Incidental Mutation 'R6660:Rgsl1'
ID 526791
Institutional Source Beutler Lab
Gene Symbol Rgsl1
Ensembl Gene ENSMUSG00000042641
Gene Name regulator of G-protein signaling like 1
Synonyms 4930415K13Rik, Rgsl2
MMRRC Submission 044780-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6660 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 153655127-153719888 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 153701512 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 314 (N314I)
Ref Sequence ENSEMBL: ENSMUSP00000135642 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000124558] [ENSMUST00000185164]
AlphaFold A0A5F8MPV0
Predicted Effect possibly damaging
Transcript: ENSMUST00000124558
AA Change: N314I

PolyPhen 2 Score 0.699 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000135642
Gene: ENSMUSG00000042641
AA Change: N314I

DomainStartEndE-ValueType
low complexity region 122 136 N/A INTRINSIC
low complexity region 242 254 N/A INTRINSIC
low complexity region 316 325 N/A INTRINSIC
Pfam:RGS 644 754 7.1e-12 PFAM
transmembrane domain 956 973 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134030
Predicted Effect probably benign
Transcript: ENSMUST00000184095
Predicted Effect probably benign
Transcript: ENSMUST00000185164
AA Change: N349I

PolyPhen 2 Score 0.094 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000139340
Gene: ENSMUSG00000042641
AA Change: N349I

