Incidental Mutation 'R6658:Gpr161'
ID 526694
Institutional Source Beutler Lab
Gene Symbol Gpr161
Ensembl Gene ENSMUSG00000040836
Gene Name G protein-coupled receptor 161
Synonyms vl, LOC240888
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R6658 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 165123358-165154314 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 165134136 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 133 (T133S)
Ref Sequence ENSEMBL: ENSMUSP00000136621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111450] [ENSMUST00000178700]
AlphaFold B2RPY5
Predicted Effect probably benign
Transcript: ENSMUST00000111450
AA Change: T116S

PolyPhen 2 Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000107077
Gene: ENSMUSG00000040836
AA Change: T116S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 48 261 1.1e-6 PFAM
Pfam:7tm_1 57 337 3e-47 PFAM
low complexity region 476 489 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000178700
AA Change: T133S

PolyPhen 2 Score 0.496 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000136621
Gene: ENSMUSG00000040836
AA Change: T133S

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 63 273 1.5e-7 PFAM
Pfam:7tm_1 72 352 9.2e-48 PFAM
low complexity region 491 504 N/A INTRINSIC
Meta Mutation Damage Score 0.1168 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.7%
  • 20x: 96.5%
Validation Efficiency 96% (53/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Upon ligand binding, G protein-coupled receptors, such as GPR161, activate cytoplasmic G proteins (see GNAS, MIM 139320), allowing the receptors to transduce extracellular signals across the plasma membrane into the cell. Phosphorylation of the receptor attenuates signaling (Matteson et al., 2008 [PubMed 18250320]).[supplied by OMIM, Aug 2008]
PHENOTYPE: Mice homozygous for a null mutation display complete embryonic lethality during organogenesis, extensive craniofacial abnormalities, ventralization of the neural tube with expansion of the floor plate, absence of limb development, and caudal spina bifida. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts7 A G 9: 90,077,353 (GRCm39) N1340S probably damaging Het
Akr1b1 C T 6: 34,286,939 (GRCm39) V206M possibly damaging Het
Antxr1 C A 6: 87,261,291 (GRCm39) R167L probably damaging Het
BC107364 T C 3: 96,348,026 (GRCm39) S88G unknown Het
Cfap100 T G 6: 90,390,400 (GRCm39) E80A probably damaging Het
Dhx8 C A 11: 101,655,748 (GRCm39) H1107Q probably damaging Het
Dip2c G A 13: 9,543,213 (GRCm39) probably null Het
Dpep2 A T 8: 106,716,542 (GRCm39) D212E probably benign Het
Dpep3 T C 8: 106,705,728 (GRCm39) T66A probably benign Het
Fat4 G T 3: 38,997,077 (GRCm39) M1765I probably benign Het
Gbgt1 G A 2: 28,394,998 (GRCm39) R212H probably benign Het
Gimap4 T C 6: 48,668,338 (GRCm39) S215P possibly damaging Het
Grin2c G T 11: 115,149,108 (GRCm39) S163R possibly damaging Het
Grip2 T A 6: 91,763,472 (GRCm39) N109Y probably damaging Het
H60c G A 10: 3,210,270 (GRCm39) T93I possibly damaging Het
Hmgcl A G 4: 135,682,962 (GRCm39) N138S probably damaging Het
Hoxa3 G T 6: 52,147,058 (GRCm39) Y398* probably null Het
Igkv1-132 A G 6: 67,737,091 (GRCm39) N19S probably benign Het
Ikbip A G 10: 90,932,181 (GRCm39) N275S probably benign Het
Il7 T A 3: 7,642,239 (GRCm39) T33S probably benign Het
Iqgap2 A T 13: 95,796,840 (GRCm39) Y1105N probably damaging Het
Lmo7 A G 14: 102,148,281 (GRCm39) D934G possibly damaging Het
Mroh4 T C 15: 74,492,978 (GRCm39) Q310R possibly damaging Het
Mtmr14 C A 6: 113,242,437 (GRCm39) Y22* probably null Het
Muc5b G T 7: 141,422,244 (GRCm39) probably null Het
Naga T G 15: 82,214,975 (GRCm39) K328Q probably benign Het
Neo1 G A 9: 58,829,132 (GRCm39) T589I probably benign Het
Nme5 A C 18: 34,711,639 (GRCm39) I34S probably damaging Het
Nrip2 T C 6: 128,385,199 (GRCm39) L210P possibly damaging Het
