Incidental Mutation 'R6647:Tas2r138'
ID 526121
Institutional Source Beutler Lab
Gene Symbol Tas2r138
Ensembl Gene ENSMUSG00000058250
Gene Name taste receptor, type 2, member 138
Synonyms T2R138, mt2r31, Tas2r38
MMRRC Submission 044768-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6647 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 40589249-40590244 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 40589733 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 171 (T171K)
Ref Sequence ENSEMBL: ENSMUSP00000075876 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076565]
AlphaFold Q7TQA6
Predicted Effect possibly damaging
Transcript: ENSMUST00000076565
AA Change: T171K

PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000075876
Gene: ENSMUSG00000058250
AA Change: T171K

DomainStartEndE-ValueType
Pfam:TAS2R 11 315 3.8e-64 PFAM
Meta Mutation Damage Score 0.3429 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.6%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agl T C 3: 116,544,060 (GRCm39) T1416A probably damaging Het
Atp7b A G 8: 22,518,494 (GRCm39) S103P probably damaging Het
Ces1h A C 8: 94,078,654 (GRCm39) *563G probably null Het
Cfap157 G T 2: 32,669,086 (GRCm39) A339E probably benign Het
Crebbp C T 16: 3,937,670 (GRCm39) A698T possibly damaging Het
Cyp2b13 A G 7: 25,785,324 (GRCm39) H231R possibly damaging Het
Ddx31 A T 2: 28,765,750 (GRCm39) T483S probably damaging Het
Defa25 A T 8: 21,575,201 (GRCm39) D60V possibly damaging Het
Dnah5 G A 15: 28,403,633 (GRCm39) A3453T probably benign Het
Dnah6 A T 6: 73,115,743 (GRCm39) F1500I probably damaging Het
Eprs1 C T 1: 185,146,621 (GRCm39) A1217V probably damaging Het
Ermp1 T C 19: 29,604,335 (GRCm39) Y481C probably benign Het
Fmn2 T A 1: 174,420,670 (GRCm39) N635K unknown Het
Fras1 A G 5: 96,883,061 (GRCm39) D2531G probably damaging Het
Frat1 C T 19: 41,819,264 (GRCm39) Q220* probably null Het
Gcc2 T A 10: 58,123,103 (GRCm39) probably null Het
Gm3285 T C 10: 77,698,447 (GRCm39) probably benign Het
Gm9857 T C 3: 108,847,379 (GRCm39) probably benign Het
Grin2b C A 6: 135,710,108 (GRCm39) W1146L probably damaging Het
Hells T A 19: 38,919,948 (GRCm39) L33I probably benign Het
Ift81 T A 5: 122,748,229 (GRCm39) R54* probably null Het
Ints12 G A 3: 132,802,639 (GRCm39) R41Q possibly damaging Het
Katnal2 C T 18: 77,067,733 (GRCm39) E403K probably benign Het
Kcnk1 A G 8: 126,722,199 (GRCm39) M1V probably null Het
Kdm5a A G 6: 120,389,422 (GRCm39) T950A probably benign Het
Kdr G A 5: 76,113,549 (GRCm39) A773V probably damaging Het
Lats1 G C 10: 7,573,271 (GRCm39) M118I possibly damaging Het
Mug1 A G 6: 121,817,200 (GRCm39) I90V probably benign Het
Nid2 A G 14: 19,852,484 (GRCm39) D1064G probably benign Het
Nkx2-4 A T 2: 146,926,187 (GRCm39) I225N possibly damaging Het
Nlrp4e A G 7: 23,020,740 (GRCm39) D409G probably benign Het
Ogfod2 G C 5: 124,252,866 (GRCm39) R292P possibly damaging Het
