Incidental Mutation 'R6589:Cramp1l'
ID 526388
Institutional Source Beutler Lab
Gene Symbol Cramp1l
Ensembl Gene ENSMUSG00000038002
Gene Name cramped chromatin regulator homolog 1
Synonyms 5830477H08Rik, Tce4
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6589 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 24961228-25015230 bp(-) (GRCm38)
Type of Mutation splice site (4 bp from exon)
DNA Base Change (assembly) T to C at 24977492 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000073060 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073337]
AlphaFold Q6PG95
Predicted Effect probably null
Transcript: ENSMUST00000073337
SMART Domains Protein: ENSMUSP00000073060
Gene: ENSMUSG00000038002

DomainStartEndE-ValueType
low complexity region 11 20 N/A INTRINSIC
low complexity region 29 43 N/A INTRINSIC
low complexity region 51 64 N/A INTRINSIC
low complexity region 100 126 N/A INTRINSIC
low complexity region 134 147 N/A INTRINSIC
SANT 159 219 3.68e-3 SMART
low complexity region 479 503 N/A INTRINSIC
low complexity region 548 562 N/A INTRINSIC
low complexity region 792 803 N/A INTRINSIC
low complexity region 833 845 N/A INTRINSIC
low complexity region 889 903 N/A INTRINSIC
low complexity region 1069 1086 N/A INTRINSIC
low complexity region 1113 1124 N/A INTRINSIC
low complexity region 1141 1156 N/A INTRINSIC
low complexity region 1171 1185 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.0%
Validation Efficiency 100% (26/26)
MGI Phenotype PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit cleft palate. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd55 G A 13: 112,348,863 probably null Het
Asic2 G T 11: 80,886,604 A427D possibly damaging Het
B3gnt2 T A 11: 22,837,117 I24F probably damaging Het
BC030500 T C 8: 58,912,922 probably benign Het
Cdh4 G A 2: 179,881,996 probably null Het
Fam19a2 T A 10: 123,704,392 V51E probably damaging Het
Fam72a A T 1: 131,533,816 I80F probably damaging Het
Fbxo43 T C 15: 36,162,540 T174A probably damaging Het
Fgf11 C A 11: 69,799,435 V109L probably damaging Het
Fggy A G 4: 95,597,638 I74V probably benign Het
Fshr T C 17: 88,988,607 D224G probably damaging Het
Gm5415 A T 1: 32,546,711 D39E probably benign Het
Gm6465 A G 5: 11,848,161 T81A possibly damaging Het
Gm9268 T A 7: 43,023,598 S142T possibly damaging Het
Hdac9 T C 12: 34,215,029 E908G probably damaging Het
Hspa4l T G 3: 40,757,055 L121V probably damaging Het
Klk1b16 A G 7: 44,141,470 D232G probably benign Het
Lpl G T 8: 68,896,807 M328I probably benign Het
Mgat4a T C 1: 37,444,895 E498G probably damaging Het
Mup11 T A 4: 60,659,541 Q91L possibly damaging Het
Myoc T A 1: 162,648,619 Y297* probably null Het
Olfr126 T A 17: 37,850,836 Y81* probably null Het
Siva1 A G 12: 112,646,838 E40G probably damaging Het
Smarca2 T A 19: 26,619,884 H55Q possibly damaging Het
Taf1b A G 12: 24,556,528 E449G possibly damaging Het
Tcaf3 A T 6: 42,594,061 N252K possibly damaging Het
Trim3 A G 7: 105,617,960 L404P probably damaging Het
Vmn2r114 T C 17: 23,291,668 T613A probably damaging Het
Zfp358 T A 8: 3,495,907 F163Y probably damaging Het
Other mutations in Cramp1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00566:Cramp1l APN 17 24983951 missense probably benign 0.11
IGL01360:Cramp1l APN 17 24997573 missense probably damaging 1.00
IGL01966:Cramp1l APN 17 24982943 missense probably benign 0.01
