Incidental Mutation 'R6638:Vmn1r35'
| ID |
525578 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r35
|
| Ensembl Gene |
ENSMUSG00000060699 |
| Gene Name |
vomeronasal 1 receptor 35 |
| Synonyms |
V1rc12 |
| MMRRC Submission |
044759-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R6638 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
66655778-66656668 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 66655848 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 274
(T274I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154707
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000071414]
[ENSMUST00000227346]
[ENSMUST00000227354]
[ENSMUST00000227749]
[ENSMUST00000227961]
|
| AlphaFold |
Q8R2E2 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000071414
AA Change: T274I
PolyPhen 2
Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000071362
Gene: ENSMUSG00000060699
AA Change: T274I
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
28 |
293 |
1.2e-54 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227346
AA Change: T107I
PolyPhen 2
Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227354
AA Change: T274I
PolyPhen 2
Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000227749
AA Change: T274I
PolyPhen 2
Score 0.634 (Sensitivity: 0.87; Specificity: 0.91)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227961
AA Change: T107I
PolyPhen 2
Score 0.100 (Sensitivity: 0.93; Specificity: 0.86)
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.7%
- 20x: 92.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
A |
13: 77,451,521 (GRCm39) |
N868K |
probably benign |
Het |
| Cep112 |
T |
C |
11: 108,746,696 (GRCm39) |
S980P |
probably damaging |
Het |
| Dlk1 |
A |
G |
12: 109,426,204 (GRCm39) |
E95G |
probably damaging |
Het |
| Dnah6 |
A |
T |
6: 73,012,263 (GRCm39) |
|
probably null |
Het |
| Dppa2 |
A |
T |
16: 48,134,523 (GRCm39) |
H118L |
possibly damaging |
Het |
| Eif4enif1 |
T |
C |
11: 3,192,463 (GRCm39) |
S740P |
probably damaging |
Het |
| Eva1b |
T |
C |
4: 126,043,265 (GRCm39) |
S102P |
probably benign |
Het |
| Fndc3a |
G |
A |
14: 72,796,688 (GRCm39) |
R637* |
probably null |
Het |
| Fras1 |
A |
T |
5: 96,905,953 (GRCm39) |
D3119V |
possibly damaging |
Het |
| Hmgcr |
T |
C |
13: 96,795,490 (GRCm39) |
T360A |
probably benign |
Het |
| Kif21a |
A |
G |
15: 90,850,610 (GRCm39) |
V1017A |
probably damaging |
Het |
| Lats2 |
A |
G |
14: 57,936,822 (GRCm39) |
S556P |
probably damaging |
Het |
| Lrrc7 |
A |
G |
3: 157,840,940 (GRCm39) |
F1366S |
probably benign |
Het |
| Mtmr2 |
C |
A |
9: 13,707,429 (GRCm39) |
A327E |
probably damaging |
Het |
| Naip6 |
C |
A |
13: 100,436,909 (GRCm39) |
S538I |
probably benign |
Het |
| Or9r3 |
T |
C |
10: 129,947,739 (GRCm39) |
T307A |
probably benign |
Het |
| Ovch2 |
A |
T |
7: 107,388,301 (GRCm39) |
H426Q |
probably benign |
Het |
| Plxna1 |
A |
T |
6: 89,301,382 (GRCm39) |
V1506E |
probably damaging |
Het |
| Poldip3 |
A |
T |
15: 83,017,401 (GRCm39) |
S225T |
probably damaging |
Het |
| Polr3h |
A |
G |
15: 81,802,505 (GRCm39) |
L108P |
possibly damaging |
Het |
| Prss44 |
G |
A |
9: 110,646,271 (GRCm39) |
V333M |
probably damaging |
Het |
| Ptprk |
C |
T |
10: 28,471,807 (GRCm39) |
R1432C |
probably damaging |
Het |
| Rpl36al |
A |
G |
12: 69,229,708 (GRCm39) |
L68P |
probably damaging |
Het |
| Tagap |
T |
C |
17: 8,145,906 (GRCm39) |
S26P |
possibly damaging |
Het |
| Vapb |
A |
G |
2: 173,613,362 (GRCm39) |
K87R |
probably damaging |
Het |
| Wdsub1 |
A |
T |
2: 59,700,785 (GRCm39) |
|
probably benign |
Het |
| Xrcc5 |
C |
T |
1: 72,422,521 (GRCm39) |
S651L |
possibly damaging |
Het |
| Zfyve27 |
T |
A |
19: 42,169,936 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Vmn1r35 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00962:Vmn1r35
|
APN |
6 |
66,656,361 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01417:Vmn1r35
|
APN |
6 |
66,656,191 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01517:Vmn1r35
|
APN |
6 |
66,656,434 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02142:Vmn1r35
|
APN |
6 |
66,656,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02178:Vmn1r35
|
APN |
6 |
66,656,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02383:Vmn1r35
|
APN |
6 |
66,655,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02383:Vmn1r35
|
APN |
6 |
66,655,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02493:Vmn1r35
|
APN |
6 |
66,656,463 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R0360:Vmn1r35
|
UTSW |
6 |
66,655,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0364:Vmn1r35
|
UTSW |
6 |
66,655,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0599:Vmn1r35
|
UTSW |
6 |
66,656,497 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1447:Vmn1r35
|
UTSW |
6 |
66,655,890 (GRCm39) |
missense |
probably benign |
0.13 |
|
R1781:Vmn1r35
|
UTSW |
6 |
66,656,550 (GRCm39) |
missense |
probably benign |
0.24 |
|
R2096:Vmn1r35
|
UTSW |
6 |
66,655,929 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2937:Vmn1r35
|
UTSW |
6 |
66,655,950 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2938:Vmn1r35
|
UTSW |
6 |
66,655,950 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R3937:Vmn1r35
|
UTSW |
6 |
66,656,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3938:Vmn1r35
|
UTSW |
6 |
66,656,057 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4386:Vmn1r35
|
UTSW |
6 |
66,656,573 (GRCm39) |
nonsense |
probably null |
|
|
R5329:Vmn1r35
|
UTSW |
6 |
66,656,490 (GRCm39) |
nonsense |
probably null |
|
|
R7175:Vmn1r35
|
UTSW |
6 |
66,655,906 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7448:Vmn1r35
|
UTSW |
6 |
66,656,219 (GRCm39) |
start gained |
probably benign |
|
|
R7825:Vmn1r35
|
UTSW |
6 |
66,656,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9139:Vmn1r35
|
UTSW |
6 |
66,655,933 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9415:Vmn1r35
|
UTSW |
6 |
66,656,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGAATCTTGCTTTGCTGCTTG -3'
(R):5'- AGAGCCTCCCCTGAGAAAAG -3'
Sequencing Primer
(F):5'- ATCCAGAGGATCATGTGAGCTCTTC -3'
(R):5'- AGGGCCACTCATACCATCTTG -3'
|
| Posted On |
2018-06-22 |
Incidental Mutation