Incidental Mutation 'R6657:Vmn1r173'
ID 526664
Institutional Source Beutler Lab
Gene Symbol Vmn1r173
Ensembl Gene ENSMUSG00000115021
Gene Name vomeronasal 1 receptor 173
Synonyms Gm5892
MMRRC Submission
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.536) question?
Stock # R6657 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 23700703-23711009 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 23702895 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 185 (M185K)
Ref Sequence ENSEMBL: ENSMUSP00000153884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000174055] [ENSMUST00000226233] [ENSMUST00000227987]
AlphaFold E9Q8V7
Predicted Effect probably damaging
Transcript: ENSMUST00000174055
AA Change: M185K

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000134645
Gene: ENSMUSG00000115021
AA Change: M185K

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:V1R 43 301 5.3e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226233
AA Change: M185K

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000227987
AA Change: M185K

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 94.0%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405L10Rik T G 8: 105,708,818 L36R probably damaging Het
Akr1b3 C T 6: 34,310,004 V206M possibly damaging Het
Akr1b7 A C 6: 34,416,200 D106A probably damaging Het
Bhlhe40 TG TGG 6: 108,664,857 254 probably null Het
Chst5 C T 8: 111,890,274 R238Q probably benign Het
Cpxm2 T C 7: 132,049,077 Y618C probably damaging Het
Csnk1d T C 11: 120,964,994 E405G possibly damaging Het
Ctsh A T 9: 90,060,502 M37L probably benign Het
Eml5 T G 12: 98,791,405 I1843L probably damaging Het
Ep400 C A 5: 110,693,545 probably benign Het
Fbln2 A G 6: 91,259,750 N749S possibly damaging Het
Gpc5 A G 14: 115,370,198 H404R probably benign Het
Hyal6 A G 6: 24,734,758 D230G possibly damaging Het
Itga5 T C 15: 103,350,795 D735G probably damaging Het
Kansl2 T A 15: 98,524,670 Q339L possibly damaging Het
Lrp4 T A 2: 91,492,053 M1078K probably benign Het
Mmp24 A T 2: 155,798,179 Y143F probably damaging Het
Mroh7 A T 4: 106,702,500 C743* probably null Het
Myh14 T C 7: 44,637,846 N618D probably damaging Het
Myo19 A T 11: 84,897,196 M324L probably benign Het
Nectin2 T C 7: 19,738,140 N108S probably benign Het
Nrg2 A G 18: 36,196,589 I191T probably damaging Het
Odf4 T C 11: 68,926,812 N18D probably benign Het
Olfr1109 T A 2: 87,093,059 I113F probably benign Het
Pcsk2 T G 2: 143,690,366 L145V probably damaging Het
Pdzrn3 C A 6: 101,151,022 Q894H probably benign Het
Pfpl G A 19: 12,429,926 V514I probably benign Het
Plbd1 A T 6: 136,617,252 M333K probably damaging Het
Plec A T 15: 76,178,156 M2554K possibly damaging Het
Psmb5 A G 14: 54,614,383 Y115H possibly damaging Het
Rictor A G 15: 6,759,496 N198D possibly damaging Het
Rsrc2 A G 5: 123,739,567 probably benign Het
Sec16a C T 2: 26,425,864 W262* probably null Het
Sfmbt1 A G 14: 30,766,096 D8G possibly damaging Het
Sptbn5 T G 2: 120,076,400 probably benign Het
Sqor A G 2: 122,807,594 D139G possibly damaging Het
Sugt1 A T 14: 79,607,261 T139S probably benign Het
