|Institutional Source||Beutler Lab|
|Gene Name||taste receptor, type 2, member 138|
|Synonyms||mt2r31, T2R138, Tas2r38|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6647 (G1)|
|Chromosomal Location||40612315-40613310 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to T at 40612799 bp|
|Amino Acid Change||Threonine to Lysine at position 171 (T171K)|
|Ref Sequence||ENSEMBL: ENSMUSP00000075876 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000076565]|
|Predicted Effect||possibly damaging
AA Change: T171K
PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
AA Change: T171K
|Meta Mutation Damage Score||0.09|
|Coding Region Coverage||
|Validation Efficiency||98% (53/54)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tas2r138||
(F):5'- GACTTCATAGTCCTCATGTGACTC -3'
(R):5'- AAGCCATCCTCACTCTCTGG -3'
(F):5'- ATAGTCCTCATGTGACTCCCCAG -3'
(R):5'- CTCTCTGGATGATTGCAAACCAAGTG -3'