Incidental Mutation 'R6633:Wnt2b'
ID 525282
Institutional Source Beutler Lab
Gene Symbol Wnt2b
Ensembl Gene ENSMUSG00000027840
Gene Name wingless-type MMTV integration site family, member 2B
Synonyms Wnt13
MMRRC Submission 044755-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6633 (G1)
Quality Score 193.009
Status Validated
Chromosome 3
Chromosomal Location 104852588-104869237 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 104858372 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 299 (Y299C)
Ref Sequence ENSEMBL: ENSMUSP00000029429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029429]
AlphaFold O70283
Predicted Effect probably damaging
Transcript: ENSMUST00000029429
AA Change: Y299C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029429
Gene: ENSMUSG00000027840
AA Change: Y299C

DomainStartEndE-ValueType
low complexity region 10 28 N/A INTRINSIC
low complexity region 37 50 N/A INTRINSIC
WNT1 72 378 2.03e-189 SMART
Meta Mutation Damage Score 0.9408 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.8%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit no discernable phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatf C A 11: 84,402,308 (GRCm39) probably null Het
Acot7 C T 4: 152,262,716 (GRCm39) P30L probably benign Het
Adam24 T G 8: 41,133,526 (GRCm39) D331E probably benign Het
Adamdec1 T C 14: 68,810,601 (GRCm39) D185G probably benign Het
Adgrg7 T C 16: 56,550,649 (GRCm39) I688V probably benign Het
Adgrv1 A T 13: 81,716,762 (GRCm39) F779I probably damaging Het
Agtr1a A G 13: 30,565,450 (GRCm39) I172V probably benign Het
Anapc4 C T 5: 53,023,288 (GRCm39) H710Y possibly damaging Het
Arf1 T C 11: 59,103,370 (GRCm39) N179S probably benign Het
Arhgef40 C T 14: 52,234,888 (GRCm39) P1064S probably damaging Het
Btnl1 A G 17: 34,604,305 (GRCm39) N362S possibly damaging Het
Ccdc80 T C 16: 44,915,271 (GRCm39) F9S possibly damaging Het
Ccdc96 G A 5: 36,642,533 (GRCm39) E180K probably benign Het
Cdh2 A T 18: 16,773,605 (GRCm39) N241K probably benign Het
Cdk8 C A 5: 146,235,656 (GRCm39) S261* probably null Het
Csf2rb2 T C 15: 78,173,152 (GRCm39) E236G probably benign Het
Dgcr8 A T 16: 18,102,046 (GRCm39) S79T possibly damaging Het
Dnah5 A T 15: 28,293,933 (GRCm39) Y1346F probably benign Het
Dock6 A G 9: 21,731,627 (GRCm39) V1194A probably benign Het
Dock6 A G 9: 21,732,799 (GRCm39) S1129P probably damaging Het
Ephb2 C G 4: 136,411,307 (GRCm39) S451T probably benign Het
Esco1 T A 18: 10,595,738 (GRCm39) probably benign Het
Fcer1a C G 1: 173,054,293 (GRCm39) probably null Het
Gbx2 TCCCCC TCCCCCC 1: 89,856,442 (GRCm39) probably null Het
Gm44511 T A 6: 128,803,205 (GRCm39) D2V probably damaging Het
H2-Q2 A G 17: 35,561,363 (GRCm39) T19A probably damaging Het
Herc1 G T 9: 66,346,534 (GRCm39) E1967* probably null Het
Hic1 G T 11: 75,060,324 (GRCm39) H8N unknown Het
Irx4 G T 13: 73,416,545 (GRCm39) A314S probably benign Het
Jarid2 C A 13: 45,038,353 (GRCm39) H84N probably damaging Het
Klk1b27 A T 7: 43,705,234 (GRCm39) I134F probably damaging Het
Kprp T C 3: 92,732,600 (GRCm39) Y150C probably damaging Het
Lama5 G A 2: 179,833,455 (GRCm39) P1519L probably damaging Het
Lrp10 T C 14: 54,706,531 (GRCm39) V489A probably benign Het
Mrgpra6 A G 7: 46,838,493 (GRCm39) I235T possibly damaging Het
Naip1 A G 13: 100,559,584 (GRCm39) M1140T probably benign Het
Naip1 C T 13: 100,559,593 (GRCm39) R1137Q probably benign Het
Or4c12 T C 2: 89,773,710 (GRCm39) I250V probably benign Het
Plcl2 A G 17: 50,947,168 (GRCm39) I1016V probably benign Het
Plekhb1 A G 7: 100,294,846 (GRCm39) Y122H probably damaging Het
Polr2a A G 11: 69,626,339 (GRCm39) S1604P possibly damaging Het
Ppp6r2 G A 15: 89,137,458 (GRCm39) probably null Het
Rag1 T A 2: 101,473,055 (GRCm39) R696W probably damaging Het
Rusc2 T C 4: 43,414,852 (GRCm39) F53L probably damaging Het
Rxylt1 G A 10: 121,932,958 (GRCm39) R7W probably damaging Het
Tango6 T C 8: 107,444,637 (GRCm39) V514A probably benign Het
Tex30 A C 1: 44,127,084 (GRCm39) H64Q probably benign Het
Tmbim7 A G 5: 3,707,659 (GRCm39) probably null Het
Tpcn1 A G 5: 120,682,529 (GRCm39) M493T probably benign Het
Tpx2 T G 2: 152,709,274 (GRCm39) F35V probably damaging Het
Vmn1r3 G A 4: 3,184,971 (GRCm39) T112I probably benign Het
Other mutations in Wnt2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00229:Wnt2b APN 3 104,860,449 (GRCm39) missense possibly damaging 0.87
IGL02058:Wnt2b APN 3 104,854,408 (GRCm39) missense probably benign 0.04
IGL02638:Wnt2b APN 3 104,862,032 (GRCm39) missense probably benign 0.25
R0881:Wnt2b UTSW 3 104,860,513 (GRCm39) splice site probably benign
R1971:Wnt2b UTSW 3 104,861,933 (GRCm39) splice site probably benign
R2004:Wnt2b UTSW 3 104,860,331 (GRCm39) missense probably damaging 1.00
R4431:Wnt2b UTSW 3 104,860,256 (GRCm39) missense probably damaging 1.00
R5216:Wnt2b UTSW 3 104,868,661 (GRCm39) missense possibly damaging 0.96
R6046:Wnt2b UTSW 3 104,858,339 (GRCm39) missense probably damaging 1.00
R6653:Wnt2b UTSW 3 104,860,502 (GRCm39) missense probably damaging 1.00
R6827:Wnt2b UTSW 3 104,854,408 (GRCm39) missense probably benign 0.04
R7352:Wnt2b UTSW 3 104,854,493 (GRCm39) missense probably benign 0.05
R7634:Wnt2b UTSW 3 104,854,432 (GRCm39) missense probably damaging 1.00
R8099:Wnt2b UTSW 3 104,854,408 (GRCm39) missense possibly damaging 0.48
R8972:Wnt2b UTSW 3 104,858,475 (GRCm39) missense possibly damaging 0.79
X0061:Wnt2b UTSW 3 104,868,676 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTAACATATGACCTGCCAGCCTG -3'
(R):5'- TGTGAGTGGCTCCTGTACTC -3'

Sequencing Primer
(F):5'- CTCAAGACAAGGTTTTCATGTAAGG -3'
(R):5'- GTACTCTGCGCACCTGCTG -3'
Posted On 2018-06-22