Tcp11 G A 17: 28,071,672 P159S probably damaging Het
Tmem262 A G 19: 6,080,512 T89A possibly damaging Het
Tnfaip6 C A 2: 52,043,783 T50N probably damaging Het
Ttll9 T C 2: 152,984,262 Y131H probably damaging Het
Vmn2r111 T C 17: 22,559,051 N549S possibly damaging Het
Vmn2r52 G A 7: 10,159,163 T683I probably damaging Het
Vps53 A T 11: 76,134,427 I197N probably damaging Het
Washc4 T A 10: 83,558,618 F269L possibly damaging Het
Wdfy4 C T 14: 33,047,251 V2086M possibly damaging Het
Zfp592 A T 7: 81,025,486 T733S possibly damaging Het
Zfp599 A G 9: 22,250,242 F209S probably damaging Het
Other mutations in Vmn1r173
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01490:Vmn1r173 APN 7 23702707 missense probably benign 0.01
IGL01637:Vmn1r173 APN 7 23702948 missense probably damaging 0.96
IGL01878:Vmn1r173 APN 7 23702452 missense probably damaging 1.00
IGL02036:Vmn1r173 APN 7 23702896 missense probably benign 0.04
IGL02039:Vmn1r173 APN 7 23702896 missense probably benign 0.04
IGL02171:Vmn1r173 APN 7 23702896 missense probably benign 0.04
IGL02209:Vmn1r173 APN 7 23703161 missense probably benign 0.25
PIT4515001:Vmn1r173 UTSW 7 23702486 nonsense probably null
R0157:Vmn1r173 UTSW 7 23702397 missense probably damaging 0.99
R0226:Vmn1r173 UTSW 7 23703083 missense possibly damaging 0.65
R0482:Vmn1r173 UTSW 7 23702791 missense probably damaging 0.99
R0792:Vmn1r173 UTSW 7 23702735 missense probably benign 0.01
R1242:Vmn1r173 UTSW 7 23703225 missense probably damaging 1.00
R1390:Vmn1r173 UTSW 7 23702898 missense possibly damaging 0.82
R1641:Vmn1r173 UTSW 7 23703108 missense probably benign 0.06
R1867:Vmn1r173 UTSW 7 23703235 missense unknown
R2325:Vmn1r173 UTSW 7 23703112 nonsense probably null
R3863:Vmn1r173 UTSW 7 23702552 missense probably damaging 1.00
R4407:Vmn1r173 UTSW 7 23703016 missense probably damaging 1.00
R4717:Vmn1r173 UTSW 7 23703212 missense probably damaging 1.00
R4841:Vmn1r173 UTSW 7 23702936 missense probably damaging 1.00
R4842:Vmn1r173 UTSW 7 23702936 missense probably damaging 1.00
R5966:Vmn1r173 UTSW 7 23702687 missense probably benign 0.00
R6022:Vmn1r173 UTSW 7 23702835 missense probably benign 0.07
R6114:Vmn1r173 UTSW 7 23702829 missense possibly damaging 0.53
R7165:Vmn1r173 UTSW 7 23702651 missense probably benign 0.00
R7195:Vmn1r173 UTSW 7 23702459 missense probably damaging 0.99
R7201:Vmn1r173 UTSW 7 23702158 start gained probably benign
R7533:Vmn1r173 UTSW 7 23702646 missense probably benign 0.05
R7951:Vmn1r173 UTSW 7 23703255 missense unknown
R8351:Vmn1r173 UTSW 7 23702532 nonsense probably null
R8374:Vmn1r173 UTSW 7 23702495 missense probably damaging 0.98
R8427:Vmn1r173 UTSW 7 23702534 missense probably damaging 0.99
R8451:Vmn1r173 UTSW 7 23702532 nonsense probably null
R8923:Vmn1r173 UTSW 7 23702343 start codon destroyed probably null 1.00
R9126:Vmn1r173 UTSW 7 23702583 missense probably benign 0.23
X0022:Vmn1r173 UTSW 7 23702587 missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- TGTGTCCTGAGCACTTACCAG -3'
(R):5'- CATGAGAATTGTGTATGCTGCTC -3'

Sequencing Primer
(F):5'- TGTTCCTGGCAAATGGAGTAGAATG -3'
(R):5'- CTGGCCTCTGGTTGAAGTCC -3'
Posted On 2018-07-23