Incidental Mutation 'R6640:Klri2'
ID525719
Institutional Source Beutler Lab
Gene Symbol Klri2
Ensembl Gene ENSMUSG00000043932
Gene Namekiller cell lectin-like receptor family I member 2
SynonymsA530090P03Rik
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #R6640 (G1)
Quality Score225.009
Status Validated
Chromosome6
Chromosomal Location129729041-129740484 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to C at 129732195 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 231 (F231L)
Ref Sequence ENSEMBL: ENSMUSP00000052805 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050385]
Predicted Effect probably benign
Transcript: ENSMUST00000050385
AA Change: F231L

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000052805
Gene: ENSMUSG00000043932
AA Change: F231L

DomainStartEndE-ValueType
transmembrane domain 82 104 N/A INTRINSIC
CLECT 132 245 7.01e-6 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.6%
Validation Efficiency 97% (31/32)
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 A T 6: 128,553,285 N936K probably benign Het
Abca2 A T 2: 25,447,003 Y2318F possibly damaging Het
Aldh1b1 A G 4: 45,803,868 T469A possibly damaging Het
Ccdc136 A G 6: 29,412,960 D382G possibly damaging Het
Dapk1 A G 13: 60,716,814 K141E probably damaging Het
Dnah6 A T 6: 73,024,293 W3973R probably damaging Het
Dock10 G T 1: 80,533,838 S1518* probably null Het
Doxl2 A G 6: 48,977,671 D581G probably benign Het
Elovl5 C A 9: 77,979,913 Y195* probably null Het
Fbxl21 T A 13: 56,537,009 W309R probably damaging Het
Gm10020 G T 15: 52,477,620 noncoding transcript Het
Gm10801 C CGTG 2: 98,663,807 probably null Het
Gpx1 A G 9: 108,340,096 D133G probably damaging Het
Hoxd1 T A 2: 74,763,262 V54E probably damaging Het
Kcnh3 T C 15: 99,241,768 V876A probably benign Het
Mogat1 T G 1: 78,523,774 S158R probably damaging Het
Myo1c C T 11: 75,671,635 P918S probably benign Het
Olfr1008 T A 2: 85,689,935 C169S probably damaging Het
Olfr695 T A 7: 106,714,040 I214F probably damaging Het
Otog G A 7: 46,261,743 A673T possibly damaging Het
Pigm T C 1: 172,377,687 V330A probably damaging Het
Rab33b A G 3: 51,484,479 T50A possibly damaging Het
Raver2 C T 4: 101,131,303 P371L probably damaging Het
Sh3rf2 T A 18: 42,101,640 Y163N probably damaging Het
Slc1a1 T C 19: 28,894,570 probably null Het
Slc6a18 T A 13: 73,664,282 Y563F possibly damaging Het
Sp3 A G 2: 72,971,114 L185P possibly damaging Het
Thbs2 T C 17: 14,673,368 D850G possibly damaging Het
Tmem161b C A 13: 84,222,418 probably benign Het
Tmtc2 T A 10: 105,573,749 M1L probably benign Het
Trpm2 C T 10: 77,937,826 R585Q probably benign Het
Trpm3 T A 19: 22,978,582 I1126K probably damaging Het
Ugt1a6b A C 1: 88,107,794 T285P probably benign Het
Vps13b A G 15: 35,617,696 T1181A possibly damaging Het
Other mutations in Klri2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00672:Klri2 APN 6 129733071 missense probably damaging 1.00
R0137:Klri2 UTSW 6 129732208 missense possibly damaging 0.95
R0371:Klri2 UTSW 6 129732143 makesense probably null
R0396:Klri2 UTSW 6 129740288 missense possibly damaging 0.77
R0671:Klri2 UTSW 6 129740208 missense probably benign
R0903:Klri2 UTSW 6 129733776 missense possibly damaging 0.46
R1353:Klri2 UTSW 6 129739086 missense probably damaging 1.00
R1557:Klri2 UTSW 6 129732211 missense probably damaging 0.99
R1642:Klri2 UTSW 6 129738874 missense probably benign 0.00
R2221:Klri2 UTSW 6 129740309 missense probably damaging 0.99
R6044:Klri2 UTSW 6 129740284 missense probably damaging 0.98
R6236:Klri2 UTSW 6 129738895 missense probably benign
R6582:Klri2 UTSW 6 129739133 missense possibly damaging 0.65
R6883:Klri2 UTSW 6 129733022 missense probably benign
R8330:Klri2 UTSW 6 129733731 missense probably damaging 0.99
RF009:Klri2 UTSW 6 129733774 frame shift probably null
Predicted Primers PCR Primer
(F):5'- CAGTTACTGGACATACATGGTATTG -3'
(R):5'- AAAGCTTATCGTCCACTCATAACTCTG -3'

Sequencing Primer
(F):5'- ATAAACAGCATCTTCTCAGTTCAG -3'
(R):5'- ATCGTCCACTCATAACTCTGTTTTC -3'
Posted On2018-06-22