Incidental Mutation 'R6623:Vmn1r217'
ID |
524623 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r217
|
Ensembl Gene |
ENSMUSG00000115791 |
Gene Name |
vomeronasal 1 receptor 217 |
Synonyms |
V1rh14 |
MMRRC Submission |
044745-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.202)
|
Stock # |
R6623 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
13 |
Chromosomal Location |
23298004-23298900 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 23298846 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 19
(I19F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000154563
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000091721]
[ENSMUST00000227110]
[ENSMUST00000228656]
|
AlphaFold |
Q8R270 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000091721
AA Change: I19F
PolyPhen 2
Score 0.651 (Sensitivity: 0.87; Specificity: 0.91)
|
SMART Domains |
Protein: ENSMUSP00000089314 Gene: ENSMUSG00000115791 AA Change: I19F
Domain | Start | End | E-Value | Type |
transmembrane domain
|
9 |
31 |
N/A |
INTRINSIC |
Pfam:V1R
|
33 |
296 |
7.1e-37 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227110
AA Change: I19F
PolyPhen 2
Score 0.651 (Sensitivity: 0.87; Specificity: 0.91)
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228656
AA Change: I19F
PolyPhen 2
Score 0.651 (Sensitivity: 0.87; Specificity: 0.91)
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.4%
- 10x: 97.2%
- 20x: 91.1%
|
Validation Efficiency |
100% (29/29) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 31 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc10 |
T |
C |
17: 46,634,388 (GRCm39) |
K460E |
probably damaging |
Het |
Acaca |
A |
C |
11: 84,262,325 (GRCm39) |
|
probably null |
Het |
Adamts1 |
A |
G |
16: 85,592,525 (GRCm39) |
S628P |
probably benign |
Het |
Ankrd13a |
A |
G |
5: 114,924,818 (GRCm39) |
N101S |
probably benign |
Het |
Asic5 |
G |
A |
3: 81,915,892 (GRCm39) |
V281M |
probably damaging |
Het |
Atxn7 |
T |
C |
14: 14,099,972 (GRCm38) |
S553P |
probably damaging |
Het |
Cstdc2 |
A |
T |
2: 148,692,682 (GRCm39) |
I40K |
probably benign |
Het |
Fndc3c1 |
G |
C |
X: 105,478,679 (GRCm39) |
L724V |
possibly damaging |
Homo |
Hmcn1 |
A |
G |
1: 150,634,057 (GRCm39) |
F843S |
probably benign |
Het |
Igkv10-96 |
T |
G |
6: 68,609,158 (GRCm39) |
S46R |
probably damaging |
Het |
Itfg2 |
G |
T |
6: 128,388,620 (GRCm39) |
A289D |
probably damaging |
Het |
Klc1 |
C |
A |
12: 111,772,475 (GRCm39) |
N597K |
probably damaging |
Het |
Lnx2 |
A |
G |
5: 146,961,297 (GRCm39) |
V545A |
probably damaging |
Het |
Map3k11 |
A |
G |
19: 5,745,631 (GRCm39) |
I344V |
probably damaging |
Het |
Muc6 |
G |
A |
7: 141,223,981 (GRCm39) |
|
probably benign |
Het |
Myrf |
C |
A |
19: 10,200,723 (GRCm39) |
A317S |
probably benign |
Het |
Ncoa2 |
A |
T |
1: 13,251,521 (GRCm39) |
C251S |
probably damaging |
Het |
Or52i2 |
T |
G |
7: 102,319,241 (GRCm39) |
