Incidental Mutation 'R6644:Trank1'
ID 526011
Institutional Source Beutler Lab
Gene Symbol Trank1
Ensembl Gene ENSMUSG00000062296
Gene Name tetratricopeptide repeat and ankyrin repeat containing 1
Synonyms A230061D21Rik, LOC235639, C030048J01Rik, Lba1
MMRRC Submission 044765-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6644 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 111311739-111395775 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 111364834 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 642 (I642K)
Ref Sequence ENSEMBL: ENSMUSP00000077697 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078626]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000078626
AA Change: I642K

PolyPhen 2 Score 0.852 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000077697
Gene: ENSMUSG00000062296
AA Change: I642K

DomainStartEndE-ValueType
low complexity region 4 30 N/A INTRINSIC
low complexity region 34 52 N/A INTRINSIC
low complexity region 113 129 N/A INTRINSIC
Blast:TPR 144 177 1e-15 BLAST
Blast:TPR 178 209 8e-13 BLAST
Blast:ANK 332 361 1e-6 BLAST
ANK 369 405 5.29e0 SMART
ANK 538 567 2.11e2 SMART
ANK 572 609 7.29e2 SMART
ANK 621 652 1.21e2 SMART
low complexity region 887 895 N/A INTRINSIC
low complexity region 1152 1172 N/A INTRINSIC
Blast:AAA 1351 1569 1e-6 BLAST
low complexity region 2166 2177 N/A INTRINSIC
low complexity region 2395 2411 N/A INTRINSIC
low complexity region 2636 2649 N/A INTRINSIC
low complexity region 2966 2983 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.5%
  • 20x: 92.3%
Validation Efficiency 100% (50/50)
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 C T 10: 80,008,764 (GRCm38) P1461L probably damaging Het
Abhd14a T C 9: 106,444,273 (GRCm38) Y10C probably damaging Het
Adcy2 C T 13: 68,668,552 (GRCm38) V772M possibly damaging Het
Apob A G 12: 8,009,077 (GRCm38) M2487V probably damaging Het
B4galnt1 T C 10: 127,171,793 (GRCm38) probably null Het
Cabp7 C T 11: 4,740,396 (GRCm38) V76I probably benign Het
Cbr3 A G 16: 93,690,511 (GRCm38) Y194C probably damaging Het
Cdk18 G A 1: 132,122,069 (GRCm38) Q58* probably null Het
Cryba4 T C 5: 112,246,762 (GRCm38) D167G probably damaging Het
Czib T G 4: 107,894,922 (GRCm38) I130S probably damaging Het
Dner T C 1: 84,395,707 (GRCm38) N588S probably damaging Het
Dnm1l T C 16: 16,329,873 (GRCm38) I343V probably benign Het
Eif1ad16 A G 12: 88,018,690 (GRCm38) F28L probably benign Het
Fam168b C A 1: 34,836,741 (GRCm38) G21V probably damaging Het
Fbxw17 G A 13: 50,423,219 (GRCm38) R49Q probably damaging Het
Garin2 T A 12: 78,715,286 (GRCm38) D241E probably damaging Het
Gm10332 T A 14: 54,820,159 (GRCm38) F59I probably damaging Het
Gnai3 A G 3: 108,123,536 (GRCm38) probably null Het
Helz T A 11: 107,632,261 (GRCm38) M75K possibly damaging Het
Hnrnph3 C T 10: 63,018,893 (GRCm38) probably benign Het
