Incidental Mutation 'R6613:Trip10'
ID 526312
Institutional Source Beutler Lab
Gene Symbol Trip10
Ensembl Gene ENSMUSG00000019487
Gene Name thyroid hormone receptor interactor 10
Synonyms Cip4
MMRRC Submission 044736-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.753) question?
Stock # R6613 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 57556455-57570665 bp(+) (GRCm39)
Type of Mutation splice site (33 bp from exon)
DNA Base Change (assembly) A to G at 57562197 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019631] [ENSMUST00000224152] [ENSMUST00000224885] [ENSMUST00000224947] [ENSMUST00000225664]
AlphaFold Q8CJ53
Predicted Effect probably null
Transcript: ENSMUST00000019631
SMART Domains Protein: ENSMUSP00000019631
Gene: ENSMUSG00000019487

DomainStartEndE-ValueType
FCH 1 94 9.95e-29 SMART
coiled coil region 117 197 N/A INTRINSIC
low complexity region 310 318 N/A INTRINSIC
PDB:2KE4|A 332 425 3e-35 PDB
low complexity region 433 455 N/A INTRINSIC
low complexity region 458 467 N/A INTRINSIC
SH3 489 546 2.44e-11 SMART
Predicted Effect probably null
Transcript: ENSMUST00000224152
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224261
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224586
Predicted Effect probably null
Transcript: ENSMUST00000224885
Predicted Effect probably null
Transcript: ENSMUST00000224947
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225523
Predicted Effect probably benign
Transcript: ENSMUST00000225664
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.9%
Validation Efficiency 97% (37/38)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased insulin-stimulated glucose uptake in adipocytes and decreased circulating glucose levels. Mice homozygous for another knock-out allele exhibit impaired integrin-dependent T-cell trafficking. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano2 G A 6: 125,783,619 (GRCm39) probably null Het
Arfgef1 A T 1: 10,264,621 (GRCm39) I475N possibly damaging Het
Atg16l2 C T 7: 100,939,788 (GRCm39) probably null Het
Atp2c2 T G 8: 120,482,760 (GRCm39) L874R probably damaging Het
C2cd3 T A 7: 100,044,448 (GRCm39) S343R possibly damaging Het
C4b A T 17: 34,952,539 (GRCm39) S1167T probably damaging Het
Cacna1i G A 15: 80,205,460 (GRCm39) G139S probably damaging Het
Chil6 A T 3: 106,297,191 (GRCm39) F317I probably benign Het
Cngb1 A T 8: 95,992,638 (GRCm39) V199E possibly damaging Het
Dcn A T 10: 97,330,902 (GRCm39) T79S probably benign Het
Dcxr A G 11: 120,617,832 (GRCm39) V48A probably benign Het
Dnajc13 A T 9: 104,091,076 (GRCm39) D668E probably benign Het
Dnajc28 C A 16: 91,413,246 (GRCm39) E357* probably null Het
Dock7 A G 4: 98,866,197 (GRCm39) Y1198H probably damaging Het
Flot1 A G 17: 36,136,703 (GRCm39) D167G probably damaging Het
Gpn1 T C 5: 31,654,696 (GRCm39) probably null Het
Hyou1 A T 9: 44,293,795 (GRCm39) I242F probably damaging Het
Igfbpl1 T C 4: 45,813,447 (GRCm39) N256S probably benign Het
Kif20b C T 19: 34,914,384 (GRCm39) Q390* probably null Het
Lhfpl2 T A 13: 94,311,003 (GRCm39) F91Y probably damaging Het
Magi1 G A 6: 93,722,654 (GRCm39) T408I probably damaging Het
Mttp T C 3: 137,814,839 (GRCm39) N479D probably damaging Het
Myom3 T C 4: 135,539,770 (GRCm39) V1339A possibly damaging Het
