Mutagenetix > Incidental Mutations

Incidental Mutation 'R6644:Gm6803'

526031

Institutional Source

Beutler Lab

Gene Symbol

Gm6803

Ensembl Gene

ENSMUSG00000096803

Gene Name

predicted gene 6803

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Not available question?

Stock #

R6644 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

88018337-88018771 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 88018690 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 28 (F28L)

Ref Sequence

ENSEMBL: ENSMUSP00000137317 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000178301]

Predicted Effect

probably benign
Transcript: ENSMUST00000178301
AA Change: F28L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000137317
Gene: ENSMUSG00000096803
AA Change: F28L

Domain	Start	End	E-Value	Type
low complexity region	3	25	N/A	INTRINSIC
eIF1a	28	110	7.09e-44	SMART
low complexity region	132	144	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.5%
20x: 92.3%

Validation Efficiency

100% (50/50)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
0610037L13Rik	T	G	4: 107,894,922	I130S	probably damaging	Het
Abca7	C	T	10: 80,008,764	P1461L	probably damaging	Het
Abhd14a	T	C	9: 106,444,273	Y10C	probably damaging	Het
Adcy2	C	T	13: 68,668,552	V772M	possibly damaging	Het
Apob	A	G	12: 8,009,077	M2487V	probably damaging	Het
B4galnt1	T	C	10: 127,171,793		probably null	Het
Cabp7	C	T	11: 4,740,396	V76I	probably benign	Het
Cbr3	A	G	16: 93,690,511	Y194C	probably damaging	Het
Cdk18	G	A	1: 132,122,069	Q58*	probably null	Het
Cryba4	T	C	5: 112,246,762	D167G	probably damaging	Het
Dner	T	C	1: 84,395,707	N588S	probably damaging	Het
Dnm1l	T	C	16: 16,329,873	I343V	probably benign	Het
Fam168b	C	A	1: 34,836,741	G21V	probably damaging	Het
Fam71d	T	A	12: 78,715,286	D241E	probably damaging	Het
Fbxw17	G	A	13: 50,423,219	R49Q	probably damaging	Het
Gm10332	T	A	14: 54,820,159	F59I	probably damaging	Het
Gm8765	A	G	13: 50,702,035	T570A	possibly damaging	Het
Gnai3	A	G	3: 108,123,536		probably null	Het
Helz	T	A	11: 107,632,261	M75K	possibly damaging	Het
Hnrnph3	C	T	10: 63,018,893		probably benign	Het
Ifi211	C	T	1: 173,905,552	C181Y	probably benign	Het
Immp1l	A	G	2: 105,937,045	K83R	probably damaging	Het
Itga6	G	A	2: 71,841,124	G740R	probably damaging	Het
Klhl1	T	C	14: 96,517,918	T134A	probably benign	Het
Klhl7	A	G	5: 24,149,246	D353G	probably damaging	Het
Map3k1	A	G	13: 111,752,449	S1325P	probably benign	Het
Map3k4	A	G	17: 12,232,410		probably null	Het
Meioc	G	A	11: 102,668,460		probably null	Het
Mfap5	T	C	6: 122,520,596	F26L	probably damaging	Het
Myo5a	A	G	9: 75,146,967	T386A	probably damaging	Het
Npc1l1	A	T	11: 6,214,013	L1266Q	probably damaging	Het
Npc1l1	G	T	11: 6,214,014	L1266M	probably damaging	Het
Olfr1221	A	G	2: 89,111,981	M177T	probably benign	Het
Olfr612	C	A	7: 103,539,058	V59F	possibly damaging	Het
Pbld1	T	A	10: 63,075,063	S233T	probably damaging	Het
Phf12	A	G	11: 78,026,092	*789W	probably null	Het
Sf3b2	A	T	19: 5,279,964		probably null	Het
Slc23a3	A	G	1: 75,128,547	I459T	probably damaging	Het
Sptbn2	C	G	19: 4,749,012	R2037G	probably benign	Het
Stard9	A	C	2: 120,695,772	M837L	probably benign	Het
Stx5a	A	T	19: 8,755,248		probably benign	Het
Tmc7	A	G	7: 118,538,162	V719A	probably benign	Het
Trank1	T	A	9: 111,364,834	I642K	possibly damaging	Het
Trim34a	T	C	7: 104,261,037	Y349H	probably damaging	Het
Uba7	A	G	9: 107,981,472	Y834C	possibly damaging	Het
Ube2d1	A	G	10: 71,256,700	S105P	possibly damaging	Het
Vps13a	A	G	19: 16,744,919	V343A	possibly damaging	Het
Zbtb37	G	A	1: 161,032,073	Q221*	probably null	Het
Zfp119b	T	C	17: 55,939,148	N346S	probably benign	Het
Zfp708	G	T	13: 67,070,721	T358K	possibly damaging	Het

Other mutations in Gm6803

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1602:Gm6803	UTSW	12	88018364	missense	probably benign	0.00
R1603:Gm6803	UTSW	12	88018364	missense	probably benign	0.00
R2157:Gm6803	UTSW	12	88018711	missense	unknown
R2508:Gm6803	UTSW	12	88018488	missense	probably damaging	1.00
R4092:Gm6803	UTSW	12	88018424	missense	possibly damaging	0.50
R4328:Gm6803	UTSW	12	88018515	missense	possibly damaging	0.94
R5022:Gm6803	UTSW	12	88018711	missense	unknown
R5057:Gm6803	UTSW	12	88018711	missense	unknown
R5302:Gm6803	UTSW	12	88018546	missense	probably damaging	1.00
R5360:Gm6803	UTSW	12	88018495	missense	probably benign	0.03
R5747:Gm6803	UTSW	12	88018596	missense	possibly damaging	0.93
R6028:Gm6803	UTSW	12	88018361	missense	possibly damaging	0.70
R6275:Gm6803	UTSW	12	88018485	missense	probably benign	0.01
R7689:Gm6803	UTSW	12	88018489	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TAGGCCTTCAGACTTCTTGC -3'
(R):5'- AAGCGTATAGTAGCTCTTGGAAC -3'

Sequencing Primer
(F):5'- GGATTGTACTTTAAGATCACATCAGC -3'
(R):5'- CTTGGAACTGATTCAAAGCCACTGTC -3'

Posted On

2018-06-22