Ifi211 C T 1: 173,905,552 (GRCm38) C181Y probably benign Het
Immp1l A G 2: 105,937,045 (GRCm38) K83R probably damaging Het
Itga6 G A 2: 71,841,124 (GRCm38) G740R probably damaging Het
Klhl1 T C 14: 96,517,918 (GRCm38) T134A probably benign Het
Klhl7 A G 5: 24,149,246 (GRCm38) D353G probably damaging Het
Map3k1 A G 13: 111,752,449 (GRCm38) S1325P probably benign Het
Map3k4 A G 17: 12,232,410 (GRCm38) probably null Het
Meioc G A 11: 102,668,460 (GRCm38) probably null Het
Mfap5 T C 6: 122,520,596 (GRCm38) F26L probably damaging Het
Myo5a A G 9: 75,146,967 (GRCm38) T386A probably damaging Het
Npc1l1 A T 11: 6,214,013 (GRCm38) L1266Q probably damaging Het
Npc1l1 G T 11: 6,214,014 (GRCm38) L1266M probably damaging Het
Or4c116 A G 2: 89,111,981 (GRCm38) M177T probably benign Het
Or51aa2 C A 7: 103,539,058 (GRCm38) V59F possibly damaging Het
Pbld1 T A 10: 63,075,063 (GRCm38) S233T probably damaging Het
Phf12 A G 11: 78,026,092 (GRCm38) *789W probably null Het
Sf3b2 A T 19: 5,279,964 (GRCm38) probably null Het
Slc23a3 A G 1: 75,128,547 (GRCm38) I459T probably damaging Het
Spata31e4 A G 13: 50,702,035 (GRCm38) T570A possibly damaging Het
Sptbn2 C G 19: 4,749,012 (GRCm38) R2037G probably benign Het
Stard9 A C 2: 120,695,772 (GRCm38) M837L probably benign Het
Stx5a A T 19: 8,755,248 (GRCm38) probably benign Het
Tmc7 A G 7: 118,538,162 (GRCm38) V719A probably benign Het
Trim34a T C 7: 104,261,037 (GRCm38) Y349H probably damaging Het
Uba7 A G 9: 107,981,472 (GRCm38) Y834C possibly damaging Het
Ube2d1 A G 10: 71,256,700 (GRCm38) S105P possibly damaging Het
Vps13a A G 19: 16,744,919 (GRCm38) V343A possibly damaging Het
Zbtb37 G A 1: 161,032,073 (GRCm38) Q221* probably null Het
Zfp119b T C 17: 55,939,148 (GRCm38) N346S probably benign Het
Zfp708 G T 13: 67,070,721 (GRCm38) T358K possibly damaging Het
Other mutations in Trank1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00234:Trank1 APN 9 111,392,609 (GRCm38) missense probably damaging 1.00
IGL00467:Trank1 APN 9 111,364,666 (GRCm38) splice site probably benign
IGL00569:Trank1 APN 9 111,345,511 (GRCm38) missense possibly damaging 0.69
IGL00585:Trank1 APN 9 111,349,290 (GRCm38) missense possibly damaging 0.82
IGL01070:Trank1 APN 9 111,366,793 (GRCm38) missense probably damaging 1.00
IGL01134:Trank1 APN 9 111,391,781 (GRCm38) missense probably benign
IGL01154:Trank1 APN 9 111,386,400 (GRCm38) missense probably benign 0.00
IGL01355:Trank1 APN 9 111,365,520 (GRCm38) missense possibly damaging 0.94
IGL01407:Trank1 APN 9 111,364,722 (GRCm38) missense probably damaging 0.99
IGL01410:Trank1 APN 9 111,365,049 (GRCm38) missense probably benign 0.00
IGL01410:Trank1 APN 9 111,365,259 (GRCm38) missense probably benign 0.00
IGL01504:Trank1 APN 9 111,373,544 (GRCm38) missense probably damaging 1.00
IGL01744:Trank1 APN 9 111,349,363 (GRCm38) missense probably damaging 1.00