Nin T C 12: 70,077,728 (GRCm39) K1733E probably damaging Het
Or5k1 C A 16: 58,617,894 (GRCm39) C105F probably damaging Het
Pdzrn4 T C 15: 92,575,455 (GRCm39) I287T probably damaging Het
Ptprt A G 2: 161,372,367 (GRCm39) V1435A probably damaging Het
Rpap3 T C 15: 97,579,722 (GRCm39) probably null Het
Scin A G 12: 40,129,714 (GRCm39) Y360H probably benign Het
Sfxn5 A G 6: 85,246,890 (GRCm39) probably null Het
Sgo1 A G 17: 53,986,085 (GRCm39) S369P probably damaging Het
Skil T A 3: 31,152,029 (GRCm39) C184S probably null Het
Srcin1 A G 11: 97,424,653 (GRCm39) M607T possibly damaging Het
Ssc5d C T 7: 4,936,292 (GRCm39) P513S possibly damaging Het
Vmn2r114 T A 17: 23,529,220 (GRCm39) Q294L possibly damaging Het
Zc3h12c A G 9: 52,027,412 (GRCm39) V650A possibly damaging Het
Other mutations in Trip10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01071:Trip10 APN 17 57,561,332 (GRCm39) missense possibly damaging 0.91
IGL01639:Trip10 APN 17 57,561,165 (GRCm39) unclassified probably benign
IGL01758:Trip10 APN 17 57,568,409 (GRCm39) missense possibly damaging 0.51
IGL02184:Trip10 APN 17 57,564,272 (GRCm39) missense probably damaging 1.00
IGL02554:Trip10 APN 17 57,570,135 (GRCm39) missense probably damaging 0.99
IGL02641:Trip10 APN 17 57,569,411 (GRCm39) missense probably benign 0.06
R0092:Trip10 UTSW 17 57,557,798 (GRCm39) missense possibly damaging 0.46
R0139:Trip10 UTSW 17 57,568,633 (GRCm39) splice site probably null
R0179:Trip10 UTSW 17 57,569,349 (GRCm39) splice site probably benign
R1173:Trip10 UTSW 17 57,560,363 (GRCm39) missense probably damaging 0.98
R1416:Trip10 UTSW 17 57,557,800 (GRCm39) missense probably damaging 1.00
R2223:Trip10 UTSW 17 57,570,039 (GRCm39) missense possibly damaging 0.70
R2259:Trip10 UTSW 17 57,562,135 (GRCm39) missense probably benign 0.00
R3950:Trip10 UTSW 17 57,560,411 (GRCm39) critical splice donor site probably null
R4420:Trip10 UTSW 17 57,562,448 (GRCm39) missense probably benign 0.05
R4643:Trip10 UTSW 17 57,568,658 (GRCm39) nonsense probably null
R4940:Trip10 UTSW 17 57,570,017 (GRCm39) missense possibly damaging 0.65
R5189:Trip10 UTSW 17 57,568,288 (GRCm39) critical splice acceptor site probably null
R5595:Trip10 UTSW 17 57,569,460 (GRCm39) missense probably damaging 1.00
R5946:Trip10 UTSW 17 57,557,963 (GRCm39) missense probably damaging 0.99
R6738:Trip10 UTSW 17 57,563,899 (GRCm39) missense probably benign
R6948:Trip10 UTSW 17 57,569,448 (GRCm39) missense probably damaging 1.00
R6994:Trip10 UTSW 17 57,562,331 (GRCm39) missense probably damaging 1.00
R7489:Trip10 UTSW 17 57,557,966 (GRCm39) missense probably damaging 1.00
R7729:Trip10 UTSW 17 57,569,442 (GRCm39) missense probably damaging 1.00
R7750:Trip10 UTSW 17 57,568,667 (GRCm39) missense possibly damaging 0.58
R8260:Trip10 UTSW 17 57,564,314 (GRCm39) missense probably benign
R8781:Trip10 UTSW 17 57,562,313 (GRCm39) missense probably benign 0.01
R9005:Trip10 UTSW 17 57,569,416 (GRCm39) missense probably damaging 0.99
R9108:Trip10 UTSW 17 57,560,519 (GRCm39) missense probably damaging 1.00
RF024:Trip10 UTSW 17 57,562,045 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACTTCCCTATCAAGCCTGGG -3'
(R):5'- AGGCACTCGGTTGATAACTTGG -3'

Sequencing Primer
(F):5'- TCTCCAGAAGCTGCAGGACATG -3'
(R):5'- GCACTCGGTTGATAACTTGGCTAAAG -3'
Posted On 2018-06-22