|Institutional Source||Beutler Lab|
|Gene Name||neuropeptide Y receptor Y5|
|Is this an essential gene?||Probably non essential (E-score: 0.111)|
|Stock #||R6602 (G1)|
|Chromosomal Location||66679965-66688128 bp(-) (GRCm38)|
|Type of Mutation||frame shift|
|DNA Base Change (assembly)||GCTGTGAAACACTG to GCTG at 66681540 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000148589 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000070810] [ENSMUST00000211920] [ENSMUST00000212563]|
AA Change: 196
AA Change: 196
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (43/43)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for neuropeptide Y and peptide YY. The encoded protein appears to be involved in regulating food intake, with defects in this gene being associated with eating disorders. Also, the encoded protein is involved in a pathway that protects neuroblastoma cells from chemotherapy-induced cell death, providing a possible therapeutic target against neuroblastoma. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
PHENOTYPE: Homozygotes for a null allele show increased susceptibility to diet-induced obesity and a reduced orexigenic response to select agonists. Homozygotes for a reporter allele show mild late-onset obesity, increased adiposity, polyphagia, and exacerbated obesity parameters after chronic NPY infusion. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Npy5r||
(F):5'- GCTTATACTCCTGCAGACACTAG -3'
(R):5'- CAGTGGATGTTCGGCAAAGC -3'
(F):5'- CCTGCAGACACTAGTATGACTTACTG -3'
(R):5'- AGCCATGTGCCATATCATGC -3'