|Institutional Source||Beutler Lab|
|Gene Name||kallikrein related-peptidase 10|
|Synonyms||NES1, PRSSL1, 2300002A13Rik|
|Is this an essential gene?||Probably non essential (E-score: 0.074)|
|Stock #||R6641 (G1)|
|Chromosomal Location||43781035-43785410 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 43784900 bp|
|Amino Acid Change||Aspartic acid to Tyrosine at position 239 (D239Y)|
|Ref Sequence||ENSEMBL: ENSMUSP00000014058 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000014058]|
|Predicted Effect||possibly damaging
AA Change: D239Y
PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)
AA Change: D239Y
|Predicted Effect||noncoding transcript
|Meta Mutation Damage Score||0.1795|
|Coding Region Coverage||
|Validation Efficiency||100% (32/32)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Klk10||
(F):5'- ATGCCACCATCACCTCTGTG -3'
(R):5'- TACTAGAACTTTCTCAGCCACC -3'
(F):5'- ACCATCACCTCTGTGTGTATC -3'
(R):5'- TCTGCATTTGTGAGCAGAGAAC -3'