Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01128:Togaram1'

52482

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Togaram1

Ensembl Gene

ENSMUSG00000035614

Gene Name

TOG array regulator of axonemal microtubules 1

Synonyms

Fam179b, A430041B07Rik

Accession Numbers

Is this an essential gene?

Possibly non essential (E-score: 0.316) question?

Stock #

IGL01128

Quality Score

Status

Chromosome

Chromosomal Location

64965804-65022573 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 64980876 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 880 (T880A)

Ref Sequence

ENSEMBL: ENSMUSP00000152616 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000066296] [ENSMUST00000223166]

Predicted Effect

probably benign
Transcript: ENSMUST00000066296
AA Change: T880A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000070382
Gene: ENSMUSG00000035614
AA Change: T880A

Domain	Start	End	E-Value	Type
low complexity region	2	17	N/A	INTRINSIC
low complexity region	61	77	N/A	INTRINSIC
low complexity region	79	92	N/A	INTRINSIC
low complexity region	94	105	N/A	INTRINSIC
low complexity region	115	132	N/A	INTRINSIC
TOG	339	574	3.38e-23	SMART
low complexity region	804	815	N/A	INTRINSIC
low complexity region	988	1001	N/A	INTRINSIC
low complexity region	1011	1024	N/A	INTRINSIC
low complexity region	1033	1041	N/A	INTRINSIC
coiled coil region	1177	1206	N/A	INTRINSIC
TOG	1251	1486	4.37e-8	SMART
TOG	1533	1776	1.53e-12	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221400

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221808

Predicted Effect

probably benign
Transcript: ENSMUST00000221836

Predicted Effect

probably benign
Transcript: ENSMUST00000223166
AA Change: T880A

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223311

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110038F14Rik	G	A	15: 76,950,275	V124I	probably damaging	Het
Adgrf5	G	T	17: 43,422,509	D75Y	possibly damaging	Het
Aen	G	A	7: 78,907,302	M299I	probably damaging	Het
Ahi1	A	G	10: 21,074,433	T128A	probably benign	Het
Bves	T	A	10: 45,353,848	F249L	probably damaging	Het
Capns1	T	C	7: 30,190,133	I214V	probably benign	Het
Cgnl1	G	T	9: 71,724,561	Q503K	possibly damaging	Het
Ep300	A	G	15: 81,630,006		probably benign	Het
Fam117b	T	A	1: 59,969,018	F337Y	probably damaging	Het
Fam178b	A	T	1: 36,644,354	V95E	probably damaging	Het
Gak	T	A	5: 108,592,370	M560L	probably damaging	Het
Gna11	C	A	10: 81,530,884	A331S	probably damaging	Het
Gtf3c3	A	C	1: 54,428,876	F201V	possibly damaging	Het
Kat6b	G	A	14: 21,660,860	R734H	probably benign	Het
Lag3	T	C	6: 124,909,417	D191G	probably damaging	Het
Mttp	T	A	3: 138,133,997		probably null	Het
Nlgn3	A	T	X: 101,320,092	T790S	probably benign	Het
Olfr1487	G	A	19: 13,619,746	E195K	probably damaging	Het
Olfr743	A	G	14: 50,533,949	D179G	probably damaging	Het
Pkd2l2	T	A	18: 34,417,015	Y238N	probably damaging	Het
Plg	A	T	17: 12,396,699		probably benign	Het
Ptprm	A	T	17: 67,042,101	C376S	probably damaging	Het
Rexo1	T	C	10: 80,549,739	D495G	probably benign	Het
Rims1	A	T	1: 22,534,175	V315D	probably damaging	Het
Ros1	G	A	10: 52,142,328	Q745*	probably null	Het
Satb1	A	G	17: 51,805,289	V99A	probably damaging	Het
Sema3e	C	T	5: 14,232,115	P422S	probably damaging	Het
Stkld1	G	T	2: 26,951,471	W476L	probably benign	Het
Syna	T	C	5: 134,559,480	D205G	probably damaging	Het
Tas2r134	G	T	2: 51,627,659	C50F	probably damaging	Het
Uckl1	T	C	2: 181,570,337	E363G	probably damaging	Het
Yeats2	T	A	16: 20,161,968		probably benign	Het