IGL02043:Trank1 APN 9 111,363,960 (GRCm38) missense probably damaging 0.98
IGL02104:Trank1 APN 9 111,390,712 (GRCm38) missense possibly damaging 0.85
IGL02193:Trank1 APN 9 111,367,276 (GRCm38) missense probably benign 0.43
IGL02581:Trank1 APN 9 111,383,125 (GRCm38) missense probably benign 0.00
IGL02630:Trank1 APN 9 111,373,075 (GRCm38) missense possibly damaging 0.70
IGL02839:Trank1 APN 9 111,364,756 (GRCm38) missense probably damaging 1.00
IGL02897:Trank1 APN 9 111,367,517 (GRCm38) missense probably damaging 0.99
IGL03065:Trank1 APN 9 111,390,293 (GRCm38) missense possibly damaging 0.64
IGL03123:Trank1 APN 9 111,367,407 (GRCm38) missense probably damaging 1.00
IGL03143:Trank1 APN 9 111,366,087 (GRCm38) missense probably damaging 1.00
IGL03323:Trank1 APN 9 111,352,116 (GRCm38) missense probably damaging 1.00
1mM(1):Trank1 UTSW 9 111,392,981 (GRCm38) missense probably damaging 1.00
PIT4486001:Trank1 UTSW 9 111,390,107 (GRCm38) missense probably damaging 1.00
PIT4812001:Trank1 UTSW 9 111,347,912 (GRCm38) missense probably damaging 1.00
R0035:Trank1 UTSW 9 111,366,776 (GRCm38) missense probably benign 0.00
R0064:Trank1 UTSW 9 111,343,195 (GRCm38) missense probably damaging 1.00
R0064:Trank1 UTSW 9 111,343,195 (GRCm38) missense probably damaging 1.00
R0089:Trank1 UTSW 9 111,392,910 (GRCm38) missense probably benign 0.00
R0207:Trank1 UTSW 9 111,366,253 (GRCm38) missense probably damaging 1.00
R0255:Trank1 UTSW 9 111,366,024 (GRCm38) missense possibly damaging 0.92
R0334:Trank1 UTSW 9 111,392,940 (GRCm38) missense probably damaging 1.00
R0334:Trank1 UTSW 9 111,365,353 (GRCm38) missense probably benign 0.00
R0383:Trank1 UTSW 9 111,391,477 (GRCm38) missense probably benign 0.08
R0421:Trank1 UTSW 9 111,391,839 (GRCm38) missense probably damaging 1.00
R0494:Trank1 UTSW 9 111,391,293 (GRCm38) missense probably benign 0.19
R0518:Trank1 UTSW 9 111,333,808 (GRCm38) missense probably damaging 1.00
R0560:Trank1 UTSW 9 111,391,086 (GRCm38) missense possibly damaging 0.88
R0637:Trank1 UTSW 9 111,390,441 (GRCm38) missense probably damaging 1.00
R0731:Trank1 UTSW 9 111,365,488 (GRCm38) missense probably damaging 1.00
R0761:Trank1 UTSW 9 111,366,613 (GRCm38) missense probably damaging 1.00
R0766:Trank1 UTSW 9 111,347,469 (GRCm38) missense probably benign 0.45
R0827:Trank1 UTSW 9 111,349,417 (GRCm38) unclassified probably benign
R1005:Trank1 UTSW 9 111,333,721 (GRCm38) missense probably benign 0.13
R1108:Trank1 UTSW 9 111,365,307 (GRCm38) missense probably benign 0.00
R1155:Trank1 UTSW 9 111,366,970 (GRCm38) missense possibly damaging 0.95
R1470:Trank1 UTSW 9 111,343,232 (GRCm38) missense possibly damaging 0.91
R1470:Trank1 UTSW 9 111,343,232 (GRCm38) missense possibly damaging 0.91
R1596:Trank1 UTSW 9 111,366,290 (GRCm38) missense possibly damaging 0.93
R1601:Trank1 UTSW 9 111,373,477 (GRCm38) missense probably damaging 1.00
