Incidental Mutation 'R6633:Adgrg7'
| ID |
525350 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrg7
|
| Ensembl Gene |
ENSMUSG00000022755 |
| Gene Name |
adhesion G protein-coupled receptor G7 |
| Synonyms |
9130020O16Rik, Gpr128 |
| MMRRC Submission |
044755-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6633 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
56544972-56616218 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 56550649 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 688
(I688V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023437
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023437]
|
| AlphaFold |
Q8BM96 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023437
AA Change: I688V
PolyPhen 2
Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000023437
Gene: ENSMUSG00000022755
AA Change: I688V
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
SCOP:d1edmb_
|
52 |
76 |
1e-3 |
SMART |
|
GPS
|
376 |
424 |
6.16e-8 |
SMART |
|
Pfam:7tm_2
|
428 |
712 |
4.5e-40 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.7%
- 20x: 92.8%
|
| Validation Efficiency |
100% (50/50) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced body weight gain and increased frequency of peristalsis and slow wave potential in the small intestine. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 51 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatf |
C |
A |
11: 84,402,308 (GRCm39) |
|
probably null |
Het |
| Acot7 |
C |
T |
4: 152,262,716 (GRCm39) |
P30L |
probably benign |
Het |
| Adam24 |
T |
G |
8: 41,133,526 (GRCm39) |
D331E |
probably benign |
Het |
| Adamdec1 |
T |
C |
14: 68,810,601 (GRCm39) |
D185G |
probably benign |
Het |
| Adgrv1 |
A |
T |
13: 81,716,762 (GRCm39) |
F779I |
probably damaging |
Het |
| Agtr1a |
A |
G |
13: 30,565,450 (GRCm39) |
I172V |
probably benign |
Het |
| Anapc4 |
C |
T |
5: 53,023,288 (GRCm39) |
H710Y |
possibly damaging |
Het |
| Arf1 |
T |
C |
11: 59,103,370 (GRCm39) |
N179S |
probably benign |
Het |
| Arhgef40 |
C |
T |
14: 52,234,888 (GRCm39) |
P1064S |
probably damaging |
Het |
| Btnl1 |
A |
G |
17: 34,604,305 (GRCm39) |
N362S |
possibly damaging |
Het |
| Ccdc80 |
T |
C |
16: 44,915,271 (GRCm39) |
F9S |
possibly damaging |
Het |
| Ccdc96 |
G |
A |
5: 36,642,533 (GRCm39) |
E180K |
probably benign |
Het |
| Cdh2 |
A |
T |
18: 16,773,605 (GRCm39) |
N241K |
probably benign |
Het |
| Cdk8 |
C |
A |
5: 146,235,656 (GRCm39) |
S261* |
probably null |
Het |
| Csf2rb2 |
T |
C |
15: 78,173,152 (GRCm39) |
E236G |
probably benign |
Het |
| Dgcr8 |
A |
T |
16: 18,102,046 (GRCm39) |
S79T |
possibly damaging |
Het |
| Dnah5 |
A |
T |
15: 28,293,933 (GRCm39) |
Y1346F |
probably benign |
Het |
| Dock6 |
A |
G |
9: 21,731,627 (GRCm39) |
V1194A |
probably benign |
Het |
| Dock6 |
A |
G |
9: 21,732,799 (GRCm39) |
S1129P |
probably damaging |
Het |
| Ephb2 |
C |
G |
4: 136,411,307 (GRCm39) |
S451T |
probably benign |
Het |
| Esco1 |
T |
A |
18: 10,595,738 (GRCm39) |
|
probably benign |
Het |
| Fcer1a |
C |
G |
1: 173,054,293 (GRCm39) |
|
probably null |
Het |
| Gbx2 |
TCCCCC |
TCCCCCC |
1: 89,856,442 (GRCm39) |
|
probably null |
Het |
| Gm44511 |
T |
A |
6: 128,803,205 (GRCm39) |
D2V |
probably damaging |
Het |
| H2-Q2 |
A |
G |
17: 35,561,363 (GRCm39) |
T19A |
probably damaging |
Het |
| Herc1 |
G |
T |
9: 66,346,534 (GRCm39) |
E1967* |
probably null |
Het |
| Hic1 |
G |
T |
11: 75,060,324 (GRCm39) |
H8N |
