Incidental Mutation 'R6636:Adgrl4'
ID 525442
Institutional Source Beutler Lab
Gene Symbol Adgrl4
Ensembl Gene ENSMUSG00000039167
Gene Name adhesion G protein-coupled receptor L4
Synonyms EGF-TM7 receptor, Eltd1, 1110033N21Rik, Etl
MMRRC Submission 044757-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6636 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 151143519-151250718 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 151223410 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Stop codon at position 621 (W621*)
Ref Sequence ENSEMBL: ENSMUSP00000041939 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046977]
AlphaFold Q923X1
Predicted Effect probably null
Transcript: ENSMUST00000046977
AA Change: W621*
SMART Domains Protein: ENSMUSP00000041939
Gene: ENSMUSG00000039167
AA Change: W621*

DomainStartEndE-ValueType
EGF 21 57 9.13e0 SMART
EGF_CA 58 107 4.88e-9 SMART
EGF_CA 108 157 4.88e-9 SMART
Pfam:GAIN 182 390 6.8e-38 PFAM
GPS 414 467 1.25e-17 SMART
Pfam:7tm_2 473 709 2.5e-58 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198893
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.7%
  • 20x: 92.8%
Validation Efficiency 98% (41/42)
MGI Phenotype PHENOTYPE: For a targeted mutation, no significant differences were detected between homozygous mice and controls in a high-throughput screen. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 A G 15: 64,659,251 (GRCm39) V513A probably damaging Het
Ap4m1 A G 5: 138,170,437 (GRCm39) probably benign Het
Atp6v1b2 T C 8: 69,554,026 (GRCm39) Y68H probably damaging Het
AY761185 T A 8: 21,434,556 (GRCm39) probably null Het
C3ar1 T C 6: 122,828,013 (GRCm39) D68G probably damaging Het
Cdh10 A T 15: 18,985,259 (GRCm39) I308F probably damaging Het
Coq8a A T 1: 180,006,552 (GRCm39) S112T probably benign Het
Dmgdh A T 13: 93,845,706 (GRCm39) E453D probably benign Het
Fryl C A 5: 73,290,655 (GRCm39) R83L probably benign Het
Gm4861 C T 3: 137,256,760 (GRCm39) probably null Het
Gnai1 T C 5: 18,478,472 (GRCm39) D231G probably damaging Het
Hfe C G 13: 23,890,778 (GRCm39) E120D possibly damaging Het
Hfe T C 13: 23,890,779 (GRCm39) E120G possibly damaging Het
Hgd A G 16: 37,435,736 (GRCm39) N149S possibly damaging Het
Kcnb1 T C 2: 166,947,774 (GRCm39) D358G probably damaging Het
Lama2 C A 10: 27,000,564 (GRCm39) V1653L probably benign Het
Lamc1 A T 1: 153,117,721 (GRCm39) I947N possibly damaging Het
Lamp3 A G 16: 19,519,983 (GRCm39) F67L probably benign Het
Ltbp2 T C 12: 84,922,612 (GRCm39) I132V probably benign Het
Muc4 C T 16: 32,575,255 (GRCm39) P1280L probably benign Het
Muc5ac T C 7: 141,372,342 (GRCm39) Y2659H possibly damaging Het
Nmbr T C 10: 14,645,978 (GRCm39) S168P probably benign Het
Nsl1 A G 1: 190,807,324 (GRCm39) T168A probably benign Het
Or2g7 G A 17: 38,378,115 (GRCm39) D18N probably damaging Het