R1751:Trank1 UTSW 9 111,391,479 (GRCm38) missense probably benign
R1754:Trank1 UTSW 9 111,392,871 (GRCm38) missense probably benign 0.00
R1767:Trank1 UTSW 9 111,391,479 (GRCm38) missense probably benign
R1768:Trank1 UTSW 9 111,392,927 (GRCm38) missense probably damaging 0.96
R1809:Trank1 UTSW 9 111,392,825 (GRCm38) missense probably benign 0.34
R1912:Trank1 UTSW 9 111,390,709 (GRCm38) missense probably benign 0.00
R1920:Trank1 UTSW 9 111,347,928 (GRCm38) critical splice donor site probably null
R1960:Trank1 UTSW 9 111,391,628 (GRCm38) missense probably damaging 1.00
R1993:Trank1 UTSW 9 111,378,832 (GRCm38) missense probably benign 0.20
R2012:Trank1 UTSW 9 111,365,028 (GRCm38) missense probably benign
R2025:Trank1 UTSW 9 111,392,039 (GRCm38) missense probably benign 0.01
R2050:Trank1 UTSW 9 111,364,788 (GRCm38) missense probably damaging 1.00
R2857:Trank1 UTSW 9 111,366,933 (GRCm38) missense probably benign 0.00
R2912:Trank1 UTSW 9 111,392,483 (GRCm38) missense probably damaging 0.98
R2962:Trank1 UTSW 9 111,352,080 (GRCm38) missense probably damaging 1.00
R3030:Trank1 UTSW 9 111,391,530 (GRCm38) missense possibly damaging 0.63
R3821:Trank1 UTSW 9 111,378,819 (GRCm38) missense probably damaging 1.00
R3822:Trank1 UTSW 9 111,378,819 (GRCm38) missense probably damaging 1.00
R3892:Trank1 UTSW 9 111,364,759 (GRCm38) missense probably benign 0.03
R4105:Trank1 UTSW 9 111,352,197 (GRCm38) missense probably damaging 1.00
R4166:Trank1 UTSW 9 111,373,524 (GRCm38) nonsense probably null
R4237:Trank1 UTSW 9 111,367,035 (GRCm38) missense probably benign 0.04
R4239:Trank1 UTSW 9 111,367,035 (GRCm38) missense probably benign 0.04
R4394:Trank1 UTSW 9 111,365,197 (GRCm38) missense possibly damaging 0.86
R4417:Trank1 UTSW 9 111,365,968 (GRCm38) missense probably benign 0.17
R4611:Trank1 UTSW 9 111,362,261 (GRCm38) missense probably damaging 1.00
R4694:Trank1 UTSW 9 111,392,061 (GRCm38) missense probably benign 0.40
R4731:Trank1 UTSW 9 111,390,410 (GRCm38) missense probably damaging 1.00
R4843:Trank1 UTSW 9 111,366,078 (GRCm38) missense probably benign 0.00
R4852:Trank1 UTSW 9 111,391,895 (GRCm38) missense possibly damaging 0.68
R4859:Trank1 UTSW 9 111,365,010 (GRCm38) missense probably benign 0.17
R4868:Trank1 UTSW 9 111,365,641 (GRCm38) missense probably damaging 1.00
R5080:Trank1 UTSW 9 111,389,221 (GRCm38) missense probably damaging 0.99
R5156:Trank1 UTSW 9 111,390,694 (GRCm38) missense probably damaging 1.00
R5174:Trank1 UTSW 9 111,365,559 (GRCm38) missense probably benign 0.00
R5234:Trank1 UTSW 9 111,386,467 (GRCm38) missense probably damaging 1.00
R5386:Trank1 UTSW 9 111,362,402 (GRCm38) missense probably benign 0.12
R5419:Trank1 UTSW 9 111,391,301 (GRCm38) missense probably damaging 1.00
R5435:Trank1 UTSW 9 111,391,890 (GRCm38) missense probably benign 0.00