Oprk1 C T 1: 5,672,507 (GRCm39) P215S probably damaging Het
Or5d36 A T 2: 87,901,053 (GRCm39) F224L probably benign Het
Or6c35 T A 10: 129,169,033 (GRCm39) C94* probably null Het
Or7g27 T A 9: 19,249,925 (GRCm39) H56Q possibly damaging Het
Or8g21 T C 9: 38,906,210 (GRCm39) I174V possibly damaging Het
Pcdhb16 A G 18: 37,612,225 (GRCm39) K395R possibly damaging Het
Ptprg C A 14: 11,962,714 (GRCm38) P171T probably damaging Het
Pycard T C 7: 127,592,741 (GRCm39) T29A probably benign Het
Rap1gap2 G A 11: 74,298,754 (GRCm39) A452V probably benign Het
Rasgrf1 C G 9: 89,892,516 (GRCm39) T1072S probably benign Het
Rc3h2 G A 2: 37,272,956 (GRCm39) R707* probably null Het
Rsf1 G A 7: 97,229,117 (GRCm39) probably benign Het
Senp7 T C 16: 55,993,618 (GRCm39) I767T probably damaging Het
Setd7 A G 3: 51,450,183 (GRCm39) V81A probably benign Het
Shisal2a A G 4: 108,225,224 (GRCm39) S113P probably benign Het
Shkbp1 A G 7: 27,041,800 (GRCm39) S685P probably benign Het
Snrnp200 A G 2: 127,068,372 (GRCm39) E904G probably damaging Het
Spata22 T A 11: 73,245,526 (GRCm39) probably null Het
Spata31e2 T A 1: 26,721,659 (GRCm39) N1174Y probably damaging Het
Tor1aip1 T C 1: 155,893,999 (GRCm39) D77G possibly damaging Het
Vav3 A T 3: 109,434,732 (GRCm39) H421L probably benign Het
Vmn1r43 A G 6: 89,846,841 (GRCm39) L215P probably damaging Het
Vmn2r100 T A 17: 19,742,785 (GRCm39) S386R probably benign Het
Xpa T A 4: 46,183,089 (GRCm39) R233S probably benign Het
Other mutations in Tas2r138
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00550:Tas2r138 APN 6 40,589,520 (GRCm39) missense probably benign 0.07
IGL01468:Tas2r138 APN 6 40,589,410 (GRCm39) missense probably benign 0.22
IGL02626:Tas2r138 APN 6 40,589,649 (GRCm39) missense possibly damaging 0.61
IGL03008:Tas2r138 APN 6 40,590,116 (GRCm39) missense probably damaging 1.00
R0595:Tas2r138 UTSW 6 40,589,799 (GRCm39) missense probably damaging 1.00
R2845:Tas2r138 UTSW 6 40,589,701 (GRCm39) missense probably benign 0.09
R2975:Tas2r138 UTSW 6 40,590,198 (GRCm39) missense probably benign 0.00
R4202:Tas2r138 UTSW 6 40,589,410 (GRCm39) missense possibly damaging 0.95
R4923:Tas2r138 UTSW 6 40,589,820 (GRCm39) missense possibly damaging 0.82
R5526:Tas2r138 UTSW 6 40,589,914 (GRCm39) missense probably benign 0.00
R6869:Tas2r138 UTSW 6 40,589,355 (GRCm39) missense probably damaging 1.00
R8781:Tas2r138 UTSW 6 40,589,850 (GRCm39) missense probably benign 0.00
R8786:Tas2r138 UTSW 6 40,589,611 (GRCm39) missense probably damaging 1.00
R9200:Tas2r138 UTSW 6 40,589,494 (GRCm39) missense probably damaging 1.00
R9258:Tas2r138 UTSW 6 40,590,129 (GRCm39) missense probably damaging 1.00
R9475:Tas2r138 UTSW 6 40,589,392 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GACTTCATAGTCCTCATGTGACTC -3'
(R):5'- AAGCCATCCTCACTCTCTGG -3'

Sequencing Primer
(F):5'- ATAGTCCTCATGTGACTCCCCAG -3'
(R):5'- CTCTCTGGATGATTGCAAACCAAGTG -3'
Posted On 2018-06-22