembl Gene ENSMUSG00000016520
Gene Name ligand of numb-protein X 2
Synonyms
MMRRC Submission 044745-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R6623 (G1)
Quality Score 180.009
Status Validated
Chromosome 5
Chromosomal Location 146953465-147013385 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 146961297 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 545 (V545A)
Ref Sequence ENSEMBL: ENSMUSP00000016664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016664]
AlphaFold Q91XL2
Predicted Effect probably damaging
Transcript: ENSMUST00000016664
AA Change: V545A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000016664
Gene: ENSMUSG00000016520
AA Change: V545A

DomainStartEndE-ValueType
RING 51 88 2.06e-6 SMART
low complexity region 103 114 N/A INTRINSIC
PDZ 242 317 2.25e-17 SMART
PDZ 348 421 2.97e-17 SMART
PDZ 474 553 7.37e-13 SMART
PDZ 606 683 1.27e-16 SMART
Meta Mutation Damage Score 0.7059 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.2%
  • 20x: 91.1%
Validation Efficiency 100% (29/29)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,634,388 (GRCm39) K460E probably damaging Het
Acaca A C 11: 84,262,325 (GRCm39) probably null Het
Adamts1 A G 16: 85,592,525 (GRCm39) S628P probably benign Het
Ankrd13a A G 5: 114,924,818 (GRCm39) N101S probably benign Het
Asic5 G A 3: 81,915,892 (GRCm39) V281M probably damaging Het
Atxn7 T C 14: 14,099,972 (GRCm38) S553P probably damaging Het
Cstdc2 A T 2: 148,692,682 (GRCm39) I40K probably benign Het
Fndc3c1 G C X: 105,478,679 (GRCm39) L724V possibly damaging Homo
Hmcn1 A G 1: 150,634,057 (GRCm39) F843S probably benign Het
Igkv10-96 T G 6: 68,609,158 (GRCm39) S46R probably damaging Het
Itfg2 G T 6: 128,388,620 (GRCm39) A289D probably damaging Het
Klc1 C A 12: 111,772,475 (GRCm39) N597K probably damaging Het
Map3k11 A G 19: 5,745,631 (GRCm39) I344V probably damaging Het
Muc6 G A 7: 141,223,981 (GRCm39) probably benign Het
Myrf C A 19: 10,200,723 (GRCm39) A317S probably benign Het
Ncoa2 A T 1: 13,251,521 (GRCm39) C251S probably damaging Het
Or52i2 T G 7: 102,319,241 (GRCm39) M38R possibly damaging Het
Pcdhb12 C T 18: 37,570,711 (GRCm39) T619I possibly damaging Het
Plxna1 A T 6: 89,299,753 (GRCm39) M1672K probably damaging Het
Prl G T 13: 27,245,492 (GRCm39) V72L probably benign Het
Prokr2 G T 2: 132,215,494 (GRCm39) N161K probably damaging Het
Ryr2 T C 13: 11,724,951 (GRCm39) D2454G probably damaging Het
Slc2a12 T A 10: 22,540,799 (GRCm39) M218K probably damaging Het
Sorcs3 C T 19: 48,776,944 (GRCm39) A992V probably benign Het
Stxbp2 T C 8: 3,682,561 (GRCm39) I50T probably damaging Het
Supt20 A G 3: 54,625,715 (GRCm39) I570M possibly damaging Het
Sv2b T A 7: 74,856,132 (GRCm39) I53F probably damaging Het
Vmn1r113 T A 7: 20,521,991 (GRCm39) M261K probably benign Het
Vmn1r217 T A 13: 23,298,846 (GRCm39) I19F possibly damaging Het
Vmn2r45 T C 7: 8,474,500 (GRCm39) T843A probably benign Het
Vmn2r69 T A 7: 85,056,309 (GRCm39) I610L possibly damaging Het
Other mutations in Lnx2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02593:Lnx2 APN 5 146,969,825 (GRCm39) missense possibly damaging 0.81
IGL02657:Lnx2 APN 5 146,964,984 (GRCm39) missense probably damaging 1.00
IGL02820:Lnx2 APN 5 146,978,877 (GRCm39) missense probably damaging 0.98
R0051:Lnx2 UTSW 5 146,966,163 (GRCm39) missense probably damaging 0.96
R0389:Lnx2 UTSW 5 146,955,850 (GRCm39) missense possibly damaging 0.51
R0482:Lnx2 UTSW 5 146,955,771 (GRCm39) missense probably damaging 0.99
R1601:Lnx2 UTSW 5 146,970,329 (GRCm39) missense probably damaging 0.99
R1604:Lnx2 UTSW 5 146,966,135 (GRCm39) missense probably benign 0.02
R1647:Lnx2 UTSW 5 146,964,152 (GRCm39) missense probably benign 0.04
R3001:Lnx2 UTSW 5 146,955,825 (GRCm39) missense probably benign 0.00
R3002:Lnx2 UTSW 5 146,955,825 (GRCm39) missense probably benign 0.00
R4734:Lnx2 UTSW 5 146,965,947 (GRCm39) missense probably damaging 1.00
R4960:Lnx2 UTSW 5 146,955,850 (GRCm39) missense probably benign 0.09
R5387:Lnx2 UTSW 5 146,964,964 (GRCm39) missense probably benign 0.00
R5689:Lnx2 UTSW 5 146,965,961 (GRCm39) missense probably damaging 1.00
R5950:Lnx2 UTSW 5 146,961,160 (GRCm39) critical splice donor site probably null
R6161:Lnx2 UTSW 5 146,978,836 (GRCm39) splice site probably null
R7086:Lnx2 UTSW 5 146,956,988 (GRCm39) splice site probably null
R7320:Lnx2 UTSW 5 146,956,943 (GRCm39) missense possibly damaging 0.71
R7701:Lnx2 UTSW 5 146,961,333 (GRCm39) missense probably damaging 1.00
R7887:Lnx2 UTSW 5 146,955,853 (GRCm39) missense probably damaging 1.00
R8153:Lnx2 UTSW 5 146,964,906 (GRCm39) missense probably benign
R8267:Lnx2 UTSW 5 146,965,901 (GRCm39) missense probably damaging 1.00
R8298:Lnx2 UTSW 5 146,961,327 (GRCm39) missense probably benign 0.05
R8384:Lnx2 UTSW 5 146,966,138 (GRCm39) missense probably benign 0.01
R8446:Lnx2 UTSW 5 146,970,169 (GRCm39) missense probably benign
R8971:Lnx2 UTSW 5 146,970,236 (GRCm39) missense probably benign
R9378:Lnx2 UTSW 5 146,961,180 (GRCm39) missense probably benign 0.16
R9468:Lnx2 UTSW 5 146,979,289 (GRCm39) start gained probably benign
R9711:Lnx2 UTSW 5 146,961,376 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGCACTGGGTGAGTTAACC -3'
(R):5'- CCATCAATTAGTTGGCAAGCAG -3'

Sequencing Primer
(F):5'- CACTGGGTGAGTTAACCGTGTAAC -3'
(R):5'- AGGAGCTTCGGGGAGTCAC -3'
Posted On 2018-06-22