R5444:Trank1 UTSW 9 111,392,958 (GRCm38) missense probably benign 0.04
R5543:Trank1 UTSW 9 111,366,112 (GRCm38) missense probably damaging 0.97
R5560:Trank1 UTSW 9 111,390,567 (GRCm38) missense probably damaging 1.00
R5772:Trank1 UTSW 9 111,366,676 (GRCm38) missense possibly damaging 0.86
R5774:Trank1 UTSW 9 111,391,226 (GRCm38) missense probably damaging 1.00
R5843:Trank1 UTSW 9 111,365,860 (GRCm38) missense possibly damaging 0.59
R5858:Trank1 UTSW 9 111,392,536 (GRCm38) missense probably benign
R5878:Trank1 UTSW 9 111,366,685 (GRCm38) missense possibly damaging 0.93
R5900:Trank1 UTSW 9 111,391,716 (GRCm38) missense probably damaging 1.00
R5917:Trank1 UTSW 9 111,362,417 (GRCm38) missense probably benign 0.38
R5954:Trank1 UTSW 9 111,365,133 (GRCm38) missense probably benign 0.13
R6041:Trank1 UTSW 9 111,377,796 (GRCm38) missense possibly damaging 0.94
R6112:Trank1 UTSW 9 111,391,737 (GRCm38) missense probably damaging 1.00
R6165:Trank1 UTSW 9 111,391,872 (GRCm38) missense probably benign 0.00
R6255:Trank1 UTSW 9 111,352,246 (GRCm38) critical splice donor site probably null
R6395:Trank1 UTSW 9 111,367,200 (GRCm38) missense probably damaging 1.00
R6567:Trank1 UTSW 9 111,347,521 (GRCm38) missense probably benign 0.02
R6724:Trank1 UTSW 9 111,365,916 (GRCm38) missense probably damaging 1.00
R6788:Trank1 UTSW 9 111,390,679 (GRCm38) missense probably damaging 1.00
R6831:Trank1 UTSW 9 111,377,899 (GRCm38) missense probably benign 0.00
R6934:Trank1 UTSW 9 111,373,090 (GRCm38) missense probably damaging 0.99
R7127:Trank1 UTSW 9 111,365,796 (GRCm38) missense possibly damaging 0.85
R7206:Trank1 UTSW 9 111,345,515 (GRCm38) critical splice donor site probably null
R7236:Trank1 UTSW 9 111,373,074 (GRCm38) missense possibly damaging 0.93
R7247:Trank1 UTSW 9 111,367,512 (GRCm38) missense probably damaging 1.00
R7292:Trank1 UTSW 9 111,377,870 (GRCm38) missense probably benign 0.02
R7310:Trank1 UTSW 9 111,367,126 (GRCm38) missense probably damaging 1.00
R7431:Trank1 UTSW 9 111,362,402 (GRCm38) missense probably benign 0.12
R7448:Trank1 UTSW 9 111,366,349 (GRCm38) missense probably benign 0.01
R7477:Trank1 UTSW 9 111,364,957 (GRCm38) missense probably benign 0.00
R7514:Trank1 UTSW 9 111,364,756 (GRCm38) missense probably damaging 1.00
R7595:Trank1 UTSW 9 111,365,991 (GRCm38) missense probably damaging 1.00
R7637:Trank1 UTSW 9 111,365,296 (GRCm38) missense possibly damaging 0.71
R7648:Trank1 UTSW 9 111,391,685 (GRCm38) missense probably benign
R7737:Trank1 UTSW 9 111,366,012 (GRCm38) nonsense probably null
R7784:Trank1 UTSW 9 111,364,103 (GRCm38) missense probably damaging 1.00
R7884:Trank1 UTSW 9 111,392,516 (GRCm38) missense probably benign
R7912:Trank1 UTSW 9 111,391,528 (GRCm38) missense probably benign 0.04
R7938:Trank1 UTSW 9 111,365,028 (GRCm38) missense probably benign
R7979:Trank1 UTSW 9 111,377,899 (GRCm38) missense probably benign 0.00
