Mutagenetix > Incidental Mutation

Incidental Mutation 'R6637:Vmn2r26'

525526

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

044758-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.094) question?

Stock #

R6637 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

124001717-124038994 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 124038650 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 742 (I742F)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably damaging
Transcript: ENSMUST00000032238
AA Change: I742F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: I742F

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158682

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 97.4%
20x: 92.1%

Validation Efficiency

100% (34/34)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl4	G	A	3: 151,223,410 (GRCm39)	W621*	probably null	Het
Adh1	T	A	3: 137,988,231 (GRCm39)	C98*	probably null	Het
Alms1	A	G	6: 85,596,716 (GRCm39)	H514R	possibly damaging	Het
Ap4m1	A	G	5: 138,170,437 (GRCm39)		probably benign	Het
Atp6v1b2	T	C	8: 69,554,026 (GRCm39)	Y68H	probably damaging	Het
Cdh3	G	C	8: 107,237,973 (GRCm39)	V56L	probably benign	Het
Col3a1	C	T	1: 45,386,890 (GRCm39)	T234I	probably damaging	Het
Cxadr	C	T	16: 78,130,391 (GRCm39)	T186M	possibly damaging	Het
Dmgdh	A	T	13: 93,845,706 (GRCm39)	E453D	probably benign	Het
Fbxo16	A	G	14: 65,533,210 (GRCm39)		probably null	Het
Fign	A	G	2: 63,858,252 (GRCm39)		probably benign	Het
Hfe	C	G	13: 23,890,778 (GRCm39)	E120D	possibly damaging	Het
Hfe	T	C	13: 23,890,779 (GRCm39)	E120G	possibly damaging	Het
Invs	G	A	4: 48,416,203 (GRCm39)		probably null	Het
Kcnb1	T	C	2: 166,947,774 (GRCm39)	D358G	probably damaging	Het
Kcnk5	A	C	14: 20,194,789 (GRCm39)	M183R	probably null	Het
Lamp3	A	G	16: 19,519,983 (GRCm39)	F67L	probably benign	Het
Lrrc8b	A	C	5: 105,628,137 (GRCm39)	D161A	possibly damaging	Het
Lrriq1	A	T	10: 103,057,293 (GRCm39)	F169Y	probably benign	Het
Lsamp	T	A	16: 41,353,743 (GRCm39)	V2D	possibly damaging	Het
Ltbp2	T	C	12: 84,922,612 (GRCm39)	I132V	probably benign	Het
Muc4	C	T	16: 32,575,255 (GRCm39)	P1280L	probably benign	Het
Muc5ac	T	C	7: 141,372,342 (GRCm39)	Y2659H	possibly damaging	Het
Or2g7	G	A	17: 38,378,115 (GRCm39)	D18N	probably damaging	Het
Or4a27	T	C	2: 88,559,185 (GRCm39)	I253V	probably benign	Het
Or5b113	T	C	19: 13,342,589 (GRCm39)	V199A	probably benign	Het
Or5t15	T	G	2: 86,681,784 (GRCm39)	K86T	probably benign	Het
Spa17	A	T	9: 37,523,270 (GRCm39)	S6T	probably benign	Het
Ston2	G	C	12: 91,680,886 (GRCm39)	T126S	probably damaging	Het
Tal1	A	G	4: 114,925,789 (GRCm39)	N286S	probably damaging	Het
Tbr1	A	G	2: 61,641,974 (GRCm39)	D150G	probably benign	Het
Tgm7	T	A	2: 120,931,571 (GRCm39)	R197S	probably damaging	Het
Topaz1	A	T	9: 122,578,851 (GRCm39)	Q587L	probably benign	Het
Ubxn4	C	A	1: 128,204,824 (GRCm39)	Q505K	probably damaging	Het
Vcl	A	G	14: 21,053,200 (GRCm39)	E405G	probably damaging	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124,038,566 (GRCm39)	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124,038,715 (GRCm39)	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124,030,833 (GRCm39)	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124,027,632 (GRCm39)	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124,038,584 (GRCm39)	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124,038,777 (GRCm39)	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124,003,100 (GRCm39)	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124,003,091 (GRCm39)	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124,016,754 (GRCm39)	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124,027,778 (GRCm39)	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124,016,858 (GRCm39)	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124,038,992 (GRCm39)	makesense	probably null
R0083:Vmn2r26	UTSW	6	124,030,940 (GRCm39)	splice site	probably null
R0682:Vmn2r26	UTSW	6	124,038,129 (GRCm39)	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124,038,603 (GRCm39)	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124,030,872 (GRCm39)	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124,027,667 (GRCm39)	missense	probably benign
R1579:Vmn2r26	UTSW	6	124,016,706 (GRCm39)	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124,038,431 (GRCm39)	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124,038,369 (GRCm39)	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124,001,730 (GRCm39)	missense	probably benign
R1956:Vmn2r26	UTSW	6	124,030,846 (GRCm39)	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124,038,144 (GRCm39)	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124,038,196 (GRCm39)	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124,016,708 (GRCm39)	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124,038,309 (GRCm39)	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124,002,938 (GRCm39)	missense	probably benign
R4490:Vmn2r26	UTSW	6	124,027,697 (GRCm39)	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124,038,150 (GRCm39)	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124,038,375 (GRCm39)	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124,030,924 (GRCm39)	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124,003,070 (GRCm39)	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124,038,832 (GRCm39)	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124,038,285 (GRCm39)	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124,027,676 (GRCm39)	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124,016,408 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124,002,925 (GRCm39)	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124,038,633 (GRCm39)	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124,016,830 (GRCm39)	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124,016,519 (GRCm39)	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124,038,444 (GRCm39)	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124,038,348 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124,003,039 (GRCm39)	missense	probably benign	0.17
R6927:Vmn2r26	UTSW	6	124,016,057 (GRCm39)	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124,016,741 (GRCm39)	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124,038,255 (GRCm39)	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124,016,727 (GRCm39)	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124,038,948 (GRCm39)	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124,002,914 (GRCm39)	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124,016,700 (GRCm39)	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124,016,606 (GRCm39)	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124,016,321 (GRCm39)	missense	probably benign
R7696:Vmn2r26	UTSW	6	124,038,494 (GRCm39)	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124,038,704 (GRCm39)	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124,016,758 (GRCm39)	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124,001,914 (GRCm39)	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124,038,887 (GRCm39)	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124,002,995 (GRCm39)	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124,016,577 (GRCm39)	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124,001,877 (GRCm39)	missense	probably benign	0.00
R8914:Vmn2r26	UTSW	6	124,038,983 (GRCm39)	missense	probably benign
R9333:Vmn2r26	UTSW	6	124,003,009 (GRCm39)	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124,016,333 (GRCm39)	missense	probably benign
R9436:Vmn2r26	UTSW	6	124,002,826 (GRCm39)	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124,038,137 (GRCm39)	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124,016,448 (GRCm39)	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- GGCAAAGACCTTCATTGTGG -3'
(R):5'- CCTTTCGAGCTCAGGTAAGC -3'

Sequencing Primer
(F):5'- CAAAGACCTTCATTGTGGTTATGGC -3'
(R):5'- GTAAGCTGGTACAAAAGAAATCCAC -3'

Posted On

2018-06-22