Incidental Mutation 'IGL01123:Vmn1r200'
ID52587
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r200
Ensembl Gene ENSMUSG00000101073
Gene Namevomeronasal 1 receptor 200
SynonymsV1rh3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.226) question?
Stock #IGL01123
Quality Score
Status
Chromosome13
Chromosomal Location22390373-22400052 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 22395401 bp
ZygosityHeterozygous
Amino Acid Change Tryptophan to Arginine at position 116 (W116R)
Ref Sequence ENSEMBL: ENSMUSP00000153883 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074324] [ENSMUST00000226157] [ENSMUST00000227326] [ENSMUST00000228726]
Predicted Effect probably benign
Transcript: ENSMUST00000074324
AA Change: W125R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000073934
Gene: ENSMUSG00000101073
AA Change: W125R

DomainStartEndE-ValueType
Pfam:V1R 24 307 5.5e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091731
AA Change: W125R
SMART Domains Protein: ENSMUSP00000089325
Gene: ENSMUSG00000069291
AA Change: W125R

DomainStartEndE-ValueType
Pfam:TAS2R 2 291 1.3e-8 PFAM
Pfam:V1R 34 297 3.8e-37 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226157
AA Change: W125R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226901
Predicted Effect probably benign
Transcript: ENSMUST00000227326
AA Change: W116R

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000228726
AA Change: W125R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik G T 10: 28,973,938 D167E probably damaging Het
Aadat A T 8: 60,526,614 E170V probably benign Het
Acsf2 T C 11: 94,570,450 E300G probably benign Het
Agbl3 C T 6: 34,846,976 Q859* probably null Het
Arhgap11a T C 2: 113,834,773 probably benign Het
Arhgef40 C A 14: 51,994,346 Q730K probably damaging Het
Armc3 C T 2: 19,201,805 P13L possibly damaging Het
B3gnt2 T A 11: 22,836,490 T233S probably benign Het
Bnc1 G A 7: 81,973,707 Q591* probably null Het
Bsn A T 9: 108,115,986 F856I probably damaging Het
CK137956 T A 4: 127,935,850 T558S probably benign Het
Coq8b G A 7: 27,240,084 V180I probably damaging Het
Csmd1 A T 8: 17,534,928 L16Q possibly damaging Het
Dhx37 A G 5: 125,419,088 S769P possibly damaging Het
Diras1 T A 10: 81,022,415 M1L probably damaging Het
Fam161b A G 12: 84,357,664 W81R probably benign Het
Fat4 A T 3: 38,957,269 I2173L probably benign Het
Fbn2 T C 18: 58,104,081 T617A possibly damaging Het
Gabrq G A X: 72,836,833 D311N probably benign Het
Isl2 G T 9: 55,545,462 G335C probably damaging Het
Kbtbd7 T C 14: 79,428,612 V628A probably damaging Het
Kmt2d T C 15: 98,837,148 M5378V unknown Het
Lrrc23 G T 6: 124,778,819 D75E probably benign Het
Mab21l3 G A 3: 101,835,130 T38M probably benign Het
Matn1 T C 4: 130,950,011 I177T possibly damaging Het
Mtor T C 4: 148,453,037 S60P probably benign Het
Naip6 T C 13: 100,304,438 E278G probably benign Het
Nsun6 T C 2: 15,048,978 I7V possibly damaging Het
Pabpc6 A T 17: 9,668,147 S492T probably benign Het
Pakap C T 4: 57,757,627 Q188* probably null Het
Pom121 A T 5: 135,391,706 V287D unknown Het
Ptprq A T 10: 107,686,218 F624Y probably damaging Het
Ptprr A G 10: 116,188,317 T178A probably benign Het
Pygm A G 19: 6,391,394 N473S probably benign Het
Ros1 A T 10: 52,120,809 Y1256N probably damaging Het
Scpep1 T C 11: 88,941,328 N192S possibly damaging Het
Serpina1f A G 12: 103,694,006 S6P possibly damaging Het
Sgca T A 11: 94,972,287 Q80L probably damaging Het
Skint6 A G 4: 112,804,682 L1235P possibly damaging Het
Slc23a2 A C 2: 132,056,816 N600K probably benign Het
Spata20 T C 11: 94,483,395 T350A probably benign Het
Syne1 G T 10: 5,344,921 Y1227* probably null Het
Unc13c T C 9: 73,933,197 Y124C probably benign Het
Usp40 G A 1: 87,986,123 T416I probably benign Het
Vps4a T C 8: 107,039,219 probably benign Het
Zfyve16 A G 13: 92,492,522 V1469A probably damaging Het
Other mutations in Vmn1r200
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00970:Vmn1r200 APN 13 22395723 missense probably damaging 1.00
IGL01943:Vmn1r200 APN 13 22395927 missense possibly damaging 0.77
IGL02691:Vmn1r200 APN 13 22395258 missense probably damaging 1.00
R0491:Vmn1r200 UTSW 13 22395191 missense probably benign 0.00
R0507:Vmn1r200 UTSW 13 22395548 missense probably benign 0.00
R0530:Vmn1r200 UTSW 13 22395497 missense probably damaging 1.00
R1033:Vmn1r200 UTSW 13 22395890 missense probably damaging 1.00
R1054:Vmn1r200 UTSW 13 22395454 missense probably damaging 1.00
R1714:Vmn1r200 UTSW 13 22395470 missense possibly damaging 0.96
R1920:Vmn1r200 UTSW 13 22395493 missense probably damaging 1.00
R2118:Vmn1r200 UTSW 13 22395183 missense probably damaging 1.00
R3784:Vmn1r200 UTSW 13 22395855 missense possibly damaging 0.82
R4827:Vmn1r200 UTSW 13 22395095 missense probably benign 0.00
R5285:Vmn1r200 UTSW 13 22395287 missense possibly damaging 0.51
R5299:Vmn1r200 UTSW 13 22395775 nonsense probably null
R6127:Vmn1r200 UTSW 13 22395203 missense probably benign 0.07
R7167:Vmn1r200 UTSW 13 22395317 missense possibly damaging 0.91
R7854:Vmn1r200 UTSW 13 22395839 missense probably benign 0.08
R7937:Vmn1r200 UTSW 13 22395839 missense probably benign 0.08
R8061:Vmn1r200 UTSW 13 22395283 nonsense probably null
Posted On2013-06-21