Incidental Mutation 'R6645:Vmn2r6'
ID 526055
Institutional Source Beutler Lab
Gene Symbol Vmn2r6
Ensembl Gene ENSMUSG00000090581
Gene Name vomeronasal 2, receptor 6
Synonyms EG620718, EG667069
MMRRC Submission 044766-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.241) question?
Stock # R6645 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 64537561-64565298 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 64556876 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 179 (V179E)
Ref Sequence ENSEMBL: ENSMUSP00000135148 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165012] [ENSMUST00000176481]
AlphaFold H3BK29
Predicted Effect probably damaging
Transcript: ENSMUST00000165012
AA Change: V90E

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: V90E

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 1.4e-72 PFAM
Pfam:Peripla_BP_6 58 244 1.2e-10 PFAM
Pfam:NCD3G 458 511 1.8e-17 PFAM
Pfam:7tm_3 542 779 3.9e-76 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000176481
AA Change: V179E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: V179E

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 88 505 9.8e-77 PFAM
Pfam:Peripla_BP_6 142 331 3.4e-10 PFAM
Pfam:NCD3G 547 600 5.4e-17 PFAM
Pfam:7tm_3 633 867 3.9e-47 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.0%
  • 20x: 93.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anp32e T A 3: 95,937,102 (GRCm38) F95I probably damaging Het
Arap1 A G 7: 101,408,111 (GRCm38) K628R possibly damaging Het
Arid4b A T 13: 14,120,152 (GRCm38) E6D probably damaging Het
Atxn10 G T 15: 85,376,703 (GRCm38) probably null Het
Ccdc170 A G 10: 4,560,974 (GRCm38) I678V possibly damaging Het
Ccdc18 T A 5: 108,138,930 (GRCm38) V110D probably benign Het
Cep85l C T 10: 53,301,672 (GRCm38) E322K probably benign Het
Cilp A T 9: 65,279,305 (GRCm38) Y894F possibly damaging Het
Ddx4 A G 13: 112,641,174 (GRCm38) S62P possibly damaging Het
Dph7 T C 2: 24,965,651 (GRCm38) V154A probably benign Het
Ephb6 T C 6: 41,617,272 (GRCm38) S579P probably benign Het
Fam53a G T 5: 33,600,784 (GRCm38) Q332K probably benign Het
Fancm A G 12: 65,106,100 (GRCm38) D1110G probably damaging Het
Fh1 A T 1: 175,614,876 (GRCm38) V136E possibly damaging Het
Greb1 G T 12: 16,698,579 (GRCm38) H1132Q probably benign Het
Jph1 A G 1: 17,091,761 (GRCm38) S226P probably damaging Het
Kbtbd8 C T 6: 95,126,749 (GRCm38) R460* probably null Het
Lama5 T A 2: 180,179,670 (GRCm38) N3059Y probably damaging Het
Lipc G A 9: 70,803,748 (GRCm38) T289I probably damaging Het
Lrrc2 T C 9: 110,970,107 (GRCm38) W241R probably damaging Het
Mfn2 T A 4: 147,894,612 (GRCm38) I88F probably damaging Het
Mms19 G C 19: 41,955,191 (GRCm38) N366K probably benign Het
Myo15a A G 11: 60,477,292 (GRCm38) T293A probably benign Het
Ndfip2 T A 14: 105,292,273 (GRCm38) Y179N probably damaging Het
Notch4 A G 17: 34,587,816 (GRCm38) D1909G probably benign Het
Obscn C T 11: 59,085,262 (GRCm38) S2013N probably damaging Het
Oca2 G T 7: 56,314,774 (GRCm38) A357S probably benign Het
Or8b43 T C 9: 38,448,923 (GRCm38) L17S probably damaging Het
Or8g35 T A 9: 39,470,266 (GRCm38) L153F probably benign Het
Pde7b C A 10: 20,610,566 (GRCm38) probably null Het
Ppef2 T C 5: 92,230,461 (GRCm38) N625S probably benign Het
Prom1 A T 5: 44,047,514 (GRCm38) L192Q probably damaging Het
Satb2 T C 1: 56,797,007 (GRCm38) I542V possibly damaging Het
Sgpp2 C T 1: 78,360,162 (GRCm38) T59M probably damaging Het
Skint6 T C 4: 112,892,038 (GRCm38) T782A possibly damaging Het
Slc13a4 G T 6: 35,268,839 (GRCm38) Q624K probably benign Het
Slc9a3 T A 13: 74,164,172 (GRCm38) H629Q probably damaging Het
