Mutagenetix > Incidental Mutation

Incidental Mutation 'R6594:Gm15293'

526390

Institutional Source

Beutler Lab

Gene Symbol

Gm15293

Ensembl Gene

ENSMUSG00000079116

Gene Name

predicted gene 15293

Synonyms

MMRRC Submission

044718-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R6594 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

21201561-21202539 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 21202455 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000106382 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110754]

AlphaFold

D3YX02

Predicted Effect

probably null
Transcript: ENSMUST00000110754

SMART Domains

Protein: ENSMUSP00000106382
Gene: ENSMUSG00000079116

Domain	Start	End	E-Value	Type
Pfam:Defensin_propep	1	51	3.5e-24	PFAM
DEFSN	64	92	7.12e-7	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.2%
20x: 94.9%

Validation Efficiency

96% (52/54)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aass	T	C	6: 23,113,433	N296S	probably benign	Het
Abca13	A	T	11: 9,294,632	N2165I	possibly damaging	Het
Anpep	T	A	7: 79,841,361		probably null	Het
Bcl2a1b	A	C	9: 89,207,594	I145L	probably benign	Het
Ccar2	G	A	14: 70,140,476	L687F	probably damaging	Het
Cd69	A	G	6: 129,269,574		probably null	Het
Chchd10	A	C	10: 75,936,324	Q43P	probably damaging	Het
Ddx55	A	G	5: 124,566,925	E415G	probably damaging	Het
Dhx40	A	T	11: 86,785,773	C172S	possibly damaging	Het
Epha1	G	A	6: 42,364,691	T475I	probably benign	Het
Eri1	T	C	8: 35,482,533	T91A	probably damaging	Het
Fscn1	C	T	5: 142,970,028	A158V	probably benign	Het
Gm11437	C	T	11: 84,164,560	G77R	probably null	Het
Gm15922	T	A	7: 3,736,499	K457*	probably null	Het
Golm1	T	C	13: 59,664,227	N94D	possibly damaging	Het
Gpat2	G	C	2: 127,431,918	G294R	possibly damaging	Het
Haus4	C	A	14: 54,543,811	E269D	possibly damaging	Het
Hyou1	T	C	9: 44,389,322	M896T	probably benign	Het
Itpr2	T	A	6: 146,190,480	M2174L	possibly damaging	Het
Kars	T	C	8: 111,993,667		probably benign	Het
Kif1a	T	C	1: 93,021,313	M1488V	probably benign	Het
Lrp2	T	C	2: 69,439,923	T4106A	possibly damaging	Het
Lrrc20	G	A	10: 61,482,446	V16I	possibly damaging	Het
Mecr	T	A	4: 131,854,693	V162E	probably damaging	Het
Ms4a4a	C	A	19: 11,386,414	A102E	probably damaging	Het
Mycn	T	C	12: 12,940,050	D115G	probably damaging	Het
Ninj2	A	T	6: 120,198,789	T138S	possibly damaging	Het
Oasl2	G	A	5: 114,906,775	V121I	probably benign	Het
Olfr458	A	T	6: 42,460,375	S215T	probably benign	Het
Olfr832	T	C	9: 18,944,831	F61S	probably damaging	Het
Olfr982	T	C	9: 40,074,943	L216P	probably damaging	Het
Pcdha11	A	C	18: 37,011,182	I109L	probably benign	Het
Pon1	A	G	6: 5,185,314	L62P	probably damaging	Het
Rp1l1	A	T	14: 64,031,677	K1571*	probably null	Het
Sec24d	G	T	3: 123,293,763	G193C	probably damaging	Het
Sema3b	A	T	9: 107,598,826	M732K	probably benign	Het
Serpinb8	T	C	1: 107,597,471	M1T	probably null	Het
Sgip1	T	A	4: 102,962,479	V594E	probably damaging	Het
Slc3a2	T	C	19: 8,708,046	S197G	probably damaging	Het
Slc44a5	T	C	3: 154,259,023	V520A	possibly damaging	Het
Surf6	G	T	2: 26,902,749	D13E	possibly damaging	Het
Tmem94	G	A	11: 115,798,286	R1341H	probably damaging	Het
Tns2	G	A	15: 102,110,559	R395Q	probably benign	Het
Traf7	A	G	17: 24,509,839	V591A	possibly damaging	Het
Trim72	T	C	7: 128,010,048	S341P	probably damaging	Het
Trps1	A	G	15: 50,830,955	V398A	probably damaging	Het
Ube2m	C	A	7: 13,037,690	E14*	probably null	Het
Unc119	T	A	11: 78,347,220	Y10N	probably damaging	Het
Ush2a	T	C	1: 188,910,798	L4119P	possibly damaging	Het
Vcp	A	T	4: 42,993,826	I102N	probably damaging	Het
Vmn2r4	A	G	3: 64,389,310	S685P	probably damaging	Het
Vmn2r58	T	C	7: 41,837,111	M787V	possibly damaging	Het
Vmn2r72	T	C	7: 85,749,684	H487R	probably benign	Het
Xcr1	A	G	9: 123,856,244	I151T	probably benign	Het
Zfp658	T	C	7: 43,567,277	S24P	possibly damaging	Het
Zfyve16	T	C	13: 92,513,818	D886G	probably benign	Het

Other mutations in Gm15293

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1077:Gm15293	UTSW	8	21202433	missense	probably benign	0.00
R3762:Gm15293	UTSW	8	21201737	missense	probably damaging	0.99
R4963:Gm15293	UTSW	8	21201758	missense	probably damaging	0.98
R5170:Gm15293	UTSW	8	21201680	missense	probably damaging	1.00
R6148:Gm15293	UTSW	8	21202412	missense	probably benign	0.00

Predicted Primers

Posted On

2018-06-25