Other mutations in Togaram1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00593:Togaram1	APN	12	65006399	missense	probably damaging	1.00
IGL01406:Togaram1	APN	12	64995578	missense	possibly damaging	0.81
IGL01534:Togaram1	APN	12	64966547	missense	probably damaging	0.99
IGL01569:Togaram1	APN	12	64982662	missense	possibly damaging	0.81
IGL01927:Togaram1	APN	12	64976702	missense	probably benign	0.31
IGL02066:Togaram1	APN	12	64983421	missense	probably damaging	1.00
IGL02746:Togaram1	APN	12	64966496	nonsense	probably null
IGL02878:Togaram1	APN	12	64992626	missense	possibly damaging	0.60
IGL02947:Togaram1	APN	12	65021500	missense	probably damaging	1.00
IGL02961:Togaram1	APN	12	64966710	missense	probably damaging	1.00
PIT4810001:Togaram1	UTSW	12	64983512	missense	probably damaging	1.00
R0483:Togaram1	UTSW	12	65007031	missense	probably damaging	1.00
R0519:Togaram1	UTSW	12	64966002	unclassified	probably benign
R0584:Togaram1	UTSW	12	64967505	missense	probably damaging	1.00
R0646:Togaram1	UTSW	12	65021466	missense	probably damaging	1.00
R0749:Togaram1	UTSW	12	64982698	missense	possibly damaging	0.87
R0891:Togaram1	UTSW	12	64982647	missense	probably benign	0.01
R1111:Togaram1	UTSW	12	65006341	missense	probably damaging	1.00
R1349:Togaram1	UTSW	12	65011145	missense	probably damaging	0.99
R1531:Togaram1	UTSW	12	64966265	missense	probably benign	0.01
R1618:Togaram1	UTSW	12	64967073	missense	possibly damaging	0.47
R1672:Togaram1	UTSW	12	65021568	missense	probably benign	0.00
R1789:Togaram1	UTSW	12	65002635	missense	possibly damaging	0.47
R1822:Togaram1	UTSW	12	64995635	missense	probably damaging	0.98
R1930:Togaram1	UTSW	12	64966935	missense	probably damaging	1.00
R1931:Togaram1	UTSW	12	64966935	missense	probably damaging	1.00
R2006:Togaram1	UTSW	12	65019140	missense	probably damaging	1.00
R2018:Togaram1	UTSW	12	65002659	missense	possibly damaging	0.76
R2304:Togaram1	UTSW	12	64976856	splice site	probably null
R2345:Togaram1	UTSW	12	65008632	missense	probably benign	0.05
R2407:Togaram1	UTSW	12	64967670	missense	probably damaging	1.00
R2853:Togaram1	UTSW	12	65016612	missense	probably benign	0.40
R3123:Togaram1	UTSW	12	64966344	missense	probably damaging	1.00
R3124:Togaram1	UTSW	12	64966344	missense	probably damaging	1.00
R3125:Togaram1	UTSW	12	64966344	missense	probably damaging	1.00
R3693:Togaram1	UTSW	12	64983509	missense	probably benign	0.34
R3857:Togaram1	UTSW	12	64980859	missense	possibly damaging	0.64
R3870:Togaram1	UTSW	12	65002645	missense	probably benign	0.00
R3871:Togaram1	UTSW	12	65002645	missense	probably benign	0.00
R4398:Togaram1	UTSW	12	64980856	missense	probably benign
R4578:Togaram1	UTSW	12	65020326	missense	probably damaging	1.00
R4579:Togaram1	UTSW	12	64967907	missense	probably damaging	1.00
R4621:Togaram1	UTSW	12	64982450	missense	possibly damaging	0.87
R4623:Togaram1	UTSW	12	64982450	missense	possibly damaging	0.87
R4655:Togaram1	UTSW	12	64967120	missense	possibly damaging	0.91
R5080:Togaram1	UTSW	12	64983403	missense	probably benign	0.02
R5459:Togaram1	UTSW	12	64967736	missense	probably damaging	1.00
R5652:Togaram1	UTSW	12	65016650	missense	probably benign	0.13
R5857:Togaram1	UTSW	12	64995557	missense	possibly damaging	0.64
R5997:Togaram1	UTSW	12	64995538	missense	probably benign	0.00
R6090:Togaram1	UTSW	12	64967801	missense	probably benign	0.07
R6117:Togaram1	UTSW	12	64967487	missense	probably damaging	1.00
R6221:Togaram1	UTSW	12	64966546	missense	probably damaging	1.00
R6505:Togaram1	UTSW	12	64966590	missense	possibly damaging	0.78
R6545:Togaram1	UTSW	12	64978207	missense	possibly damaging	0.90
R6706:Togaram1	UTSW	12	65002609	missense	probably benign	0.16
R7041:Togaram1	UTSW	12	65020386	missense	possibly damaging	0.76
R7199:Togaram1	UTSW	12	64995518	missense	probably benign
R7284:Togaram1	UTSW	12	65008680	missense	probably benign	0.09
R7451:Togaram1	UTSW	12	64996975	missense	probably damaging	1.00
R7504:Togaram1	UTSW	12	64992617	missense	possibly damaging	0.79
R7560:Togaram1	UTSW	12	65011142	missense	possibly damaging	0.52
R7802:Togaram1	UTSW	12	64966984	nonsense	probably null
R7842:Togaram1	UTSW	12	64966459	missense	probably damaging	1.00
R7922:Togaram1	UTSW	12	64967738	missense	probably damaging	1.00
R8466:Togaram1	UTSW	12	64986442	missense	probably benign	0.00
R8523:Togaram1	UTSW	12	65020314	missense	probably damaging	1.00
X0021:Togaram1	UTSW	12	64966184	missense	probably benign	0.00
Z1177:Togaram1	UTSW	12	64966208	missense	possibly damaging	0.74

Posted On

2013-06-21