Incidental Mutation 'R6605:Gpr26'
ID |
525596 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gpr26
|
Ensembl Gene |
ENSMUSG00000040125 |
Gene Name |
G protein-coupled receptor 26 |
Synonyms |
9630036A11Rik |
MMRRC Submission |
044728-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.062)
|
Stock # |
R6605 (G1)
|
Quality Score |
196.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
131567891-131587362 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to A
at 131585893 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Threonine
at position 288
(A288T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000041664
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000045840]
[ENSMUST00000124096]
|
AlphaFold |
Q8BZA7 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000045840
AA Change: A288T
PolyPhen 2
Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000041664 Gene: ENSMUSG00000040125 AA Change: A288T
Domain | Start | End | E-Value | Type |
Pfam:7TM_GPCR_Srsx
|
15 |
309 |
1.9e-7 |
PFAM |
Pfam:7tm_1
|
22 |
294 |
1.4e-33 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
SMART Domains |
Protein: ENSMUSP00000130971 Gene: ENSMUSG00000030849
Domain | Start | End | E-Value | Type |
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.1678 |
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.5%
- 10x: 97.9%
- 20x: 93.8%
|
Validation Efficiency |
92% (35/38) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016] PHENOTYPE: Mice homozygous for one null allele exhibit increased anxiety- and depression-related behaviors and alcohol preference. Female mice homozygous for another allele display increased susceptibility to diet-induced obesity with increased food intake. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 39 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc6 |
T |
A |
7: 45,630,481 (GRCm39) |
I1260F |
probably damaging |
Het |
Acat2 |
A |
G |
17: 13,162,774 (GRCm39) |
V358A |
probably benign |
Het |
Adgrv1 |
G |
A |
13: 81,636,081 (GRCm39) |
A3476V |
possibly damaging |
Het |
Akap13 |
A |
G |
7: 75,229,516 (GRCm39) |
N150D |
probably damaging |
Het |
Asb2 |
G |
T |
12: 103,311,943 (GRCm39) |
Q60K |
probably benign |
Het |
Asxl3 |
A |
T |
18: 22,650,134 (GRCm39) |
R708* |
probably null |
Het |
Cd79b |
C |
T |
11: 106,203,539 (GRCm39) |
G116D |
probably damaging |
Het |
Copg2 |
A |
G |
6: 30,835,757 (GRCm39) |
F218S |
probably benign |
Het |
Defa5 |
A |
C |
8: 21,787,604 (GRCm39) |
E50D |
possibly damaging |
Het |
Efcab3 |
T |
A |
11: 104,890,107 (GRCm39) |
|
probably null |
Het |
Eva1c |
T |
A |
16: 90,663,236 (GRCm39) |
V91D |
probably damaging |
Het |
Fosb |
T |
C |
7: 19,043,283 (GRCm39) |
Y25C |
probably damaging |
Het |
Gm5141 |
G |
A |
13: 62,922,201 (GRCm39) |
H323Y |
probably damaging |
Het |
Gpr19 |
T |
C |
6: 134,847,398 (GRCm39) |
N58S |
probably benign |
Het |
Gucy2g |
T |
A |
19: 55,229,460 (GRCm39) |
Q70L |
probably damaging |
Het |
Ifit2 |
C |
T |
19: 34,550,897 (GRCm39) |
R146* |
probably null |
Het |
Lgr5 |
A |
C |
10: 115,293,772 (GRCm39) |
N408K |
possibly damaging |
Het |
Lrp1 |
G |
A |
10: 127,396,005 (GRCm39) |
H2422Y |
probably damaging |
Het |
Mief1 |
T |
A |
15: 80,132,692 (GRCm39) |
Y191* |
probably null |
Het |
Npr3 |
C |
G |
15: 11,905,518 (GRCm39) |
A70P |
probably damaging |
Het |
Or2y1b |
A |
T |
11: 49,208,541 (GRCm39) |
H56L |
probably damaging |
Het |
Pcnt |
A |
G |
10: 76,265,032 (GRCm39) |
|
probably null |
Het |
Pnlip |
A |
T |
19: 58,660,174 (GRCm39) |
D29V |
probably benign |
Het |
Pnpt1 |
T |
A |