IGL02211:Cramp1l APN 17 24977636 missense possibly damaging 0.94
IGL02474:Cramp1l APN 17 24985050 missense probably damaging 0.98
IGL02798:Cramp1l APN 17 24968920 splice site probably benign
IGL03340:Cramp1l APN 17 24973542 missense probably damaging 1.00
R0106:Cramp1l UTSW 17 24972376 missense probably benign 0.30
R1054:Cramp1l UTSW 17 24983177 missense probably damaging 1.00
R1220:Cramp1l UTSW 17 24982237 missense probably damaging 1.00
R1341:Cramp1l UTSW 17 24977540 missense probably damaging 1.00
R1491:Cramp1l UTSW 17 24972349 missense probably benign 0.17
R1610:Cramp1l UTSW 17 24983951 missense probably benign 0.11
R1649:Cramp1l UTSW 17 24983243 missense probably damaging 1.00
R1795:Cramp1l UTSW 17 24964910 missense probably damaging 1.00
R1856:Cramp1l UTSW 17 24968978 missense probably damaging 1.00
R1881:Cramp1l UTSW 17 24977682 splice site probably benign
R1968:Cramp1l UTSW 17 24964939 missense probably damaging 1.00
R2047:Cramp1l UTSW 17 25003215 nonsense probably null
R2099:Cramp1l UTSW 17 24973085 missense probably benign 0.01
R2298:Cramp1l UTSW 17 24997480 missense probably damaging 0.96
R3752:Cramp1l UTSW 17 24971558 missense probably damaging 1.00
R3821:Cramp1l UTSW 17 24974782 missense probably damaging 1.00
R3861:Cramp1l UTSW 17 24997614 splice site probably benign
R4399:Cramp1l UTSW 17 24979585 missense probably damaging 1.00
R4847:Cramp1l UTSW 17 24985089 missense probably damaging 1.00
R4883:Cramp1l UTSW 17 24982319 missense probably benign
R5579:Cramp1l UTSW 17 24973113 missense possibly damaging 0.89
R5631:Cramp1l UTSW 17 24985603 missense possibly damaging 0.93
R5716:Cramp1l UTSW 17 24974735 missense probably damaging 0.99
R6631:Cramp1l UTSW 17 24983957 missense probably benign 0.40
R7307:Cramp1l UTSW 17 24974745 missense possibly damaging 0.94
R7323:Cramp1l UTSW 17 24982405 missense possibly damaging 0.90
R7672:Cramp1l UTSW 17 24982466 missense probably damaging 0.96
R7832:Cramp1l UTSW 17 24983222 missense probably damaging 0.96
R8071:Cramp1l UTSW 17 24982700 missense probably damaging 0.99
R8244:Cramp1l UTSW 17 24971410 missense probably damaging 1.00
R8430:Cramp1l UTSW 17 24977562 missense probably damaging 1.00
R8783:Cramp1l UTSW 17 24974758 missense probably damaging 0.99
R8890:Cramp1l UTSW 17 24983140 missense probably damaging 1.00
R8892:Cramp1l UTSW 17 24983140 missense probably damaging 1.00
R8894:Cramp1l UTSW 17 24983140 missense probably damaging 1.00
R8937:Cramp1l UTSW 17 24983982 missense probably damaging 0.99
R8941:Cramp1l UTSW 17 24983140 missense probably damaging 1.00
R9029:Cramp1l UTSW 17 25013910 missense probably damaging 1.00
R9047:Cramp1l UTSW 17 24979629 missense possibly damaging 0.90
R9149:Cramp1l UTSW 17 24968946 missense probably damaging 0.99
R9262:Cramp1l UTSW 17 25013946 missense probably damaging 0.99
R9460:Cramp1l UTSW 17 25003307 missense probably damaging 1.00
R9614:Cramp1l UTSW 17 24982809 missense probably damaging 1.00
R9615:Cramp1l UTSW 17 24982809 missense probably damaging 1.00
R9651:Cramp1l UTSW 17 24982809 missense probably damaging 1.00
R9652:Cramp1l UTSW 17 24982809 missense probably damaging 1.00
R9653:Cramp1l UTSW 17 24982809 missense probably damaging 1.00
R9665:Cramp1l UTSW 17 24977571 missense probably damaging 1.00
R9753:Cramp1l UTSW 17 24972346 missense possibly damaging 0.81
Predicted Primers
Posted On 2018-06-25