Incidental Mutation 'R6590:Or10k2'
ID 524692
Institutional Source Beutler Lab
Gene Symbol Or10k2
Ensembl Gene ENSMUSG00000047286
Gene Name olfactory receptor family 10 subfamily K member 2
Synonyms Olfr370, GA_x6K02T2NUPS-11609807-11610751, MOR267-16
MMRRC Submission 044714-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R6590 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 84267722-84268817 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 84267904 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 44 (V44L)
Ref Sequence ENSEMBL: ENSMUSP00000149251 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058609] [ENSMUST00000209408] [ENSMUST00000214156]
AlphaFold E9Q848
Predicted Effect probably benign
Transcript: ENSMUST00000058609
AA Change: V44L

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000055435
Gene: ENSMUSG00000047286
AA Change: V44L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 1.6e-44 PFAM
Pfam:7tm_1 41 290 6.2e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209408
AA Change: V44L

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000214156
AA Change: V44L

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 94.1%
Validation Efficiency 100% (28/28)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 C T 2: 69,115,062 (GRCm39) G628D probably damaging Het
Ahnak G T 19: 8,986,945 (GRCm39) G2743V probably benign Het
Akr1c14 A T 13: 4,113,713 (GRCm39) T82S possibly damaging Het
Ccdc7b A G 8: 129,904,700 (GRCm39) T113A probably benign Het
Cep152 A T 2: 125,406,290 (GRCm39) L1414Q probably damaging Het
Chd8 T C 14: 52,464,694 (GRCm39) E658G possibly damaging Het
Clca3a1 G C 3: 144,719,644 (GRCm39) A442G probably damaging Het
Coro6 A G 11: 77,356,606 (GRCm39) T105A probably benign Het
Cux1 A G 5: 136,368,971 (GRCm39) I232T probably damaging Het
Dmrt1 A G 19: 25,523,449 (GRCm39) T267A probably benign Het
Fam149a G T 8: 45,802,071 (GRCm39) A387E probably damaging Het
Fat4 G A 3: 39,037,688 (GRCm39) G3780D probably damaging Het
Igf2r A T 17: 12,910,824 (GRCm39) L1998* probably null Het
Iqcf6 C T 9: 106,504,501 (GRCm39) T55I possibly damaging Het
Mterf3 G A 13: 67,065,110 (GRCm39) L264F probably damaging Het
Or8g32 A G 9: 39,305,845 (GRCm39) I253V probably benign Het
Pcdhgb7 A T 18: 37,886,050 (GRCm39) I407F probably benign Het
Pip4k2b T C 11: 97,620,393 (GRCm39) D114G probably damaging Het
Plbd1 G T 6: 136,612,598 (GRCm39) N198K probably damaging Het
Prkcb T C 7: 121,888,737 (GRCm39) I57T probably damaging Het
Ralgapa1 C T 12: 55,769,558 (GRCm39) probably null Het
Slc26a8 A G 17: 28,863,629 (GRCm39) I710T possibly damaging Het
Smc2 A T 4: 52,449,375 (GRCm39) I179L probably benign Het
Tmub2 C T 11: 102,178,345 (GRCm39) H83Y probably damaging Het
Trip11 C A 12: 101,851,710 (GRCm39) D785Y possibly damaging Het
Vill A G 9: 118,890,975 (GRCm39) T194A probably benign Het
Vmn2r59 T C 7: 41,695,890 (GRCm39) D174G probably damaging Het
Other mutations in Or10k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01621:Or10k2 APN 8 84,268,247 (GRCm39) missense probably benign 0.00
IGL02481:Or10k2 APN 8 84,268,015 (GRCm39) missense possibly damaging 0.70
IGL02499:Or10k2 APN 8 84,267,812 (GRCm39) missense possibly damaging 0.83
IGL02832:Or10k2 APN 8 84,268,100 (GRCm39) missense probably damaging 1.00
R0315:Or10k2 UTSW 8 84,268,001 (GRCm39) missense possibly damaging 0.90
R0330:Or10k2 UTSW 8 84,268,142 (GRCm39) missense probably damaging 1.00
R1737:Or10k2 UTSW 8 84,268,045 (GRCm39) missense probably benign 0.05
R1973:Or10k2 UTSW 8 84,268,421 (GRCm39) missense probably benign 0.00
R2157:Or10k2 UTSW 8 84,268,250 (GRCm39) missense probably benign 0.00
R4687:Or10k2 UTSW 8 84,268,489 (GRCm39) missense probably damaging 1.00
R5639:Or10k2 UTSW 8 84,267,973 (GRCm39) missense probably damaging 1.00
R6150:Or10k2 UTSW 8 84,267,782 (GRCm39) missense probably benign 0.02
R6682:Or10k2 UTSW 8 84,268,187 (GRCm39) missense probably benign 0.00
R6690:Or10k2 UTSW 8 84,267,904 (GRCm39) missense probably benign 0.08
R7846:Or10k2 UTSW 8 84,268,526 (GRCm39) missense probably damaging 1.00
R7886:Or10k2 UTSW 8 84,268,576 (GRCm39) missense possibly damaging 0.95
R8349:Or10k2 UTSW 8 84,268,301 (GRCm39) missense probably damaging 1.00
R8361:Or10k2 UTSW 8 84,268,715 (GRCm39) missense possibly damaging 0.86
R8449:Or10k2 UTSW 8 84,268,301 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTACGGCTGTCAATCTCCTG -3'
(R):5'- GAACATTTGGATGGCGCAG -3'

Sequencing Primer
(F):5'- CTTCTCGAGTGTGTAAGGATTTCC -3'
(R):5'- CAGCCGAGGAAAGAGATGCTC -3'
Posted On 2018-06-22