Nup93 A G 8: 95,030,807 (GRCm39) D424G probably benign Het
Or12e9 T C 2: 87,202,497 (GRCm39) V207A probably benign Het
Or1e26 G A 11: 73,479,874 (GRCm39) S230F probably damaging Het
Papss1 T A 3: 131,311,696 (GRCm39) V308E probably benign Het
Pilrb1 T A 5: 137,855,789 (GRCm39) Y34F probably benign Het
Pira2 T A 7: 3,845,300 (GRCm39) E319D probably benign Het
Pkhd1 G A 1: 20,682,929 (GRCm39) T91M probably damaging Het
Prph2 A G 17: 47,230,790 (GRCm39) T228A probably benign Het
Ranbp17 G T 11: 33,169,214 (GRCm39) S1000* probably null Het
Rbm27 A C 18: 42,457,178 (GRCm39) H651P probably damaging Het
Scyl2 A T 10: 89,476,835 (GRCm39) D763E probably benign Het
Sltm A G 9: 70,488,644 (GRCm39) Y598C probably damaging Het
Smc2 A T 4: 52,451,322 (GRCm39) K322I probably benign Het
Tcf4 G A 18: 69,790,873 (GRCm39) R271Q probably null Het
Tex36 C T 7: 133,196,140 (GRCm39) D87N probably damaging Het
Tex44 A C 1: 86,354,751 (GRCm39) H220P probably benign Het
Tjp1 T C 7: 64,950,825 (GRCm39) D1683G possibly damaging Het
Trav7-2 T C 14: 53,628,573 (GRCm39) S104P probably damaging Het
Trim55 C T 3: 19,745,719 (GRCm39) R532C probably damaging Het
Ube3c T A 5: 29,807,215 (GRCm39) L338Q probably damaging Het
Ush2a A G 1: 188,546,556 (GRCm39) H3444R possibly damaging Het
Vars1 A G 17: 35,234,717 (GRCm39) D1182G probably benign Het
Vit T A 17: 78,930,232 (GRCm39) I399N possibly damaging Het
Vmn1r16 A T 6: 57,300,091 (GRCm39) L177* probably null Het
Other mutations in Gpr161
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00595:Gpr161 APN 1 165,146,372 (GRCm39) missense probably benign
IGL01090:Gpr161 APN 1 165,134,149 (GRCm39) missense probably damaging 1.00
IGL01151:Gpr161 APN 1 165,149,078 (GRCm39) missense probably damaging 1.00
IGL01763:Gpr161 APN 1 165,144,820 (GRCm39) missense probably benign 0.09
IGL03206:Gpr161 APN 1 165,149,218 (GRCm39) missense probably damaging 1.00
IGL03279:Gpr161 APN 1 165,138,098 (GRCm39) missense probably damaging 1.00
IGL03378:Gpr161 APN 1 165,138,077 (GRCm39) missense probably damaging 0.99
IGL03147:Gpr161 UTSW 1 165,144,877 (GRCm39) missense probably benign 0.30
R0367:Gpr161 UTSW 1 165,144,805 (GRCm39) splice site probably benign
R1827:Gpr161 UTSW 1 165,134,136 (GRCm39) missense possibly damaging 0.94
R1970:Gpr161 UTSW 1 165,133,927 (GRCm39) missense probably damaging 0.97
R1991:Gpr161 UTSW 1 165,134,132 (GRCm39) missense probably damaging 0.98
R2425:Gpr161 UTSW 1 165,138,192 (GRCm39) missense possibly damaging 0.83
R4805:Gpr161 UTSW 1 165,134,029 (GRCm39) missense probably damaging 1.00
R5416:Gpr161 UTSW 1 165,149,030 (GRCm39) missense probably benign 0.00
R5546:Gpr161 UTSW 1 165,133,982 (GRCm39) missense possibly damaging 0.88
R5547:Gpr161 UTSW 1 165,133,982 (GRCm39) missense possibly damaging 0.88
R5824:Gpr161 UTSW 1 165,138,560 (GRCm39) missense possibly damaging 0.94
R6152:Gpr161 UTSW 1 165,137,864 (GRCm39) missense possibly damaging 0.58
R6924:Gpr161 UTSW 1 165,149,188 (GRCm39) missense possibly damaging 0.83
R7128:Gpr161 UTSW 1 165,138,026 (GRCm39) missense possibly damaging 0.92
R7216:Gpr161 UTSW 1 165,134,115 (GRCm39) missense probably benign 0.22
R7540:Gpr161 UTSW 1 165,146,404 (GRCm39) missense probably damaging 1.00
R8171:Gpr161 UTSW 1 165,134,005 (GRCm39) missense probably damaging 0.98
R9053:Gpr161 UTSW 1 165,134,166 (GRCm39) splice site probably benign
R9076:Gpr161 UTSW 1 165,133,757 (GRCm39) missense possibly damaging 0.49
R9259:Gpr161 UTSW 1 165,138,025 (GRCm39) missense probably damaging 1.00
R9449:Gpr161 UTSW 1 165,146,389 (GRCm39) nonsense probably null
R9469:Gpr161 UTSW 1 165,133,896 (GRCm39) missense possibly damaging 0.61
Predicted Primers PCR Primer
(F):5'- CCTCAGCAACAAGTTCGTCTTC -3'
(R):5'- ACGCACGGGAACATCATATG -3'

Sequencing Primer
(F):5'- AACAAGTTCGTCTTCAGCCTGAC -3'
(R):5'- CATCATATGAGGTACTTGACTGTCC -3'
Posted On 2018-07-23