Slitrk3 G T 3: 73,049,861 (GRCm38) A526E probably benign Het
Spata31e2 T A 1: 26,683,117 (GRCm38) D994V probably benign Het
Sptssa T C 12: 54,646,490 (GRCm38) Y53C probably damaging Het
Srsf10 T C 4: 135,863,563 (GRCm38) S159P possibly damaging Het
Tbce T C 13: 14,005,229 (GRCm38) T341A probably benign Het
Tdrd6 A G 17: 43,624,532 (GRCm38) L1875P probably benign Het
Tkt G A 14: 30,570,211 (GRCm38) G425R probably damaging Het
Tmprss7 T C 16: 45,690,963 (GRCm38) I17M possibly damaging Het
Ttc21b T C 2: 66,236,377 (GRCm38) S311G probably benign Het
Ubr5 A G 15: 38,029,506 (GRCm38) Y492H probably damaging Het
Ush2a T C 1: 188,523,331 (GRCm38) I1535T probably damaging Het
Vmn2r17 A T 5: 109,428,381 (GRCm38) N373Y probably damaging Het
Vps13b A G 15: 35,910,305 (GRCm38) E3405G probably benign Het
Wac A T 18: 7,973,523 (GRCm38) Q212H probably damaging Het
Washc4 C T 10: 83,572,195 (GRCm38) R555* probably null Het
Zmat4 G A 8: 23,797,401 (GRCm38) probably null Het
Other mutations in Vmn2r6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01547:Vmn2r6 APN 3 64,538,104 (GRCm38) missense probably damaging 1.00
IGL01968:Vmn2r6 APN 3 64,556,345 (GRCm38) missense possibly damaging 0.94
IGL02009:Vmn2r6 APN 3 64,537,902 (GRCm38) missense possibly damaging 0.61
IGL02039:Vmn2r6 APN 3 64,556,189 (GRCm38) missense probably damaging 1.00
IGL02652:Vmn2r6 APN 3 64,556,328 (GRCm38) missense probably benign 0.24
IGL02737:Vmn2r6 APN 3 64,556,490 (GRCm38) missense possibly damaging 0.55
IGL02808:Vmn2r6 APN 3 64,556,496 (GRCm38) missense probably damaging 1.00
IGL03066:Vmn2r6 APN 3 64,565,153 (GRCm38) missense probably damaging 0.99
IGL03331:Vmn2r6 APN 3 64,538,007 (GRCm38) missense probably damaging 1.00
BB010:Vmn2r6 UTSW 3 64,559,803 (GRCm38) missense probably benign 0.02
BB020:Vmn2r6 UTSW 3 64,559,803 (GRCm38) missense probably benign 0.02
R0010:Vmn2r6 UTSW 3 64,559,545 (GRCm38) nonsense probably null
R0206:Vmn2r6 UTSW 3 64,539,912 (GRCm38) missense probably benign
R0206:Vmn2r6 UTSW 3 64,539,912 (GRCm38) missense probably benign
R0208:Vmn2r6 UTSW 3 64,539,912 (GRCm38) missense probably benign
R0427:Vmn2r6 UTSW 3 64,559,587 (GRCm38) missense probably damaging 1.00
R0466:Vmn2r6 UTSW 3 64,556,302 (GRCm38) missense probably damaging 1.00
R1018:Vmn2r6 UTSW 3 64,556,840 (GRCm38) missense probably benign 0.00
R1104:Vmn2r6 UTSW 3 64,538,066 (GRCm38) missense possibly damaging 0.93
R1186:Vmn2r6 UTSW 3 64,565,067 (GRCm38) missense probably benign 0.01
R1245:Vmn2r6 UTSW 3 64,556,790 (GRCm38) missense possibly damaging 0.53
R1295:Vmn2r6 UTSW 3 64,538,273 (GRCm38) missense probably damaging 1.00
R1473:Vmn2r6 UTSW 3 64,538,158 (GRCm38) nonsense probably null
R1498:Vmn2r6 UTSW 3 64,556,469 (GRCm38) missense probably damaging 1.00
R1925:Vmn2r6 UTSW 3 64,556,277 (GRCm38) missense possibly damaging 0.87
R2044:Vmn2r6 UTSW 3 64,537,841 (GRCm38) missense probably damaging 0.96
R2069:Vmn2r6 UTSW 3 64,556,098 (GRCm38) missense possibly damaging 0.89
R2253:Vmn2r6 UTSW 3 64,559,718 (GRCm38) missense probably damaging 1.00
R2261:Vmn2r6 UTSW 3 64,556,669 (GRCm38) missense probably benign 0.24
R2262:Vmn2r6 UTSW 3 64,556,669 (GRCm38) missense probably benign 0.24
R2350:Vmn2r6 UTSW 3 64,556,352 (GRCm38) missense probably benign 0.01
R2680:Vmn2r6 UTSW 3 64,538,286 (GRCm38) missense possibly damaging 0.91
R2846:Vmn2r6 UTSW 3 64,556,790 (GRCm38) missense possibly damaging 0.53
R2860:Vmn2r6 UTSW 3 64,547,339 (GRCm38) missense probably benign 0.00
R2861:Vmn2r6 UTSW 3 64,547,339 (GRCm38) missense probably benign 0.00
R3766:Vmn2r6 UTSW 3 64,556,508 (GRCm38) missense probably benign 0.19