Or4a27 T C 2: 88,559,185 (GRCm39) I253V probably benign Het
Or5b113 T C 19: 13,342,589 (GRCm39) V199A probably benign Het
Or8s5 A G 15: 98,238,831 (GRCm39) F13S probably benign Het
Pde1c A C 6: 56,157,087 (GRCm39) V191G probably damaging Het
Proc T A 18: 32,256,813 (GRCm39) I285F probably benign Het
R3hdm1 GAA GAAA 1: 128,090,548 (GRCm39) probably null Het
Rsf1 G GACGGCGGCT 7: 97,229,116 (GRCm39) probably benign Homo
Spa17 A T 9: 37,523,270 (GRCm39) S6T probably benign Het
Spp1 T C 5: 104,588,396 (GRCm39) V267A possibly damaging Het
Stk17b A T 1: 53,800,247 (GRCm39) Y244N probably damaging Het
Tal1 A G 4: 114,925,789 (GRCm39) N286S probably damaging Het
Tgm7 T A 2: 120,931,571 (GRCm39) R197S probably damaging Het
Tmcc3 T A 10: 94,414,286 (GRCm39) V27E probably benign Het
Topaz1 A T 9: 122,578,851 (GRCm39) Q587L probably benign Het
Trim33 C T 3: 103,261,035 (GRCm39) A1061V probably damaging Het
Ttll1 C G 15: 83,384,147 (GRCm39) W160S probably damaging Het
Utp25 A T 1: 192,796,075 (GRCm39) F197I probably damaging Het
Wnt7a A G 6: 91,371,540 (GRCm39) Y141H probably benign Het
Other mutations in Adgrl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00488:Adgrl4 APN 3 151,248,478 (GRCm39) missense probably damaging 1.00
IGL00694:Adgrl4 APN 3 151,145,033 (GRCm39) splice site probably benign
IGL01143:Adgrl4 APN 3 151,205,866 (GRCm39) splice site probably null
IGL01359:Adgrl4 APN 3 151,248,923 (GRCm39) missense probably damaging 1.00
IGL01947:Adgrl4 APN 3 151,216,428 (GRCm39) critical splice donor site probably null
IGL02149:Adgrl4 APN 3 151,205,991 (GRCm39) missense possibly damaging 0.95
IGL02324:Adgrl4 APN 3 151,203,511 (GRCm39) missense probably damaging 1.00
IGL02562:Adgrl4 APN 3 151,144,949 (GRCm39) missense probably damaging 1.00
IGL02644:Adgrl4 APN 3 151,198,007 (GRCm39) missense probably benign 0.00
trivial UTSW 3 151,223,247 (GRCm39) missense probably benign 0.07
R0077:Adgrl4 UTSW 3 151,223,418 (GRCm39) missense probably damaging 1.00
R0116:Adgrl4 UTSW 3 151,223,247 (GRCm39) missense probably benign 0.07
R0331:Adgrl4 UTSW 3 151,203,577 (GRCm39) missense probably benign 0.00
R0601:Adgrl4 UTSW 3 151,204,066 (GRCm39) splice site probably benign
R0613:Adgrl4 UTSW 3 151,248,859 (GRCm39) splice site probably benign
R1293:Adgrl4 UTSW 3 151,213,081 (GRCm39) missense probably benign 0.00
R1463:Adgrl4 UTSW 3 151,216,233 (GRCm39) missense probably damaging 0.98
R1697:Adgrl4 UTSW 3 151,223,248 (GRCm39) missense probably damaging 1.00
R1731:Adgrl4 UTSW 3 151,246,623 (GRCm39) missense possibly damaging 0.64
R1765:Adgrl4 UTSW 3 151,248,872 (GRCm39) missense probably damaging 1.00
R1782:Adgrl4 UTSW 3 151,248,442 (GRCm39) nonsense probably null
R1888:Adgrl4 UTSW 3 151,144,914 (GRCm39) missense probably benign 0.11
R1888:Adgrl4 UTSW 3 151,144,914 (GRCm39) missense probably benign 0.11