DomainStartEndE-ValueType
low complexity region 157 171 N/A INTRINSIC
low complexity region 277 289 N/A INTRINSIC
low complexity region 351 360 N/A INTRINSIC
Pfam:RGS 679 789 4.1e-11 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 98.3%
  • 20x: 95.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actg1 A T 11: 120,237,581 (GRCm39) I289N probably damaging Het
Atg5 A G 10: 44,170,651 (GRCm39) N99S probably benign Het
Ccdc88a A G 11: 29,432,663 (GRCm39) Q1223R probably benign Het
Cdc42 T C 4: 137,056,145 (GRCm39) D122G probably benign Het
Cpxm1 A G 2: 130,238,069 (GRCm39) S127P probably damaging Het
Cyfip2 A G 11: 46,140,634 (GRCm39) C730R possibly damaging Het
Ddx60 T A 8: 62,409,273 (GRCm39) H436Q probably benign Het
Dnah17 T C 11: 117,991,014 (GRCm39) Y1236C probably benign Het
Ep400 G A 5: 110,867,313 (GRCm39) R1000* probably null Het
Ergic3 A G 2: 155,859,754 (GRCm39) I227V probably damaging Het
Fam227b G T 2: 125,986,227 (GRCm39) P13Q probably damaging Het
Gal A G 19: 3,460,108 (GRCm39) L121P possibly damaging Het
Garin2 T C 12: 78,762,131 (GRCm39) V265A possibly damaging Het
Ifi207 T C 1: 173,556,972 (GRCm39) T589A probably benign Het
Intu T C 3: 40,586,100 (GRCm39) V27A probably benign Het
Lama1 A T 17: 68,111,495 (GRCm39) I2249L probably benign Het
Pdc T C 1: 150,209,086 (GRCm39) Y190H probably damaging Het
Pmm2 T C 16: 8,473,506 (GRCm39) L240P probably damaging Het
Polr1a T C 6: 71,944,358 (GRCm39) V1275A probably damaging Het
Rpe65 A T 3: 159,320,345 (GRCm39) N301Y probably damaging Het
Ryr1 A G 7: 28,737,770 (GRCm39) probably null Het
Sh3bp4 A G 1: 89,080,888 (GRCm39) S902G possibly damaging Het
Slc44a4 A T 17: 35,149,201 (GRCm39) R705W probably damaging Het
Slc4a10 A G 2: 62,080,747 (GRCm39) I325V possibly damaging Het
Spns1 A G 7: 125,974,237 (GRCm39) probably null Het
Syt6 T G 3: 103,532,960 (GRCm39) L363R probably damaging Het
Ttn A G 2: 76,544,759 (GRCm39) V32781A probably benign Het
Ube2l6 A G 2: 84,636,852 (GRCm39) T99A probably damaging Het
Unc13b A T 4: 43,177,412 (GRCm39) probably benign Het
Vmn1r189 A T 13: 22,286,066 (GRCm39) L257H possibly damaging Het
Vmn2r111 T C 17: 22,778,032 (GRCm39) N549S possibly damaging Het
Zfpm2 T C 15: 40,518,981 (GRCm39) probably null Het
Other mutations in Rgsl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01372:Rgsl1 APN 1 153,701,887 (GRCm39) missense probably damaging 1.00
IGL02253:Rgsl1 APN 1 153,669,513 (GRCm39) missense probably damaging 1.00
IGL02345:Rgsl1 APN 1 153,679,755 (GRCm39) splice site probably null
IGL02409:Rgsl1 APN 1 153,701,989 (GRCm39) missense possibly damaging 0.53
IGL02587:Rgsl1 APN 1 153,675,684 (GRCm39) missense probably damaging 1.00
IGL02652:Rgsl1 APN 1 153,701,236 (GRCm39) missense probably damaging 1.00
IGL02797:Rgsl1 APN 1 153,683,454 (GRCm39) missense probably damaging 1.00
IGL03032:Rgsl1 APN 1 153,701,948 (GRCm39) missense possibly damaging 0.53
IGL03082:Rgsl1 APN 1 153,675,693 (GRCm39) missense possibly damaging 0.86
IGL03123:Rgsl1 APN 1 153,701,687 (GRCm39) missense probably damaging 1.00
IGL03213:Rgsl1 APN 1 153,701,587 (GRCm39) missense probably benign 0.12
IGL03410:Rgsl1 APN 1 153,669,501 (GRCm39) missense probably null 0.82
Bam UTSW 1 153,669,898 (GRCm39) missense probably benign 0.00
Candygram UTSW 1 153,697,245 (GRCm39) nonsense probably null
wham UTSW 1 153,678,038 (GRCm39) missense probably benign 0.02
IGL03050:Rgsl1 UTSW 1 153,701,422 (GRCm39) missense possibly damaging 0.60
PIT4519001:Rgsl1 UTSW 1 153,701,716 (GRCm39) missense possibly damaging 0.96
R0149:Rgsl1 UTSW 1 153,669,510 (GRCm39) missense probably damaging 1.00
R0536:Rgsl1 UTSW 1 153,701,927 (GRCm39) missense probably damaging 1.00
R0633:Rgsl1 UTSW 1 153,719,853 (GRCm39) missense possibly damaging 0.72
R0726:Rgsl1 UTSW 1 153,678,074 (GRCm39) missense probably damaging 1.00
R0839:Rgsl1 UTSW 1 153,677,980 (GRCm39) critical splice donor site probably null
R1240:Rgsl1 UTSW 1 153,660,937 (GRCm39) missense probably benign 0.18
R1355:Rgsl1 UTSW 1 153,683,507 (GRCm39) start codon destroyed probably null 0.23
R1491:Rgsl1 UTSW 1 153,701,672 (GRCm39) missense possibly damaging 0.93
