Mutagenetix > Incidental Mutations

Incidental Mutation 'R6653:Vmn2r112'

526534

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r112

Ensembl Gene

ENSMUSG00000094921

Gene Name

vomeronasal 2, receptor 112

Synonyms

EG628185

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R6653 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

22601148-22619133 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 22601179 bp

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 11 (L11Q)

Ref Sequence

ENSEMBL: ENSMUSP00000094994 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097381]

Predicted Effect

probably null
Transcript: ENSMUST00000097381
AA Change: L11Q

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: L11Q

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.8e-32	PFAM
Pfam:NCD3G	512	565	5.8e-21	PFAM
Pfam:7tm_3	598	833	6.5e-54	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 98.6%
20x: 96.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca15	T	G	7: 120,346,006	L435R	probably benign	Het
Abcc2	T	A	19: 43,812,502	H627Q	probably benign	Het
Ankhd1	A	T	18: 36,600,783		probably null	Het
Ankrd50	T	A	3: 38,457,361	I286F	probably damaging	Het
Asb15	A	G	6: 24,562,633	N198S	probably benign	Het
B4galnt2	T	A	11: 95,891,921	M22L	probably benign	Het
Bcdin3d	T	C	15: 99,470,815	T168A	probably damaging	Het
Bmp1	A	T	14: 70,490,618	W624R	probably damaging	Het
Cdh4	C	T	2: 179,780,428	A115V	probably benign	Het
Cfap53	A	G	18: 74,300,209	T122A	probably damaging	Het
Chsy1	A	G	7: 66,110,193	K95E	probably benign	Het
Csde1	C	A	3: 103,052,868	P604T	probably damaging	Het
Cts7	A	T	13: 61,355,003	L237Q	probably damaging	Het
Cutal	C	T	2: 34,885,921	T88I	probably benign	Het
Dlg4	G	T	11: 70,023,953		probably benign	Het
Dnah7c	C	A	1: 46,649,340	T1890K	probably benign	Het
Dnah7c	A	G	1: 46,649,351	S1894G	probably benign	Het
Eif2b4	C	T	5: 31,192,207	E53K	possibly damaging	Het
Erp44	T	C	4: 48,205,130	I288V	probably null	Het
Fcamr	A	G	1: 130,813,202	T453A	possibly damaging	Het
Glb1l3	T	C	9: 26,859,588	T61A	probably benign	Het
Gpr26	T	C	7: 131,984,101	S267P	probably benign	Het
Heatr6	A	T	11: 83,759,365	T216S	probably benign	Het
Hephl1	C	T	9: 15,081,964	V525I	probably damaging	Het
Jak2	T	A	19: 29,288,710	I517N	probably benign	Het
Kbtbd4	T	A	2: 90,909,769	Y499*	probably null	Het
Kif1a	A	T	1: 93,077,698	I118N	probably damaging	Het
Klhdc7b	A	G	15: 89,387,089	S725G	probably benign	Het
Mfsd13a	T	C	19: 46,367,866	F137L	probably damaging	Het
Myo7a	T	A	7: 98,054,503	Y1977F	probably damaging	Het
Naip2	C	T	13: 100,152,136	V1194I	probably benign	Het
Naip2	T	G	13: 100,161,844	K561N	probably benign	Het
Nkx2-4	G	T	2: 147,083,940	A334E	possibly damaging	Het
Nlrp9c	T	A	7: 26,371,322	N945Y	probably damaging	Het
Olfr1507	C	T	14: 52,490,793	R57Q	probably benign	Het
Olfr30	A	T	11: 58,455,568	I127N	probably damaging	Het
Olfr44	A	G	9: 39,484,752	V164A	probably benign	Het
Pcdha7	A	G	18: 36,974,486	Q188R	probably benign	Het
Phf3	A	T	1: 30,805,023	S1618R	possibly damaging	Het
Phip	C	A	9: 82,900,741	E884*	probably null	Het
Plxnc1	C	A	10: 94,943,876	V235L	probably damaging	Het
Qser1	A	G	2: 104,780,260	V1226A	possibly damaging	Het
Ros1	G	T	10: 52,142,203	S786R	probably damaging	Het
Rps6ka5	A	G	12: 100,551,536	S769P	probably damaging	Het
Sfxn3	G	A	19: 45,049,915		probably null	Het
Specc1	T	G	11: 62,146,418	S813A	probably damaging	Het
Spry1	T	C	3: 37,642,722	I38T	probably damaging	Het
Tagap	T	C	17: 7,933,714	V577A	probably benign	Het
Tmem44	T	C	16: 30,537,551	D110G	probably damaging	Het
Ubn2	A	G	6: 38,434,462	E97G	possibly damaging	Het
Ubr4	C	A	4: 139,473,624	H4706Q	possibly damaging	Het
Usp25	T	A	16: 77,059,288	N256K	probably benign	Het
Wnt2b	C	A	3: 104,953,186	R135L	probably damaging	Het
Zfp60	T	C	7: 27,748,726	F273S	probably benign	Het