R3870:Vmn2r6 UTSW 3 64,556,621 (GRCm38) missense probably damaging 0.96
R4018:Vmn2r6 UTSW 3 64,556,472 (GRCm38) missense probably benign 0.05
R4024:Vmn2r6 UTSW 3 64,538,250 (GRCm38) missense possibly damaging 0.73
R4026:Vmn2r6 UTSW 3 64,538,250 (GRCm38) missense possibly damaging 0.73
R4227:Vmn2r6 UTSW 3 64,537,948 (GRCm38) missense probably damaging 0.99
R4526:Vmn2r6 UTSW 3 64,537,724 (GRCm38) missense probably benign 0.32
R4570:Vmn2r6 UTSW 3 64,559,647 (GRCm38) missense probably benign 0.31
R4894:Vmn2r6 UTSW 3 64,547,408 (GRCm38) missense probably benign
R4934:Vmn2r6 UTSW 3 64,556,345 (GRCm38) missense probably damaging 0.99
R5057:Vmn2r6 UTSW 3 64,537,786 (GRCm38) missense probably damaging 1.00
R5059:Vmn2r6 UTSW 3 64,537,623 (GRCm38) missense possibly damaging 0.89
R5148:Vmn2r6 UTSW 3 64,556,594 (GRCm38) missense probably damaging 0.99
R5155:Vmn2r6 UTSW 3 64,538,514 (GRCm38) missense probably benign 0.44
R5179:Vmn2r6 UTSW 3 64,537,990 (GRCm38) missense probably benign 0.00
R5256:Vmn2r6 UTSW 3 64,556,842 (GRCm38) missense probably benign 0.33
R5861:Vmn2r6 UTSW 3 64,556,033 (GRCm38) missense probably benign 0.00
R5950:Vmn2r6 UTSW 3 64,565,231 (GRCm38) missense probably benign 0.05
R6081:Vmn2r6 UTSW 3 64,556,532 (GRCm38) missense probably benign 0.25
R6173:Vmn2r6 UTSW 3 64,559,755 (GRCm38) missense probably damaging 1.00
R6190:Vmn2r6 UTSW 3 64,538,003 (GRCm38) missense probably benign 0.04
R6240:Vmn2r6 UTSW 3 64,556,805 (GRCm38) missense probably damaging 1.00
R6433:Vmn2r6 UTSW 3 64,547,380 (GRCm38) nonsense probably null
R6791:Vmn2r6 UTSW 3 64,538,159 (GRCm38) missense probably damaging 1.00
R7265:Vmn2r6 UTSW 3 64,556,774 (GRCm38) missense probably benign 0.00
R7503:Vmn2r6 UTSW 3 64,539,951 (GRCm38) nonsense probably null
R7562:Vmn2r6 UTSW 3 64,556,520 (GRCm38) missense probably benign 0.00
R7584:Vmn2r6 UTSW 3 64,565,262 (GRCm38) missense probably benign 0.07
R7611:Vmn2r6 UTSW 3 64,565,142 (GRCm38) missense probably damaging 0.98
R7759:Vmn2r6 UTSW 3 64,556,570 (GRCm38) missense probably damaging 1.00
R7834:Vmn2r6 UTSW 3 64,538,022 (GRCm38) missense probably damaging 1.00
R7933:Vmn2r6 UTSW 3 64,559,803 (GRCm38) missense probably benign 0.02
R7982:Vmn2r6 UTSW 3 64,559,820 (GRCm38) missense probably damaging 1.00
R8024:Vmn2r6 UTSW 3 64,559,824 (GRCm38) missense probably benign 0.40
R8074:Vmn2r6 UTSW 3 64,547,643 (GRCm38) intron probably benign
R8169:Vmn2r6 UTSW 3 64,539,889 (GRCm38) missense probably benign 0.01
R8337:Vmn2r6 UTSW 3 64,556,105 (GRCm38) nonsense probably null
R8736:Vmn2r6 UTSW 3 64,559,800 (GRCm38) missense probably damaging 1.00
R8962:Vmn2r6 UTSW 3 64,556,155 (GRCm38) missense probably damaging 1.00
R9139:Vmn2r6 UTSW 3 64,556,856 (GRCm38) missense probably benign 0.12
R9206:Vmn2r6 UTSW 3 64,559,611 (GRCm38) missense probably damaging 0.97
R9295:Vmn2r6 UTSW 3 64,556,063 (GRCm38) missense probably benign 0.00
R9332:Vmn2r6 UTSW 3 64,547,250 (GRCm38) missense probably benign 0.01
R9616:Vmn2r6 UTSW 3 64,538,303 (GRCm38) missense probably damaging 1.00
R9663:Vmn2r6 UTSW 3 64,556,128 (GRCm38) missense possibly damaging 0.90
R9685:Vmn2r6 UTSW 3 64,556,660 (GRCm38) missense probably benign 0.19
X0020:Vmn2r6 UTSW 3 64,538,450 (GRCm38) missense probably benign
X0066:Vmn2r6 UTSW 3 64,547,378 (GRCm38) missense probably damaging 1.00
Z1176:Vmn2r6 UTSW 3 64,556,325 (GRCm38) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- AACACAAAGGTTGGCCCTCTC -3'
(R):5'- TGTCAAAATTGTCCCCATCTACAC -3'

Sequencing Primer
(F):5'- AAAGGTTGGCCCTCTCCATTTC -3'
(R):5'- TTGTCCCCATCTACACCCAGAAAG -3'
Posted On 2018-06-22