R1688:Rgsl1 UTSW 1 153,680,422 (GRCm39) missense probably damaging 0.98
R1694:Rgsl1 UTSW 1 153,680,422 (GRCm39) missense probably damaging 0.98
R1842:Rgsl1 UTSW 1 153,675,543 (GRCm39) missense probably damaging 1.00
R2008:Rgsl1 UTSW 1 153,701,651 (GRCm39) missense possibly damaging 0.53
R2114:Rgsl1 UTSW 1 153,693,295 (GRCm39) missense probably benign
R2116:Rgsl1 UTSW 1 153,693,295 (GRCm39) missense probably benign
R2176:Rgsl1 UTSW 1 153,701,014 (GRCm39) splice site probably benign
R2229:Rgsl1 UTSW 1 153,698,104 (GRCm39) missense possibly damaging 0.72
R2895:Rgsl1 UTSW 1 153,703,294 (GRCm39) missense probably damaging 1.00
R3923:Rgsl1 UTSW 1 153,679,876 (GRCm39) critical splice acceptor site probably null
R4001:Rgsl1 UTSW 1 153,693,330 (GRCm39) missense probably damaging 1.00
R4434:Rgsl1 UTSW 1 153,678,087 (GRCm39) missense possibly damaging 0.52
R4489:Rgsl1 UTSW 1 153,703,282 (GRCm39) missense probably benign 0.27
R4649:Rgsl1 UTSW 1 153,693,328 (GRCm39) missense probably benign 0.01
R4925:Rgsl1 UTSW 1 153,688,023 (GRCm39) missense probably benign 0.01
R4928:Rgsl1 UTSW 1 153,669,514 (GRCm39) missense probably damaging 1.00
R5045:Rgsl1 UTSW 1 153,697,268 (GRCm39) nonsense probably null
R5304:Rgsl1 UTSW 1 153,703,238 (GRCm39) missense probably damaging 0.97
R5331:Rgsl1 UTSW 1 153,678,038 (GRCm39) missense probably benign 0.02
R5373:Rgsl1 UTSW 1 153,666,053 (GRCm39) missense probably benign 0.33
R5374:Rgsl1 UTSW 1 153,666,053 (GRCm39) missense probably benign 0.33
R5566:Rgsl1 UTSW 1 153,669,520 (GRCm39) missense probably damaging 1.00
R5649:Rgsl1 UTSW 1 153,701,639 (GRCm39) missense possibly damaging 0.93
R6062:Rgsl1 UTSW 1 153,675,618 (GRCm39) missense possibly damaging 0.72
R6142:Rgsl1 UTSW 1 153,687,984 (GRCm39) missense probably benign 0.01
R6158:Rgsl1 UTSW 1 153,679,767 (GRCm39) missense possibly damaging 0.72
R6184:Rgsl1 UTSW 1 153,703,194 (GRCm39) missense probably benign 0.08
R6273:Rgsl1 UTSW 1 153,703,211 (GRCm39) missense possibly damaging 0.96
R6384:Rgsl1 UTSW 1 153,703,291 (GRCm39) missense possibly damaging 0.86
R6419:Rgsl1 UTSW 1 153,698,117 (GRCm39) missense probably damaging 0.98
R6568:Rgsl1 UTSW 1 153,697,292 (GRCm39) missense possibly damaging 0.72
R6745:Rgsl1 UTSW 1 153,698,063 (GRCm39) missense probably benign 0.18
R6892:Rgsl1 UTSW 1 153,697,245 (GRCm39) nonsense probably null
R6974:Rgsl1 UTSW 1 153,675,568 (GRCm39) missense probably damaging 1.00
R7172:Rgsl1 UTSW 1 153,701,966 (GRCm39) missense possibly damaging 0.72
R7200:Rgsl1 UTSW 1 153,660,945 (GRCm39) missense probably benign 0.33
R7275:Rgsl1 UTSW 1 153,679,876 (GRCm39) critical splice acceptor site probably null
R7313:Rgsl1 UTSW 1 153,683,622 (GRCm39) critical splice acceptor site probably null
R7341:Rgsl1 UTSW 1 153,669,591 (GRCm39) missense probably benign 0.01
R7448:Rgsl1 UTSW 1 153,719,847 (GRCm39) critical splice donor site probably null
R7662:Rgsl1 UTSW 1 153,701,225 (GRCm39) missense probably benign
R7703:Rgsl1 UTSW 1 153,669,610 (GRCm39) missense possibly damaging 0.73
R7846:Rgsl1 UTSW 1 153,701,783 (GRCm39) missense possibly damaging 0.53
R8408:Rgsl1 UTSW 1 153,701,435 (GRCm39) missense possibly damaging 0.96
R8860:Rgsl1 UTSW 1 153,697,100 (GRCm39) nonsense probably null
R8894:Rgsl1 UTSW 1 153,698,119 (GRCm39) critical splice acceptor site probably null
R9043:Rgsl1 UTSW 1 153,717,567 (GRCm39) missense possibly damaging 0.73
R9187:Rgsl1 UTSW 1 153,669,613 (GRCm39) missense possibly damaging 0.53
R9280:Rgsl1 UTSW 1 153,669,898 (GRCm39) missense probably benign 0.00
R9326:Rgsl1 UTSW 1 153,679,768 (GRCm39) missense probably benign 0.01
R9388:Rgsl1 UTSW 1 153,693,355 (GRCm39) missense probably benign
R9479:Rgsl1 UTSW 1 153,657,445 (GRCm39) missense unknown
X0020:Rgsl1 UTSW 1 153,701,131 (GRCm39) missense probably benign 0.33
X0065:Rgsl1 UTSW 1 153,679,779 (GRCm39) missense possibly damaging 0.84
Z1177:Rgsl1 UTSW 1 153,701,734 (GRCm39) missense not run
Z1177:Rgsl1 UTSW 1 153,693,356 (GRCm39) missense possibly damaging 0.70
Predicted Primers PCR Primer
(F):5'- GTACCCAAAGGAGAGGCTTC -3'
(R):5'- TATGAGCATCAAGAAATCCCGC -3'

Sequencing Primer
(F):5'- CGCTTGAGAGACTTCTTGACAAC -3'
(R):5'- AGTACTCAAGCAAGAAGGCC -3'
Posted On 2018-07-23