R8064:Trank1 UTSW 9 111,352,076 (GRCm38) nonsense probably null
R8100:Trank1 UTSW 9 111,392,793 (GRCm38) missense probably damaging 1.00
R8124:Trank1 UTSW 9 111,378,927 (GRCm38) missense probably benign 0.31
R8198:Trank1 UTSW 9 111,390,812 (GRCm38) missense probably benign 0.09
R8219:Trank1 UTSW 9 111,364,909 (GRCm38) missense probably damaging 1.00
R8223:Trank1 UTSW 9 111,365,889 (GRCm38) missense probably damaging 1.00
R8316:Trank1 UTSW 9 111,349,302 (GRCm38) missense probably benign 0.38
R8347:Trank1 UTSW 9 111,367,249 (GRCm38) missense probably damaging 1.00
R8436:Trank1 UTSW 9 111,391,382 (GRCm38) missense possibly damaging 0.86
R8489:Trank1 UTSW 9 111,390,275 (GRCm38) missense probably benign 0.01
R8682:Trank1 UTSW 9 111,365,344 (GRCm38) missense probably benign 0.01
R8768:Trank1 UTSW 9 111,389,276 (GRCm38) missense probably benign 0.00
R8770:Trank1 UTSW 9 111,390,824 (GRCm38) missense probably benign 0.00
R8829:Trank1 UTSW 9 111,347,523 (GRCm38) missense probably benign
R8838:Trank1 UTSW 9 111,364,905 (GRCm38) missense probably benign 0.03
R8855:Trank1 UTSW 9 111,312,221 (GRCm38) missense unknown
R8929:Trank1 UTSW 9 111,378,935 (GRCm38) missense possibly damaging 0.93
R9047:Trank1 UTSW 9 111,362,432 (GRCm38) missense probably damaging 0.99
R9090:Trank1 UTSW 9 111,345,479 (GRCm38) missense probably damaging 1.00
R9114:Trank1 UTSW 9 111,333,775 (GRCm38) missense probably damaging 1.00
R9133:Trank1 UTSW 9 111,391,702 (GRCm38) missense possibly damaging 0.93
R9177:Trank1 UTSW 9 111,392,511 (GRCm38) missense probably benign 0.00
R9178:Trank1 UTSW 9 111,367,200 (GRCm38) missense probably damaging 1.00
R9271:Trank1 UTSW 9 111,345,479 (GRCm38) missense probably damaging 1.00
R9314:Trank1 UTSW 9 111,365,981 (GRCm38) missense probably damaging 1.00
R9373:Trank1 UTSW 9 111,365,191 (GRCm38) missense probably benign 0.25
R9380:Trank1 UTSW 9 111,392,670 (GRCm38) missense probably benign 0.07
R9435:Trank1 UTSW 9 111,364,822 (GRCm38) missense probably benign 0.04
R9501:Trank1 UTSW 9 111,347,875 (GRCm38) missense probably benign 0.00
R9593:Trank1 UTSW 9 111,362,297 (GRCm38) missense probably benign 0.30
R9601:Trank1 UTSW 9 111,373,125 (GRCm38) missense probably benign 0.18
R9729:Trank1 UTSW 9 111,391,469 (GRCm38) missense probably damaging 1.00
X0064:Trank1 UTSW 9 111,343,236 (GRCm38) missense possibly damaging 0.57
Z1088:Trank1 UTSW 9 111,364,710 (GRCm38) missense probably damaging 0.99
Z1177:Trank1 UTSW 9 111,392,870 (GRCm38) missense possibly damaging 0.47
Z1177:Trank1 UTSW 9 111,367,377 (GRCm38) missense possibly damaging 0.83
Z1177:Trank1 UTSW 9 111,311,902 (GRCm38) missense unknown
Predicted Primers PCR Primer
(F):5'- TGGCTTTGTACTCACAGGATTCTG -3'
(R):5'- TGAGCTGAGATGTATGGCCAG -3'

Sequencing Primer
(F):5'- CAGGATTCTGTTTATGTCTTTCAGC -3'
(R):5'- GCAGAAGATCTGGAGAGCCTC -3'
Posted On 2018-06-22