Incidental Mutation 'R6609:Mettl15'
ID 525800
Institutional Source Beutler Lab
Gene Symbol Mettl15
Ensembl Gene ENSMUSG00000057234
Gene Name methyltransferase like 15
Synonyms 0610027B03Rik, Mett5d1
MMRRC Submission 044732-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # R6609 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 108922642-109111093 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 108967687 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 200 (R200G)
Ref Sequence ENSEMBL: ENSMUSP00000116829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081631] [ENSMUST00000147770]
AlphaFold Q9DCL4
Predicted Effect probably null
Transcript: ENSMUST00000081631
AA Change: R200G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000080337
Gene: ENSMUSG00000057234
AA Change: R200G

DomainStartEndE-ValueType
Pfam:Methyltransf_5 69 406 1.5e-90 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147376
Predicted Effect probably null
Transcript: ENSMUST00000147770
AA Change: R200G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000116829
Gene: ENSMUSG00000057234
AA Change: R200G

DomainStartEndE-ValueType
Pfam:Methyltransf_5 69 230 1.6e-47 PFAM
Meta Mutation Damage Score 0.3089 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.5%
Validation Efficiency 100% (34/34)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 C T 12: 118,892,497 (GRCm39) V421I probably damaging Het
Bpifb3 T A 2: 153,762,568 (GRCm39) probably null Het
C1rl T C 6: 124,485,583 (GRCm39) V318A probably benign Het
Cacna1b C T 2: 24,543,061 (GRCm39) V1264M probably damaging Het
Cacna1s A G 1: 136,041,129 (GRCm39) D1551G probably benign Het
Cdc42bpa T G 1: 179,928,839 (GRCm39) probably null Het
Cdc7 G A 5: 107,120,924 (GRCm39) R182H probably benign Het
Cep20 TTGTG TTG 16: 14,118,009 (GRCm39) probably null Het
Cyth1 A T 11: 118,061,686 (GRCm39) L309Q probably damaging Het
Dnah6 G A 6: 73,030,678 (GRCm39) T3378I possibly damaging Het
Get4 A G 5: 139,254,820 (GRCm39) probably benign Het
Gm136 T A 4: 34,746,526 (GRCm39) M162L probably benign Het
Grik5 G T 7: 24,714,951 (GRCm39) S681* probably null Het
Hsf5 C T 11: 87,526,779 (GRCm39) P484S probably damaging Het
Kcnc2 G C 10: 112,107,761 (GRCm39) G51R probably benign Het
Kl A T 5: 150,912,427 (GRCm39) K725N probably benign Het
Lama3 G A 18: 12,646,735 (GRCm39) V144M probably damaging Het
Lrrc14 T C 15: 76,598,453 (GRCm39) V363A probably benign Het
Mki67 T C 7: 135,301,558 (GRCm39) T1159A possibly damaging Het
Muc6 G C 7: 141,226,700 (GRCm39) probably benign Het
Ndufb5 C G 3: 32,795,832 (GRCm39) T8R probably benign Het
Or4f60 T C 2: 111,902,509 (GRCm39) M140V probably benign Het
Or6ae1 C A 7: 139,742,476 (GRCm39) R129L probably benign Het
Pde1a T A 2: 79,736,484 (GRCm39) D15V probably damaging Het
Plcg2 G A 8: 118,294,909 (GRCm39) G191S probably benign Het
Ptprq T C 10: 107,408,829 (GRCm39) T1895A probably damaging Het
Pxdn T C 12: 30,052,940 (GRCm39) V1039A probably benign Het
Slc26a5 T C 5: 22,024,717 (GRCm39) I456V possibly damaging Het
Smco4 C T 9: 15,456,031 (GRCm39) A39V probably damaging Het
Tmem102 T A 11: 69,695,940 (GRCm39) L40F probably damaging Het
Ylpm1 C G 12: 85,062,051 (GRCm39) P651A unknown Het
Zfp985 A T 4: 147,667,578 (GRCm39) M149L probably benign Het
Zfp985 T C 4: 147,668,124 (GRCm39) F331L probably damaging Het
Other mutations in Mettl15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Mettl15 APN 2 108,923,521 (GRCm39) nonsense probably null
IGL00657:Mettl15 APN 2 108,923,552 (GRCm39) missense probably damaging 1.00
IGL02684:Mettl15 APN 2 108,961,925 (GRCm39) missense probably damaging 0.97
IGL03367:Mettl15 APN 2 108,961,916 (GRCm39) missense probably benign 0.10
R1433:Mettl15 UTSW 2 108,923,266 (GRCm39) missense probably benign 0.00
R1538:Mettl15 UTSW 2 108,962,010 (GRCm39) critical splice acceptor site probably null
R3890:Mettl15 UTSW 2 109,021,924 (GRCm39) missense probably benign 0.03
R5464:Mettl15 UTSW 2 109,021,967 (GRCm39) missense probably benign 0.00
R7619:Mettl15 UTSW 2 108,923,220 (GRCm39) nonsense probably null
R7737:Mettl15 UTSW 2 108,967,723 (GRCm39) missense probably damaging 0.99
R8914:Mettl15 UTSW 2 108,967,625 (GRCm39) intron probably benign
R9121:Mettl15 UTSW 2 109,104,948 (GRCm39) missense
R9159:Mettl15 UTSW 2 108,923,444 (GRCm39) missense probably damaging 1.00
R9192:Mettl15 UTSW 2 109,104,810 (GRCm39) nonsense probably null
R9364:Mettl15 UTSW 2 108,961,960 (GRCm39) missense probably benign 0.06
R9566:Mettl15 UTSW 2 108,923,592 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- CAAAGAGATGTGTGTATGCAAGCAC -3'
(R):5'- AAGCTCTGTTGGGCCAGTTC -3'

Sequencing Primer
(F):5'- TGTGTGTATGCAAGCACAAAAATG -3'
(R):5'- CAGTTCAGCCAAGCGGAG -3'
Posted On 2018-06-22