M38R |
possibly damaging |
Het |
Pcdhb12 |
C |
T |
18: 37,570,711 (GRCm39) |
T619I |
possibly damaging |
Het |
Plxna1 |
A |
T |
6: 89,299,753 (GRCm39) |
M1672K |
probably damaging |
Het |
Prl |
G |
T |
13: 27,245,492 (GRCm39) |
V72L |
probably benign |
Het |
Prokr2 |
G |
T |
2: 132,215,494 (GRCm39) |
N161K |
probably damaging |
Het |
Ryr2 |
T |
C |
13: 11,724,951 (GRCm39) |
D2454G |
probably damaging |
Het |
Slc2a12 |
T |
A |
10: 22,540,799 (GRCm39) |
M218K |
probably damaging |
Het |
Sorcs3 |
C |
T |
19: 48,776,944 (GRCm39) |
A992V |
probably benign |
Het |
Stxbp2 |
T |
C |
8: 3,682,561 (GRCm39) |
I50T |
probably damaging |
Het |
Supt20 |
A |
G |
3: 54,625,715 (GRCm39) |
I570M |
possibly damaging |
Het |
Sv2b |
T |
A |
7: 74,856,132 (GRCm39) |
I53F |
probably damaging |
Het |
Vmn1r113 |
T |
A |
7: 20,521,991 (GRCm39) |
M261K |
probably benign |
Het |
Vmn2r45 |
T |
C |
7: 8,474,500 (GRCm39) |
T843A |
probably benign |
Het |
Vmn2r69 |
T |
A |
7: 85,056,309 (GRCm39) |
I610L |
possibly damaging |
Het |
|
Other mutations in Vmn1r217 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL03404:Vmn1r217
|
APN |
13 |
23,298,810 (GRCm39) |
missense |
probably benign |
0.10 |
R0147:Vmn1r217
|
UTSW |
13 |
23,298,107 (GRCm39) |
missense |
probably benign |
|
R0325:Vmn1r217
|
UTSW |
13 |
23,298,764 (GRCm39) |
missense |
probably damaging |
1.00 |
R1249:Vmn1r217
|
UTSW |
13 |
23,298,818 (GRCm39) |
missense |
probably benign |
0.01 |
R1554:Vmn1r217
|
UTSW |
13 |
23,298,464 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1777:Vmn1r217
|
UTSW |
13 |
23,298,495 (GRCm39) |
missense |
probably benign |
0.03 |
R2061:Vmn1r217
|
UTSW |
13 |
23,298,698 (GRCm39) |
missense |
probably benign |
0.19 |
R2168:Vmn1r217
|
UTSW |
13 |
23,298,714 (GRCm39) |
nonsense |
probably null |
|
R3122:Vmn1r217
|
UTSW |
13 |
23,298,249 (GRCm39) |
missense |
probably damaging |
1.00 |
R4832:Vmn1r217
|
UTSW |
13 |
23,298,159 (GRCm39) |
missense |
probably damaging |
1.00 |
R6500:Vmn1r217
|
UTSW |
13 |
23,298,073 (GRCm39) |
nonsense |
probably null |
|
R6909:Vmn1r217
|
UTSW |
13 |
23,298,108 (GRCm39) |
missense |
probably benign |
|
R7708:Vmn1r217
|
UTSW |
13 |
23,298,269 (GRCm39) |
missense |
probably benign |
0.01 |
R8223:Vmn1r217
|
UTSW |
13 |
23,298,369 (GRCm39) |
missense |
probably benign |
0.03 |
R8774:Vmn1r217
|
UTSW |
13 |
23,298,108 (GRCm39) |
missense |
probably benign |
|
R8774-TAIL:Vmn1r217
|
UTSW |
13 |
23,298,108 (GRCm39) |
missense |
probably benign |
|
R9129:Vmn1r217
|
UTSW |
13 |
23,298,876 (GRCm39) |
missense |
probably benign |
0.24 |
R9182:Vmn1r217
|
UTSW |
13 |
23,298,495 (GRCm39) |
missense |
probably benign |
0.03 |
|
Predicted Primers |
PCR Primer
(F):5'- CAGCCTATGTCATCCAGGAAG -3'
(R):5'- GGGACCTCATCTGCAACATTAC -3'
Sequencing Primer
(F):5'- GTCATCCAGGAAGTTTCTTAAACC -3'
(R):5'- GGACCTCATCTGCAACATTACATGTG -3'
|
Posted On |
2018-06-22 |