11: 29,088,567 (GRCm39) |
F277I |
possibly damaging |
Het |
Pou2f2 |
A |
C |
7: 24,793,006 (GRCm39) |
V441G |
probably damaging |
Het |
Prdm4 |
A |
G |
10: 85,740,002 (GRCm39) |
V459A |
probably benign |
Het |
Ptprs |
A |
T |
17: 56,729,195 (GRCm39) |
V855E |
probably damaging |
Het |
Rflna |
A |
G |
5: 125,088,352 (GRCm39) |
T100A |
probably benign |
Het |
Rnd2 |
C |
T |
11: 101,359,825 (GRCm39) |
L57F |
probably damaging |
Het |
Spata31h1 |
A |
T |
10: 82,131,871 (GRCm39) |
S380T |
probably benign |
Het |
Syn3 |
A |
G |
10: 85,893,428 (GRCm39) |
S472P |
unknown |
Het |
Taar8a |
A |
T |
10: 23,952,674 (GRCm39) |
I93F |
possibly damaging |
Het |
Taok2 |
T |
A |
7: 126,477,930 (GRCm39) |
D207V |
probably damaging |
Het |
Tpst2 |
A |
T |
5: 112,424,600 (GRCm39) |
|
probably benign |
Homo |
Trdv2-1 |
A |
G |
14: 54,183,999 (GRCm39) |
N77S |
possibly damaging |
Het |
Wdr17 |
A |
C |
8: 55,134,559 (GRCm39) |
V18G |
probably benign |
Het |
Zbtb17 |
T |
C |
4: 141,192,261 (GRCm39) |
V402A |
probably damaging |
Het |
Zfp772 |
T |
C |
7: 7,208,547 (GRCm39) |
E99G |
possibly damaging |
Het |
Zw10 |
A |
G |
9: 48,980,926 (GRCm39) |
D442G |
probably benign |
Het |
|
Other mutations in Gpr26 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01065:Gpr26
|
APN |
7 |
131,569,230 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01345:Gpr26
|
APN |
7 |
131,569,161 (GRCm39) |
missense |
possibly damaging |
0.90 |
IGL01658:Gpr26
|
APN |
7 |
131,585,834 (GRCm39) |
missense |
probably benign |
|
IGL02724:Gpr26
|
APN |
7 |
131,576,121 (GRCm39) |
critical splice donor site |
probably null |
|
R0408:Gpr26
|
UTSW |
7 |
131,576,001 (GRCm39) |
splice site |
probably null |
|
R0408:Gpr26
|
UTSW |
7 |
131,569,249 (GRCm39) |
missense |
possibly damaging |
0.81 |
R0547:Gpr26
|
UTSW |
7 |
131,586,026 (GRCm39) |
missense |
probably benign |
0.01 |
R2508:Gpr26
|
UTSW |
7 |
131,568,823 (GRCm39) |
missense |
probably damaging |
0.98 |
R4088:Gpr26
|
UTSW |
7 |
131,568,805 (GRCm39) |
missense |
probably benign |
0.00 |
R4630:Gpr26
|
UTSW |
7 |
131,568,709 (GRCm39) |
missense |
probably damaging |
1.00 |
R4680:Gpr26
|
UTSW |
7 |
131,576,082 (GRCm39) |
missense |
probably benign |
0.34 |
R4756:Gpr26
|
UTSW |
7 |
131,569,230 (GRCm39) |
missense |
probably damaging |
1.00 |
R5229:Gpr26
|
UTSW |
7 |
131,585,976 (GRCm39) |
missense |
probably damaging |
1.00 |
R5610:Gpr26
|
UTSW |
7 |
131,568,694 (GRCm39) |
missense |
possibly damaging |
0.94 |
R6653:Gpr26
|
UTSW |
7 |
131,585,830 (GRCm39) |
missense |
probably benign |
0.00 |
R7213:Gpr26
|
UTSW |
7 |
131,569,219 (GRCm39) |
missense |
probably damaging |
1.00 |
R7351:Gpr26
|
UTSW |
7 |
131,576,094 (GRCm39) |
missense |
probably damaging |
1.00 |
R7768:Gpr26
|
UTSW |
7 |
131,576,077 (GRCm39) |
missense |
probably damaging |
0.99 |
R7887:Gpr26
|
UTSW |
7 |
131,568,702 (GRCm39) |
missense |
probably benign |
|
R8822:Gpr26
|
UTSW |
7 |
131,568,997 (GRCm39) |
missense |
probably damaging |
0.98 |
R9382:Gpr26
|
UTSW |
7 |
131,568,963 (GRCm39) |
missense |
probably damaging |
1.00 |
R9508:Gpr26
|
UTSW |
7 |
131,585,830 (GRCm39) |
missense |
probably benign |
0.00 |
Z1088:Gpr26
|
UTSW |
7 |
131,585,823 (GRCm39) |
frame shift |
probably null |
|
Z1176:Gpr26
|
UTSW |
7 |
131,568,954 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Gpr26
|
UTSW |
7 |
131,568,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- AGTGCCTAATCAATGCTCATTGC -3'
(R):5'- CGTTCTGAACTCCCCATCAG -3'
Sequencing Primer
(F):5'- AATGCTCATTGCCACCATTTTTG -3'
(R):5'- CATCAGGAGAGTGGTCCTTCATTC -3'
|
Posted On |
2018-06-22 |