Other mutations in Vmn2r112

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Vmn2r112	APN	17	22618936	missense	probably benign	0.13
IGL01021:Vmn2r112	APN	17	22618904	missense	probably damaging	1.00
IGL01122:Vmn2r112	APN	17	22603007	missense	probably benign	0.00
IGL01360:Vmn2r112	APN	17	22618622	missense	probably benign	0.03
IGL01536:Vmn2r112	APN	17	22605155	missense	probably damaging	1.00
IGL02148:Vmn2r112	APN	17	22619032	missense	probably damaging	1.00
IGL02465:Vmn2r112	APN	17	22614994	missense	probably damaging	1.00
PIT4576001:Vmn2r112	UTSW	17	22614931	missense	probably benign	0.00
R0278:Vmn2r112	UTSW	17	22603006	missense	probably benign	0.44
R0328:Vmn2r112	UTSW	17	22605270	missense	probably benign	0.01
R0583:Vmn2r112	UTSW	17	22618949	missense	probably damaging	1.00
R0831:Vmn2r112	UTSW	17	22614999	missense	probably damaging	0.99
R1080:Vmn2r112	UTSW	17	22618999	missense	probably damaging	1.00
R1245:Vmn2r112	UTSW	17	22603247	missense	probably benign	0.03
R1321:Vmn2r112	UTSW	17	22618519	nonsense	probably null
R1381:Vmn2r112	UTSW	17	22618486	missense	probably damaging	1.00
R1514:Vmn2r112	UTSW	17	22602844	missense	probably benign	0.40
R1519:Vmn2r112	UTSW	17	22618903	missense	possibly damaging	0.83
R1572:Vmn2r112	UTSW	17	22603144	missense	possibly damaging	0.61
R1590:Vmn2r112	UTSW	17	22615008	critical splice donor site	probably null
R1640:Vmn2r112	UTSW	17	22605116	missense	probably benign	0.01
R2221:Vmn2r112	UTSW	17	22601233	missense	possibly damaging	0.86
R2223:Vmn2r112	UTSW	17	22601233	missense	possibly damaging	0.86
R2310:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2312:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2337:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2339:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2340:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2341:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2342:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2401:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2860:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2861:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R2926:Vmn2r112	UTSW	17	22615003	missense	possibly damaging	0.90
R3236:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3237:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3977:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R3979:Vmn2r112	UTSW	17	22603115	missense	probably damaging	0.98
R4168:Vmn2r112	UTSW	17	22603088	missense	probably benign	0.01
R4256:Vmn2r112	UTSW	17	22618412	missense	probably damaging	1.00
R4386:Vmn2r112	UTSW	17	22601322	missense	probably benign	0.36
R4912:Vmn2r112	UTSW	17	22603382	missense	probably damaging	0.99
R4947:Vmn2r112	UTSW	17	22602879	missense	probably benign	0.02
R5446:Vmn2r112	UTSW	17	22618250	missense	probably damaging	1.00
R5870:Vmn2r112	UTSW	17	22619023	missense	probably benign	0.00
R6351:Vmn2r112	UTSW	17	22601278	missense	probably benign
R6384:Vmn2r112	UTSW	17	22605155	missense	probably damaging	1.00
R6390:Vmn2r112	UTSW	17	22605249	missense	probably benign	0.01
R6401:Vmn2r112	UTSW	17	22603551	nonsense	probably null
R6405:Vmn2r112	UTSW	17	22618235	missense	probably damaging	1.00
R6620:Vmn2r112	UTSW	17	22603101	missense	probably benign	0.00
R6648:Vmn2r112	UTSW	17	22618486	missense	probably damaging	1.00
R6649:Vmn2r112	UTSW	17	22601179	missense	probably null	1.00
R6654:Vmn2r112	UTSW	17	22603469	missense	possibly damaging	0.89
R6700:Vmn2r112	UTSW	17	22603481	missense	possibly damaging	0.53
R6993:Vmn2r112	UTSW	17	22603214	missense	probably benign	0.01
R7052:Vmn2r112	UTSW	17	22602526	missense	probably benign
R7454:Vmn2r112	UTSW	17	22603307	missense	probably benign	0.00
R7763:Vmn2r112	UTSW	17	22603118	missense	probably damaging	1.00
R8032:Vmn2r112	UTSW	17	22603394	missense	probably benign	0.21
R8177:Vmn2r112	UTSW	17	22603613	missense	possibly damaging	0.47
R8263:Vmn2r112	UTSW	17	22605159	missense	probably damaging	1.00
R8395:Vmn2r112	UTSW	17	22618606	missense	possibly damaging	0.94
R8492:Vmn2r112	UTSW	17	22602489	missense	probably benign	0.03
Z1088:Vmn2r112	UTSW	17	22605078	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- ATGATTCCTCCAGGGGTGAG -3'
(R):5'- CTTGGGAAACATTCATGATGACTG -3'

Sequencing Primer
(F):5'- TTCCTCCAGGGGTGAGGAAAC -3'
(R):5'- CATGATGACTGTACATGGAAAACAC -3'

Posted On

2018-07-23