Incidental Mutation 'IGL01086:Tmem161b'
ID 52550
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem161b
Ensembl Gene ENSMUSG00000035762
Gene Name transmembrane protein 161B
Synonyms 2810446P07Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL01086
Quality Score
Status
Chromosome 13
Chromosomal Location 84370415-84444085 bp(+) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) T to C at 84370541 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152891 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057495] [ENSMUST00000223827] [ENSMUST00000223862] [ENSMUST00000225069] [ENSMUST00000224525]
AlphaFold Q8C2L6
Predicted Effect probably benign
Transcript: ENSMUST00000057495
SMART Domains Protein: ENSMUSP00000055208
Gene: ENSMUSG00000035762

DomainStartEndE-ValueType
Pfam:Tmemb_161AB 2 485 1.3e-213 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180894
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185973
Predicted Effect probably benign
Transcript: ENSMUST00000223827
Predicted Effect probably benign
Transcript: ENSMUST00000223862
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224501
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225212
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225126
Predicted Effect probably benign
Transcript: ENSMUST00000225069
Predicted Effect probably benign
Transcript: ENSMUST00000224525
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice exhibit lethality before genotyping age. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700016H13Rik T A 5: 103,796,729 (GRCm39) R104S probably damaging Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Aim2 A G 1: 173,282,999 (GRCm39) Y27C probably damaging Het
Apol7b T C 15: 77,308,114 (GRCm39) E127G probably damaging Het
Atp10a T C 7: 58,474,066 (GRCm39) F1118L probably damaging Het
Cacna1e T C 1: 154,347,347 (GRCm39) D940G probably benign Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Clip4 G A 17: 72,131,789 (GRCm39) V376I probably benign Het
Cmklr2 T C 1: 63,222,650 (GRCm39) E195G probably benign Het
Coro6 C A 11: 77,357,374 (GRCm39) C194* probably null Het
Crebbp T C 16: 3,997,416 (GRCm39) M223V probably benign Het
Dkk4 T A 8: 23,116,857 (GRCm39) C157S probably damaging Het
Dnah14 T C 1: 181,579,611 (GRCm39) L3048S probably benign Het
Dscaml1 T C 9: 45,613,960 (GRCm39) probably benign Het
Gria2 T C 3: 80,599,688 (GRCm39) Y732C probably damaging Het
Igkv4-59 T C 6: 69,415,707 (GRCm39) I7V probably benign Het
Lamc3 T C 2: 31,788,488 (GRCm39) F216S probably damaging Het
Lcn6 T C 2: 25,570,792 (GRCm39) F61L probably benign Het
Nup205 T A 6: 35,185,871 (GRCm39) probably benign Het
Or5w18 T A 2: 87,633,544 (GRCm39) Y266* probably null Het
Otof C T 5: 30,533,617 (GRCm39) probably null Het
Pik3c2b T C 1: 133,019,356 (GRCm39) C1035R probably damaging Het
Pla1a T C 16: 38,227,984 (GRCm39) N298D probably benign Het
Poteg T A 8: 27,963,648 (GRCm39) probably benign Het
Pwp1 T C 10: 85,715,757 (GRCm39) probably null Het
Scel A G 14: 103,849,827 (GRCm39) I631V probably benign Het
Scn3a T A 2: 65,300,503 (GRCm39) M1288L probably benign Het
Serpina11 T A 12: 103,952,329 (GRCm39) D147V probably damaging Het
Shroom3 T A 5: 93,096,311 (GRCm39) C1266S probably benign Het
Slc12a7 A G 13: 73,962,962 (GRCm39) Y1054C probably damaging Het
Srms A G 2: 180,854,216 (GRCm39) V117A probably damaging Het
Tmem94 A T 11: 115,681,110 (GRCm39) T158S probably benign Het
Tomm40l T C 1: 171,047,878 (GRCm39) probably null Het
Traf6 A G 2: 101,515,128 (GRCm39) I95V probably benign Het
Ttc13 A G 8: 125,402,085 (GRCm39) I686T probably damaging Het
Zmat2 C T 18: 36,929,163 (GRCm39) H104Y probably damaging Het
Other mutations in Tmem161b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00666:Tmem161b APN 13 84,442,715 (GRCm39) splice site probably benign
IGL01150:Tmem161b APN 13 84,440,526 (GRCm39) nonsense probably null
IGL01566:Tmem161b APN 13 84,442,881 (GRCm39) missense probably benign 0.35
IGL02183:Tmem161b APN 13 84,420,373 (GRCm39) missense probably damaging 1.00
IGL02481:Tmem161b APN 13 84,432,112 (GRCm39) missense probably damaging 0.99
IGL02519:Tmem161b APN 13 84,442,863 (GRCm39) missense probably damaging 1.00
IGL03207:Tmem161b APN 13 84,442,714 (GRCm39) splice site probably benign
R6836_Tmem161b_587 UTSW 13 84,370,537 (GRCm39) start gained probably benign
R0015:Tmem161b UTSW 13 84,370,533 (GRCm39) splice site probably null
R0376:Tmem161b UTSW 13 84,440,502 (GRCm39) missense probably benign 0.43
R0613:Tmem161b UTSW 13 84,399,439 (GRCm39) missense probably damaging 1.00
R1925:Tmem161b UTSW 13 84,408,348 (GRCm39) missense probably benign 0.07
R1935:Tmem161b UTSW 13 84,441,585 (GRCm39) missense probably damaging 1.00
R1936:Tmem161b UTSW 13 84,441,585 (GRCm39) missense probably damaging 1.00
R2325:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R2988:Tmem161b UTSW 13 84,440,574 (GRCm39) nonsense probably null
R4327:Tmem161b UTSW 13 84,399,359 (GRCm39) missense probably damaging 1.00
R4525:Tmem161b UTSW 13 84,405,921 (GRCm39) missense probably benign 0.00
R4558:Tmem161b UTSW 13 84,399,363 (GRCm39) missense possibly damaging 0.50
R5133:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R5134:Tmem161b UTSW 13 84,442,887 (GRCm39) missense possibly damaging 0.94
R5727:Tmem161b UTSW 13 84,434,909 (GRCm39) missense possibly damaging 0.63
R5875:Tmem161b UTSW 13 84,442,977 (GRCm39) missense probably damaging 1.00
R6217:Tmem161b UTSW 13 84,399,363 (GRCm39) missense possibly damaging 0.50
R6527:Tmem161b UTSW 13 84,420,383 (GRCm39) missense probably benign 0.06
R6550:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6551:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6553:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6554:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6640:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6641:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6685:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6836:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6837:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R6838:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7077:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7078:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7386:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7388:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7429:Tmem161b UTSW 13 84,430,866 (GRCm39) critical splice acceptor site probably null
R7430:Tmem161b UTSW 13 84,430,866 (GRCm39) critical splice acceptor site probably null
R7547:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7548:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7634:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R7636:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8094:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8095:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8255:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8257:Tmem161b UTSW 13 84,370,537 (GRCm39) start gained probably benign
R8669:Tmem161b UTSW 13 84,420,288 (GRCm39) critical splice acceptor site probably null
R9049:Tmem161b UTSW 13 84,442,754 (GRCm39) missense probably benign
R9092:Tmem161b UTSW 13 84,440,503 (GRCm39) missense possibly damaging 0.69
R9316:Tmem161b UTSW 13 84,430,855 (GRCm39) missense possibly damaging 0.84
R9326:Tmem161b UTSW 13 84,440,602 (GRCm39) nonsense probably null
Posted On 2013-06-21