unknown |
Het |
| Irx4 |
G |
T |
13: 73,416,545 (GRCm39) |
A314S |
probably benign |
Het |
| Jarid2 |
C |
A |
13: 45,038,353 (GRCm39) |
H84N |
probably damaging |
Het |
| Klk1b27 |
A |
T |
7: 43,705,234 (GRCm39) |
I134F |
probably damaging |
Het |
| Kprp |
T |
C |
3: 92,732,600 (GRCm39) |
Y150C |
probably damaging |
Het |
| Lama5 |
G |
A |
2: 179,833,455 (GRCm39) |
P1519L |
probably damaging |
Het |
| Lrp10 |
T |
C |
14: 54,706,531 (GRCm39) |
V489A |
probably benign |
Het |
| Mrgpra6 |
A |
G |
7: 46,838,493 (GRCm39) |
I235T |
possibly damaging |
Het |
| Naip1 |
A |
G |
13: 100,559,584 (GRCm39) |
M1140T |
probably benign |
Het |
| Naip1 |
C |
T |
13: 100,559,593 (GRCm39) |
R1137Q |
probably benign |
Het |
| Or4c12 |
T |
C |
2: 89,773,710 (GRCm39) |
I250V |
probably benign |
Het |
| Plcl2 |
A |
G |
17: 50,947,168 (GRCm39) |
I1016V |
probably benign |
Het |
| Plekhb1 |
A |
G |
7: 100,294,846 (GRCm39) |
Y122H |
probably damaging |
Het |
| Polr2a |
A |
G |
11: 69,626,339 (GRCm39) |
S1604P |
possibly damaging |
Het |
| Ppp6r2 |
G |
A |
15: 89,137,458 (GRCm39) |
|
probably null |
Het |
| Rag1 |
T |
A |
2: 101,473,055 (GRCm39) |
R696W |
probably damaging |
Het |
| Rusc2 |
T |
C |
4: 43,414,852 (GRCm39) |
F53L |
probably damaging |
Het |
| Rxylt1 |
G |
A |
10: 121,932,958 (GRCm39) |
R7W |
probably damaging |
Het |
| Tango6 |
T |
C |
8: 107,444,637 (GRCm39) |
V514A |
probably benign |
Het |
| Tex30 |
A |
C |
1: 44,127,084 (GRCm39) |
H64Q |
probably benign |
Het |
| Tmbim7 |
A |
G |
5: 3,707,659 (GRCm39) |
|
probably null |
Het |
| Tpcn1 |
A |
G |
5: 120,682,529 (GRCm39) |
M493T |
probably benign |
Het |
| Tpx2 |
T |
G |
2: 152,709,274 (GRCm39) |
F35V |
probably damaging |
Het |
| Vmn1r3 |
G |
A |
4: 3,184,971 (GRCm39) |
T112I |
probably benign |
Het |
| Wnt2b |
T |
C |
3: 104,858,372 (GRCm39) |
Y299C |
probably damaging |
Het |
|
| Other mutations in Adgrg7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01783:Adgrg7
|
APN |
16 |
56,568,282 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03122:Adgrg7
|
APN |
16 |
56,590,725 (GRCm39) |
splice site |
probably benign |
|
|
orchard
|
UTSW |
16 |
56,545,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
sevin
|
UTSW |
16 |
56,562,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0632:Adgrg7
|
UTSW |
16 |
56,562,952 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0673:Adgrg7
|
UTSW |
16 |
56,593,849 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1690:Adgrg7
|
UTSW |
16 |
56,615,993 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2009:Adgrg7
|
UTSW |
16 |
56,582,236 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2017:Adgrg7
|
UTSW |
16 |
56,553,169 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2132:Adgrg7
|
UTSW |
16 |
56,588,281 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2153:Adgrg7
|
UTSW |
16 |
56,572,791 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2229:Adgrg7
|
UTSW |
16 |
56,572,766 (GRCm39) |
missense |
probably benign |
|
|
R2436:Adgrg7
|
UTSW |
16 |
56,582,308 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2878:Adgrg7
|
UTSW |
16 |
56,570,817 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2981:Adgrg7
|
UTSW |
16 |
56,570,769 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4014:Adgrg7
|
UTSW |
16 |
56,562,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4023:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4024:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4026:Adgrg7