R1957:Adgrl4 UTSW 3 151,216,416 (GRCm39) missense possibly damaging 0.94
R2128:Adgrl4 UTSW 3 151,205,838 (GRCm39) missense probably benign 0.00
R2180:Adgrl4 UTSW 3 151,205,779 (GRCm39) missense probably damaging 0.96
R2238:Adgrl4 UTSW 3 151,205,779 (GRCm39) missense probably damaging 0.96
R2474:Adgrl4 UTSW 3 151,248,361 (GRCm39) missense probably benign 0.01
R2697:Adgrl4 UTSW 3 151,216,260 (GRCm39) missense probably damaging 1.00
R3835:Adgrl4 UTSW 3 151,216,254 (GRCm39) missense probably damaging 1.00
R4499:Adgrl4 UTSW 3 151,216,422 (GRCm39) missense possibly damaging 0.81
R4640:Adgrl4 UTSW 3 151,205,947 (GRCm39) unclassified probably benign
R4747:Adgrl4 UTSW 3 151,213,077 (GRCm39) missense probably benign 0.01
R5428:Adgrl4 UTSW 3 151,248,323 (GRCm39) missense probably damaging 1.00
R5510:Adgrl4 UTSW 3 151,203,467 (GRCm39) missense possibly damaging 0.89
R5717:Adgrl4 UTSW 3 151,197,971 (GRCm39) missense probably benign 0.01
R6106:Adgrl4 UTSW 3 151,246,622 (GRCm39) missense possibly damaging 0.67
R6343:Adgrl4 UTSW 3 151,223,443 (GRCm39) missense probably damaging 1.00
R6419:Adgrl4 UTSW 3 151,144,953 (GRCm39) missense probably damaging 1.00
R6468:Adgrl4 UTSW 3 151,198,012 (GRCm39) missense probably benign
R6637:Adgrl4 UTSW 3 151,223,410 (GRCm39) nonsense probably null
R6687:Adgrl4 UTSW 3 151,248,392 (GRCm39) missense probably benign 0.00
R6856:Adgrl4 UTSW 3 151,205,755 (GRCm39) missense probably benign 0.00
R6887:Adgrl4 UTSW 3 151,248,370 (GRCm39) missense possibly damaging 0.46
R7041:Adgrl4 UTSW 3 151,144,959 (GRCm39) missense probably benign 0.00
R7527:Adgrl4 UTSW 3 151,144,887 (GRCm39) missense probably benign 0.08
R7597:Adgrl4 UTSW 3 151,248,895 (GRCm39) missense probably damaging 1.00
R7751:Adgrl4 UTSW 3 151,197,946 (GRCm39) missense probably damaging 0.99
R8556:Adgrl4 UTSW 3 151,216,302 (GRCm39) missense probably damaging 0.98
R8696:Adgrl4 UTSW 3 151,248,344 (GRCm39) missense probably damaging 1.00
R8698:Adgrl4 UTSW 3 151,203,512 (GRCm39) missense probably damaging 1.00
R8795:Adgrl4 UTSW 3 151,216,416 (GRCm39) missense probably benign 0.03
R9226:Adgrl4 UTSW 3 151,198,064 (GRCm39) critical splice donor site probably null
R9655:Adgrl4 UTSW 3 151,248,450 (GRCm39) missense probably damaging 0.96
R9755:Adgrl4 UTSW 3 151,216,418 (GRCm39) missense probably benign 0.01
R9767:Adgrl4 UTSW 3 151,207,394 (GRCm39) missense probably benign 0.16
R9784:Adgrl4 UTSW 3 151,214,948 (GRCm39) missense probably damaging 1.00
X0053:Adgrl4 UTSW 3 151,203,470 (GRCm39) missense probably damaging 1.00
Z1088:Adgrl4 UTSW 3 151,205,812 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTTGGATTCTCAGCATCTTTAGGATAC -3'
(R):5'- CCCCAGGAGATGTGAATGAATG -3'

Sequencing Primer
(F):5'- TAGGATACAGATATTATGGAACCACG -3'
(R):5'- GTGAATGAATGGTAATTGCTTTTCAC -3'
Posted On 2018-06-22