Incidental Mutation 'R6604:Vmn2r29'
| ID |
525541 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r29
|
| Ensembl Gene |
ENSMUSG00000095730 |
| Gene Name |
vomeronasal 2, receptor 29 |
| Synonyms |
6430701C03Rik |
| MMRRC Submission |
044727-MU
|
| Accession Numbers |
|
| Essential gene? |
Not available
|
| Stock # |
R6604 (G1)
|
| Quality Score |
111.008 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
7234326-7250327 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 7234858 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 676
(V676E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131990
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170922]
[ENSMUST00000173842]
[ENSMUST00000209325]
[ENSMUST00000209833]
[ENSMUST00000210333]
|
| AlphaFold |
L7N2D4 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170922
AA Change: V676E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000131990
Gene: ENSMUSG00000095730
AA Change: V676E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
469 |
2e-34 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
1.4e-20 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2e-55 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173842
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209325
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209788
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000209833
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000210333
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211433
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 98.1%
- 20x: 94.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447A16Rik |
A |
G |
15: 37,439,823 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
T |
G |
11: 9,328,384 (GRCm39) |
F3486V |
probably damaging |
Het |
| Adcy9 |
A |
G |
16: 4,122,271 (GRCm39) |
L830P |
probably damaging |
Het |
| Aurkb |
T |
A |
11: 68,939,388 (GRCm39) |
L157* |
probably null |
Het |
| Bbs10 |
T |
G |
10: 111,136,965 (GRCm39) |
L693V |
possibly damaging |
Het |
| Dna2 |
G |
T |
10: 62,803,522 (GRCm39) |
|
probably null |
Het |
| Efcab3 |
T |
A |
11: 104,589,772 (GRCm39) |
L123* |
probably null |
Het |
| Ext1 |
A |
G |
15: 52,946,555 (GRCm39) |
F550L |
probably damaging |
Het |
| Gm5129 |
A |
G |
5: 29,940,765 (GRCm39) |
|
probably benign |
Het |
| Golm1 |
A |
G |
13: 59,786,197 (GRCm39) |
Y332H |
probably damaging |
Het |
| Gpbp1l1 |
C |
T |
4: 116,430,702 (GRCm39) |
P58S |
probably benign |
Het |
| Grk4 |
A |
T |
5: 34,877,208 (GRCm39) |
D301V |
probably damaging |
Het |
| Haus1 |
T |
C |
18: 77,851,797 (GRCm39) |
E106G |
probably damaging |
Het |
| Hpd |
T |
C |
5: 123,318,964 (GRCm39) |
|
probably null |
Het |
| Kcnj6 |
C |
A |
16: 94,563,504 (GRCm39) |
E313D |
probably damaging |
Het |
| Lmna |
A |
G |
3: 88,395,589 (GRCm39) |
V57A |
probably damaging |
Het |
| Lrrtm1 |
T |
C |
6: 77,221,221 (GRCm39) |
F226S |
possibly damaging |
Het |
| Otogl |
T |
C |
10: 107,657,895 (GRCm39) |
|
probably null |
Het |
| Pgr |
A |
C |
9: 8,946,867 (GRCm39) |
T703P |
possibly damaging |
Het |
| Ppig |
T |
C |
2: 69,571,925 (GRCm39) |
S215P |
unknown |
Het |
| Pramel28 |
T |
C |
4: 143,692,567 (GRCm39) |
R145G |
probably benign |
Het |
| Rasgrp3 |
A |
C |
17: 75,810,110 (GRCm39) |
N270T |
probably benign |
Het |
| Rp1 |
C |
A |
1: 4,089,351 (GRCm39) |
K1305N |
unknown |
Het |
| Shc1 |
A |
G |
3: 89,329,186 (GRCm39) |
Y10C |
probably damaging |
Het |
| Slc12a1 |
G |
T |
2: 125,026,735 (GRCm39) |
D457Y |
probably damaging |
Het |
| Sncaip |
A |
G |
18: 53,038,918 (GRCm39) |
Q544R |
possibly damaging |
Het |
| Socs5 |
T |
C |
17: 87,442,553 (GRCm39) |
Y498H |
probably damaging |
Het |
| Szt2 |
T |
C |
4: 118,242,671 (GRCm39) |
D1472G |
probably benign |
Het |
| Tmem163 |
A |
G |
1: 127,419,347 (GRCm39) |
M286T |
possibly damaging |
Het |
| Tmem236 |
A |
G |
2: 14,179,512 (GRCm39) |
T38A |
probably benign |
Het |
| Vps13d |
A |
G |
4: 144,907,694 (GRCm39) |
V56A |
probably damaging |
Het |
| Xirp2 |
T |
C |
2: 67,340,189 (GRCm39) |
I810T |
possibly damaging |
Het |
| Zfp958 |
T |
C |
8: 4,678,245 (GRCm39) |
L90P |
probably damaging |
Het |
|
| Other mutations in Vmn2r29 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00959:Vmn2r29
|
APN |
7 |
7,244,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02232:Vmn2r29
|
APN |
7 |
7,244,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Vmn2r29
|
UTSW |
7 |
7,243,085 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R3775:Vmn2r29
|
UTSW |
7 |
7,243,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6173:Vmn2r29
|
UTSW |
7 |
7,234,369 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6747:Vmn2r29
|
UTSW |
7 |
7,234,421 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6878:Vmn2r29
|
UTSW |
7 |
7,244,863 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6899:Vmn2r29
|
UTSW |
7 |
7,244,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7533:Vmn2r29
|
UTSW |
7 |
7,244,656 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7578:Vmn2r29
|
UTSW |
7 |
7,234,441 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7703:Vmn2r29
|
UTSW |
7 |
7,234,864 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7917:Vmn2r29
|
UTSW |
7 |
7,234,727 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8325:Vmn2r29
|
UTSW |
7 |
7,244,941 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8335:Vmn2r29
|
UTSW |
7 |
7,234,445 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8418:Vmn2r29
|
UTSW |
7 |
7,244,939 (GRCm39) |
missense |
probably benign |
|
|
R9562:Vmn2r29
|
UTSW |
7 |
7,244,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9565:Vmn2r29
|
UTSW |
7 |
7,244,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9734:Vmn2r29
|
UTSW |
7 |
7,234,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTAACTGAGCCCTTGTTGCAC -3'
(R):5'- TGACACTCCTATTGTGAAGGCC -3'
Sequencing Primer
(F):5'- AGCCCTTGTTGCACACAATGATG -3'
(R):5'- CTCCTATTGTGAAGGCCAATAACAG -3'
|
| Posted On |
2018-06-22 |
Incidental Mutation