|
UTSW |
16 |
56,550,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4551:Adgrg7
|
UTSW |
16 |
56,568,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4834:Adgrg7
|
UTSW |
16 |
56,553,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Adgrg7
|
UTSW |
16 |
56,550,711 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5145:Adgrg7
|
UTSW |
16 |
56,562,682 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5377:Adgrg7
|
UTSW |
16 |
56,550,669 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5549:Adgrg7
|
UTSW |
16 |
56,570,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5915:Adgrg7
|
UTSW |
16 |
56,550,748 (GRCm39) |
splice site |
probably null |
|
|
R5957:Adgrg7
|
UTSW |
16 |
56,593,790 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6146:Adgrg7
|
UTSW |
16 |
56,593,829 (GRCm39) |
missense |
probably benign |
0.21 |
|
R6198:Adgrg7
|
UTSW |
16 |
56,597,556 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6233:Adgrg7
|
UTSW |
16 |
56,599,005 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6337:Adgrg7
|
UTSW |
16 |
56,572,788 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6693:Adgrg7
|
UTSW |
16 |
56,590,587 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6812:Adgrg7
|
UTSW |
16 |
56,616,161 (GRCm39) |
start gained |
probably benign |
|
|
R6841:Adgrg7
|
UTSW |
16 |
56,570,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6868:Adgrg7
|
UTSW |
16 |
56,593,839 (GRCm39) |
missense |
probably benign |
|
|
R7076:Adgrg7
|
UTSW |
16 |
56,562,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7146:Adgrg7
|
UTSW |
16 |
56,550,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7232:Adgrg7
|
UTSW |
16 |
56,597,515 (GRCm39) |
splice site |
probably null |
|
|
R7266:Adgrg7
|
UTSW |
16 |
56,590,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7376:Adgrg7
|
UTSW |
16 |
56,545,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7390:Adgrg7
|
UTSW |
16 |
56,553,207 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7401:Adgrg7
|
UTSW |
16 |
56,562,781 (GRCm39) |
missense |
probably benign |
0.43 |
|
R7496:Adgrg7
|
UTSW |
16 |
56,553,220 (GRCm39) |
missense |
probably benign |
|
|
R7540:Adgrg7
|
UTSW |
16 |
56,570,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8147:Adgrg7
|
UTSW |
16 |
56,562,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8354:Adgrg7
|
UTSW |
16 |
56,616,045 (GRCm39) |
start gained |
probably benign |
|
|
R8372:Adgrg7
|
UTSW |
16 |
56,616,114 (GRCm39) |
start gained |
probably benign |
|
|
R8393:Adgrg7
|
UTSW |
16 |
56,582,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8454:Adgrg7
|
UTSW |
16 |
56,616,045 (GRCm39) |
start gained |
probably benign |
|
|
R8723:Adgrg7
|
UTSW |
16 |
56,582,282 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8891:Adgrg7
|
UTSW |
16 |
56,572,762 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9017:Adgrg7
|
UTSW |
16 |
56,553,211 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9570:Adgrg7
|
UTSW |
16 |
56,570,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9604:Adgrg7
|
UTSW |
16 |
56,597,570 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9628:Adgrg7
|
UTSW |
16 |
56,553,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGCCCATACCAACCGATGC -3'
(R):5'- TGGGCAGTTGAACATGCATG -3'
Sequencing Primer
(F):5'- TGCACACTCACTGCATGG -3'
(R):5'- CAGTTGAACATGCATGCTAGC -3'
|
| Posted On |
2018-06-22 |
Incidental Mutation